73 results about "Brain dysfunction" patented technology

This invention provides compositions, methods and process of producing extracts and pure compounds from Xanthoceras sorbifolia. The extract comprises saponins and other constituents including alkaloids, coumarins, saccharides, proteins, polysaccharides, glycosides, tannins, acid, flavonoids and others. The composition can be used for treating cancer and other conditions, such as arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, coronary heart disease, headache, kidney disorder, and impotence; for improving cerebral functions; or for curing enuresis, frequent micturition, urinary incontinence, dementia, weak intelligence and Alzheimer's disease, autism, brain trauma, Parkinson's, cerebral dysfunctions, and treating arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, headache, dizziness, kidney disorder. This invention provides compounds of oleanene triterpenoidal saponin in nature with the characteristics that at least one angeloyl group attached to Carbon 21 or / and 22, or / and linked to the sugar. The compounds of the present invention have various pharmaceutical and therapeutic applications.

The present invention provides an electrode designed for implantation into the central nervous system (CNS) of a mammal, wherein said electrode is substantially coated with interleukin-1 receptor antagonist (IL-1ra) or a coating composition comprising it, and the IL-1ra actively inhibits scarring on or around the surface of the electrode when implanted into the CNS. The electrode of the invention may be used for brain recording and / or stimulation, and can thus be used for treatment of a brain dysfunction, a brain disease or disorder, or a brain injury, as well as for brain computer interface, brain machine interface, or electrotherapy.

Systems and methods provided utilize gaze-tracking to measure quantitatively and accurately the ability of an athlete or other subject suspected of a concussion to maintain gaze within a figure-eight pattern during a given period of time. The fixation icon is presented at increasing velocities, with multiple staged velocities constituting the preferred embodiment. Utilizing a figure-eight pattern is preferred. Total tracking error time is tabulated during each velocity stage of the test protocol, and total tracking error time occurring during a given velocity stage is compared to a subject's baseline, e.g., a pre-season Individual Bioperformance Level (IBL) for that velocity stage. Systems and methods disclosed may be used to help prevent debilitating neurological damage in our athlete population, as well as having important military applications related to PTSD, and to other mission-critical performance endeavors.

The invention provides an emulsion composition containing nervonic acid, an emulsifier and water, wherein content of water in the emulsion composition is more than 70% in weight ratio, particle size of a fat globule in the emulsion composition is less than 5Mum, weight ratio of the emulsifier to the nervonic acid is 1:(0.1-6), and the emulsifier comprises one or more than one of the following substances: sucrose fatty acid ester, glyceryl monostearate, glycerol distearate, polyglycerol fatty acid ester, sodium stearoyl lactate and sorbitan fatty acid ester. The invention also provides a preparation method of the emulsion composition and application of the emulsion composition in a health product which is orally taken for supplementing the nervonic acid or unsaturated fatty acid and is used for preventing and treating diseases such as cranial nerve degenerative change, disordered brain function and the like.

The present invention discloses a medicine composition. Said medicine composition contains troxerutin obtained by making rutin undergo the process of hydroxyethylation, brain extract extracted from brain tissue of mammal except for human being and ganglioside extracted from brain tissue of mammal except for human being. Said invention also provides the concrete mixing ratio of the above-mentioned three components, and provides its preparation process and application.

The invention provides a crossed transcranial magnetic stimulation coil for improving stimulation depth, the coil is composed of an 8-shaped coil and a Halo coil, the Halo coil surrounds the short axis of the 8-shaped coil, and the upper boundary of the Halo coil is always above the center of the 8-shaped coil. The two parts of the 8-shaped coil are respectively connected with currents in opposite directions to generate a focusing magnetic field, the current direction of the upper boundary of the Halo coil is consistent with the current direction of the tangent position of the 8-shaped coil, and the advantage of stimulation depth is provided. The influence of the Halo coil on the 8-shaped coil is changed by changing the included angle and the distance between the Halo coil and the 8-shaped coil, so that the change relationship between the focusing property and the stimulation depth of the crossed coil is balanced. Based on evaluation standards, compared with an existing deep HFA stimulation coil, the deep HFA stimulation coil has higher stimulation intensity, smaller focusing area and better stimulation depth, and a novel tool with high potential is provided for transcranial magnetic stimulation research and treatment of deep brain dysfunction diseases.

