Nano artificial dura mater with multi functional-layers and preparation method thereof

Abstract

The invention provides a nano artificial dura mater with a plurality of functional layers, which comprises a structure with at least two layers; the layer facing the brain is a hydrophobic anti-adhesion electrospun layer; and the layer back to the brain is a hydrophilic nano cytoskeletal layer. The invention also provides a method for preparing the nano artificial dura mater, which comprises the following steps: preparing an electrospun solution of a hydrophobic polymer; preparing an electrospun solution of a hydrophilic polymer; preparing the prepared electrospun solution of the hydrophobic polymer into the hydrophobic anti-adhesion electrospun layer through static spinning; and preparing the hydrophilic nano cytoskeletal layer on the anti-adhesion electrospun layer from the prepared electrospun solution of the hydrophilic polymer through static spinning, receiving a membrane structure, and obtaining the nano artificial dura mater. The mechanical features of the nano artificial dura mater can meet the requirements on tensile strength and flexibility of adaptation diseases; and the nano artificial dura mater can be freely cut as required, and has wide application prospect.

Description

technical field [0001] The invention relates to a nano-artificial dura mater with multiple functional layers and a preparation method thereof, belonging to the technical field of biomedicine. Background technique [0002] Dural defects are common in neurosurgery clinical work. Open craniocerebral injuries (industry, traffic, war, etc.), tumor erosion, congenital meningeal defects and other craniocerebral diseases can cause dural defects. The dural defect needs to be repaired in time to prevent cerebrospinal fluid from overflowing, to prevent the swelling of the brain and the compression of atmospheric pressure, otherwise it will endanger human life. Dural defects can also cause complications such as intracranial infection, brain adhesions, and subcutaneous fluid, often causing diseases such as epilepsy, headache, and brain dysfunction. [0003] Although there are many substitutes for dura mater, the materials for repairing dura mater can be divided into four categories: aut...

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Problems solved by technology

[0004] ①At present, autofascia reconstruction of dura mater is still the standard for clinical application, but the incidence of cerebrospinal fluid leakage and subcutaneous fluid in the early postoperative period is still high, which can easily lead to complications such as adhesions, which may cause non-healing or dysfunction of the donor site

[0005] ② Allogeneic and heterogeneous materials cannot completely avoid immune rejection, and the residual antigens will lead to different degrees of inflammatory reactions, resulting in fibrosis and brain adhesions

[0009] ⑥Different non-absorbable materials have their own shortcomings: for example, metals are not conducive to CT, MRI and radiological examination and treatment; Thick scars can be formed on the outside of the cloth, and the underside is easy to adhere to the brain; the carbon fiber itself has limited mechanical properties

[0010] ⑦ Existing absorbable artificial meninges have certain defects in degradation speed and degradation performance, and the scope of clinical application is limited

[0011] In short, there are deficiencies in the clinical application of artificial meninges at present, which are not conducive to large-scale industrial production and clinical promotion.

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