858 results about "Effective treatment" patented technology

The invention discloses a deep learning-based lung cancer early screening system, and particularly relates to the technical field of medical assistance, which comprises an intelligent data ecological module, an intelligent analysis and diagnosis module, an intelligent decision support module and a user interaction management module. According to the invention, cross-mechanism data sharing and cooperative training are realized by using data semantic understanding and federated sharing technologies, transparency and traceability of data are ensured through a block chain technology, and in an intelligent analysis and diagnosis module, a deep learning model comprehensively analyzes a multi-modal image and identifies molecular features of cancer cells, so that the accuracy of cancer diagnosis is improved. Potential early-stage lung cancer signs are found through an unsupervised learning algorithm, individual risks are dynamically evaluated, focus development is tracked, and an intelligent decision support module combines personalized treatment suggestions, optimizes clinical pathways and multidisciplinary collaboration, provides accurate decision suggestions and assists doctors in making scientific and effective treatment schemes.

The invention provides a medicine for preventing and treating cerebral arterial thrombosis, and belongs to the technical field of neuromedicine. The medicine comprises salmon polypeptide as shown in SEQ ID NO.1 and a pharmaceutically acceptable carrier, and experimental results show that the salmon polypeptide has good safety, can effectively improve oxygen-glucose deprivation / reoxygenation injury of brain cells, and remarkably reduces neurological impairment and cerebral infarction of mice suffering from cerebral arterial thrombosis. The invention also discloses a pharmaceutical composition for treating cerebral arterial thrombosis. The pharmaceutical composition comprises the salmon polypeptide and edaravone. The composition shows a remarkable synergistic effect, compared with the single use of the salmon polypeptide or edaravone, the composition can more remarkably reduce neurological impairment and cerebral infarction, and the actual effect is obviously superior to the theoretical superposition effect. Therefore, the invention provides a novel and more effective treatment scheme for the treatment of cerebral arterial thrombosis.

The invention discloses a closed-loop deep brain regulation and control system for epilepsy treatment, and the system comprises an electroencephalogram signal collection module which collects neural electrophysiological signals in real time by implanting a recording electrode in a cerebral cortex or hippocampal brain area; the electroencephalogram signal real-time analysis module is used for outputting the epileptic seizure period prediction probability xi through a seven-layer full-connection neural network based on the 33-dimensional feature vector so as to realize epileptic seizure early warning; when the zeta is greater than or equal to a threshold value, the electrical stimulation regulation and control module is used for triggering electrical stimulation, filtering out a frequency band required to be regulated and controlled according to filtering, calculating and predicting electrical stimulation intensity and then correcting and outputting pulse stimulation, so that personalized electrical stimulation regulation and control are carried out on a specific frequency band, and detection is continuously carried out until the frequency band becomes normal; and the medicine intervention module is used for triggering a micro-injection pump to carry out medicine infusion through a pulse signal. According to the system, epilepsy treatment is improved from empirical parameter adjustment to accurate regulation and control based on real-time nerve physiological signals, and a safer and more effective treatment choice is provided for a drug-refractory epilepsy patient.

The invention provides a dynamic adjustment method based on a depression mind-correcting treatment scheme, and relates to the technical field of medical care information, and the method comprises the steps: collecting multi-dimensional information of a patient, and collecting life behavior risk data, psychological scale data and cognitive function evaluation data; comprehensively evaluating the depression level of the patient; determining the priority of a treatment therapy module according to the multi-dimensional information of the patient; generating an initial treatment scheme; calculating a daily task comprehensive weight value, and dynamically adjusting the training content of the next day; and evaluating the state of the patient in stages, recalculating the priority of each therapy module, and optimizing the therapeutic scheme. Through multi-dimensional data fusion evaluation and intelligent algorithm dynamic adjustment, a complete closed-loop feedback optimization system is constructed, precision and individuation of a depression treatment scheme are achieved, the treatment effect and patient compliance are effectively improved, the recurrence risk is reduced, and a more scientific and effective treatment scheme is provided for depression patients.

