50 results about "Brain aneurysm" patented technology

Disclosed is a system for the treatment of cerebral aneurysms using a stent and a aneurysm pocket fill structure delivery system. One embodiment of the present invention uses a highly radiopaque, drug eluting stent that is deployed with its sidewall over the ostium of the aneurysm pocket. A fill structure delivery catheter is then advanced through the patient's vascular system until the catheter's distal end is situated within the aneurysm pocket. Compressed aneurysm pocket filling structures are then pushed through the fill structure delivery catheter. As the aneurysm pocket filling structures emerge from an opening in the catheter's distal end, they promptly expand so that their minimum dimension is sufficiently large so that they cannot pass through the spaces between the struts of the stent that cover the ostium of the aneurysm pocket.

A device for in situ treatment of vascular or cerebral aneurysms comprises an occlusion device having a flexible, longitudinally extending elastomeric matrix member that assumes a non-linear shape to conformally fill a targeted site. The occlusion device comprises a flexible, longitudinally extending elastomeric matrix member, wherein the device assumes a non-linear shape capable of fully, substantially, or partially conformally filling a targeted vascular site. In one embodiment the vascular occlusion device comprises a first longitudinally extending structural element having a longitudinally extending lumen and an outer surface; a second longitudinally extending structural element extending through the lumen; and an elastomeric matrix member surrounding the outer surface, wherein the second structural member does not engage or attach to the first structural element or the elastomeric matrix.

An implant for treating brain aneurysms, especially terminal aneurysms, comprises a neck cover and elongate shaft removably secured to an embolic delivery catheter. As such, the shaft aids in directing and placing the cover at the aneurysm neck, protecting the delivery catheter from adhesion with the embolic material, and securing the cover in place with connection or adhesion of the shaft to the embolic material delivered through the catheter. The implant can be anchored at the aneurysm either by interface and / or adhesion of the shaft or shaft and cover with the resident embolic materials.

An apparatus and method for stabilization of aneurysm is disclosed. The apparatus comprises an ultraviolet radiation generator for generating UV radiation having a wavelength, strongly absorbed by the DNA and a catheter including means for delivering the ultraviolet radiation to the aneurysm. The distal end of the catheter is placed inside the aneurysm. Stabilization of the aneurysm is achieved by forming a mural arterial thrombus inside the aneurysm. To make irradiation possible, the blood is displaced from the aneurysm by a steady stream of UV radiation transparent fluid. The injury to the endothelium that triggers the thrombus formation is caused by UV radiation delivered to the aneurysm. In several days after intervention the thrombus becomes fully organized, leaving on the inside surface of the aneurysm a thick layer of fibrotic tissue that stabilizes the aneurysm.

A method and device for occluding an aneurysm. The device may include a wire having a shape memory. The wire may define a coil. The wire may further define a first substantially spherical helix and a second substantially spherical helix nested within the first substantially spherical helix. A catheter may be included, being releaseably engageable to the wire, the wire being at least partially disposed within the catheter.

Devices and methods for treating aneurysms are disclosed. The devices are adapted and configured to modify blood flow at the aneurysm. More specifically, the invention discloses devices and methods for treating cerebral aneurysms using devices adapted and configured to be delivered to a blood vessel in the brain on a distal tip of a microcatheter. The aneurysm devices comprise: a device adapted to be delivered to a blood vessel aneurysm on a distal tip of a catheter and further adapted to modify blood flow at the aneurysm.

A method for furnishing a therapeutic-agent-containing medical device is provided. The method comprises: (a) providing a reactive layer comprising a cross-linking agent on a medical device surface; and (b) subsequently applying a polymer-containing layer, which comprises a polymer and a therapeutic agent, over the reactive layer. The cross-linking agent interacts with the polymer to form a cross-linked polymeric region that comprises the therapeutic agent. Examples of medical devices include implantable or insertable medical devices, for example, catheters, balloon, cerebral aneurysm filler coils, arterio-venous shunts and stents.

The invention relates to devices, a systems, and associated methods for use, delivery, and manufacture for changing the blood flow into an aneurysm designed to induce aneurysm thrombosis and / or the exclusion from blood flow and pressure of the aneurysm in order to prevent further growth and eventual rupture. In some embodiments, the various aspects of the invention are directed to treating a cerebral aneurysm.

