115 results about "Hematoma" patented technology

The invention discloses a cerebral hemorrhage prognosis analysis system fusing images and clinical data, and the system comprises the steps: carrying out the collection time point alignment of cerebral hemorrhage image data and clinical diagnosis and treatment data, and constructing a multi-modal time sequence association data set; hematoma region segmentation and surrounding structure compression analysis are carried out, and hematoma morphological features and placeholder effect features are extracted to form an image risk feature set; carrying out index fluctuation analysis and collaborative abnormal mode identification based on clinical data, and screening risk sensitive indexes with a linkage relationship to form a clinical risk factor set; consistency detection is carried out on the two types of risk features, deviation causes are traced, modal weight configuration is determined according to the consistency detection, differential fusion is executed, and a fusion prognosis feature vector is generated; two-dimensional risk layering of function prognosis and survival prognosis is carried out, the confidence coefficient is evaluated and predicted in combination with modal consistency and feature stability, a structured prognosis analysis report with a confidence level is output, and interpretable decision support is provided for prognosis evaluation of cerebral hemorrhage patients.

The invention relates to a cerebral hemorrhage hematoma enlargement prediction method, system and device and a medium. The method comprises the following steps: acquiring baseline NCCT and CTA images of a patient; hematoma segmentation and three-dimensional reconstruction are carried out, and a key quantitative feature surface regularity index (SRI) and a density variation coefficient (DCV) are calculated; and inputting the SRI, the DCV and the clinical variables into the prediction model, and outputting the hematoma expansion risk probability. The prediction model is subjected to variable screening and strict verification, and risk visualization is realized through a column graph. The system comprises an image processing module, a feature calculation module, a prediction analysis module and a visualization module. According to the method, SRI and DCV are innovatively introduced to accurately quantify the hematoma morphology and density characteristics, and clinical variables are combined, so that the prediction accuracy and stability are remarkably improved; the efficiency is improved through AI-assisted segmentation; and the column graph enhances the model interpretability and the clinical decision support capability.

The traction type midwifery assist device comprises an outer head sleeve and an inner head sleeve, and the outer head sleeve comprises an outer sleeve and an elastic clamping jaw; the inner head sleeve comprises a sleeve body, a traction pull rod and a covered edge. On one hand, on the basis of collaborative design of the elastic clamping jaws and the sleeve body, initial wrapping can be formed along with automatic outward expansion and inward contraction of the fetal head during midwifery, the edge of the sleeve opening is driven to be overturned and tightened inwards by means of the opposite acting force of the traction pull rod and the outer sleeve, dynamic gradual wrapping of the fetal head is achieved, wrapping traction can be achieved after the outer head sleeve is detached outwards, and the operation is convenient. The risk of fetal head slippage is reduced, the traction stability is enhanced, scalp hematoma, tissue injury and maternal soft birth canal injury possibly caused by traditional negative pressure suction are effectively avoided, and the safety of a mother and an infant is improved; and on the other hand, the matching of the claw tips and the covered edges is ingeniously utilized, so that the interference of the covered edges on the size change of the sleeve opening is reduced, and a smaller covering opening can be provided during inward turning covering so as to increase the covering force formed by the sleeve body and the fetal head.

The invention discloses a cerebral hemorrhage risk prediction method and system based on multi-modal learning, and relates to the technical field of medical detection. The cerebral hemorrhage risk prediction method and system based on multi-modal learning comprises the following steps: S1, collecting craniocerebral multi-modal data, and preprocessing the craniocerebral multi-modal data; s2, identifying a high-gray-scale suspicious region, quantifying bleeding features of the corresponding region, and marking a suspected hematoma region; s3, the cerebral hemorrhage risk degree of the suspected hematoma area is evaluated, the risk level is judged based on the evaluation result, and a hierarchical regulation and control strategy is generated; and S4, based on the cerebral hemorrhage risk assessment results of the current assessment period and the historical assessment period, performing quantitative assessment on the cerebral hemorrhage risk level fluctuation state, and dynamically updating the risk threshold. The problems that in early cerebral hemorrhage recognition in the prior art, tiny hemorrhage lesions are difficult to find, risk dynamic evaluation cannot be achieved, and therefore clinical judgment and intervention opportunities are affected are solved.

