29 results about "Brain hemorrhages" patented technology

The invention relates to the technical field, in particular to a cerebral hemorrhage intelligent decision support system based on deep adaptive feature fusion, which comprises a multi-modal data standardization module, a cross-modal feature fusion module, a focus segmentation calculation module, a hemorrhage type identification module and an illness state grading output module. According to the method, deep association between fusion features and bleeding types is mined through an attention mechanism, related feature indexes are converted into standardized scores by referring to clinical common scoring standards, model attention weight distribution is optimized by combining actual prognosis result deviation, the suitability of illness state grading and the clinical scoring standards is improved, and the probability of illness state grading is lowered. An accurate grading result and prognosis prediction reference are provided for clinical treatment decision and rehabilitation intervention; effective data are screened from multiple types of brain images according to image quality related indexes, clinical text key information extraction and association labeling are combined, data integrity and consistency verification is carried out at the same time, and the standardization degree of multi-source data is improved.

The application discloses a brain hemorrhage prognosis improvement method based on intestinal flora regulation and relates to the technical field of intestinal microecology.The application comprises the following steps: detecting feces, starting intervention if the enterococcus abundance and neuroinflammatory metabolic markers exceed the standard, stopping the use of conventional nutrient solution, perfusing a special component containing sugar analogs, blocking the energy uptake of enterococcus, simultaneously providing a carbon source for beneficial bacteria, synchronously perfusing a microsphere suspension containing a molecular capture function, adsorbing and fixing proinflammatory metabolic waste in the intestinal tract, blocking the blood entry of the proinflammatory metabolic waste, perfusing live bacteria with different functions three times in time sequence, sequentially completing the acidification of the environment, constructing a bacterial membrane barrier and repairing the intestinal epithelium, and re-detecting after each round of intervention, selecting the maintenance period or adjusting the intensity and then recycling according to the decrease of enterococcus and markers.The application can limit the competitive advantage of enterococcus in the utilization of carbon sources after brain hemorrhage by sequentially implementing competitive inhibition of the phosphotransferase system and multi-species ecological niche occupation.

The application provides a traditional Chinese medicine preparation for treating or improving cerebral hemorrhage and a preparation method thereof, and relates to the technical field of traditional Chinese medicine pharmacy. The traditional Chinese medicine preparation is composed of nacre, antelope horn powder, dragon's blood, Herba Schizonepetae, Prunella vulgaris, Stink-bug, Smilax riparia, bamboo juice, dried tangerine or orange peel, clubmoss, radix puerariae, Zizania aquatica and leaf of Chinese pear. The preparation has a significant therapeutic effect on cerebral hemorrhage, can obviously improve the neurological deficit of cerebral hemorrhage rats, reduce the water content of brain tissue to alleviate brain edema, simultaneously alleviate the inflammatory response in the body, thereby playing a neuroprotective effect on cerebral hemorrhage rats. In addition, the preparation can obviously improve the consciousness state of cerebral hemorrhage patients, alleviate the degree of neurological deficit, relieve the related TCM syndromes of the patients, simultaneously effectively improve the daily life ability of the patients, significantly improve the total effective rate of clinical treatment, and no obvious adverse reactions are observed in the treatment process, and the safety is good, thereby providing a safe and effective treatment scheme for the conservative treatment of cerebral hemorrhage.

The invention provides a traditional Chinese medicine preparation for treating or improving cerebral hemorrhage and a preparation method thereof, and relates to the technical field of traditional Chinese medicine pharmacy, the traditional Chinese medicine preparation is composed of nacre mother of pearl, antelope horn powder, dragon's blood, motherwort fruit, selfheal, aspongopus, radix actinidiae chinensis, bamboo juice, pericarpium citri reticulatae, selaginella tamariscina, radix puerariae, zizania aquatica and folium eriobotryae. The traditional Chinese medicine composition can obviously improve neurological impairment of cerebral hemorrhage rats, reduce the water content of brain tissues to relieve encephaledema and reduce inflammatory response in vivo, thereby playing a role in protecting the nerves of the cerebral hemorrhage rats. Besides, the preparation can obviously improve the consciousness state of a cerebral hemorrhage patient, relieve the degree of neurological impairment, relieve related traditional Chinese medicine syndromes of the patient, effectively improve the daily living ability of the patient and obviously improve the total effective rate of clinical treatment, no obvious adverse reaction is observed in the treatment process, and the preparation is good in safety and free of toxic and side effects. And a safe and effective treatment scheme is provided for the conservative treatment of cerebral hemorrhage.

