23 results about "Embolization material" patented technology

The present application relates to the technical field of hydrogel, in particular to an injectable temperature-responsive enhanced composite double-network magnetic particle gel, a preparation method and application thereof, the hydrogel is composed of a particle gel network formed by gelatin nanoparticles and Fe3O4 nanoparticles through electrostatic interaction and a poly-N-isopropyl acrylamide (PNIPAM) based temperature-sensitive polymer gel network. At room temperature, the hydrogel has excellent shear thinning and self-healing properties, and can be easily injected through a needle and a microcatheter. When the temperature rises to human body temperature (37 DEG C), the temperature-sensitive polymer phase transition crosslinking enhances the mechanical properties of the gel network. The hydrogel is injectable in vitro, temperature-responsive in vivo, meets the requirements of vascular interventional embolization materials, and can be magnetically heated under an alternating magnetic field, and is used for liver cancer embolization combined with magnetic heating treatment. The preparation method is simple, has high biocompatibility, and has great clinical application potential.

Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a permeable implant having a radially constrained state configured for delivery within a catheter lumen, an expanded state, and a plurality of elongate filaments that are woven together. The implant may include a cavity in a proximal section that may optionally house embolic material, such as coils. Alternatively, the implant may have an expanded preset shape that is different than an expanded preset shape that is assumed after deployment in an aneurysm. The expanded preset shape may be frustoconical. Alternatively, the implant may include an outer skirt coupled to a proximal section of the permeable implant.

Systems and methods for performing embolization to treat various medical indications and targets (e.g., bleeding, tumors) utilize a mixture of embolization particles and delivery media at very low concentrations of embolization material while intermittently injecting contrast agent boluses for visualizing progression of embolization. The systems and methods are also automated to minimize user interaction, and may also incorporate sensor and feedback control processes to control the systems and methods when performing embolization.

The present invention relates to an embolization microcatheter, comprising: a delivery section having a delivery cavity; an embolization section, one end near the distal end is recessed towards the embolization cavity of the embolization section and forms a pressure relief portion having a pressure relief hole; one end of the embolization section near the proximal end is sleeved on one end of the delivery section near the distal end, and the embolization cavity is communicated with the delivery cavity; during embolization, an embolization material is continuously injected into the embolization cavity through the delivery cavity, the pressure relief portion bulges outwards in a direction away from the embolization cavity, and then the embolization section gradually expands from the direction of the distal end towards the direction of the proximal end, and promotes the separation of the embolization section from the delivery section to achieve the purpose of embolizing blood vessels. When the embolization cavity is filled with the embolization material, the embolization material will squeeze the wall of the embolization cavity and increase the diameter of the wall of the embolization cavity, thereby promoting the separation of the embolization section from the delivery section to achieve the purpose of embolizing the target blood vessel jointly by the embolization section and the embolization material.

Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a permeable implant having a radially constrained state configured for delivery within a catheter lumen, an expanded state, and a plurality of elongate filaments that are woven together. The implant may include a cavity in a proximal section that may optionally house embolic material, such as coils. Alternatively, the implant may have an expanded preset shape that is different than an expanded preset shape that is assumed after deployment in an aneurysm. The expanded preset shape may be frustoconical. Alternatively, the implant may include an outer skirt coupled to a proximal section of the permeable implant.

Materials, methods, and systems are provided that are particularly useful for embolizing, for example, a target vascular sac using microgels applied with a microrobot. The microrobot comprises a microgel based on a self-healing material for on-demand controllable aggregation, magnetic agents, such as magnetite nanoparticles, encapsulated in microgels for driving and aggregating microrobots at targeted intravascular locations under physiological blood flow and imaging agents, such as tantalum microparticles, for accurately tracking microrobots in living organisms through clinical medical devices. Related systems and methods are disclosed for delivering and guiding microrobots to accumulate and gather at targeted locations to provide on-demand and reliable embolization therapy under real-time monitoring.

