400 results about "Effective treatment" patented technology

The invention provides a novel anti-human DKK-1 monoclonal antibody, aiming at solving the problems that osteoporosis antibody drugs developed in China at present are biosimilar drugs, and the existing antibody drugs also have certain defects, for example, Romosozumab is easy to cause cardiovascular adverse reactions, and DKK-1 antibody drugs aiming at osteoporosis do not appear on the market globally. According to the present invention, the rarely researched DKK-1 is adopted as the target spot to research the humanized DKK-1 antibody, such that the foundation is laid for the clinic and the effectiveness of the DKK-1 antibody, the treatment approach with the excellent effect is provided for the patient, and the problem of the lack of the innovation of the domestic antibody drug for treating osteoporosis can be hopefully solved.

System and methods for alerting a healthcare provider to prescribed treatments having reduced or no effectiveness due to genetic composition is provided. A database containing treatments known to have reduced or no efficacy in persons having particular genetic markers is queried to determine whether any treatments prescribed by, or likely to be prescribed by, a healthcare provider to the patient are known to have reduced or no efficacy in persons having the same certain genetic markers as the patient. An alert indicating such information is displayed at a healthcare provider system.

The invention relates to the field of biomedicine, particularly provides a copper-based nano-enzyme as well as a preparation method and application thereof, and aims to solve the problems that in the prior art, clinical treatment on primary sclerosing cholangitis (PSC) is difficult in diagnosis and lacks of effective treatment drugs. The copper-based nano-enzyme comprises a nano-enzyme carrier and a copper-based nano-enzyme, wherein the nano-enzyme carrier is a two-dimensional nanosheet formed by copper ions, gallic acid and ursodesoxycholic acid through coordinate bonds; the probe molecule is a cyanine dye molecule connected to the surface of the nano-enzyme carrier through a covalent bond; wherein the fluorescence intensity of the copper-based nano enzyme is enhanced after the action of the alkaline phosphatase. The three functions of alkaline phosphatase responsive diagnosis, nano-enzyme catalytic treatment and ursodesoxycholic acid hepatic targeting are innovatively and synergistically integrated into one nano platform, the treatment function can be executed while specific imaging diagnosis is performed on diseases, and a new strategy is provided for diagnosis and treatment of diseases such as PSC.

The invention relates to application of tsRNA-3025a as a prognostic marker of acute myocardial infarction and a treatment target spot of myocardial ischemia reperfusion injury. A DNA (Deoxyribonucleic Acid) sequence corresponding to the tsRNA-3025a is shown as SEQ ID NO: 1: 5 '-ATCCTGCCGACTACGCCA-3'. The tsRNA-3025a can be used for treating acute myocardial infarction and myocardial ischemia reperfusion injury. In the aspect of prognosis, a detection kit is provided, and the risk of heart failure and short-term adverse events of a patient is evaluated by quantitatively detecting the expression level of the tsRNA. In the aspect of treatment, the invention provides the application of the anti-tagomir for inhibiting the function or expression of tsRNA-3025a in the preparation of the medicine for treating the myocardial ischemia reperfusion injury, and the anti-tagomir is subjected to specific chemical modification. A novel biomarker is provided for prognosis risk stratification of acute myocardial infarction, and an effective treatment strategy is provided for prevention and treatment of myocardial ischemia-reperfusion injury.

The invention discloses multi-component inulin hydrogel as well as a preparation method and application thereof, and belongs to the technical field of nano materials and medicines.The multi-component inulin hydrogel is characterized in that a medicine L-alanyl-L-glutamine contributing to intestinal mucosa repair is entrapped in the inulin hydrogel; the multi-component inulin hydrogel has the advantages that the multi-component inulin hydrogel is prepared from the inulin and composite nanoparticles (namely mesoporous polydopamine-gallium composite nanoparticles) composed of an active oxygen scavenger polydopamine and an antibacterial agent gallium ions, the repairing capacity on intestinal barriers is further enhanced, and the prepared multi-component inulin hydrogel can be used for effectively treating inflammatory bowel diseases and non-alcoholic steatohepatitis.