The utility model relates to a non-contact type multifunctional neurosurgery brain cotton and gelatin sponge transfer tray which comprises an upper tray and a lower tray which can be combined, a hollow cylinder is arranged at one corner of the upper tray, a pin hole column matched with the hollow cylinder through a pin shaft is arranged at one corner of the lower tray, a plurality of partition plates are arranged in the upper tray, and the partition plates are arranged in the lower tray. The upper tray is divided into a plurality of brain cotton storage areas through the partition plates, and a downward-concave circular groove used for storing an aneurysm temporary clip is formed in the lower tray. The utility model designs a double-layer opening and closing type handheld tray which can be opened in a fan-shaped manner when in use. Four kinds of brain cotton of different sizes and models can be placed on the first layer, and meanwhile brain cotton threads can be stretched and cannot be wound mutually; gelatin sponges with different sizes and models can be placed on the second layer, and an aneurysm temporary clip can be placed on the circular sunken part. When a doctor uses the device, a nurse can deliver the brain cotton and the gelatin sponge at the same time, delivery time is saved, and the device is of great significance in dealing with cerebral hemorrhage in an emergency.

The invention belongs to the technical field of biological medicine, and particularly relates to a nano-micelle preparation loaded with minocycline and application of the nano-micelle preparation to treatment of cerebral hemorrhage, the nano-micelle preparation is prepared by taking a polyethylene glycol-polycaprolactone nano material PEG3000-PCL2000 as a carrier, and jointly loading minocycline MINO and a CD147 monoclonal antibody Anti-CD147, so that the nano-micelle preparation is prepared. And the bionic nano-drug MINO (at) PNM (at) CD147 with an active targeting function is constructed. The nano-micelle preparation has a brain targeting property and can be enriched in cerebral hemorrhage tissues, so that the local drug concentration and the treatment efficiency are remarkably improved; the traditional Chinese medicine composition can improve neurological impairment caused by cerebral hemorrhage and significantly reduce the volume of cerebral hematoma, and has an obvious treatment effect on cerebral hemorrhage; the number of inflammatory cells in the peripheral area of hematoma and expression of inflammatory mediators can be remarkably reduced, and therefore the inflammatory response in cerebral hemorrhage tissue is relieved.

The present specification relates to the technical field of medical robots, and specifically discloses a cerebral hemorrhage surgery planning system and method, wherein the system comprises: an image storage device configured to store preoperative brain image data of a target object; an image processing device configured to read the preoperative brain image data of the target object from the image storage device; further configured to identify a cerebral hemorrhage type of the target object based on the preoperative brain image data; and further configured to determine a target cerebral hemorrhage surgery mode of the target object according to the preoperative brain image data and the cerebral hemorrhage type. The above scheme can realize automatic hematoma type identification and personalized surgery planning, and improve the efficiency and reliability of surgery planning.

The application discloses application of a MAC-1 agonist in preparation of a medicine for treating and / or relieving cerebral hemorrhage. Specifically disclosed is the use of Leukadherin-1 (LA-1) or a pharmaceutically acceptable salt, isomer or derivative thereof in preparation of a medicine for treating cerebral hemorrhage and secondary brain injury thereof. The medicine can inhibit the migration of immune cells across the blood-brain barrier, reduce cerebral edema, promote hematoma absorption and reduce neural inflammation by regulating the MAC-1-mediated immune adhesion signal pathway, thereby exerting a neuroprotective effect. Meanwhile, a pharmaceutical composition containing the MAC-1 agonist is provided. The application provides a new target and a drug development strategy for cerebral hemorrhage treatment.