An embolization device for treating ischemic stroke is disclosed, having a surface, wherein the body portion is configured to have a radiopaque and electropositive surface under physiological conditions when the device is emplaced, which ionically binds a blood component in an amount effective to promote stability of device in situ to bind to a tissue component in an amount effective to increase adhesion of the device as compared to a device without an electropositive surface. Embolic coils being so delivered are electrolytically detachable in under 10 seconds, according to the disclosed vascular implant systems.

The invention discloses a cerebral aneurysm hemodynamic index evaluation method, system and device and a medium. The evaluation method comprises the following steps: acquiring human body cerebral artery image data; carrying out anatomical modeling on the human body cerebral artery medical image data to obtain a cerebral aneurysm anatomical model; fluid mechanics calculation processing is conductedon the cerebral aneurysm anatomical model, and outputting a calculation result; and adding the calculation result to a corresponding position of the cerebral aneurysm anatomical model, and carrying out visual display of hemodynamic indexes. According to the method, the system, the equipment and the medium, the hemodynamic indexes of the cerebral aneurysm can be obtained according to the medical image data of the human cerebral artery. Therefore, the relationship between the hemodynamic characteristics and the occurrence, development and rupture of the aneurysm can be analyzed based on the obtained hemodynamic indexes, and a theoretical basis is provided for risk factor assessment and interventional therapy of the cerebral aneurysm.

Devices for treating aneurysms are disclosed. The devices are adapted and configured to modify blood flow at the aneurysm. More specifically, the invention discloses devices for treating cerebral aneurysms using devices adapted and configured to be delivered to a blood vessel in the brain on a distal tip of a microcatheter. The aneurysm devices comprise: a device adapted to be delivered to a blood vessel aneurysm on a distal tip of a catheter and further adapted to modify blood flow at the aneurysm.

Disclosed is an antithrombotic neurovascular device useful for the treatment of brain aneurysms and / or acute ischemic stroke. The device comprises a mechanical structure, which may be a stent, stent-like structure, or flow diverter, and a drug-eluting coating. This device is designed for local delivery of antiplatelet medication to the site of device implantation in order to improve outcomes for the population of brain aneurysm and / or acute ischemic stroke patients currently being treated with stents, and for use with patients presenting with ruptured aneurysms, in whom systemic dual antiplatelet therapy is contraindicated. The coating comprises an antiplatelet drug, preferably, a GPIIb / IIIa receptor inhibitor, more preferably, abcixmab, and optionally comprises a polymeric binder that functions as a drug modulating polymer. Also disclosed are methods for producing the antithrombotic neurovascular device, and using the device for the treatment of brain aneurysms and / or acute ischemic stroke.

An endovascular bare stent belongs to the technical field of biomedical engineering. The stent is a tubelike mesh-screen stent 1 which is arranged in the blood vessels along the vessel wall. The invention is characterized in that the cross-section of the mesh-screen of the mesh stent 1 takes the shape of a trapezium. The long edge of the trapezium is the outer side 3 of the mesh-screen stent. The short edge of the trapezium is the inner side 2 of the mesh-screen stent. The ratio of short side of the trapezium to long side of the trapezium is less than 50 percent. The penetrating ratio of the mesh-screen of the mesh-screen stent 1 is 40 percent to 80 percent. After the stent covers the aneurysm, the resistance of the blood flowing into the tumor cavity is large, and the resistance of the blood flowing out of the tumor cavity is small; therefore, the blood flowing in the tumor cavity is inhibited so as to reach the purpose of treatment. The stent has little effect on perforating branches vessel, can easily be sent to tortuous intracranial artery, thereby causing the nerves involved in the treatment of cerebral aneurysms more extensive, saving more patients, and being good Gospel for doctors and patients.

Methods and systems for controlling aneurysm initiation or formation in an individual are presented; the technique comprises receiving morphological data of an artery being indicative of at least first and second geometrical parameters of the artery along its trajectory; analyzing the data to identify at least one flow-diverting location along the artery satisfying first and second predetermined conditions of the geometrical parameters; classifying the individual as having or not having disposition for future formation of an aneurysm, depending respectively on whether the at least one flow-diverting location is identified or not and generating classification data; and generating prediction data for the individual with regard to future aneurysm formation.