The invention provides a gastric cancer intestinal microbial marker, application thereof and a method for constructing a gastric cancer detection model, and belongs to the technical field of biomedicine. The method comprises the following steps: extracting biomarkers related to gastric cancer pathogenesis and progress from metagenome data, constructing a random forest model by using a random forest algorithm, and training and testing the constructed random forest model by using a training set and a test set to obtain a gastric cancer detection model. According to the gastric cancer detection model constructed based on the gastric cancer intestinal microbial marker, the specificity is 97.2964%, the sensitivity is 94%, the accuracy is 93.40649%, the model efficiency and conformity are high, and the condition of gastric cancer can be accurately predicted and evaluated. Based on the gastric cancer intestinal microbiological marker and the gastric cancer detection model, the disease condition of a gastric cancer patient can be accurately predicted and evaluated, a doctor can make a more effective treatment scheme, the survival rate and life quality of the patient are improved, and the treatment effect is improved.

The invention provides a novel anti-human DKK-1 monoclonal antibody, aiming at solving the problems that osteoporosis antibody drugs developed in China at present are biosimilar drugs, and the existing antibody drugs also have certain defects, for example, Romosozumab is easy to cause cardiovascular adverse reactions, and DKK-1 antibody drugs aiming at osteoporosis do not appear on the market globally. According to the present invention, the rarely researched DKK-1 is adopted as the target spot to research the humanized DKK-1 antibody, such that the foundation is laid for the clinic and the effectiveness of the DKK-1 antibody, the treatment approach with the excellent effect is provided for the patient, and the problem of the lack of the innovation of the domestic antibody drug for treating osteoporosis can be hopefully solved.

The invention belongs to the technical field of probiotics, and particularly relates to lactobacillus reuteri ShuiMian with a sleep aiding effect and application of the lactobacillus reuteri ShuiMian. A new ShuiMian strain is separated from feces of a healthy infant in Guangzhou city, Guangdong province, PTZ is adopted to construct a zebra fish insomnia model, and research finds that the strain can inhibit eye movement frequency, inhibit brain discharge, reduce dopamine secretion, promote GABA secretion and promote Gabra gene expression, and the zebra fish insomnia model can be used for treating insomnia. The effect of promoting sleep is achieved. Therefore, the strain has a unique sleep-promoting mechanism, can assist in developing novel sleep-promoting medicines in the field of medicines, and provides a safer and more effective treatment scheme for insomnia patients. In the health care industry, a nutritional supplement can be prepared, the mass sleep quality is improved, and the development of sleep health related industries is promoted.

The invention relates to the technical field of medicines, in particular to novel application of orifice-opening and deafness-removing pills in preparation of anti-dizziness medicines. Experiments prove that the administration group can remarkably shorten the standing time consumption of a vertigo mouse caused by movement on the horizontal rod and reduce the vertigo response index, so that the movement vertigo model mouse can stand stably on the horizontal rod more quickly; abnormal changes of indexes such as ACTH, NE and CREB in mouse serum and BDNF, CREB, 5-HT and DA in brain caused by motion vertigo can be remarkably reversed. Therefore, the orifice-opening and deafness-removing pill has an obvious anti-dizziness effect, can be used as an active ingredient for preparing the anti-dizziness medicine, and is an effective treatment medicine especially for dizziness induced by movement. According to the invention, new indications of the orifice-opening and deafness-removing pill except deafness, tinnitus and otitis media are expanded. In anti-dizziness treatment, compared with dizziness stop, the traditional Chinese medicine composition can avoid digestive system reaction, cardiovascular reaction, central nervous system reaction and other side effects caused by dizziness stop.

Treatment of hyperinsulinemic hypoglycemia comprises administration of an effective amount of a glucagon-like peptide-1 receptor antagonist (GLP1RA) alone or in combination with an amylinomimetic agent or any anti-gastric emptying agent. Patients suffering from hyperinsulinemic hypoglycemia after bariatric surgery experience particular benefit, as there is no current method effective for their treatment. Prevention or reduction of acute adverse effects of postprandial hypoglycemia, such as palpitations, tremor, weakness, sweating, confusion, fatigue, blurred vision, seizures, or loss of consciousness, and prevention of chronic adverse effects of hyperinsulinemic hypoglycemia, such as cognitive impairment, can be achieved by treatment with GLP1RA.

The invention discloses an intelligent emergency pre-examination triage method and system based on big data, and relates to the technical field of pre-examination triage. According to the intelligent emergency pre-examination triage method based on the big data, the pre-examination data of the patient including the real-time physiological monitoring data and the main information is obtained, the pre-triage department and the disease deterioration probability are determined, then the treatment capacity coefficient of the pre-triage department is evaluated, and therefore the final triage strategy is determined, accurate matching of the departments can be achieved based on the big data, and the accuracy of the triage strategy is improved. The condition deterioration probability is dynamically evaluated, and the department treatment ability is comprehensively considered, so that a scientific triage strategy is formulated, the emergency triage efficiency and accuracy are improved, and a more timely and effective treatment opportunity is won for patients; the problems that in traditional emergency pre-examination triage, department matching is not accurate, disease deterioration risk assessment is not timely, and hospital disposal capacity is not sufficiently considered can be solved.

