The present invention provides improved methods, systems, devices and kits for performing
lung volume reduction in patients suffering from chronic obstructive
pulmonary disease or other conditions where isolation of a
lung segment or reduction of
lung volume is desired. The methods are minimally invasive with instruments being introduced through the mouth (endotracheally) and rely on isolating the target
lung tissue segment from other regions of the lung. Isolation is achieved by deploying an obstructive device in a lung passageway leading to the target
lung tissue segment. Once the obstructive device is anchored in place, the segment can be aspirated through the device. This may be achieved by a number of methods, including
coupling an
aspiration catheter to an inlet port on the obstruction device and aspirating through the port. Or, providing the port with a valve which allows outflow of gas from the isolated
lung tissue segment
during expiration of the
respiratory cycle but prevents inflow of air during inspiration. In addition, a number of other methods may be used. The obstructive device may remain as an
implant, to maintain isolation and optionally allow subsequent aspiration, or the device may be removed at any time.