Methods and systems for modeling cerebral aneurysm and their incoming and outgoing vessels from 3D image data are disclosed. Aneurysms and vessels are segmented from their background using a graph-cuts method. Begin and end of vessels are determined. Construction of a centerline of the incoming and outgoing vessels using a measure of vesselness in calculating a minimum cost path in a graph with nodes being representation of pixels is also disclosed. Vessel surface models are constructed from sub-voxel cross-sectional segmentation. The interpolation of vessels inside an aneurysm based on smooth continuity is disclosed. Selection of endo-vascular stents based on interpolation results is also provided.

The invention relates to devices, a systems, and associated methods for use, delivery, and manufacture for changing the blood flow into an aneurysm designed to induce aneurysm thrombosis and / or the exclusion from blood flow and pressure of the aneurysm in order to prevent further growth and eventual rupture. In some embodiments, the various aspects of the invention are directed to treating a cerebral aneurysm.

The invention relates to a haemodynamic index data processing method and system. The method comprises collecting medical image data and clinical measurement data; performing image segmentation processing according to the medical image data and the clinical measurement data, and generating specific anatomical model data of the interested blood vessel by using a center line extraction algorithm; carrying out grid division processing on the specific anatomical model data, and carrying out fluid mechanics simulation processing by utilizing boundary conditions, so as to obtain distribution condition data of hemodynamic indexes, the distribution condition data comprising wall surface shear stress, time average wall surface shear stress, an oscillation shear index and a speed streamline; and carrying out visualization processing on the distribution condition data of the hemodynamic indexes so as to display the distribution condition data on a three-dimensional model of the cerebral aneurysm. According to the method and the system, the distribution condition of the haemodynamic indexes in the interested blood vessel can be simulated, visualized and displayed, the processing speed is high, and the visualization precision is high.

The invention relates to a medical apparatus, in particular to a nanometer electrospinning fiber stent for intravascular interventional therapy of intracranial aneurysm. The fiber stent comprises a stent body and a pushing device, wherein the stent body is of a cylindrical net-shaped structure which is formed by weaving a nickel-titanium alloy wire, and the two ends of the stent body are respectively provided with four X-ray-opaque marking points, so as to ensure the accurate release of the stent; the surface of the middle section of the stent body is attached with a large amount of nanometer electrospinning fibers, and the starting point and the finish point of the middle section attached with the nanometer electrospinning fibers are respectively provided with two X-ray-opaque marking points, so as to assist the development positioning in the stent release process, and ensure that the middle section can completely cover an aneurysm neck in the stent releasing process. The fiber stent has the advantages that the dynamics of blood in the intracranial aneurysm can be changed, the formation and organization of thrombus in the aneurysm, and the regeneration of skin cells in blood vessels of the aneurysm neck are promoted, and the purpose of reconstructing an aneurysm-carrying artery is realized; meanwhile, the smoothness of the aneurysm-carrying artery and branch arteries is maintained.

The invention generally relates to co-axial stent and catheter systems and medical procedures utilizing these systems. The co-axial stent system is characterized by two-coaxial stents, including an outer resorbable stent and an inner metal stent used to effect deployment of the resorbable stent. The stents may use for treatment of unstable plaque and / or thrombus at the carotid bifurcation and particularly those that are not causing any significant stenosis. The stents may also be used for treatment of cerebral aneurysms. The invention further describes related, equipment, uses and kits for the treatment of unstable plaque and / or thrombus and / or aneurysms.

This document provides methods and materials related to assessing brain conditions within mammals. For example, methods and materials that can be used to determine whether or not a mammal (e.g., a human) with a brain aneurysm is likely to experience brain aneurysm rupture are provided.

The invention discloses an occlusion device for treating intracranial aneurysm or cerebral aneurysm. The occlusion device comprises a mesh, the mesh has an expanded state and a low configuration statefor intravascular delivery to an aneurysm, the mesh includes a first end portion, a second end portion, and a length extending between the first and second end portions, and a first lateral edge, a second lateral edge, and a width extending between the first and second lateral edges. The mesh may have a predetermined shape in the deployed state, wherein (a) the mesh is curved along its width, (b)the mesh is curved along its length, and (c) the mesh has an undulating profile across at least a portion of one or both of its length or its width. The mesh is configured to be placed within the aneurysm in the deployed state such that the mesh extends over a neck of the aneurysm.