System and methods for alerting a healthcare provider to prescribed treatments having reduced or no effectiveness due to genetic composition is provided. A database containing treatments known to have reduced or no efficacy in persons having particular genetic markers is queried to determine whether any treatments prescribed by, or likely to be prescribed by, a healthcare provider to the patient are known to have reduced or no efficacy in persons having the same certain genetic markers as the patient. An alert indicating such information is displayed at a healthcare provider system.

The invention discloses primers and a kit for rapidly detecting canine respiratory tract pathogens and a preparation method, and belongs to the technical field of biology. The kit comprises five groups of specific primers for rapidly detecting the canine respiratory pathogens, can rapidly and accurately detect the five respiratory pathogens of canine parainfluenza virus, canine distemper virus, canine adenovirus type II, canine crown virus and canine bordetella within 15 minutes, and is low in detection cost and low in detection environment requirement. The kit can be applied to clinical rapid diagnosis and on-site screening to timely diagnose infection, so that veterinarians can rapidly take effective treatment measures; the technical problems of short time consumption, high accuracy, low cost and simple operation cannot be simultaneously considered in the detection process in the prior art are solved.

The invention discloses a construction method of a neurodegenerative disease diagnosis model based on soluble TREM2 molecules, and relates to the technical field of biomarker detection. The invention comprises XX. According to the method, a plurality of biomarkers and a machine learning algorithm are combined, a corresponding model is obtained, disease prediction and treatment are more accurate and comprehensive, the diagnosis accuracy is improved, compared with a traditional diagnosis method in the prior art, diseases can be recognized in the early stage, and through multi-center verification and data fusion, the diagnosis accuracy is improved. The technology has higher universality and adaptability in different regions and crowds, while the prior art mostly focuses on a single region or crowd and supports a personalized diagnosis and treatment scheme, more effective treatment measures can be formulated according to the specific conditions of patients through the design of the personalized diagnosis and treatment scheme, and the treatment effect is better. However, the prior art generally depends on a universal treatment scheme.

An infusion pump is configured to provide one or more context cues to a user while the user programs the infusion pump to deliver an infusion therapy. In some embodiments, the infusion pump includes a display configured to display a keypad and to receive input from a user, a processor in communication with the display, and a memory in communication with the processor. The memory stores instructions that cause a keypad sequence monitor to receive context parameters, the context parameters corresponding to a drug selection, a drug concentration selection, or a clinical care area in which the drug is to be infused. The keypad sequence monitor accesses a drug library using the context parameter to determine a valid parameter range corresponding to a range of values between lower and upper soft limit values stored in the drug library. The keypad sequence monitor is further configured to receive an treatment parameter value from the user and display one or more context cues upon determining that the received treatment parameter value is outside of a valid treatment parameter range, but would be within a valid treatment parameter range if one of the context parameters were changed.

The invention relates to the technical field of nerve regulation and control, and provides a closed-loop ultrasonic brain-computer interface regulation and control method for improving post-stroke dysfunction, which comprises the following steps: S1, constructing integrated closed-loop ultrasonic brain-computer interface equipment which comprises a behavior control unit, a signal generator unit, a power amplifier unit and an electrophysiological signal monitoring unit; s2, constructing a mouse model, and embedding an electrode provided for the electrophysiological signal monitoring unit for monitoring; s3, dividing the mouse model into a random stimulation group and a brain-computer interface treatment group, and simultaneously performing closed-loop ultrasonic stimulation for preset time; s4, after closed-loop ultrasonic stimulation for a preset time, performing various behavioral test evaluations including representation of a sensory movement function and representation of an emotional emotion function; and S5, carrying out neural circuit remodeling evaluation, and observing the projection change of the high-order thalamus PO nuclei region of the mouse to the primary cortex. In the aspects of targeting, closed-loop control and integrated design, the method is expected to become a novel and effective post-stroke dysfunction treatment method.

