489 results about "Ergothioneine" patented technology

The invention discloses a hydroxytyrosol-ergothioneine eutectic crystal as well as a preparation method and application thereof, and belongs to the technical fields of medicines, foods, daily chemicals and the like. The invention provides a hydroxytyrosol-ergothioneine eutectic crystal. The X-ray powder diffraction pattern of the hydroxytyrosol-ergothioneine eutectic crystal has characteristic diffraction peaks at least corresponding to the positions where the 2 theta value is 4.21 degrees + / -0.2 degrees, 8.36 degrees + / -0.2 degrees, 12.29 degrees + / -0.2 degrees, 15.29 degrees + / -0.2 degrees, 19.40 degrees + / -0.2 degrees, 20.98 degrees + / -0.2 degrees, 23.12 degrees + / -0.2 degrees and 28.73 degrees + / -0.2 degrees. According to the hydroxytyrosol-ergothioneine eutectic, the melting point of hydroxytyrosol is increased, the hygroscopicity of hydroxytyrosol is remarkably reduced, and meanwhile the stability of hydroxytyrosol and ergothioneine is enhanced. In addition, after the ergothioneine hydroxytyrosol forms the eutectic crystal, the ergothioneine hydroxytyrosol can also play better anti-oxidation and anti-aging effects.

The invention relates to an anti-oxidation composition based on a reverse micelle synergistic technology and a preparation method and application thereof, the anti-oxidation composition comprises a reverse micelle structure and an aqueous solution containing an anti-oxidation active matter, and the reverse micelle structure wraps the aqueous solution containing the anti-oxidation active matter. The reverse micelle structure is used for wrapping the water-soluble antioxidant active matter, oxidation or degradation discoloration of the water-soluble antioxidant active matter is prevented, after the antioxidant active matter such as hydroxytyrosol, ergothioneine and dipotassium glycyrrhizinate is wrapped by the reverse micelle, the stability and the effect are remarkably improved, and after the reverse micelle wrapping, the effect of the antioxidant active matter is improved by 17% or above compared with an aqueous solution before wrapping.

The invention discloses an ovarian protection composition containing ergothioneine and a preparation method of the ovarian protection composition, and relates to the technical field of ovarian protection compositions. The ovary protection composition containing the ergothioneine is prepared from the following components in parts by mass: 0.1 to 0.5 part of the ergothioneine, 0.05 to 1 part of S-equol, 1 to 5 parts of reducing coenzyme Q10, 1 to 3 parts of vitamin E, 10 to 20 parts of chitosan oligosaccharide, 30 to 50 parts of microcrystalline cellulose, 3 to 8 parts of hydroxypropyl methyl cellulose, 0.5 to 2 parts of silicon dioxide and 0.5 to 2 parts of a stabilizer. By adopting the stabilizer, photooxidation and hydrolysis of sensitive components are inhibited through molecular action, and the long-term stability of the composition in a humid and hot environment is remarkably improved in combination with the physical barrier action of silicon dioxide. Through the antioxidant synergistic effect of the ergothioneine and the vitamin E, the hormone regulation effect of the S-equol and the energy metabolism improvement effect of the coenzyme Q10, a multi-layer ovarian function protection system is constructed, and the health state of ovaries is improved. Through a special process, the tablet can be rapidly disintegrated and slowly released in an intestinal targeted manner, burst release of active ingredients is avoided, and the absorption efficiency is improved.

The invention discloses a preparation method of an oral liver protection composition containing ergothioneine, and relates to the technical field of ergothioneine application. The oral liver protection composition containing the ergothioneine is prepared from the following components in parts by mass: 0.5 to 5 parts of the ergothioneine, 10 to 30 parts of silibinin, 20 to 50 parts of a phospholipid complex, 5 to 15 parts of a liver targeting carrier, 2 to 8 parts of a disintegrating agent, 1 to 5 parts of an adhesive and 2 to 4 parts of an antioxidant. Free radicals are efficiently captured through a polycyclic conjugated pi electron system of the antioxidant, a hydrogen bond network is formed by a heteroatom bridging effect of the antioxidant, a galactose group of the liver targeting carrier and the disintegrating agent, and the stability of the system is synergistically improved; the phospholipid complex is embedded with a hydrophobic drug and a hydrophilic carrier, and the drug is accurately delivered to the liver by combining the specific recognition capability of the liver targeting carrier; the ergothioneine and the silybin form a bidirectional synergistic liver protection mechanism by removing reactive oxygen free radicals and regulating and controlling cell signal channels respectively.