The invention provides a handheld photoacoustic multi-mode vascular puncture and tissue damage diagnosis system and device, and belongs to the technical field of photoacoustic imaging. According to the handheld multispectral photoacoustic imaging device, elastic force feedback and blood vessel real-time development are integrated, and the puncture success rate is increased by 30%; by virtue of hemoglobin / collagen double-index imaging, the stress injury can be pre-warned 72 hours in advance; the 3D hematoma volume automatically calculates an error lt; and repeated puncture and missed diagnosis are remarkably reduced. The invention provides a quantitative evaluation and real-time navigation integrated scheme for vascular puncture and tissue damage, and is safe and efficient.

The invention discloses a cerebral hemorrhage heterogeneity quantitative evaluation system based on cyclic cross-attention clustering, and relates to the field of cerebral hemorrhage evaluation, and the system comprises an image segmentation module which is used for carrying out the three-dimensional segmentation of a brain plain-scan CT image through an nnU-NetV2 model, and outputting the binary masks of a hematoma region and an edema region; the feature extraction module is used for extracting high-dimensional pixel features from the mask region and generating an initial feature embedding matrix; the cyclic cross-attention clustering module is used for dynamically updating a clustering center through a multi-scale cyclic EM cross-attention mechanism and executing clustering analysis on the feature embedding matrix; the heterogeneity scoring module is used for calculating information entropy and generating hematoma and edema heterogeneity scores; and the prognosis prediction module is used for predicting the hematoma expansion risk and the neural function outcome through a machine learning model. According to the scheme, objective quantification of cerebral hemorrhage heterogeneity can be realized, and the prediction accuracy of the hematoma expansion risk and the neural function outcome is improved.

The invention belongs to the technical field of traditional Chinese medicines, and provides an external traditional Chinese medicine composition for tendon injury, blood stasis, swelling and pain and bone impediment. The traditional Chinese medicine composition comprises the following components: prepared kusnezoff monkshood root, lycopodium clavatum, garden burnet, rheum officinale, radix clematidis, ligusticum wallichii, rhizoma zingiberis, angelica sinensis, Sinkiang lithospermum, peach kernel, fried gardenia, turmeric, radix angelicae pubescentis, asarum, notopterygium root, sappan wood, red paeony root, garden balsam stem, vinegar frankincense, vinegar corydalis tuber, vinegar myrrh, vinegar rhizoma cyperi, bran-fried fructus aurantii and golden cypress. The invention further discloses a preparation method and application of the traditional Chinese medicine composition for tendon injury, blood stasis, swelling and pain and bone impediment. The traditional Chinese medicines perform respective functions in monarch, minister, assistant and guide, the whole formula has the effects of promoting blood circulation to remove blood stasis, activating meridians to stop pain, dispelling wind and eliminating dampness, and reducing swelling and removing stasis, a synergistic treatment effect on tendon injury, blood stasis, swelling and pain and bone impediment is formed through a multi-target-point synergistic effect, the limitation that a traditional Chinese medicine with a single effect is difficult to comprehensively deal with is solved, and the effect of treating both symptoms and root causes is achieved; the traditional Chinese medicine composition has remarkable social benefits and clinical application value.

The invention discloses application of an NR1D1 protein phosphorylation site in preparation of cerebral hemorrhage treatment drugs, and belongs to the technical field of molecular biology. According to the invention, the specific phosphorylation site and phosphorylation modification level of the NR1D1 protein are determined for the first time, and the NR1D1 protein can be used as a key marker for evaluating the secondary nerve injury degree of the hemorrhagic cerebral apoplexy and developing treatment and / or alleviation of the hemorrhagic cerebral apoplexy; a specific antigen peptide and an antibody for accurately detecting the NR1D1 protein phosphorylation site are further constructed, and an efficient tool is provided for molecular evaluation of hemorrhagic stroke secondary nerve injury; meanwhile, polypeptide molecules capable of inhibiting NR1D1 protein phosphorylation are researched and developed, through the dual effects of specifically blocking the phosphorylation process and reducing protein degradation, necrosis of brain tissues around hematoma after hemorrhagic cerebral apoplexy is relieved, secondary dyskinesia is improved, and the effect of inhibiting NR1D1 protein phosphorylation is achieved. And a brand new scheme is provided for molecular evaluation and targeted intervention of hemorrhagic stroke secondary nerve injury.