The invention provides a cerebral aneurysm three-dimensional detection segmentation method based on a deep convolutional neural network. The method comprises the following steps: obtaining three-dimensional medical image data to be segmented; the method comprises the following steps: initializing prediction of three-dimensional medical image data, and generating a seed point as an initial tested area; outwards expanding a region from the tested region to obtain an expanded region; inputting the expansion area into the trained flow network model, predicting the expansion area, and merging the predicted expansion area into the tested area; iterative prediction is carried out on the three-dimensional medical image data until the tested area completely covers the three-dimensional medical image data, prediction is completed, and a prediction result of the three-dimensional medical image data is obtained; and obtaining a segmentation result of the three-dimensional medical image data according to the prediction result of the three-dimensional medical image data. The thought of iterative prediction in the flow network model is introduced, and the parameter quantity of the model is reduced while the three-dimensional structure information of the sample is maintained, so that the model is more accurate and convenient.

An endovascular bare stent belongs to the technical field of biomedical engineering. The stent is a tubelike mesh-screen stent 1 which is arranged in the blood vessels along the vessel wall. The invention is characterized in that the cross-section of the mesh-screen of the mesh stent 1 takes the shape of a trapezium. The long edge of the trapezium is the outer side 3 of the mesh-screen stent. Theshort edge of the trapezium is the inner side 2 of the mesh-screen stent. The ratio of short side of the trapezium to long side of the trapezium is less than 50 percent. The penetrating ratio of the mesh-screen of the mesh-screen stent 1 is 40 percent to 80 percent. After the stent covers the aneurysm, the resistance of the blood flowing into the tumor cavity is large, and the resistance of the blood flowing out of the tumor cavity is small; therefore, the blood flowing in the tumor cavity is inhibited so as to reach the purpose of treatment. The stent has little effect on perforating branchesvessel, can easily be sent to tortuous intracranial artery, thereby causing the nerves involved in the treatment of cerebral aneurysms more extensive, saving more patients, and being good Gospel fordoctors and patients.

The invention discloses a kit for detecting the DNA methylation degree of a VGLL3 gene and application thereof. The detection kit comprises a pair of specific amplification primers for DNA methylation of the VGLL3 gene and a specific sequencing primer for DNA methylation of the VGLL3 gene, wherein the specific amplification upstream primer has a nucleotide sequence as shown in SEQ ID NO.1, the specific amplification downstream primer has a nucleotide sequence as shown in SEQ ID NO.2, and the methylation specific sequencing primer has a nucleotide sequence as shown in SEQ ID NO.3; a region where a detected sequence of the VGLL3 gene DNA is located is a specific position at the front end of the gene, and DNA methylation level analysis is carried out through a pyrosequencing technology; the DNA methylation level of the VGLL3 gene is in negative correlation with the prevalence rate of cerebral aneurysm. The kit has the advantages that the kit can be used to detect the cerebral aneurysm on the molecular level conveniently and quickly, the detection efficiency is high, the pertinence is strong, and the medicine taking the DNA methylation of VGLL3 gene as the target spot is an effective means for auxiliary diagnosis, detection and screening of the cerebral aneurysm.

Provided is a liquid embolic agent composition capable of solving problems of conventional embolic agents, which can be used in a treatment of a vascular disease such as cerebral aneurysm. The problems are solved by a liquid embolic agent composition characterized in containing a hydrogel forming component having a calcium ion entrapping ability, and an anti-biodegradation component. The hydrogel forming component having a calcium ion entrapping ability is at least one kind of acidic polysaccharide selected from the group consisting of alginate, gellan gum, carrageenan, and carboxymethyl cellulose salt; and the anti-biodegradation component is at least one kind selected from the group consisting of hydroxypropyl methylcellulose, methylcellulose, polyvinyl alcohol, polyallylamine, poly-N-vinyl acetamide, and cellulose acetate.

This document provides methods and materials related to assessing brain conditions within mammals. For example, methods and materials that can be used to determine whether or not a mammal (e.g., a human) with a brain aneurysm is likely to experience brain aneurysm rupture are provided.

The invention relates to endovascular medical implant devices, systems and methods that including a sensing device and a flow diverter device, which are effective to monitor intra- / post-operative hemodynamic properties in the location of a cerebral aneurysm and, hemodynamic alterations following placement of the system for treating ischemic diseases in carotid, coronary and peripheral arteries. The sensing device includes wireless, non-thrombogenic, highly stretchable, ultra-low profile flow sensors.