The invention provides an application of lactobacillus mucus B14.32 in traditional Chinese medicine fermentation and an anti-depression traditional Chinese medicine fermentation composition, a microbial fermentation technology is combined with traditional Chinese medicine extraction, and lactobacillus mucus B14.32 and saccharomycetes are used for carrying out two-step fermentation on traditional Chinese medicine with an anti-depression effect to obtain the anti-depression traditional Chinese medicine fermentation composition. The active ingredients of the traditional Chinese medicines are preserved to the maximum extent, the medicine effect is enhanced, the toxicity is reduced, the obtained anti-depression traditional Chinese medicine fermentation composition has the effects of resisting depression and relieving brain inflammation of depression patients, and a safer and more effective treatment scheme is provided for the depression patients.

The invention relates to the field of biomedicine, particularly provides a copper-based nano-enzyme as well as a preparation method and application thereof, and aims to solve the problems that in the prior art, clinical treatment on primary sclerosing cholangitis (PSC) is difficult in diagnosis and lacks of effective treatment drugs. The copper-based nano-enzyme comprises a nano-enzyme carrier and a copper-based nano-enzyme, wherein the nano-enzyme carrier is a two-dimensional nanosheet formed by copper ions, gallic acid and ursodesoxycholic acid through coordinate bonds; the probe molecule is a cyanine dye molecule connected to the surface of the nano-enzyme carrier through a covalent bond; wherein the fluorescence intensity of the copper-based nano enzyme is enhanced after the action of the alkaline phosphatase. The three functions of alkaline phosphatase responsive diagnosis, nano-enzyme catalytic treatment and ursodesoxycholic acid hepatic targeting are innovatively and synergistically integrated into one nano platform, the treatment function can be executed while specific imaging diagnosis is performed on diseases, and a new strategy is provided for diagnosis and treatment of diseases such as PSC.

An application method of Prevotella copri includes: applying thePrevotella copri in preventing and treating the ADHD. The Prevotella copri is applied in an effective therapeutic amount to achieve treating the ADHD, and a strain number of the Prevotella copri is JCM 13464=DSM 18205. It is indicated through animal experiments that the Prevotella copri can significantly improve hyperactive behavior, spontaneous activity levels and impulsive behavior hyperactivity. A further experimental exploration finds that the Prevotella copri can significantly increase levels of adrenocorticotropic hormone and cortisol in serum, improve neuroendocrine system dysfunction, and significantly increase gene expressions of glucocorticoid receptor (Nr3c1) and mineralocorticoid receptor (Nr3c2), thereby alleviating ADHD social dysfunction, which provides a theoretical basis for application prospects of probiotics in alleviating the ADHD.

The invention discloses application of rehmannia extracellular vesicles in preparation of a medicine for improving breast cancer bone metastasis bone injury, and belongs to the technical field of biological medicine. The preparation method comprises the following steps: cleaning the root tuber of a fresh rehmannia plant, adding a PBS (Phosphate Buffer Solution), crushing, and filtering by gauze to remove large-particle impurities; performing high-speed centrifugation on the filtrate to remove insoluble residues, then performing ultra-high-speed centrifugation to collect precipitates, re-suspending the precipitates, purifying the precipitates by adopting PEG (Polyethylene Glycol), and centrifugally collecting the precipitates, thereby obtaining the rehmannia extracellular vesicles. The rehmannia extracellular vesicles can effectively target bones, promote proliferation of bone-related cells and remarkably reduce bone injury caused by bone metastasis of breast cancer; bone protection treatment is carried out on breast cancer bone metastasis through the Chinese herbal medicine vesicles sourced from rehmannia, a safe and effective treatment scheme is provided for improving the pathological osteolysis problem caused by breast cancer bone metastasis, a new thought and technical support are provided for prevention and treatment of tumor bone metastasis related diseases, and good clinical transformation prospects are achieved.

The invention discloses an application of a benzotriazolyl piperazine compound or a salt thereof in preparation of a medicine for treating pulmonary arterial hypertension, and belongs to a new application of the benzotriazolyl piperazine compound. 3-[4-[4-(1H-benzotriazole-1-yl) butyl] piperazine-1-yl] benzisothiazole hydrochloride (PH-001) is subjected to an in-vivo animal experiment; mainly based on pharmacological experiments in a rat pulmonary arterial hypertension model induced by monocrotaline, it is found that the right ventricular systolic pressure (RVSP), the right ventricular hypertrophy index (RVHI) and the pulmonary arterial wall thickness (PAWT) of a rat are all remarkably reduced after intervention of a test sample PH-001, and the technical scheme opens up a new way for clinical application in the field of pulmonary arterial hypertension treatment. Therefore, PH symptoms and disease course development are effectively relieved, a theoretical basis is provided for clinical development, and the traditional Chinese medicine composition is expected to become a new effective treatment strategy.