The invention provides application of AQP1 protein as a target spot in preparation of a diagnostic reagent and a therapeutic drug for hypoglycaemia nephropathy, and belongs to the technical field of biological medicines.The AQP1 protein is used as the target spot, AQP1 protein expression is reduced by adopting an inhibitor, and the hypoglycaemia nephropathy is obtained. According to the present invention, with the application of the kit, the effects of reducing the renal tubule injury markers in the urine, reducing the glomerular filtration rate or relieving the kidney tissue hypoxia can be achieved, the new idea is provided for the early prevention and treatment of the diabetic nephropathy (DKD), and the early recognition and the effective treatment of the kidney injury of the diabetic patient can be well achieved.

The invention discloses application of 2-aminoethoxy diphenyl borate (2-APB) in preparation of a medicine for improving endometrial receptivity and treating diseases related to the endometrial receptivity, and belongs to the technical field of biological medicine. A large number of experiments prove that 2-APB specifically activates a TRPM6 channel, enhances calcium ion influx and activates a calcium-dependent CaM-CaMKII-Ecadherin signal axis, so that expression of receptivity markers (such as E-cadherin and ICAM-1) is up-regulated, and endometrial receptivity is improved. The problems of poor targeting property and high toxicity of the traditional calcium ion carrier are solved, and a safe and effective treatment strategy is provided for a patient suffering from repeated implantation failure (RIF).

Described herein are a method and a device for noninvasive stimulation of the Vagus nerve. The device is a multichannel device configured to provide non-invasive alternating stimulation of the left and right ear branches of the Vagus nerve as well as acupuncture points of the earlobes using various waveforms. Advantageously, the waveforms are designed to prevent acquired tolerance of the Vagus nerve stimulation thereby creating more effective treatments for a patient.

The present application relates to the technical field of orthodontic monitoring analysis, in particular to a real-time monitoring analysis system for orthodontic treatment, in which a contact state information acquisition module and a displacement response information acquisition module generate a contact state change sequence and a displacement response change sequence respectively, a time sequence coupling relationship construction module constructs a time sequence coupling feature between tooth displacement response and treatment contact state based on the two sequences, an effective treatment effect identification module obtains a first treatment effect interval based on the time sequence coupling feature, an abnormal effect stripping and treatment advancement evaluation module further obtains an abnormal contact segment and a failed effect segment, and obtains a second treatment effect interval and a treatment advancement state, and a monitoring analysis application module determines a corresponding advancement level according to the treatment advancement state and generates a monitoring analysis result, which is beneficial to distinguishing a treatment effect process related to the effective movement of the target tooth position and an interference process from the continuous monitoring data, and makes the monitoring analysis result closer to the actual treatment advancement situation.

The application discloses a kind of recombinant polypeptide and its application in preparation of the drug for treating autoimmune disease.The polypeptide includes the following amino acid sequence: X1X2EX3RHRFRQLDX4;Wherein, X1 is S or A, X2 is E or Q, X3 is M or I, X4 is S or T;The length of the polypeptide is 13-18 amino acids.The polypeptide provided by the application has stronger immunogenicity, is the important antigen peptide of chronic prostatitis / chronic pelvic pain syndrome (CP / CPPS, type III prostatitis) and can be induced immune tolerance using the polypeptide, to provide effective treatment scheme for treating autoimmune disease (for example, type III prostatitis).The application also provides a kind of method for constructing mouse EAP model, using only one kind of adjuvant CFA, i.e.can successfully construct the model most matched with human chronic prostatitis / chronic pelvic pain syndrome.

