708 results about "Obstructive Pulmonary Diseases" patented technology

Applicant discloses herein relate to systems, methods, apparatuses, and non-transitory computer readable media for generating physiological signals datasets, analyzing physiological signals in the physiological signals datasets, extract fractional dynamics signatures specific to Chronic Obstructive Pulmonary Disease (COPD) medical records, and identifying, using a deep neural network (DNN), a COPD stage.

Embodiments of the present invention provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue. In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion, or a suspension of one or more ingredients. In embodiments of the present invention, amounts of the formulation and / or energy are effective to injure or damage tissue, nerves, and nerve endings in order to relieve disease symptoms.

Methods of treating a central airway obstruction (CAO), benign airway stenosis, asthma, chronic obstructive pulmonary disease (COPD), or an airway tumor in a human subject, methods of treating chronic rhinosinusitis (CRS) or chronic rhinosinusitis with nasal polyps (CRSwNP) in a human subject, methods of treating a eustachian tube disorder in a human subject, and devices and systems for performing the methods. A method of treating a central airway obstruction (CAO), benign airway stenosis, asthma, chronic obstructive pulmonary disease (COPD), or an airway tumor in a human subject includes inserting a drug-coated balloon catheter into a target site in a trachea, mainstem bronchus, bronchus intermedius, lobar bronchus, segmental bronchus, or sub-segmental bronchus, wherein the balloon is coated with a coating layer including the therapeutic agent and one or more additives. The therapeutic agent includes paclitaxel, sirolimus, or a derivative thereof. The method includes inflating the balloon to dilate the airway and deliver a therapeutic agent to the airway wall. The method includes deflating the balloon. The method also includes withdrawing the balloon catheter from the target site.

To provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue.SOLUTION: In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion or a suspension of one or more ingredients. In embodiments of the present invention, amounts of the formulation and / or energy are effective in injuring or damaging tissue, nerves and nerve endings in order to relieve disease symptoms.SELECTED DRAWING: Figure 3B

The present disclosure relates to a compound for use in treating chronic obstructive pulmonary disease (COPD) in a patient, which compound is ensifentrine or a pharmaceutically acceptable salt thereof, wherein the patient has a blood eosinophil count of <300 cells / μL, <150 cells / μL, or <100 cells / μL.

Embodiments of the present invention are directed to the treatment of hypertension, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pains, asthma, pulmonary arterial hypertension, and chronic obstructive pulmonary disease by delivering of an effective amount of formulations at desired temperature to target tissue. The formulations include gases, vapors, liquids, solutions, emulsions and suspensions of one or more ingredients. The temperature may enhance safety and efficacy of the formulations for the treatments. The amounts of the formulation and / or energy are effective to injury or damage the tissues to have a benefit of symptom relive.

The invention belongs to the field of medicines, and particularly relates to a traditional Chinese medicine compound for treating chronic obstructive pulmonary disease in a stable phase and application thereof. The traditional Chinese medicine composition is prepared from herba epimedii, rhizoma curculiginis, radix astragali, radix salviae miltiorrhizae, lumbricus, rhizoma dioscoreae nipponicae, radix ophiopogonis, radix scutellariae, radix adenophorae, rhizoma zingiberis, cortex mori radicis, rhizoma pinelliae, rhizoma coptidis and semen ginkgo, can play the main effects of tonifying lung and kidney, reducing phlegm and removing blood stasis, and is applied to the stable phase of the chronic obstructive pulmonary disease; the traditional Chinese medicine composition has a good clinical application effect in treatment of chronic obstructive pulmonary diseases, especially lung-kidney qi deficiency syndrome and phlegm-blood stasis syndrome.

The invention discloses a COPD-FE risk prediction method based on disease and symptom combination, and is applied to the technical field of chronic obstructive pulmonary disease risk prediction. Comprising the following steps: acquiring chronic obstructive pulmonary frequent acute exacerbation influence factor data of a patient; the influence factors are screened through LASSO regression and an improved Boruta algorithm respectively; the LASSO independent influence factors and the Boruta independent influence factors are combined in different modes, a Logistic regression model and an XGBoost model are trained, and a plurality of COPD-FE risk prediction models are obtained; and evaluating the performance of all the COPD-FE risk prediction models, and selecting the COPD-FE risk prediction model meeting the requirement to predict the COPD-FE risk. According to the method, clinical data of patients are collected, a risk prediction model is constructed in combination with a feature selection method and machine learning, and an optimal model is screened out through comprehensive evaluation.

