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Functional formula food and application thereof in preparation of medicine for preventing and treating secondary brain injury after cerebral hemorrhage

A formula food and functional technology, applied in the field of medicine, can solve problems such as limitations of effective treatment methods

Pending Publication Date: 2021-06-29
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although great progress has been made in the pathophysiological research of cerebral hemorrhage, effective treatment methods are still limited to surgical removal of hematoma, dehydration, reduction of intracranial pressure, and neuroprotection.

Method used

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  • Functional formula food and application thereof in preparation of medicine for preventing and treating secondary brain injury after cerebral hemorrhage
  • Functional formula food and application thereof in preparation of medicine for preventing and treating secondary brain injury after cerebral hemorrhage
  • Functional formula food and application thereof in preparation of medicine for preventing and treating secondary brain injury after cerebral hemorrhage

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 1. Reagents and animals:

[0018] Functional formula food: including DHA (docosahexaenoic acid) accounting for 5%, EPA (eicosapentaenoic acid) accounting for 5%, L-serine accounting for 40%, and taurine accounting for 35% , whey protein accounts for 10%, vitamin C accounts for 3%, vitamin E accounts for 1%, and beta-carotene accounts for 1%. Pour the weighed powder preparation into the material inlet of the V-shaped mixer, mix the powder for 5 minutes, and pour the powder preparation mixed in the special material receiving box into the special material box to complete the preparation.

[0019] Experimental animals: Adult male C57BL / 6 mice, 8-10 weeks old, weighing 20-25 g, were purchased from Shanghai Experimental Animal Center. SPF level animals were raised in Nantong University Experimental Animal Center. The temperature of the experimental animal room was 20-26 ℃ (daily temperature difference ≤ 4 ℃), humidity 40% ~ 70%, lighting 12h: 12h alternating light and dark. ...

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PUM

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Abstract

The invention discloses functional formula food and application thereof in preparation of a medicine for preventing and treating secondary brain injury after cerebral hemorrhage, and belongs to the technical field of medicines. The functional formula food is prepared from the following raw materials: docosahexaenoic acid, eicosapentaenoic acid, L-serine, taurine, whey protein, vitamin C, vitamin E and beta-carotene. The functional formula food disclosed by the invention can be used for remarkably reducing the cerebral hemorrhage volume and obviously improving the neurological function, is used for preventing and / or treating secondary brain injury after cerebral hemorrhage, and provides a new thought for medicine research on cerebral hemorrhage.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a functional formula food and its application in the preparation of drugs for the prevention and treatment of secondary brain damage after cerebral hemorrhage. Background technique [0002] Cerebral hemorrhage or hemorrhagic stroke refers to non-traumatic cerebral vascular rupture leading to spontaneous overflow of blood into the brain parenchyma, with or without blood infiltration into the subarachnoid space or ventricles. It is considered the most serious type of stroke because of its high fatality rate and high disability rate. [0003] The annual incidence of cerebral hemorrhage is 1 / 10,000 to 3 / 10,000. In the past 10 years, with the aging of the population and the increase in the incidence of stroke risk factors such as hypertension and diabetes, the number of hospitalized patients with cerebral hemorrhage has increased by 18%, and the incidence rate of Chines...

Claims

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Application Information

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IPC IPC(8): A61K38/02A61P25/00A61P7/04A23L33/12A23L33/175A23L33/19A23L33/15A23L33/105A61K31/202A61K31/198A61K31/185A61K31/375A61K31/355A61K31/015
CPCA61K31/202A61K31/198A61K31/185A61K38/02A61K31/375A61K31/355A61K31/015A61P25/00A61P7/04A23L33/12A23L33/175A23L33/19A23L33/15A23L33/105A23V2002/00A61K2300/00A23V2200/30A23V2200/322A23V2250/1868A23V2250/187A23V2250/0642A23V2250/0644A23V2250/54252A23V2250/708A23V2250/712A23V2250/211
Inventor 王国华叶莉莎姜正林张馨予骆倩倩周佳敏
Owner NANTONG UNIVERSITY
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