The application discloses a 120 emergency center ambulance task allocation method based on multi-algorithm combination optimization, and comprises the following steps: S1, acquiring the specific positions of all patients to be treated and their illness conditions, the specific positions of all idle ambulances, the specific positions of all hospitals and the treatment ability for each patient in a current time period; S2, constructing an ambulance task allocation evaluation function and a treatment effect evaluation function obtained by each patient; S3, performing path planning in combination with an A* algorithm to ensure that the ambulance selects an optimal route; and S4, using an Ito algorithm and a Newton-Raphson optimization algorithm to iteratively calculate the optimal allocation result of each patient, so that each patient can obtain emergency treatment. The application is superior to a traditional single-algorithm scheduling scheme in response time, treatment effect and resource utilization rate through multi-algorithm combination optimization, can efficiently perform multi-ambulance task allocation, and ensures that each patient can obtain timely and effective treatment.

The invention discloses an application of rapamycin in preparation of a composition for treating a hereditary spastic paraplegia SPG subtype. The rapamycin can obviously improve the motion disorder and pathological injury phenotype of an SPG80 subtype mammal model, improve the lysosome function and promote the autophagy process through mTOR inhibition, provides specific intervention for nerve cell apoptosis and a glial cell abnormal activation mechanism caused by UBAP1 deletion, fills the blank that no effective treatment means exists for the SPG subtype, and has a good application prospect. A theoretical basis is provided for clinical treatment of patients, and a reference is provided for other SPG variations (such as SPG3A).

The present invention comprises: a high-frequency oscillator that transmits high-frequency energy and includes a control unit; a high-frequency connecting line connected to the high-frequency oscillator; and a high-frequency transmission pad connected to the other end of the high-frequency connecting line and attached to the curve of facial skin in close contact with it, wherein the high-frequency transmission pad is configured such that an adhesive pad and a bipolar pad are integrated or separate. This invention relates to a non-invasive automatic facial lifting device using high-frequency energy that adheres closely to the curves of the face to be treated, thereby enabling uniform delivery of high-frequency energy to the skin, allowing for effective treatment without separate operation, minimizing the risk of excessive thermal damage to specific areas of the skin, resolving issues such as pain, scarring, and infection associated with existing invasive technologies, enhancing user convenience and safety through an automated control system and customized settings, and providing uniform treatment effects and reducing treatment time and fatigue by monitoring skin temperature in real time and delivering high-frequency energy according to set output, time, and patterns.

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition with the effects of treating atrial fibrillation and improving anxiety, a medicine and a preparation method and application thereof. When the traditional Chinese medicine composition provided by the invention is combined with auricular point pressing beans to treat patients with atrial fibrillation and anxiety, clinical symptoms of atrial fibrillation and anxiety can be further improved, specifically, the score of traditional Chinese medicine syndromes is reduced, the effective rate of electrocardiograms and the clinical effective rate of anxiety are improved, the life quality of the patients is improved, and no obvious adverse reaction exists. Meanwhile, a traditional Chinese medicine oral administration and traditional Chinese medicine external treatment combined method is adopted, syndrome differentiation treatment can be carried out from the holism concept, the holographic therapy of external treatment of internal diseases can be utilized to the maximum extent, and a simple, convenient, safe and effective treatment thought is provided for early prevention, early diagnosis and early treatment of more diseases.

The application discloses a new use of Leonurine or a pharmaceutically acceptable salt thereof in the preparation of a medicament for treating radiation-induced brain injury, specifically, providing a safe and effective therapeutic drug for iron death, neuroinflammation, neuron damage and lipid metabolism disorder accompanying the radiation-induced brain injury, solving the technical problem of lack of specific treatment means in the prior art, and having a wide clinical application prospect. Experiments adopt a C57BL / c mouse 30 Gy whole brain X-ray radiation model, and results show that Leonurine can significantly improve the body weight decrease and survival rate of the model mice, reduce the serum IL-6 and IFN-alpha levels, inhibit the activation of microglial cells in the cerebral cortex and hippocampus, protect and repair damaged neurons, and improve the ultrastructure of mitochondria and synapses; meanwhile, the expression of GPX4 and SLC7A11 proteins in the brain tissue is up-regulated, the GSH content is increased to inhibit iron death, and the levels of GPE, GPS and GPC related to lipid metabolism are restored.