The invention belongs to the technical field of biological medicine, and particularly discloses application of kaempferol in preparation of a medicine for treating chronic obstructive pulmonary disease. The invention provides application of kaempferol in preparation of a medicine for treating chronic obstructive pulmonary disease. The invention provides a medicine for treating chronic obstructive pulmonary disease. The medicine comprises kaempferol or pharmaceutically acceptable salt thereof as an active ingredient. The invention aims to provide the application of kaempferol in preparation of the medicine for treating the chronic obstructive pulmonary disease, and the chronic obstructive pulmonary disease is treated by adjusting an AMPK signal channel, a Hippo signal channel, an MAPK signal channel and a PI3K-AKT signal channel.

The invention discloses a traditional Chinese medicine composition for treating acute exacerbation of chronic obstructive pulmonary disease, which is prepared from the following raw materials in parts by weight: 6-9 parts of honey-fried ephedra, 30-40 parts of gypsum, 6-9 parts of fried semen armeniacae amarae, 9-15 parts of fructus perillae, 9-15 parts of semen lepidii, 9-15 parts of radix asteris, 9-12 parts of radix peucedani, 9-12 parts of cynanchum glaucescens, 9-15 parts of thunberg fritillary bulb, 9-15 parts of honey-fried folium eriobotryae, 6-12 parts of rhodiola rosea and 6-9 parts of liquorice. Through scientific compatibility of the traditional Chinese medicine raw materials, clinical symptoms of patients in the acute exacerbation period of the chronic obstructive pulmonary disease can be effectively relieved, the acute exacerbation frequency and degree of the patients with the chronic obstructive pulmonary disease are reduced, and lung function decline is delayed. The traditional Chinese medicine composition is free of toxic and side effects and has the advantages of being good in curative effect, fast in effect taking, high in medicine effect, not prone to relapse and the like in the aspect of treating chronic obstructive pulmonary acute exacerbation.

The invention relates to polypeptide gold nanoparticles modified by trace cigarette extract CSE (0.1%-1%) and application of the polypeptide gold nanoparticles in preparation of drugs for treating chronic obstructive pulmonary diseases. The polypeptide-modified gold nanoparticle is a polypeptide-modified gold nanoparticle as shown in a sequence SEQ ID NO: 1. It is confirmed for the first time that polypeptide (CLPFFD, SEQ ID NO: 1) gold nanoparticles modified by trace CSE (0.1%-1%) can antagonize mtDNA synthesis and inhibit mitochondrial ROS generation so as to inhibit activation of macrophage NLRP3 inflammasome, induce depolarization of macrophage and target lung macrophage in vivo to achieve anti-inflammatory activity, and the polypeptide (CLPFFD, SEQ ID NO: 1) gold nanoparticles can be used for preparing anti-inflammatory drugs. The compound has an obvious treatment effect in a COPD acute exacerbation model and a stable phase model, so that the compound can be used for preparing medicines for treating COPD. The medicine has the advantages of being remarkable in curative effect, capable of acting on specific cells in a targeted mode, convenient to track in vivo and the like, and a new treatment means is provided for COPD.

The invention belongs to the technical field of biomedicine, and discloses application of histone lactic acid modification as a target spot in preparation of a medicine for preventing or treating chronic obstructive pulmonary diseases, in particular to lactic acid modification on 18th lysine residues of histone 3, and the expression level of ATM protein in airway epithelial cells is up-regulated through the histone lactic acid modification, so that the chronic obstructive pulmonary diseases can be prevented or treated. The expression of cell senescence key genes is promoted, so that the senescence phenotype of airway epithelial cells is aggravated, and the airway epithelial cells participate in the disease process of mediating the chronic obstructive pulmonary disease. The discovery provides a new therapeutic target for the chronic obstructive pulmonary disease.

The invention belongs to the technical field of medical equipment, and particularly provides an intelligent dynamic monitoring device and method for chronic obstructive pulmonary disease based on wireless sensing, which get rid of dependence on an expiration examination mode, reduce the difficulty of examination operation, and reflect the severity and variability of airway obstruction in other signal monitoring modes. Comprehensive evaluation is carried out in combination with extrapulmonary indexes (such as lung volume change, heart rate, blood oxygen, breathing sound and gait), and automatic identification with other chronic respiratory system diseases is carried out; dynamic physiological changes of the airway are captured, continuous monitoring is achieved, and disease comprehensive management for the chronic obstructive pulmonary disease is achieved.