The invention provides a traditional Chinese medicine compound for treating sicca syndrome and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compounds. The traditional Chinese medicine compound provided by the invention has the effects of eliminating dampness and heat, removing blood stasis and promoting salivation, can safely and effectively treat sicca syndrome by improving functions of exocrine glands and regulating immunity, belongs to a pure traditional Chinese medicine preparation, and has no toxic or side effect. The traditional Chinese medicine compound is proved to be capable of remarkably relieving the sicca syndrome, relieving dry mouth and eye symptoms of a patient, relieving fatigue, regulating and controlling a plurality of signals taking RAGE / TLR4 as a core, inhibiting excessive activation of an HMGB1-RAGE / TLR4-NF-kappa B pro-inflammatory pathway from gene and protein levels, inhibiting generation of pro-inflammatory cytokines, reducing inflammatory response and improving the immunity of the patient. The effect of treating the sicca syndrome is achieved. By acting on STAT3 phosphorylation, Tfh proliferation is inhibited, IL-21 secretion is reduced, humoral immune disorder is relieved, and the sicca syndrome is treated, so that the condition of the sicca syndrome is relieved, and the prognosis of the sicca syndrome is improved.

The invention belongs to the technical field of traditional Chinese medicine health diagnosis and treatment, and particularly relates to a health data detection system, method and equipment based on traditional Chinese medicine diagnosis and treatment. According to the method, tongue image information, pulse condition information and complexion information of a patient are comprehensively collected, deep analysis and comprehensive evaluation are carried out in combination with modern science and technology means, the health condition of the patient can be reflected more accurately, the accuracy and comprehensiveness of traditional Chinese medicine diagnosis and treatment are improved, and in addition, the diagnosis and treatment accuracy of the patient is improved through trend evaluation and correlation analysis of abnormal causes. According to the method, the development trend of the health condition of the patient can be predicted, correlation analysis among different causes can be introduced according to the correlation degree and the processing priority of the abnormal causes, the cause processing strategy is further optimized, the health risk caused by improper cause processing is avoided, and the patient experience is improved. Therefore, a doctor can formulate a more accurate and effective treatment scheme, the means of traditional Chinese medicine diagnosis and treatment are enriched, and the objectivity and scientificity of traditional Chinese medicine diagnosis and treatment are improved.

The present invention discloses a medical image analysis method and system based on plain scan CT data, and relates to the technical field of medical image analysis. The medical image analysis method based on plain scan CT data obtains chest plain scan CT data of a patient, wherein the chest plain scan CT data includes chest cross-sectional image data of several scanning positions; a three-dimensional model of the patient's chest is established based on the chest plain scan CT data of the patient; the three-dimensional model of the patient's chest is segmented to obtain a three-dimensional model of the patient's lungs. The present invention automatically reconstructs a three-dimensional model of healthy lungs by using a deep learning model, and compares it with the patient's actual lung model, thereby providing a more accurate disease diagnosis. This automated comparison reduces human errors and improves the efficiency of analysis, so that doctors can quickly and accurately identify the lesion area and the degree of the disease, thereby formulating a more effective treatment plan.

The novel multichannel drainage device for liver and gall interventional therapy comprises a liquid collecting bag and a communicating pipe arranged at one end of the liquid collecting bag, a collecting barrel is arranged at the other end of the communicating pipe, and a plurality of drainage pipes are arranged at the other end of the collecting barrel; wherein sensor bodies are arranged at the middle ends of the drainage tubes, side holes are formed in the side faces of the top ends of the drainage tubes, and the drainage tubes are communicated with the collecting barrel and communicated with the communicating pipe. And a safer and more effective treatment tool is provided for liver and gall interventional therapy.