The patent document discloses a dosage form featuring a unique combination of extended-release and immediate-release components of the active ingredient. This dosage form allows for high drug loading, enabling once-daily administration while providing a sustained window of effective treatment with reduced fluctuations in drug concentration. The document also discloses a method for treating neurological or psychiatric diseases or conditions in a subject.

The invention relates to the technical field of biological medicines, and particularly discloses application of ebbeselenium in preparation of a medicine for treating male delayed gonadal hypofunction. After the ebbeselenium is adopted for intervention, the autophagy activity of testicular interstitial cells of old mice is increased, lipid autophagy is enhanced, testosterone synthesis is promoted, the serum testosterone level is remarkably improved, and the symptoms of male delayed hypogonadism (LOH) are effectively relieved; ebbeselenium simultaneously shows a relatively good delaying effect on senescence of a plurality of organs. The ebbeselenium can improve the reproductive capacity, the behavior memory capacity, the athletic capacity and the metabolic function of old mice at the same time, and synergistic and effective treatment of low serum testosterone and LOH complications is achieved. Besides, by enhancing the molecular reduction effect of PRDX1 targeting ATG4B, the ebbeselenium regulates and controls the autophagy pathway of testicular interstitial cells and enhances the functions of the testicular interstitial cells so as to promote synthesis of testosterone, and a new treatment strategy is provided for treatment of LOH.

The present invention relates to a system and a device for diagnosing disease by using artificial intelligence, and an operating method thereof. The method may comprise the steps of: acquiring an interpretation report in which interpretation results of a medical image is recorded in a non-standardized form, a prompt including a user request to be input into an artificial intelligence model for disease diagnosis, and a template for standardizing and storing information necessary for the disease diagnosis; generating, on the basis of the prompt, the template and the interpretation, report input information for diagnosing the medical image; extracting diagnosis information necessary for the disease diagnosis from the input information; recording the extracted diagnosis information in the template; transmitting the diagnosis information recorded in the template to a designated server including the artificial intelligence model; receiving diagnosis results of the medical image from the server; and providing the received diagnosis result. The present invention can improve the speed, accuracy and / or objectivity of disease diagnosis. In addition, the present invention can provide an effective treatment method on the basis of the diagnosis results. Therefore, the present invention can improve the efficiency of disease diagnosis.

The invention discloses a method, equipment, a medium and a program product for predicting different progression stages of colorectal cancer. The method is used for predicting different progression stages of colorectal cancer based on the expression quantity of target protein. According to the method, by means of a computer system and equipment, whether a subject suffers from colorectal cancer related diseases or not can be well predicted by detecting the expression level of target protein, different progression stages of the colorectal cancer can be distinguished, a new direction and means are provided for early treatment and effective treatment of the colorectal cancer, and the method is worthy of popularization and application. And the method has practical significance on clinical guidance of colorectal cancer.

The application relates to the field of triple-negative breast cancer treatment and relates to synthesis of an acid-responsive amphiphilic liposome and application of the acid-responsive amphiphilic liposome in tumor treatment. A chemotherapeutic drug, a phospholipid, cholesterol and a polyethylene glycolized lipid are dissolved in an organic solvent chloroform, vacuum rotary evaporation is carried out under certain temperature and rotation rate, a water phase is added for hydration, a polypeptide nanogold cluster solution is added for ultrasonic treatment, then crushing, molecular sieve screening, dialysis and ultrafiltration are carried out to obtain a pH-sensitive liposome; in the preparation process, the phospholipid spontaneously forms a kind of biological membrane-like phospholipid bilayer membrane vesicle in water, and the chemotherapeutic drug and the nanogold cluster are wrapped in the vesicle. The pH-sensitive liposome can target the triple-negative breast cancer tumor site through pH response, can improve the solubility of the chemotherapeutic drug, can realize high-efficiency treatment effect of the drug at a low dose, can obviously reduce the toxic side effect of the chemotherapeutic drug, and can realize effective treatment of the triple-negative breast cancer.