The invention relates to the technical field of medical health monitoring and neural networks, and provides a chronic obstructive pulmonary disease patient leaving hospital monitoring system which comprises the steps that multi-source data of a patient is acquired, and the multi-source data at least comprises daily health monitoring data and electronic medical record data; preprocessing and feature extraction are conducted on the multi-source data through a data processing module, health feature data of the patient are obtained, and the health feature data are features related to the chronic obstructive pulmonary disease condition selected from the multi-source data and comprise features based on respiratory functions, features based on lifestyles and behaviors and features based on complications and complications; and features based on drug use; integrating and updating the health feature data through a patient health condition evaluation module, and performing clustering analysis on the integrated and updated real-time health data by adopting a density-based clustering algorithm DBSCAN to obtain a health portrait of the patient; the health portrait is analyzed through a medical large model analysis module, an illness state evaluation result and a health management suggestion are obtained, and a deep learning model designed by combining a convolutional neural network CNN with a multi-modal model architecture of an attention mechanism Transform is used in the medical large model analysis module; remote monitoring, interactive communication and personalized intervention operation are executed through the remote medical intervention module according to the illness state evaluation result.

The invention discloses a chronic obstructive pulmonary disease patient screening system for the respiratory medicine department, particularly relates to the field of computer-aided diagnosis, and is used for solving the technical problems that an existing screening method is low in screening efficiency, low in patient adaptability and difficult to popularize on a large scale in a basic level. According to the system, a standardized patient medical event sequence is constructed by obtaining a target population medical record containing medicine distribution and disease diagnosis codes; identifying a characteristic medication and diagnosis mode before definite diagnosis of the chronic obstructive pulmonary disease based on a sequence pattern mining technology; constructing a medical knowledge graph by using the modes, obtaining a feature embedding vector representing a chronic obstructive pulmonary disease medical trajectory through graph neural network learning, and establishing a high-risk digital portrait; inputting the medical sequence of the person to be screened into a feature extraction model based on same map training, and generating an individualized risk probability prediction value by calculating the matching degree of the medical sequence and the digital portrait; and a screening result report is automatically generated, so that efficient and noninvasive early risk screening is realized.

According to the chronic obstructive pulmonary disease grading system and method based on the X-ray chest radiograph, the original X-ray chest radiograph is obtained, and the original X-ray chest radiograph is preprocessed; a conditional generative adversarial network is adopted to separate the preprocessed original X-ray chest radiograph, and a bone suppression image and a bone tissue feature image are obtained; inputting the bone tissue feature image into the constructed double-branch deep neural network to obtain a pulmonary parenchyma feature map and a rib feature map; obtaining a clinical variable, preprocessing the clinical variable, performing cross-modal fusion on the preprocessed clinical variable, the lung parenchyma feature map and the rib feature map, and generating a fusion feature vector; processing the fusion feature vector by combining a regression-classification output header model to obtain an FEV1% predicted value and a GOLD staging result; a conditional generative adversarial network, a double-branch deep neural network, cross-modal fusion and a joint regression-classification output head model are introduced, and low-cost, low-radiation and high-universality GOLD automatic grading can be realized.

The invention relates to the technical field of rehabilitation treatment of chronic obstructive pulmonary patients, and discloses a therapeutic scheme matching method for rehabilitation treatment of chronic obstructive pulmonary patients, comprising the following steps: step 1, a data acquisition and integration module which is responsible for collecting multi-dimensional data of patients; according to the treatment scheme matching method for the rehabilitation treatment of the chronic obstructive pulmonary disease patient, unnecessary medical resource waste can be avoided, the patient can be timely and properly treated, the overall utilization efficiency of the medical resources is improved, detailed treatment information and self-management suggestions are provided for the patient, and the patient is prevented from suffering from chronic obstructive pulmonary disease. A patient can better know the illness state and the treatment process of the patient, a personalized treatment scheme is easier to accept and execute by the patient, the treatment compliance of the patient can be improved, a large amount of real-world patient data is accumulated by the system, rich materials are provided for medical research, and through deep mining and analysis of the data, the treatment compliance of the patient can be improved. Pathogenesis, treatment effect influence factors and the like can be further explored.

The invention discloses a traditional Chinese medicine composition for treating chronic obstructive pulmonary disease as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine, the traditional Chinese medicine composition comprises the following components in parts by weight: 140-200 parts of astragalus membranaceus, 60-120 parts of rehmannia, 40-80 parts of fructus psoraleae, 15-50 parts of walnut kernel, 40-80 parts of aster, 140-200 parts of codonopsis pilosula, 50-85 parts of radix paeoniae rubra, 15-45 parts of schisandra chinensis and 50-80 parts of white mulberry root-bark. The traditional Chinese medicine composition has a good treatment effect on the chronic obstructive pulmonary disease, and meanwhile, the composition is small in side effect and small in harm to the human body.