The invention relates to a microwave-induced thermoacoustic transcranial quantitative imaging method based on a REAGU-Net network, and the method achieves the simultaneous quantitative reconstruction of dielectric constant, conductivity and sound velocity in brain tissue through the MITAT technology, and provides a new methodology for the characteristic analysis of the brain tissue. A REAGU-Net novel network is developed, an attention guiding block and a residual error inducing block are combined to process the influence of acoustic non-uniformity on reconstruction quality, and effective application of deep learning in quantitative reconstruction is shown; the technology not only shows a good result in cerebral hemorrhage detection, but also can be potentially applied to detection and diagnosis of various diseases including breast cancer, liver diseases and thyroid diseases, and a new quantitative analysis tool is provided for clinic; the DL-MITAT method provided by the invention can provide quantized physical characteristic data, and the data not only is helpful for imaging, but also can provide support for physiological information prediction and the like in subsequent electromagnetic treatment; compared with a traditional TCD or ultrasonic imaging method, the transcranial MITAT has the remarkable advantages that due to the fact that ultrasonic waves of the transcranial MITAT only need to be transmitted with the skull for one time, the possibility of image attenuation and degeneration is reduced, and the imaging quality is improved.

The application discloses a brain hemorrhage magnetic induction tomography image reconstruction method based on an improved NR algorithm, and comprises the following steps: obtaining coil detection phase data and a sensitivity matrix by using an established brain hemorrhage MIT finite element model; introducing a regularization penalty term based on a target function of a traditional NR algorithm and solving an iterative formula of the algorithm, determining optimization parameters in the algorithm by a v method, and taking a conductivity distribution calculated by using a linear back projection algorithm as an initial value of iteration of the improved NR algorithm; introducing a projection operator P Ensuring that the algorithm converges on a convex set each time; determining an optimal threshold value or a maximum number of iterations, and outputting a final conductivity distribution. Compared with a traditional magnetic induction tomography image reconstruction algorithm, the application has better image reconstruction quality, can effectively reduce image reconstruction artifacts, and can detect brain hemorrhage.

The disclosure provides a kind of cerebral hemorrhage analysis method and system based on image registration, comprising: automatically segmenting cerebral hemorrhage area in brain CT image;The cerebral CT image and the segmented cerebral hemorrhage image are pretreated;Cerebral CT image is registered according to MRI template, and the deformation field is obtained;The cerebral hemorrhage image is transformed using the deformation field;Analysis patient bleeding level and the brain area involved.Use normal brain MRI image as registration template, register patient brain CT with MRI template, extract patient hematoma feature, can quickly and effectively analyze bleeding level and the brain area involved by hematoma, provide guidance for doctors, and can be used for subsequent visualization modeling, help doctors to formulate more comprehensive treatment plan.

The invention provides an application of edible rubber seed oil in preparation of a medicine or nutritious food for preventing and / or treating hemorrhagic diseases. The edible rubber seed oil can be used for preventing and / or treating liver hemorrhage, cardiac hemorrhage and cerebral hemorrhage. The invention can provide a new safer nutritional food choice for bleeding of different organs such as liver, heart, brain and the like.

The utility model relates to the technical field of neurosurgery cerebral hemorrhage drainage, and discloses a neurosurgery cerebral hemorrhage clinical minimally invasive drainage device which comprises a first drainage tube, a connecting tube is installed on one side of the first drainage tube, a limiting block is fixed to the bottom end of a rotating handle, and a waterproof patch is fixed to the right side of a movable sleeve. And a rubber ring is fixed on the right side of the waterproof patch. When the drainage device is used, the first drainage tube can enter the hematoma position of the brain of a patient through a hole in the brain of the patient, the movable sleeve, the waterproof patch, the rubber ring and other assemblies are arranged on the outer side wall of the first drainage tube, and the first drainage tube is inserted into the head of the patient; the waterproof patch can be attached to the head of the patient through the rubber ring so as to limit the first drainage tube, so that the insertion length of the first drainage tube is controlled, the first drainage tube is stably inserted into the head of the patient according to a certain length, and the problem of rotation is not prone to occurring.

The application discloses a bioinformatics analysis method for identifying a brain hemorrhage prognosis-related gene target point, and the method comprises the following steps: obtaining brain hemorrhage transcriptome expression data, performing quality filtering and batch correction to generate a standardized expression matrix, performing differential expression analysis on the basis of the standardized expression matrix, screening prognosis-associated differential genes in combination with survival regression, constructing a weighted co-expression network to identify a prognosis key gene cluster, screening and verifying a core hub gene through hub degree, taking the intersection of the prognosis-associated differential genes and the core hub gene, filtering and interaction network clustering a core target gene through a pathological pathway, performing immune infiltration correlation analysis and survival analysis on the basis of the core target gene, and outputting the brain hemorrhage prognosis-related gene target point according to an immune correlation marker and a survival correlation index. The application integrates a differential analysis and a network analysis double strategy, confirms mechanism correlation through pathway verification and immune correlation analysis, and the screening result has statistical reliability and biological interpretability.