The invention belongs to the fields of food and biotechnology and relates to a preparation method of a fruit and vegetable fermented low-alcohol beverage. Dragon fruits, apples, carrots, pumpkins andskimmed milk powder are subjected to mixed fermentation so as to supplement proteins, folic acid, cellulose, anthocyanin, various vitamins, trace elements and the like required for a human body; and pumpkins, phytosterin and allicin are added so as to reduce the cholesterol value of the fruit and vegetable fermented beverage. The fruit and vegetable beverage prepared by the preparation method provided by the invention can be properly drunk to relieve cardiovascular and cerebrovascular diseases, brain dysfunction and cancer situations. The preparation method provided by the invention has the advantages that multiple strains are subjected to mixed fermentation, and aerobic bacteria and anaerobic bacteria are interacted, so that nutritional components of fruits and vegetables are fully utilized; mixed strains are subjected to lactic acid fermentation by utilizing soluble nutrients of the fruits and the vegetables, and lactic acid bacteria generate multiple vitamins in the fermentation process; after fruit and vegetable juice is fermented, the contents of riboflavin, thiamine, pyridoxine, glutamic acid and the like are increased, so that the nutritional value is improved; and the prepared beverage is unique in flavor, more favorable for human health and capable of improving immunity.

The present invention derives from the finding that increased levels of Toll like receptor 4 (TLR4) is associated with liver failure and renal dysfunction and / or brain dysfunction and that by decreasing TLR4 levels in vivo, the kidney and brain consequences of liver disease that are precipitated by superimposed infection or inflammation may be reduced. Accordingly, the invention provides TLR4 antagonists for use in a method of treating an individual suffering from liver disease presenting with renal or brain dysfunction.

The invention provides a method for preparing Oxiracetam, which comprises the following steps: performing alkaline treatment of 4-hydroxy-2-pyrrolidone under a water-free condition; reacting the treated 4-hydroxy-2-pyrrolidone with 2-chloroacetamide in an organic solvent in the presence of a catalyst; and after the reaction is finished, performing filtration, distillation and recrystallization toobtain the Oxiracetam. In the method, the final product can be obtained by a one-step reaction, the operation is simple and convenient, and large scale production can be realized. The invention also provides the Oxiracetam obtained by the method, which has the characteristics of high yield, high purity and good treatment effect. The invention also provides the use of the Oxiracetam obtained by the method in the preparation of medicaments for treating brain dysfunction, impaired memory and senile dementia.

An indole derivative represented by the following general formula (1):wherein at least one of R1, R2, R3, and R4 represents an alkoxy group containing 1 to 20 carbon atoms, and other groups of the R1, R2, R3, and R4 represent hydrogen, an alkyl group containing 1 to 6 carbon atoms, acetyl group, or hydroxyl group; and either one of X and Y represents —(CH2)nOH wherein n is an integer of 0 to 30, and the other one of the X and Y represents hydrogen atom; or a salt thereof; and a drug and an agent for promoting differentiation of a stem cell containing such indole derivative or its salt as an effective component, wherein the indole derivative (1) has action of inducing differentiation of neural stem cell specifically into a neuron, and this indole derivative is useful as a prophylactic or therapeutic drug for brain dysfunction or neuropathy caused by loss or degeneration of the neuron.

The present invention relates to a Chinese medicine for curing brain dysfunction. Said Chinese medicine is made from 12 Chinese medicinal materials of ginseng, lycium berry, polygala root, drynaric root, flowery knotweed root, polygonatum root and others.

A system for evaluating the degree of brain dysfunction of a subject, such as a decline in cognitive function, calculates a difference in movement functions between both hands in a coordination movement. The system includes a storage device for storing time-series data on a finger movement task of each of both hands of a test subject acquired by a movement sensor; a data processing device for analyzing the time-series data stored in the storage device; and a display device for displaying an analysis result analyzed by the data processing device. The data processing device includes a movement waveform generation unit for generating a movement waveform corresponding to the time-series data stored in the storage device; and a difference-between-hands feature quantity generation unit for generating a difference-between-hands feature quantity which represents a difference in respective finger movement tasks between both hands, based on the respective movement waveforms of both hands.