A wearable monitor is configured for early detection of internal bleeding events and particularly hematomas after vascular catheterization including cardiac catheterization. The wearable monitor is placed over an access location following the vascular catheterization procedure and the wearable monitor system periodically runs diagnostic test to detect changes in the tissue around the vascular access location. An emitter device may input an emitter input into the tissue and a detector device may then measure the emitter input after it has passed through the tissue, an emitter output. A computer may receive the data from the detector device and operate a program that determines changes in the tissue and in particular, pooling of blood in the tissue. The emitters may be electrodes that input an electromagnetic input, or an ultrasound emitter that inputs ultrasound sound waves, or a Near IR emitter that emits Near IR electromagnetic radiation.

The invention discloses an application of abscisic acid in preparation of a medicine for improving secondary brain injury after cerebral hemorrhage, the abscisic acid can relieve neuroinflammation and improve neurological function recovery by repairing microglial cell lysosome functions, enhancing phagocytic ability and promoting hematoma removal, and a new medicine strategy is provided for cerebral hemorrhage treatment.

The application discloses a post-varicose vein surgery wound compression hemostasis device, which comprises a device main body for fixing on a limb, a pressure increasing module arranged on the device main body and an anti-reverse mechanism. The pressure increasing module comprises a rotating handle rotatably arranged on the device main body, a pressure push rod with a top end threadedly connected with the rotating handle and a compression pad arranged at the bottom end of the pressure push rod; the pressure push rod is slidably connected with the device main body. When the rotating handle is rotated clockwise, the pressure push rod is driven to move towards the skin side, so that the compression pad applies compression pressure on the wound. The anti-reverse mechanism is connected with the rotating handle and is used for preventing the rotating handle from being rotated counterclockwise, thereby preventing the compression pressure from being released accidentally. The device can accurately and stably maintain the compression pressure on the wound, avoids postoperative rebleeding or hematoma formation caused by pressure attenuation, and has the characteristics of convenient operation, safety and reliability.

This invention relates to the application of LAG3 agonists in the preparation of drugs for hematoma clearance after intracerebral hemorrhage (ICH) and the application of LAG3 in regulating hematoma clearance after ICH, belonging to the field of biomedical technology. This invention utilizes a mouse ICH model to first inject a LAG3 neutralizing antibody (C9B7W) via orthotopic injection, clarifying that LAG3 can regulate the phagocytic function of microglia after ICH and participate in hematoma clearance, revealing its potential molecular target for enhancing microglia phagocytic function and promoting hematoma clearance. Furthermore, overexpression of LAG3 after ICH is demonstrated. Lag3 The study confirmed that enhanced phagocytic function of microglia accelerated hematoma clearance, demonstrating that LAG3 agonists can be used as drugs for hematoma clearance after intracerebral hemorrhage. The experimental results of this invention make it possible to apply LAG3 to the prognostic treatment of ICH, thereby advancing basic and clinical research on endogenous hematoma clearance after ICH.

The invention relates to the technical field of medical apparatus and instruments, in particular to multifunctional forearm hematoma compression equipment for cardiology department patients after coronary angiography, which comprises a base, a first supporting seat, a second supporting seat and the like, and the base is provided with the first supporting seat and the second supporting seat which are respectively used for supporting a forearm and an upper arm; the first supporting base and the second supporting base are each provided with an arc-shaped bearing plate with the concave middle, the ends of the bearing plates are each provided with an elastic fixing band, and the ends of the fixing bands are detachably connected with the bearing plates through buckles. The forearm of a patient is pressed by arranging the height-adjustable sleeve with the elastic piece, the effect of conveniently adjusting the pressing force and improving the experience of the patient is achieved, meanwhile, by arranging the buckle structure at the end of the fixing band, the fixing band can be conveniently tightened and loosened, then an ice bag can be conveniently used for cold compress, and the use effect is good. The forearm pressure of the patient is reduced, and hematoma enlargement is avoided.

The application discloses a signal processing system based on deep learning and a sensitivity enhancement method thereof, and is applied to the field of intelligent medical treatment.The application comprises the following steps: acquiring a needle tip original signal obtained through continuous monitoring in a puncture process; performing short-time Fourier transform on the basis of the original signal to obtain a channel signal short-time Fourier transform result; calculating a phase angle of the channel signal short-time Fourier transform result and then inputting the phase angle into an exponential function to obtain a channel signal feature; and inputting the channel signal feature into an element-by-element activation function to calculate a deep feature vector.The application not only shortens the operation time, but also directly reduces the risks of blood vessel injury, local hematoma and infection caused by repeated puncture, alleviates the pain of patients, and is especially beneficial to high-risk patients such as coagulation dysfunction.

