The invention relates to a multifunctional particle used for stopping human body wounds bleeding, filling, absorbing fluid, preventing adhesion and inducing tissue regeneration and repair. The absorbable particle with multiple functions of stopping bleeding, filling, absorbing the fluid, preventing the adhesion and inducing the tissue regeneration and repair comprises the following raw materials in weight percentage: 30-98.95 percent of polyanionic substance, 1-70 percent of cationic substance and/or polycationic substance, 0.05-2 percent of hyaluronic acid and/or functional factor polypeptide and 0-68.95 percent of pharmaceutical excipient. The particle is 0.01-1.0mm in particle size, and the particle is irregular in shape. The absorbable particle material with the multiple functions of stopping bleeding, filling, absorbing the fluid, preventing the adhesion and inducing the tissue regeneration and repair can be used for stopping the human body wounds bleeding, filling, absorbing fluid, preventing the adhesion and inducing the tissue regeneration and repair and is especially suitable for the wounds and defective tissues during minimally invasive surgery.