The invention relates to a veterinary hoof disease prevention and treatment composition as well as a preparation method and application thereof, and aims to solve the technical problems that existing commercial hoof bath lotion is limited in sterilization effect and relatively strong in local irritation, and a safe and efficient treatment medicament for treating cow hoof warts is lacked and the like. The invention provides a veterinary composition which comprises the following active ingredients: a glycyrrhizic acid compound, didecyl methyl ammonium bromide and polyhexamethylene guanidine salt, and the three components are combined, so that the composition has an antibacterial effect and an effect of promoting skin tissue repair at the same time. A series of tests prove that the traditional Chinese medicine composition can effectively inhibit animal pathogenic bacteria, prevent and / or treat animal limb and foot diseases and promote healing and repairing of ulcer injury. The medicament disclosed by the invention is suitable for preventing and treating limb and hoof diseases in a large-scale pasture, has the characteristics of high sterilization efficiency, good safety and effective treatment, and can improve the animal hoof health management level.

The application provides an ear treatment point positioning method and system, a laser treatment method and system based on the ear treatment point, a medium, a program and an electronic terminal. The application obtains pressing test data, brain wave data and heart rate data obtained when a probe traverses and detects a preset scanning point in a treatment area, and determines whether the scanning point is an effective treatment point such as a tender point and a hard knot point based on the pressing test data, the brain wave data and the heart rate data. The application avoids the treatment limitation caused by the fact that the existing acupuncture treatment instrument only focuses on macro positioning of an auricular point area and lacks accurate identification ability of specific treatment points in the area at a microscopic level, so that the effective auricular point treatment points can be positioned more accurately, and a more accurate and repeatable treatment and health care effect can be achieved.

This invention belongs to the field of biomedical technology, and particularly relates to a pharmaceutical composition for treating cervical cancer and its preparation method. The pharmaceutical composition for treating cervical cancer of this invention comprises the following components: a apigenin derivative and acetylvalerin in a mass ratio of 1:(0.3~0.5). This invention obtains a apigenin derivative by introducing specific functional groups onto apigenin, which exhibits high pharmacological activity against cervical cancer; synergistically acting with acetylvalerin, it effectively kills cervical cancer cells while reducing damage to normal cells, thus providing a safer and more effective treatment option for cervical cancer patients.

The present invention describes for the first time a method for preventing and / or reversing the phenomenon of premature senescence of skin cells and complex chronic wounds, characterized in that an effective amount of the growth hormone secretagogue peptide GHRP6 is applied. Also object of the present invention is a method for treating cases of complex chronic wounds that have developed primary or secondary refractoriness caused by the development of a cellular senescence process, transforming them from refractory wounds to responsive wounds in the presence of proliferative agents with which they unexpectedly manage to reverse and restart the healing process. Complex chronic wounds include cases of diabetic foot ulcers, venous ulcers, pressure ulcers, radiation ulcers, and other types of chronic wounds that are characterized by refractoriness to all types of treatment. These cases currently have no effective treatments.

The invention discloses an application of an LAMP1 inhibitor in preparation of a medicine for preventing and / or treating esophageal cancer. Specifically, the application value of the LAMP1 inhibitor Parishin C in esophageal cancer treatment is found and verified for the first time, invasion and metastasis of esophageal squamous carcinoma cells and in-vivo lymph node metastasis can be remarkably inhibited by targeting LAMP1 protein and downstream signal channels of the LAMP1 protein and Parishin C, and a new drug choice is provided for metastatic esophageal cancer lacking effective treatment means clinically.

Disclosed are a tissue expander for breast reconstruction comprising an MMP sensor and thus being capable of real-time capsular contracture monitoring and treatment, and a patient information system linked thereto. According to these, a patient or medical staff can easily check and evaluate capsular contracture, which may occur when wearing a tissue expander for breast reconstruction, and whether inflammation, a side effect, or the like is caused thereby, even outside the human body in real time. Accordingly, before or when capsular contracture occurs, effective treatment and response are possible.

