8 results about "Vascular inflammation" patented technology

The present invention relates to a polysubstituted imidazolo[4,5-c][1,2]thiazine derivative and a use of an agent comprising same as an active agent, which is useful for infectious diseases associated with vascular inflammation caused by HMGB1 protein activity. It has been found that the polysubstituted imidazolo[4,5-c][1,2]thiazine derivative of the present invention increases the sepsis survival rate as a result of searching for antiseptic effects through CLP-induced sepsis animal experiments. Accordingly, the agent comprising the polysubstituted imidazolo[4,5-c][1,2]thiazine derivative or a pharmaceutically acceptable salt thereof as an active agent may be advantageously used as a therapeutic agent for infectious diseases and vascular inflammatory diseases including sepsis caused by HMGB1 protein activity.

The invention belongs to the technical field of biological medicine, and particularly relates to a traditional Chinese medicine fermentation composition for treating vascular inflammation and a preparation method thereof. The traditional Chinese medicine fermented composition for treating vascular inflammation comprises the following components in parts by mass: 1-10 parts of folium mori, 5-15 parts of bitter gourd, 5-15 parts of radix polygonati officinalis, 1-10 parts of earthworm protein, 10-20 parts of rhizoma polygonati and 5-20 parts of corn stigma. The traditional Chinese medicine fermentation composition has the effect of reducing and treating vascular inflammation, can improve the content of LDL-C and HDL-C in serum, and has good clinical guiding significance.

The present application relates to the field of medicine, in particular to the use of POU2F2 gene or protein in screening products for preventing or treating atherosclerosis. The present application first discloses that POU2F2 can be used as a key pathogenic target of atherosclerosis, and on this basis, a candidate drug linagliptin is screened. The experimental results show that in the in vitro atherosclerosis model, linagliptin can significantly inhibit the expression of POU2F2 and down-regulate the levels of inflammatory factors and adhesion molecules. The findings clarify the mechanism of linagliptin in regulating POU2F2 related signal pathways, inhibiting vascular inflammatory response and reducing vascular endothelial damage, and fully show that it has a good clinical application prospect in preparing drugs for preventing or treating atherosclerosis and its related cardiovascular and cerebrovascular diseases.

The present invention describes a new functional biomarker of vascular inflammation and its use in predicting all-cause or cardiac mortality. The invention also provides a method for stratifying patients according to their risk of all-cause or cardiac mortality using data gathered from a computer tomography scans of a blood vessel to determine a specific combination of structural and functional biomarkers of vascular inflammation and disease.

The present invention relates to the field of nanoparticles, conjugates thereof, and their use in methods of treating or preventing vascular inflammation. The present invention also relates to methods of delivering an agent to a region of a patient's blood vessel, comprising: a) conjugating an agent to a nanoparticle to produce a conjugate; and b) delivering the conjugate to a region of a blood vessel.

The invention discloses a traditional Chinese medicine composition and application thereof in preparation of a medicine for treating vascular inflammation and endothelial injury, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following medicinal raw materials in parts by weight: 40-60 parts of artemisia vestita, 40-55 parts of semen lepidii, 30-40 parts of shellac, 20-25 parts of phyllanthus emblica, 15-30 parts of astragalus membranaceus, 10-20 parts of salvia miltiorrhiza, 8-15 parts of radix paeoniae rubra, 3-9 parts of coptis chinensis and 1-5 parts of leech. The traditional Chinese medicine composition is good in safety and good in effect, and animal experiments prove that the traditional Chinese medicine composition has a good effect on treating vascular inflammation and endothelial injury.

The present disclosure generally relates to methods for the treatment, amelioration, and / or prevention of vascular inflammatory disorders. In some aspects, the methods of the present disclosure comprise administration of an EZH2 inhibitor in a therapeutically effective amount to a subject in need thereof in order to treat, ameliorate, and / or prevent a vascular inflammatory disorder. In some aspects, the methods of the present disclosure comprise administration of an EZH2 inhibitor in a therapeutically effective amount to a subject in need thereof in order to treat, ameliorate, and / or prevent a cardiovascular disease.

The invention provides a multi-microsphere flow type fluorescence detection method for vascular inflammation markers, and belongs to the technical field of multi-microsphere flow type fluorescence detection.The multi-microsphere flow type fluorescence detection method comprises the steps that capture antibody coupling microsphere mixed liquor with different fluorescence coding characteristics is prepared; the method comprises the following steps: sequentially reacting with a to-be-detected sample, a biotin labeled detection antibody and phycoerythrin labeled streptavidin to form a sandwich immune complex, collecting a fluorescence signal by using a flow cytometry, and then carrying out self-adaptive optimization treatment on the original fluorescence signal by using a liquid dynamic correction model, according to the dynamic response characteristics of liquid neurons in the liquid reservoir layer, accurate concentration results of the five vascular inflammation markers are calculated by fitting a standard curve through a logistic regression model, and the technical problem that the multiple detection precision of the vascular inflammation markers is insufficient due to limited dynamic range of fluorescence signals and serious background noise interference is solved.