This invention discloses a
machine learning model integrating oral
microbiome and clinical features and its application in predicting
sarcopenia at high altitudes. The method targets high-altitude populations residing at altitudes >3500 meters, collecting oral
microbiome 16S rRNA
sequencing data, clinical features, and lifestyle data. Core predictive factors are selected through adaptive preprocessing and
elastic network regularized regression, and a classification model is constructed using
logistic regression. To address the sample imbalance problem in high-altitude areas, this scheme introduces a synthetic balanced sampling strategy based on
target distribution doubling; simultaneously, Platt Scaling is used for two-layer probability calibration, combined with a dynamic threshold optimization
mechanism based on F1-
Score to improve discrimination accuracy. This invention is the first to integrate oral
microbiome shaped by the high-altitude environment (such as…)… Selenomonas , Veillonella (etc.) are incorporated into the predictive model. Experiments show that the model achieves an AUC of 0.868 on the independent
test set and has advantages such as being completely non-invasive, low-cost, and highly interpretable. This invention provides an efficient early screening program for
sarcopenia in resource-scarce high-altitude areas.