This invention provides the application of fractalkine in the preparation of drugs for the prevention or treatment of white matter injury repair. In animal models of cerebral hemorrhage, it was found that the mass effect of hematoma in the basal ganglia and the neurotoxic products generated by its lysis lead to damage to surrounding white matter fiber bundles. Fractalkine plays an important role in regulating microglial activation after cerebral hemorrhage to promote white matter repair.

This invention relates to a deep learning-based system and method for predicting hematoma expansion in spontaneous intracerebral hemorrhage. The system includes a data acquisition module for acquiring the patient's baseline head CT image data, corresponding clinical information, and blood index data; a quantization feature calculation module for performing three-dimensional hematoma segmentation on the CT image data to obtain a three-dimensional hematoma mask; a multi-dimensional feature extraction module, including a three-dimensional morphological feature extraction sub-network and a temporal feature extraction sub-network; a feature fusion module for acquiring high-dimensional features; and a risk prediction module for outputting the risk probability of hematoma expansion based on the high-dimensional features and generating a corresponding visualized risk factor weight map. This system deeply integrates data-driven three-dimensional morphological depth features and temporal features with knowledge-driven surface regularity index and density variation coefficient quantization indicators, improving feature mining capabilities while ensuring sensitivity to key pathological morphologies, thus enhancing the robustness and accuracy of prediction.

Described are methods and systems for transcervical access of the cerebral arterial vasculature and treatment of cerebral occlusions, including ischemic stroke. The methods and devices may include methods and devices which may provide aspiration and passive flow reversal, those which protect the cerebral penumbra during the procedure to minimize injury to brain, as well as distal catheters and devices to remove an occlusion. The methods and devices that provide passive flow reversal may also offer to the user a degree of flow control. Devices and methods which provide a way to securely close the access site in the carotid artery to avoid the potentially devastating consequences of a transcervical hematoma are also described.

A method of aspirating a hematoma from a body space via a catheter coupled to a pump assembly includes advancing a tip of the catheter into proximity with the hematoma within the body space. The pump assembly includes a pump, a motor, a sensor, and a controller. The method further includes actuating the pump assembly to: operate the pump in a first mode during which the motor drives the pump at a first aspiration speed; receive at the controller a pressure signal associated with a catheter pressure from the sensor of the pump assembly; and on a condition that the catheter pressure is below a pressure threshold, operate the pump in a second mode during which the motor drives the pump cyclically between a second aspiration speed and an infusion speed such that the catheter pressure cycles between an upper pressure limit and a lower pressure limit.

The application discloses an intelligent indwelling needle puncture robot under ultrasonic guidance and a system thereof, and belongs to the field of medical instruments, and comprises a multi-degree-of-freedom mechanical arm system, a high-definition ultrasonic imaging module, a central processing and control unit, a man-machine interaction interface and a safety monitoring and emergency unit; the multi-degree-of-freedom mechanical arm system comprises a probe control mechanical arm and a puncture execution mechanical arm, and the probe control mechanical arm is used for clamping and adjusting the position and posture of an ultrasonic probe; the application is characterized in that the high-definition ultrasonic imaging module is used for optimizing the image, an AI blood vessel recognition and segmentation module is combined to accurately recognize the blood vessel and obtain relevant parameters, an intelligent path planning module is used for planning an optimal path for avoiding dangerous areas, and the multi-degree-of-freedom mechanical arm system is used for fine operation, so that the problem of insufficient accuracy caused by poor blood vessel conditions in manual puncture is effectively solved, the probability of repeated puncture is reduced, and complications such as blood vessel injury and hematoma are reduced.

The invention discloses an application of sunitinib in preparation of a medicine for treating secondary injury caused by intracranial hemorrhage. It is found for the first time that sunitinib can act on a CSF-1R / PI3K / Akt axis, pathological activation and pro-inflammatory response of microglial cells are effectively inhibited, the normal phagocytic function and lipid metabolism balance of the microglial cells are remarkably recovered, myelin sheath damage around hematoma is effectively relieved, and the neurological function score, the movement coordination ability and the exploration behavior of ICH mice are remarkably improved; the progress of secondary injury caused by intracranial hemorrhage is hindered from multiple dimensions, the curative effect is superior to that of a positive control drug pecetinib (PLX3397), and a brand new molecular target and an interference strategy are provided for comprehensive treatment of ICH.