A liquid embolic composition of natural polymers, water, and angiographic contrast agents improves neurovascular interventions, making them more reliable, safe, and affordable. The embolic material is made of a single component activated by blood calcium ion, which triggers coagulation, and that offers superior mechanical stability and does not cause fragmentation in the target vessel. The material retains superior long-term mechanical durability after deployment and provides sufficient visualization under fluoroscopy with iodine-based angiographic contrast compounds or other radiopaque compositions. Described herein are aqueous solutions that enable a high concentration gellan gum (greater than 0.5 wt %) to retain sol state even at the range of body temperature (30-40° C.). This discovery means that it is possible to increase the concentration of gellan gum without losing its inject-ability, yet significantly improve its mechanical stability after delivery.

Treatment of aneurysms can be improved by delivering an occlusive member (e.g., an expandable braid) to an aneurysm sac in conjunction with an embolic element (e.g., coils, embolic material). A treatment system for such treatment can include an electrolytically corrodible core wire having a proximal portion, a distal portion, and a detachment zone between the proximal portion and the distal portion. An occlusive member having a proximal hub is coupled to the core wire distal portion. A conduit extends along at least a portion of the core wire. The conduit has a lumen configured to pass an embolic element therethrough.

The invention belongs to the technical field of medical materials, and particularly relates to a liquid embolism material containing an absorbable developing agent and a preparation method of the liquid embolism material. The liquid embolism material containing the absorbable developer provided by the invention comprises a high polymer material, the absorbable developer and dimethyl sulfoxide, the absorption developer is an iodine-containing oligomer, and is prepared from an iodophenyl compound and an ester cyclic monomer or an ether cyclic monomer through ring opening polymerization under the action of a catalyst. The liquid embolism material provided by the invention can be dissolved in a dimethyl sulfoxide solvent, and can be gradually separated out to form embolism when being in contact with blood; after the absorbable developer material is transferred to tissues in a human body, the iodine-containing oligomer is gradually metabolized and discharged out of the body within 30-90 days.

The present application relates to the technical field of embolic material, in particular to a vascular embolization composition containing a biocompatible polymer and a preparation method thereof, comprising a biocompatible polymer and a biocompatible iodine-containing contrast agent; the biocompatible polymer is selected from polylactic acid-glycolic acid copolymer PLGA, polycaprolactone PCL, polyethylene glycol-polylactic acid copolymer PEG-PLA or polytrimethylene carbonate PTMC; the biocompatible iodine-containing contrast agent is selected from triiodophenoxy ethyl acrylate-hydroxyethyl methacrylate copolymer, iohexol, triiodophenol, iopromide or iopamidol; the biocompatible iodine-containing contrast agent is used to avoid metal toxicity, has high and uniform development intensity, meets clinical precise positioning, and has good compatibility and dispersibility.

The invention discloses a composite thermosensitive hydrogel embolism material and a preparation method thereof, and belongs to the technical field of biological medicines. The invention aims to solve the problems of insufficient strength, uncontrollable gel forming and development deficiency of the embolism material. The cleaning agent is composed of the following components in percentage by weight: 5 wt% of sodium alginate; 20 wt% of a developer; 8-15 wt% of a crosslinking triggering agent gelatin microsphere; 1.5 to 2 wt% of a thixotropic agent; and the balance of sterilized water for injection. The molar ratio of Ca to G is 0.3 to 0.35. At room temperature, lithium magnesium silicate forms a physical gel network, so that the material is endowed with a shear thinning characteristic, and the material can be smoothly injected through a microcatheter and stably suspends a developing agent; when the gelatin microspheres are injected into in-vivo target blood vessels at 37 DEG C, the gelatin microspheres generate thermal response phase change, released calcium ions trigger sodium alginate to generate irreversible ionic crosslinking, a high-strength chemical gel network is formed, and the gelatin microspheres are suitable for treatment of vascular diseases such as liver cancer interventional embolism and the like.

Treatment of aneurysms can be improved by delivering an occlusive member (e.g., an expandable braid) to an aneurysm sac in conjunction with an embolic element (e.g., coils, embolic material). A treatment system for such treatment can include an electrolytically corrodible core wire having a proximal portion, a distal portion, and a detachment zone between the proximal portion and the distal portion. An occlusive member having a proximal hub is coupled to the core wire distal portion. A conduit extends along at least a portion of the core wire. The conduit has a lumen configured to pass an embolic element therethrough.