The invention belongs to the field of medical image analysis, and provides a multi-modal semi-supervised image analysis and structured report generation method and application for solving the problems that standardized report generation efficiency of chronic obstructive pulmonary disease patients is low and the patients highly depend on artificial experience. Performing pretreatment; constructing an improved variational auto-encoder to obtain latent variable representation of the lung medical image data; using domain adaptive adversarial learning to align the data in the unlabeled data set to the distribution of the data in the labeled data set on the latent variable and the segmentation result; generating a preliminary report text by using a text decoder according to a hidden variable output by an encoder of the variational auto-encoder; knowledge distillation is carried out based on a pre-trained Teacher network and a text decoder, and medical terms and abbreviations in the preliminary report text are modified; and outputting the structured report. According to the invention, the lung focus can be segmented with high precision, the disease degree is quantified and the structured report is automatically generated.

The invention discloses a traditional Chinese medicine composition for treating pulmonary nodules, and belongs to the technical field of traditional Chinese medicine composition preparation. Comprising the following components in parts by weight: 10 parts of pericarpium citri reticulatae, 10 parts of rhizoma pinellinae praeparata, 10 parts of fructus aurantii immaturus, 10 parts of cortex magnoliae officinalis, 25 parts of angelica sinensis, 18 parts of ligusticum wallichii, 10 parts of rhizoma cyperi, 25 parts of honeysuckle, 12 parts of bletilla striata, 7 parts of folium artemisiae argyi, 7 parts of mint, 10 parts of radices stellariae dichotomae, 15 parts of exocarpium citri grandis, 15 parts of thunberg fritillary bulb, 15 parts of poria cocos, 15 parts of semen coicis, 10 parts of roasted rhizoma atractylodis macrocephalae, 10 parts of spina gleditsiae, 10 parts of hawthorn, 20 parts of selfheal, 20 parts of astragalus membranaceus, 12 parts of glossy privet fruit, 12 parts of fructus lycii and 4 parts of aspongopus. The invention further discloses a preparation method of the traditional Chinese medicine composition for treating pulmonary nodules. The traditional Chinese medicine has the effects of replenishing qi to invigorate the spleen, reducing phlegm and resolving masses, is mainly used for treating various types of pulmonary nodules, acute and chronic cough, chronic obstructive pulmonary disease and the like, and can be better suitable for different patients to take.

Provided herein are pharmaceutical compositions and methods for treating COPD or COPD exacerbations in subjects suffering from, for example, moderate COPD, or subjects with decreased eosinophil concentrations, or are suffering from chronic bronchitis. Also provided herein are methods of increasing trough lung function in subjects suffering from moderate COPD. In some aspects, the compound is in an inhalable pharmaceutical composition.

A respiratory tract drug delivery analysis method based on deep analysis of a lung function curve of a chronic obstructive pulmonary disease comprises the following steps: deeply and accurately analyzing the lung function curve of a patient, preprocessing image information of the lung function curve, then carrying out digital processing, carrying out feature extraction on the preprocessed image by using a convolutional neural network, and obtaining a feature extraction result; analyzing the curve data to obtain multi-type digital characteristic parameters; weight coefficients are distributed for the multiple types of digital characteristic parameters according to the influence degree, the multiple types of digital characteristic parameters and database data are compared and analyzed through a neural network, then the respiratory function of the patient is accurately evaluated, and the corresponding drug curative effect is predicted; according to the respiratory function evaluation effect and the drug prediction effect of the patient, the optimal drug inhalation condition is provided for the patient, and the treatment compliance and the treatment effect of the patient are improved by setting a personalized guidance mode.

The invention discloses a chronic obstructive pulmonary disease high risk dynamic assessment model system based on an artificial intelligence algorithm, relates to the technical field of chronic obstructive pulmonary disease high risk assessment, and aims to solve the technical problem that the timeliness and accuracy of an assessment result of an existing assessment model are limited. The medical data acquisition module is used for acquiring medical data of a subject through a wearable device, an electronic medical record system or a manually input multi-source channel, generating standardized preprocessed medical data after performing format cleaning, missing value filling and abnormal value filtering on the data, and transmitting the standardized preprocessed medical data to the memory of the cloud database; and the artificial intelligence dynamic assessment model construction module is used for constructing an artificial intelligence assessment model fusing time sequence characteristics and a nonlinear relationship based on the preprocessed medical data, and generating an intermediate result and a final parameter of risk assessment through multi-level calculation. The method has the advantage that the high risk of chronic obstructive pulmonary disease can be dynamically evaluated in real time.