The present invention relates to a cerium oxide nanocomposite, a method for preparing the same, and a composition for preventing or treating inflammatory or autoimmune diseases comprising the cerium oxide nanocomposite as an active ingredient. The present invention can be used as an excellent therapeutic composition in which the surface of cerium oxide nanoparticles is modified with an optimal content of a pyrrolidone-derived polymer to maximize both biological stability and in vivo reactive oxygen scavenging efficiency at the same time. Furthermore, the nanocomposite preparation method of the present invention can prepare uniform particles having an optimal diameter while thoroughly removing reaction residues and nitrate-derived toxicity by a simple process in which washing is performed using a sodium chloride solution of a specified concentration. The nano-composite disclosed by the invention can be used for remarkably inhibiting inflammatory reactions in various tissues. The composition is especially suitable for being used as an excellent treatment composition, and neuronal damage caused by excessive inflammatory reaction in hematoma surrounding areas after cerebral hemorrhage can be reduced to the maximum extent, so that the neurological function is recovered, and the survival rate of patients is remarkably increased.

The utility model discloses a novel coronary artery balloon dilatation catheter, which relates to the technical field of medical instruments and comprises a catheter, the outer surface of the catheter is connected with a balloon, the surface of one end of the catheter is connected with a probe in a penetrating manner, and the outer surface of one end of the catheter is provided with an adjusting unit. A plurality of miniature blades are annularly arranged on the outer surface of the balloon, the catheter is matched with the catheter through an adjusting seat, a movable column and a limiting ball, the insertion speed of the catheter is adjusted, and the placement speed of the catheter is adjusted through the matching of three adjusting blocks, a shifting block, a limiting pin, an adjusting groove, a pin hole and the movable column. The catheter inserting speed is conveniently controlled, the placing stability is improved, the operation time is shortened, the adjusting frequency is reduced, the catheter is conveniently placed in, the second catheter cavity is matched with the probe and the miniature blade, the hematoma position is conveniently broken, suction is conducted through the negative pressure device, the hematoma position is conveniently and rapidly dredged, and blood vessels are prevented from being blocked by the hematoma.

The invention belongs to the technical field of biological medicines, and particularly relates to a culture reagent composition and a culture method for a malignant tumor organ of a blood system. The invention firstly provides a reagent composition for culturing a hematological malignant tumor organoid, wherein the hematological malignant tumor comprises acute lymphoblastic leukemia or acute myeloid leukemia; the reagent composition comprises a bone marrow microenvironment simulation matrix reagent and a specific culture medium. By adopting the reagent composition provided by the invention, the hematoma organs can be efficiently cultured, and the survival rate is high. And compared with Matrigel matrigel commonly used in the field, the bone marrow microenvironment simulation matrix component adopted by the invention enables phenotypic differentiation of hematoma organs to be more accurate.

The utility model discloses an intramedullary needle for treating fracture and convenient to hold, which is provided with a treatment section and a holding section for operating and holding, and a positioning structure for holding and positioning is further arranged on the holding section. The intramedullary needle conforms to tubular bone biological fixation, the treatment section can be effectively prevented from rotating in the surgical treatment operation process through the holding section, the penetration depth and path of the treatment section can be further accurately controlled, the treatment accuracy is improved, and the treatment duration is shortened. When the intramedullary needle is used in the treatment process of metacarpal bone fracture, further damage to fracture local hematoma and periosteum can be avoided through closed reduction, blood supply of sclerotin is protected, and fracture healing is facilitated. The intramedullary needle is small in trauma, small in wound scar and beneficial to attractiveness; intramedullary fixation retains the minimally invasive characteristic of kirschner wire fixation, and the fixing effect is more stable and lasting than that of a kirschner wire, and the articular surface is not damaged.

The application provides a blood pump, which comprises a pump shell, a pipeline assembly and an impeller, the pump shell is provided with a receiving cavity; the pipeline assembly comprises a liquid outlet pipe communicated with the receiving cavity, the liquid outlet pipe is provided with a liquid outlet, the pipeline assembly is further provided with a liquid inlet, the liquid inlet is communicated with the receiving cavity, the pipeline assembly can be arranged on the ventricular wall so that the liquid inlet is located in the ventricle, the liquid outlet pipe has a certain length, so that when the pipeline assembly is arranged on the ventricular wall, the liquid outlet pipe can extend to the aortic valve through the ventricle, and the liquid outlet is located in the aorta; the impeller is rotatably arranged in the receiving cavity, so that the liquid in the receiving cavity from the liquid inlet can flow out from the liquid outlet through the liquid outlet pipe. The blood pump provided by the application can pump the blood in the ventricle to the aorta without setting an artificial blood vessel, avoids the aortic diseases such as dissection and hematoma caused by the hole on the aorta, and reduces the operation difficulty. The application further provides a ventricular assist system.