An injectable and temperature-responsive enhanced composite dual-network magnetic particle gel is a hydrogel, including a particle gel network formed by gelatin nanoparticles and Fe3O4 nanoparticles via an electrostatic interaction and a poly(N-isopropylacrylamide) (PNIPAM)-based temperature-sensitive polymer gel network. At room temperature, the hydrogel exhibits excellent shear-thinning and self-healing properties, and is easily injectable through needles and microcatheters. When raised to a human body temperature (37° C.), the temperature-sensitive polymer undergoes phase transition cross-linking, enhancing mechanical properties of the gel network. The hydrogel is injectable in vitro and exhibits temperature-responsive strengthening in vivo, meeting the requirements of a vascular interventional embolization material. The hydrogel can also generate magnetothermal heating under an alternating magnetic field, thereby achieving the embolization combined with magnetothermal therapy for liver cancer. The preparation method is simple, with high biocompatibility and a great potential for clinical applications.

The invention relates to an embolism microcatheter which comprises a conveying section with a conveying cavity; one end, close to the far end, of the embolism section is concave towards an embolism cavity of the embolism section, and a pressure relief part with a pressure relief hole is formed; the end, close to the near end, of the embolism section is arranged at the end, close to the far end, of the conveying section in a sleeving mode, and the embolism cavity is communicated with the conveying cavity; during embolism, embolism materials are continuously injected into the embolism cavity through the conveying cavity, the pressure relief part protrudes outwards in the direction away from the embolism cavity, then the embolism section is gradually expanded from the direction where the far end is located to the direction where the near end is located, the embolism section is promoted to be separated from the conveying section, and the purpose of blood vessel embolism is achieved. When the embolism cavity is filled with the embolism material, the embolism material can extrude the cavity wall of the embolism cavity, the diameter of the cavity wall of the embolism cavity is increased, and therefore the embolism section and the conveying section are promoted to be separated, and the purpose that the target blood vessel is embolized through the embolism section and the embolism material jointly is achieved.

This invention discloses an AI-powered intelligent embolization assistance system for arteriovenous malformations of the brain and spinal cord. By integrating an AI-powered intelligent embolization assistance subsystem and an image-guided platform, it matches 3D-DSA angiography images with internally stored hydrodynamic models of different embolization materials to obtain a three-dimensional vascular architecture map of the lesion and surrounding vessels. Through AI calculation, it completes virtual path planning, simulating the embolization path, three-dimensional course, and embolization range. Based on this, it provides real-time navigation of the microcatheter during EVT, intelligently following its path. After the procedure, it re-acquires 3D-DSA angiography images, performs multimodal image fusion, and assesses the embolization status, the three-dimensional relationship with surrounding structures, and potential related complications. This system enables preoperative planning and simulation of the interventional embolization path and range, and real-time navigation, tracking, and assessment of the lesion during the procedure, effectively improving the efficacy of EVT.

An aneurysm embolization device can include a body having a single, continuous piece of material that is shape set into a plurality of distinct structural components. For example, the device can have an expandable component and an atraumatic tip portion extending therefrom. Further, the tip portion can be configured to enable the device to be implanted within the aneurysm while tending to mitigate risk of puncturing the aneurysm dome or otherwise assist in framing the aneurysm in advance of placement of additional embolic material.

The invention discloses magnetic hydrogel as well as a preparation method and application thereof, and relates to the technical field of hydrogel. The magnetic hydrogel is prepared from the following raw materials: a component A, a component B and a component C, the component A comprises a magnetic functional component, a hydrophilic polymer dispersion liquid and a material containing ortho-hydroxybenzene; the component B comprises a material containing an aldehyde group; and the component C comprises a material with oxidizing property. The magnetic hydrogel disclosed by the invention has injectability, can realize directional accurate delivery under the action of an external directional magnetic field, and can be efficiently adhered to the tissue surface in a dynamic water environment, so that the stability and lasting plugging capacity of an embolism material at a target part in a blood vessel are greatly improved.

The utility model discloses a microcatheter capable of preventing backflow, which at least comprises a main body tube, the main body tube is of a multi-layer structure, and one layer of structure of the main body tube forms a closable structure at a far-end port of the main body tube; the main body tube is of a three-layer structure, namely the inner layer, the middle layer and the outer layer, the main body tube is provided with the tube cavity capable of containing embolism agents and pushing the guide wire, the outlet at the far end of the tube cavity is of a closable structure, the problem of backflow of embolism materials, contrast agents or medicine solutions in an operation can be effectively solved through the structure, and the injection efficiency can be improved. The main body tube is of a reducing structure, and the super-selectivity of the micro-catheter can be improved.