The invention relates to application of tsRNA-3025a as a prognostic marker of acute myocardial infarction and a treatment target spot of myocardial ischemia reperfusion injury. A DNA (Deoxyribonucleic Acid) sequence corresponding to the tsRNA-3025a is shown as SEQ ID NO: 1: 5 '-ATCCTGCCGACTACGCCA-3'. The tsRNA-3025a can be used for treating acute myocardial infarction and myocardial ischemia reperfusion injury. In the aspect of prognosis, a detection kit is provided, and the risk of heart failure and short-term adverse events of a patient is evaluated by quantitatively detecting the expression level of the tsRNA. In the aspect of treatment, the invention provides the application of the anti-tagomir for inhibiting the function or expression of tsRNA-3025a in the preparation of the medicine for treating the myocardial ischemia reperfusion injury, and the anti-tagomir is subjected to specific chemical modification. A novel biomarker is provided for prognosis risk stratification of acute myocardial infarction, and an effective treatment strategy is provided for prevention and treatment of myocardial ischemia-reperfusion injury.

The invention relates to the technical field of medical image area detection, and discloses a medical image key area detection system and method.The medical image key area detection system comprises an image obtaining module, an image preprocessing module, a key area positioning module, a feature extraction module and a classification and recognition module. According to the key area detection system of the medical image, the key anatomical structure or the lesion area in the image can be automatically identified and positioned through the system, so that the diagnosis efficiency of a doctor is greatly improved, an important reference can be provided for clinical decision-making of the doctor, and the accuracy of clinical decision-making is improved by accurately identifying the lesion area. According to the technical scheme, doctors can more accurately evaluate the severity of the illness state, formulate a more effective treatment scheme and even predict the development trend of the illness, so that the method has important significance in improving the treatment effect and the survival rate of patients, meanwhile, errors caused by human factors are reduced through automatic analysis, and the diagnosis reliability is improved.

The present invention relates to a group of cannabinoid derivatives as pharmaceutically active compounds and methods of preparation thereof. The cannabinoid derivatives of the invention are analogues of cannabidiol (CBD). CBD is a non-psychoactive cannabinoid which has been used to treat various diseases and disorders. While such treatments hold promise, there remains a need in the art for more effective treatments and this has been brought about by way of the cannabinoid derivatives of the invention

The invention belongs to the field of tumor medicine and the technical field of molecular biology and gene detection, and relates to application of rs17771861 in preparation of a nasopharyngeal carcinoma prognosis prediction marker, and the sequence of the SNP site rs17771861 is as shown in SEQ ID NO.1. The invention also relates to application of the SNP site rs17771861 in preparation of a nasopharyngeal carcinoma prognosis prediction marker. The invention provides an SNP (Single Nucleotide Polymorphism) marker rs17771861 related to nasopharyngeal carcinoma prognosis, application of the SNP marker rs17771861 and a detection kit capable of being used for nasopharyngeal carcinoma prognosis prediction, and the SNP marker rs17771861 is used for assisting in guiding individualized treatment and improving prognosis of tumor patients. After the kit disclosed by the invention is applied to clinical detection, prognosis of a patient can be evaluated before treatment, and a more positive and effective treatment scheme is formulated for the patient with poor prognosis, so that individualized treatment of the patient is realized, and the survival rate is increased. In addition, the kit only needs to detect peripheral blood, and has the characteristics of convenience in sampling, simplicity in operation, high timeliness and the like.

The present embodiments relate generally to therapeutic techniques and more particularly to effective treatment of neurological disorders using noninvasive methods and apparatuses. Some embodiments relate to more effective vibrotactile stimulation, i.e., stronger physiological effects with less vibration power / amplitude, by means of a vibrotactile mechanical stimulator (tactor).

The invention belongs to the technical field of biomedicine, and discloses a nano-particle for enhancing radioimmunotherapy effect through cascade reaction and application of the nano-particle, a preparation method of the nano-particle comprises the following steps: S1, synthesis of ZnO2; the preparation method comprises the following steps: dissolving ZnCl2 and PVP in absolute ethyl alcohol, adding ammonia water and H2O2, after the reaction is completed, collecting precipitates, washing, and dispersing the precipitates in absolute ethyl alcohol to prepare ZnO2; and S2, synthesis of ZnO2 (at) Cu: resuspending ZnO2 in water, sequentially adding ammonia water, a PAA solution, IPA, dopamine hydrochloride and a CuCl2 solution, stirring in a nitrogen atmosphere, centrifuging, washing with ethanol, and drying in vacuum to obtain the ZnO2 (at) Cu nano-particles, namely the nano-particles. According to the nanoparticles, the radiotherapy effect is enhanced through cascade reaction, copper death is induced, immune response is activated, effective treatment on tumors is achieved, and the problems of radiotherapy resistance and immunosuppressive tumor microenvironment are solved.