The application belongs to the technical field of medical hydrogel, and particularly relates to a preparation method of a hydrogel for treating subdural hematoma. The preparation method of the hydrogel for treating subdural hematoma comprises the following steps: subjecting a main body material to a Fenton reaction polymerization reaction to form the hydrogel for treating subdural hematoma; and the main body material is one of acrylamide-polyethylene glycol-amino, methacrylic acid polyethylene glycol ether, alpha-acrylate base-omega-carboxyl polyethylene glycol and polyethylene glycol diacrylate. The hydrogel for treating subdural hematoma has good biological safety and can be degraded in vivo.

The application provides a cerebral hemorrhage CT hematoma segmentation and puncture channel planning system, which comprises a host computer, an image segmentation module, a target planning module, an avoidance constraint module and a channel optimization module are configured on the host computer; the image segmentation module pre-processes and segments head CT image sequence data to obtain standardized three-dimensional head CT image data and multi-dimensional anatomical structure mask data; the target planning module determines puncture target core data accordingly; the avoidance constraint module generates joint avoidance data of dangerous tissues and a range of available entry areas accordingly; the channel optimization module generates a set of alternative spatial puncture paths according to the target core data, the avoidance data and the range of available entry areas, and determines a target optimal puncture channel. The application can better balance the targeting and safety of cerebral hemorrhage puncture treatment.

The present application relates to hemodialysis wound bleeding alarm technical field, specifically, it relates to a kind of hemodialysis wound bleeding alarm device based on biosensor, it includes installation box and the fixing band being arranged below installation box, sensor alarm device is arranged on installation box, disinfection component, pressing component, air cooling component and ice compress component are arranged in installation box;Through structure integration and function synergy, bleeding monitoring, dynamic disinfection, accurate ice compress and intelligent alarm are organically combined, effectively make up the deficiencies, such as the rough management of existing technology to long-term bedridden hemodialysis patient puncture point, infection and hematoma prevention and control lag, significantly improve the safety of hemodialysis passage nursing.

The invention discloses a traditional Chinese medicine composition for relieving swelling and pain and a preparation method thereof, and relates to the technical field of traditional Chinese medicine, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine components: golden cypress, dandelion, gallnut, patrinia, fructus forsythiae, safflower, corydalis tuber, pseudo-ginseng, ginkgo leaf, rice vinegar, borneol and honey. Amur corktree bark and Chinese gall have a good curative effect on acute and chronic soft tissue injuries, can relieve and eliminate local aseptic inflammation, can improve local microcirculation, can promote repair of injured tissues, and can promote skin ecchymosis and hematoma fading, the traditional Chinese medicine is an externally-applied good medicine for treating acute soft tissue injuries, the medication object is not limited, and the traditional Chinese medicine can be used for children and adults and has a good application prospect. The traditional Chinese medicine composition has the advantages that the curative effect of the traditional Chinese medicine composition meets the clinical requirements, at present, various drugs for treating contusion, tenosynovitis, bone fracture and invasive inflammation clinically exist, but most drugs take effect slowly and are poor in applicability after being used, and the traditional Chinese medicine composition preparation is remarkable in effect and convenient to use in clinical use.

The application discloses application of a MAC-1 agonist in preparation of a medicine for treating and / or relieving cerebral hemorrhage. Specifically disclosed is the use of Leukadherin-1 (LA-1) or a pharmaceutically acceptable salt, isomer or derivative thereof in preparation of a medicine for treating cerebral hemorrhage and secondary brain injury thereof. The medicine can inhibit the migration of immune cells across the blood-brain barrier, reduce cerebral edema, promote hematoma absorption and reduce neural inflammation by regulating the MAC-1-mediated immune adhesion signal pathway, thereby exerting a neuroprotective effect. Meanwhile, a pharmaceutical composition containing the MAC-1 agonist is provided. The application provides a new target and a drug development strategy for cerebral hemorrhage treatment.