An embolic material delivery device in accordance with at least some embodiments of the present technology achieves a high pressure rating with a small wall thickness. The device includes an elongate conduit body configured to extend intravascularly toward a treatment location including an aneurysm. The conduit body defines an axial lumen through which viscous embolic material is conveyed toward the aneurysm while at least a portion of the liquid embolic material is at very high pressure (e.g., 9,000 psi or greater). The conduit body includes a metal hypotube coaxially disposed around the axial lumen. The hypotube includes cuts configured to increase a flexibility of the conduit body and bridges between the cuts. The conduit body further includes an elastomeric jacket extending around at least a portion of the hypotube. An average wall thickness of the conduit body is within a range of 0.005 to 0.007 inches.

To provide an embolic material for relieving or treating musculoskeletal pain comprising gelatin particles.SOLUTION: The embolic material comprising gelatin particles can relieve or treat musculoskeletal pain by being injected into a blood vessel, embolized in the vessel, and then dissolves rapidly. The embolic material comprising gelatin particles can be effectively used as an embolic material in the medical fields and pharmaceutical industry for relieving or treating musculoskeletal pain in patients suffering from chronic pain associated with musculoskeletal disorders.SELECTED DRAWING: Figure 6

The present application relates to the field of interventional medical technology, and more particularly to a remote-controlled magnetic navigation multi-injury bleeding interventional collaborative hemostasis method. The method identifies multiple bleeding sites based on angiography images and generates a magnetic navigation path planning scheme, drives the interventional catheter to reach each bleeding site in turn through an external magnetic field, and releases magnetic responsive microspheres for embolization. Real-time monitoring of hemodynamic parameters is used to evaluate the hemostasis effect, and the subsequent path and embolization material release amount are dynamically adjusted. The method realizes precise and sequential collaborative hemostasis of multiple injury bleeding sites, and improves the efficiency and safety of interventional surgery.

The embodiment of the present application provides a balloon microcatheter and a preparation method thereof, and relates to the field of medical devices. The balloon microcatheter has a hydrophilic lubricating layer, and the hydrophilic lubricating layer is coated on the balloon shoulder of the balloon microcatheter. Since the balloon of the balloon microcatheter is only partially coated with the hydrophilic lubricating layer, that is, the shoulder of the balloon microcatheter has the hydrophilic lubricating layer, and the working section of the balloon does not have the hydrophilic lubricating layer, the balloon has both anchoring and lubricating properties, the balloon microcatheter can pass through the contrast catheter and the tortuous and narrow blood vessel without resistance, and at the same time, the working section of the balloon anchors the blood vessel wall and can buffer the recoil force generated by the infusion of embolic materials; at the same time, the partial coating form can take into account the ductility of the balloon and the hydrophilic lubricating layer, so as to avoid the cracking and falling of the hydrophilic lubricating layer when the balloon expands, or the pinhole rupture of the balloon in the expansion process due to the restraint of the hydrophilic lubricating layer.

The utility model relates to a catheter capable of simultaneously completing hemangioma embolism and intraoperative radiography, which comprises a catheter main body, a contrast agent channel and an embolism channel which are mutually independent are arranged in the catheter main body, the contrast agent channel and the embolism channel penetrate through two ends of the catheter main body, and a connector is arranged at one end of the catheter main body. The connector is provided with a contrast agent inlet and an embolism material inlet, the contrast agent inlet is communicated with one end of the contrast agent channel, the embolism material inlet is communicated with one end of the embolism channel, and the catheter body is provided with a sealing structure used for sealing or opening the other end of the contrast agent channel. By means of the integrated design, seamless switching between embolism and radiography operation is achieved, the operation process is simplified, the operation time is shortened, the embolism effect is monitored through real-time radiography, it is ensured that the release position and number of embolism materials are accurate, the number of times of catheter insertion and replacement is reduced, vascular injury and intraoperative infection risks are reduced, use of various catheters and auxiliary equipment is reduced, and the operation efficiency is improved. The operation consumable cost is reduced, and the catheter is easy to operate and wide in application range.