The invention relates to the technical field of intelligent medical treatment, and discloses a multi-channel cerebral hemorrhage minimally invasive drainage method and system.The method comprises the steps that multi-modal medical image data of the brain of a patient is obtained, and an image data set of the brain of the patient is generated; performing structure enhancement processing on the image data set to obtain a structure enhanced image set of the brain of the patient; based on the structure enhancement image set, constructing a spatial relation matrix of a hematoma area and a peripheral key anatomical structure; according to the spatial relation matrix, constructing a hematoma three-dimensional structure diagram of the brain of the patient; performing spatial distribution characteristic analysis on the hematoma three-dimensional structure diagram to obtain a preliminary drainage path scheme of the brain of the patient; performing multi-channel collaborative arrangement optimization on the preliminary drainage path scheme to obtain a final drainage path scheme of the brain of the patient; according to the invention, the accuracy of multi-channel cerebral hemorrhage minimally invasive drainage can be improved.

The invention discloses an auxiliary mechanical arm system for guiding hematoma positioning under a neuroendoscope based on deep learning, and belongs to the field of computer vision and medical instruments. According to the method, the YOLOv11 deep learning algorithm is deeply fused with the medical image three-dimensional reconstruction and robot control technology, the problem of automatic and accurate calculation of the cerebral hemorrhage focus volume is innovatively solved, the planning efficiency, the operation precision and the overall safety of the brain surgery operation are remarkably improved, and the method is suitable for popularization and application. The invention provides a brand new technical scheme for realizing precise and minimally invasive intelligent operations, and has extremely high clinical application value and wide market potential.

Methods for treating brain inflammation, including brain inflammation occurring or susceptible to occur after brain hemorrhage, which include the administration of a protein or polypeptide including a polypeptide having at least 75% sequence identity with the amino acid sequence SEQ ID NO: 1, or a pharmaceutical composition including the protein or polypeptide. Also, a method for preventing, reducing, decreasing, and / or inhibiting neuronal death, which includes the administration of a protein or polypeptide including a polypeptide having at least 75% sequence identity with the amino acid sequence SEQ ID NO: 1, or a pharmaceutical composition including the protein or polypeptide.

The invention provides a method and system for diagnosing a cerebral hemorrhage period based on a large model, and the method comprises the steps: firstly, designing a method based on the large model and non-local mean filtering to enrich a cerebral hemorrhage CT image data set based on the characteristics that the number of cerebral hemorrhage CT images is small, and the images have complex noise, and then carrying out the diagnosis of the cerebral hemorrhage period based on the large model. A light-weight network module is fused to replace an encoder module in U-net to facilitate deployment of a designed detection model, finally, an equivalent volume calculation formula is designed to calculate the amount of cerebral hemorrhage of a patient, and a detection result of a cerebral hemorrhage period is given under an overall detection architecture. And timely and effective diagnosis information is provided for rapid and accurate detection of cerebral hemorrhage clinically.

The utility model discloses a microwave antenna and a cerebral hemorrhage detection system, and relates to the technical field of biomedical engineering. Wherein the microwave antenna comprises a first curved surface dielectric layer (1a) and a second curved surface dielectric layer (1b); the first curved surface dielectric layer (1a) and the second curved surface dielectric layer (1b) are respectively provided with a first excitation port (36) and a second excitation port (55); wherein the first curved surface dielectric layer (1a) and the second curved surface dielectric layer (1b) are respectively provided with a plurality of groups of first radiation patches connected with the first excitation port (36) and a plurality of groups of second radiation patches connected with the second excitation port (55). The objective of the utility model is to solve at least one of the technical problems of ionizing radiation, high cost, high probability of missing gold first-aid time due to overlong time, unsuitability for bedside detection and pre-hospital first aid and the like in current CT and MRI brain image examination.