The present invention relates to a compound for use in a method of treating chronic obstructive pulmonary disease (COPD) in a patient suffering from COPD, which compound is ensifentrine or a pharmaceutically acceptable salt thereof, wherein: the patient is resistant to improvements in lung function; and treating COPD comprises (i) improving the symptoms of COPD in the patient and / or (ii) improving the quality of life of the patient. In some aspects, the compound is in an inhalable pharmaceutical composition.

Provided herein are pharmaceutical compositions and methods for providing blood plasma concentrations of ensifentrine to specific patient group populations including those with modified renal or hepatic impairment.

The invention provides a cough and asthma relieving compound medicine for nebulization treatment of a respiratory system as well as preparation and application of the cough and asthma relieving compound medicine. The cough and asthma relieving compound medicine takes various traditional Chinese medicinal materials such as ginkgo and ephedra as main raw materials, and further comprises compound bacteria, an osmotic pressure regulator and a cosolvent. The compound bacteria are prepared from cordyceps sinensis, bamboo fungus and pine olive in a specific mass ratio, the osmotic pressure regulator is prepared from glucose and glycerol in a specific ratio, and the cosolvent has multiple selectable components. The preparation method comprises a plurality of steps and unique processes including medicinal material extraction, salifying modification, ultrasonic extraction and the like. Clinical tests show that compared with a control group and a placebo group, the compound medicine disclosed by the invention can remarkably improve lung function related indexes of patients and reduce the level of inflammatory factors, and a visual simulation scoring method also proves that the compound medicine can effectively relieve symptoms of cough and asthma. The medicine can be used for preparing aerosol inhalation medicines for treating various respiratory diseases such as bronchial asthma and chronic obstructive pulmonary diseases, and has a good application prospect.

The present invention provides, among other things, apparatus and methods of use for treating a subject in need of assistance with breathing. In some embodiments the subject suffers from airflow obstruction. In some embodiments, the subject suffers from chronic obstructive pulmonary disease.

The invention belongs to the technical field of medical instruments. In order to solve the problems that an existing lung function detection device is low in detection result accuracy and cannot detect parameters such as the residual gas amount, the device for assisting in detecting the lung function of the chronic obstructive pulmonary disease patient is provided and comprises a detection device, a helium bottle, a sealing mask, a nose clip, an air suction pipe, an air outlet pipe, a sealing unit and a plugging switching mechanism; one end of the air suction pipe is connected with the helium tank, and the other end is connected with the plugging switching mechanism; one end of the air outlet pipe is connected with the detection device, and the other end is connected with the plugging switching mechanism; the nose clip is arranged at the upper end of the sealing mask. According to the embodiment of the invention, a subject cannot inhale external air and cannot exhale in-vivo air from the nasal cavity through the nasal clip, and the plugging switching mechanism can thoroughly open the pipe orifice of the air outlet pipe or the air inlet pipe, so that the subject can inhale or exhale easily, the detection accuracy is high, and the detection efficiency is high. And the method can be combined with a closed helium dilution method to obtain parameters such as residual gas amount.

The present application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for relieving cough and asthma, and a preparation method and application thereof. The traditional Chinese medicine composition comprises, in mass parts, perilla seed 5-15 parts, radish seed 5-15 parts, white mulberry bark 5-15 parts, orange red or processed orange red 5-15 parts, and cassia 5-15 parts. The traditional Chinese medicine composition has the effect of relieving cough and asthma, can effectively improve the clinical symptoms such as cough, expectoration and wheezing of patients with chronic obstructive pulmonary disease, promote lung rehabilitation, improve the dyspnea condition of the patients, and improve the life quality of the patients.

The invention discloses a traditional Chinese medicine composition for relieving chronic obstructive pulmonary disease and application thereof. The traditional Chinese medicine composition comprises 15-30 parts of gypsum, 5-10 parts of wrinkled gianthyssop herb, 5-10 parts of cape jasmine, 5-10 parts of divaricate saposhnikovia root, 15-20 parts of fried coix seed, 5-10 parts of fortune eupatorium herb, 10-15 parts of mulberry leaf, 15-20 parts of fried Chinese yam, 6-10 parts of fried almond, 6-10 parts of perilla leaf and 6-10 parts of caulis perllae. By adjusting the formula of the traditional Chinese medicine composition, the symptoms of the chronic obstructive pulmonary disease can be effectively relieved.