The invention discloses a combined medicine composition of a thyroid Qixia patch and a selenium yeast tablet and application of the combined medicine composition, and belongs to the technical field of medicines. The composition is composed of a thyroid and astragalus mongholicus summer patch and a selenium yeast tablet, the thyroid and astragalus mongholicus summer patch is prepared by grinding astragalus mongholicus, selfheal, radix clematidis, turmeric, airpotato yam and semen brassicae as raw materials, and adding vaseline to prepare paste. The selenium yeast tablet is used for oral administration and is matched with the thyroid qi-summer patch for external application on the neck, and the treatment course is 3 months. Clinical verifications show that the total effective rate of the composition reaches 87.80%, the composition can effectively improve symptoms such as anterior cervical mass, dysphoria, irritability and the like, reduce the level of serum TPOAb, reduce thyroid and nodule volumes and improve nodule blood flow, the safety is good, the curative effect is superior to that of pure western medicine treatment, and an effective treatment scheme is provided for related diseases.

The invention relates to a magnetic control self-conformal intestinal stent and a dynamic monitoring system, and belongs to the technical field of medical instruments, and the magnetic control self-conformal intestinal stent comprises a biodegradable main skeleton, a magnetic driving unit, a pressure sensing array and an in-vitro control device. A magnetic response material is embedded into the main framework, and form regulation and control and degradation rate control are realized through an in-vitro magnetic field; the flexible sensing array monitors intestinal wall pressure in real time, and the self-adaptive structure is linked to dynamically adapt to the intestinal tract curved surface. The in-vitro device integrates magnetic field adjustment and data processing, and supports precise positioning of the support and intelligent adjustment of the attaching force. The system improves the stability in a complex intestinal environment through magnetic coupling driving and multi-mode monitoring, early warns abnormal risks in real time, and avoids the rigid defect and monitoring lag problems of a traditional stent. The biodegradable material is combined with intelligent control, the degradation process and tissue repair are synchronized, a safe and effective treatment scheme is provided for diseases such as intestinal obstruction, and the treatment effect of a patient is improved.

This invention belongs to the field of medical technology, and specifically relates to the application of serotonin 3 receptor antagonists in the preparation of antitumor drugs. This invention, through research, demonstrates for the first time that serotonin 3 receptor antagonists can inhibit the activity of tumor cells resistant to third-generation EGFR-TKIs. More importantly, serotonin 3 receptor antagonists can not only reverse HER2 S310F mutation-mediated resistance to third-generation EGFR-TKIs, but also reverse secondary resistance to third-generation EGFR-TKIs, thus enabling their use as antitumor drugs for patients resistant to third-generation EGFR-TKIs. The combined use of serotonin 3 receptor antagonists and third-generation EGFR-TKIs exhibits a significant synergistic effect in inhibiting the proliferation of lung adenocarcinoma cells, with minimal toxic side effects on liver and kidney function, providing an effective treatment strategy for clinically reversing third-generation EGFR-TKI resistance and improving the treatment efficacy of NSCLC.

This invention discloses a method for preparing a co-loaded dual-gene targeted delivery system and its application, involving the construction and preparation of a dual-gene (pHNF4α, pFOXA3) delivery system. This delivery system can target myofibroblasts (MFs) and activated hepatic stellate cells (aHSCs) and can be used for gene therapy of liver fibrosis. This invention synthesizes the targeting carrier material PEI. 25K -PEG 2K -pPB, through electrostatic adsorption, combines with pHNF4α and pFOXA3 to form a co-loaded dual-gene targeted delivery system, F4α / A3@PP-pPB. This delivery system, through the targeting group pPB, binds to MFs (metacellular matrix cells) that lead to excessive accumulation of extracellular matrix in fibrotic livers and to PDGFR (polydimethylformamide) highly expressed on the surface of aHSCs. On the one hand, it inhibits the activation of aHSCs; on the other hand, it transdifferentiates MFs into hepatocyte-like cells (iHep). These two modes, while combating liver fibrosis, can also achieve a certain degree of liver function reconstruction through transdifferentiated iHep cells, providing new ideas and methods for the effective treatment of liver fibrosis.