The invention discloses a cerebral hemorrhage prediction method and system based on an MRI image, and relates to the technical field of medical data processing, and the method comprises the steps: obtaining an MRI image; the MRI image is input into a pseudo 3D convolution module for multi-scale feature extraction, and RGB features are obtained; carrying out attribute prediction on the RGB features, and outputting attribute features corresponding to the image attributes; inputting the attribute features corresponding to the image attributes into the image convolutional network, and outputting the prediction probability of the attention branch of the image; inputting the attribute features corresponding to the image attributes into a fuzzy system, and outputting a prediction probability of a fuzzy branch; inputting the RGB features into a multi-head self-attention module, and outputting a prediction probability of a multi-head self-attention branch; and performing weighted summation on the prediction probability of the image attention branch, the prediction probability of the fuzzy branch and the prediction probability of the multi-head self-attention branch to obtain a final prediction probability. According to the method, the problem that cerebral hemorrhage prediction lacks interpretability is solved, and cerebral hemorrhage prediction accuracy and model interpretability are effectively improved.

The invention discloses a baseline brain CT image processing method and platform and a storage medium. The platform comprises an image segmentation module used for obtaining a baseline brain CT image of a user and inputting the baseline brain CT image into a pre-trained segmentation model to obtain a brain parenchyma region bleeding image and a bleeding volume; the image vector construction module is used for inputting the brain parenchyma area bleeding image into a pre-trained radiomics model to obtain a radiomics score; constructing an image vector based on the radiomics score and the bleeding volume; the text vector construction module is used for extracting blood biochemical marker information and medical record information of the user and constructing a text vector; and the output module is used for inputting the image vector and the text vector into a pre-trained risk judgment model and outputting a risk score of the baseline brain CT image. According to the method, the baseline brain CT image can be automatically subjected to quantitative evaluation based on the image processing platform, and the cerebral hemorrhage expansion risk score is output for reference of the user.

The invention discloses a three-dimensional CT-assisted accurate positioning method for intracerebral hematoma, and relates to the technical field of neurosurgery cerebral hemorrhage preoperative positioning and intraoperative drainage navigation. In the prior art, intracerebral hematoma positioning lacks a three-dimensional-body surface quantitative transfer method taking a stable anatomical baseline as a reference, and high-precision consistency of a puncture point, direction and depth is difficult to consider under a local anesthesia condition. Therefore, according to the method provided by the invention, a standard baseline layer of the same layer of eyeball crystalline lenses on the two sides and the external auditory canal is established through craniocerebral three-dimensional CT thin-layer scanning, the front-back, left-right and up-down distances of a hematoma center point relative to a connecting line and a median sagittal line of the rear edge of the external auditory canal are measured, and spatial parameters are geometrically transferred to the body surface by using a T-shaped ruler; a hematoma center body surface projection point, a mirror image point and a puncture point are determined, coronal plane and sagittal plane bidirectional guidance is formed, and individualized catheterization depth control is achieved. The method is suitable for preoperative planning and intraoperative navigation of neurosurgery intracerebral hematoma drilling drainage.

Methods for treating brain inflammation, including brain inflammation occurring or susceptible to occur after brain hemorrhage, which include the administration of a protein or polypeptide including a polypeptide having at least 75% sequence identity with the amino acid sequence SEQ ID NO: 1, or a pharmaceutical composition including the protein or polypeptide. Also, a method for preventing, reducing, decreasing, and / or inhibiting neuronal death, which includes the administration of a protein or polypeptide including a polypeptide having at least 75% sequence identity with the amino acid sequence SEQ ID NO: 1, or a pharmaceutical composition including the protein or polypeptide.

This invention belongs to the field of pharmaceutical technology. Addressing the lack of reported applications of Astragalus injection in the preparation of drugs for treating cerebral hemorrhage, this invention proposes the use of Astragalus injection in the preparation of drugs for treating cerebral hemorrhage. Experimental results show that Astragalus injection can protect brain tissue neurons by inhibiting the HMGB1 / RAGE signaling pathway, inhibiting neuronal apoptosis, and reducing the expression of inflammatory factors in brain tissue, thereby achieving a protective effect against cerebral hemorrhage in rats. Therefore, Astragalus injection has the potential to be used as a drug for treating cerebral hemorrhage.

The utility model relates to an emergency cerebral hemorrhage detection tool which comprises a comb-shaped probe and a signal driving and resolving unit, the comb-shaped probe comprises a group of emission light sources and a multi-path detector, a gyroscope is arranged at the top of the multi-path detector, and the gyroscope is used for calibrating a measurement channel; a band-pass optical filter is arranged at a probe at the bottom of the multi-path detector; the signal driving and resolving unit comprises a lock-in amplifier, a frequency source and a laser driving module. The frequency source is electrically connected with the lock-in amplifier and the laser driving module. The laser driving module is electrically connected with the emission light source; and the lock-in amplifiers are respectively and electrically connected with the multi-path detector.

This invention provides a brain tissue dilator for continuous irrigation and suction during cerebral hemorrhage surgery, comprising a sheath with a hollow, frustum-shaped structure; the outer diameter of the distal endoscopic section of the sheath is smaller than that of the proximal endoscopic section, and the sheath also has an annular sealed channel; an inner core tube; an irrigation-suction control unit including a connecting tube sealed and fixed to the outer wall of the sheath, the connecting tube having parallel and isolated inlet and outlet, the inlet being connected to the irrigation channel, the outlet being connected to the suction channel, and the inlet being connected to a positive pressure irrigation port through a first branch pipe, the outlet being connected to a negative pressure suction port through a second branch pipe; and a fixed handle located on the outer wall of the sheath away from the connecting tube. This invention allows the surgeon to flexibly adjust the irrigation and suction operations according to the nature of the hematoma and the bleeding situation, improving the efficiency of hematoma removal.

The invention discloses a recombinant adeno-associated virus. The recombinant adeno-associated virus is prepared by the following steps: inserting a coding sequence of UBA52 protein into a pAAV-CMV plasmid; the preparation method comprises the following steps: co-transfecting a recombinant plasmid, a pHelper plasmid and a pAAV-RC9 plasmid to an AAV-293 cell; and culturing the cells, and extracting the recombinant adeno-associated virus. The recombinant adeno-associated virus can improve the motor ability of a cerebral hemorrhage subject; reducing encephaledema, hematoma level and cerebral moisture content in brain tissues of cerebral hemorrhage subjects; the mitochondrial DNA content is increased; the content of cytochrome C in cytoplasm is reduced, and the content of cytochrome C in mitochondria is increased; the content of caspase-3 and caspase-9 in the brain tissue is reduced; the content of ATP in brain tissue is increased; the number of degenerative neurons in brain tissues is reduced, and neuronal degeneration is recovered or slowed down; the apoptosis of brain tissue neurons is retarded. The recombinant adeno-associated virus has an application prospect.

The application belongs to the technical field of biological medicine, and discloses a nano regulator for treating cerebral hemorrhage, a preparation method and application thereof. First, a DNA nanoflower containing a hybridization site is prepared based on RCA technology, and is hybridized with a T structure containing a target transferrin receptor, so that the obtained carrier has the ability to cross the blood-brain barrier and gather at the damage site. Then, the nano regulator TNF@Gin is obtained by loading ginkgo flavones through non-covalent interaction. The obtained nano regulator can promote the polarization of microglial cells to the anti-inflammatory M2 phenotype, thereby reducing the level of pro-inflammatory factors and relieving excessive inflammatory response. In addition, the nano regulator can effectively clear ROS and Nrf2 / GPX4 signal pathway, and inhibit the ferroptosis of hippocampal neuron cells. The nano regulator shows high and safe treatment results, and provides a new strategy for treating cerebral hemorrhage.

This invention discloses a minimally invasive navigation system for cerebral hemorrhage based on 3D Slicer and 3D printing, relating to the fields of surgical planning and personalized navigation technology. It includes an image error correlation analysis unit that extracts three-dimensional reconstruction features of multiple brain regions of the patient from historical data. If the patient is in a certain respiratory stage, there is a corresponding respiratory state. An LSTM-random forest hybrid model is used to evaluate error weights, and a first correlation coefficient is obtained by combining the correlation between respiration and image displacement. An error verification processing unit determines if at least two respiratory states exist when the patient is in a certain respiratory stage, extracts adjacent data, and fuses preprocessed and individual difference correction factors. A path planning, registration, and navigation fusion unit uses a 3D Slicer to segment multiple brain regions of the patient to construct a three-dimensional image. Combined with respiration and individual feature corrections, a puncture path is planned around the hematoma center, providing dual guidance through visual navigation and mechanical positioning. This invention can improve positioning accuracy.