The invention discloses a fusion protein which comprises a first structural domain with an EgtD catalytic function, a second structural domain with an Egt1 catalytic function and a third structural domain with an EgtE catalytic function, and the amino acid sequence of the first structural domain with the EgtD catalytic function is shown as SEQ ID NO.1; the amino acid sequence of the second structural domain with the Egt1 catalytic function is as shown in SEQ ID NO. 2; and the amino acid sequence of the third structural domain with the EgtE catalytic function is as shown in SEQ ID NO. 3. The fusion protein is subjected to heterologous expression in engineering bacteria, so that the yield of ergothioneine is remarkably increased.

The invention discloses a genetically engineered bacterium and application of the genetically engineered bacterium in preparation of ergothioneine. The genetically engineered bacterium carries genes egtB, egtD and egtE for coding ergothioneine synthetase, and the genes egtB, egtD and egtE are assembled with a protein scaffold assembly SGP; the protein scaffold assembly SGP comprises a protein scaffold GBD, a protein scaffold SH3 and a protein scaffold PDZ. The inventor finds that the ergothioneine synthetases egtB, egtD and egtE are assembled by using the protein scaffold assembly SGP, so that the ergothioneine can be efficiently synthesized, and the protein scaffold assembly has an important application prospect.

The invention discloses a bacteriophage defense system as well as a construction method and application of the bacteriophage defense system in anti-bacteriophage engineering bacteria. The bacteriophage defense system is derived from Escherichia coli Nissle 1917, and comprises proteins as shown in SEQ ID NO.1, SEQ ID NO.2 and SEQ ID NO.3, and derived proteins of the proteins as shown in SEQ ID NO.1, SEQ ID NO.2 and SEQ ID NO.3. According to the invention, a Type II restriction-modification system with strong bacteriophage defense capability is identified from Escherichia coli Nissle 1917, and the Type II restriction-modification system is transplanted into strains such as Escherichia coli W3110, MG1655 (DE3), BL21 (DE3) and the like, so that the strains are endowed with superstrong bacteriophage resistance. The system is successfully applied to industrial engineering bacteria for producing ectoine, fine glufosinate-ammonium, ergothioneine and other products, and the bacteriophage defense capability of the industrial engineering bacteria is effectively enhanced on the basis that the production capacity of the industrial engineering bacteria is not seriously influenced.

The invention discloses a composition for treating prostatitis and a preparation method and application thereof. The composition is prepared from the following components in parts by weight: 5 to 15 parts of ergothioneine, 10 to 20 parts of cistanche total glycosides, 25 to 45 parts of phytosterol, 450 to 550 parts of pumpkin seed oil, 180 to 250 parts of fructus cannabis oil and 250 to 350 parts of auxiliary materials. Through the synergistic effect of various natural active components, the composition maintains the balance of overall metabolism of a body while reducing inflammation and inhibiting prostate cell proliferation, side effect risks possibly brought by a traditional single-component treatment scheme are avoided, and the composition has higher clinical application potential. The composition disclosed by the invention has a wide market application prospect and popularization value by virtue of good safety and compliance.

The invention belongs to the technical field of medicines, and particularly relates to a multi-effect composition containing ergothioneine, a preparation method of the multi-effect composition and application of the multi-effect composition in eye products. The multi-effect composition is prepared from ergothioneine, tromethamine and sodium hyaluronate according to the mass ratio of (0.5 to 10) to (1 to 5) to (0.5 to 3). According to the multi-effect composition containing the ergothioneine, the tromethamine in the composition can protect the stability of the ergothioneine under the conditions of illumination and high temperature; the ergosulfide can protect the activity of macromolecular sodium hyaluronate. The synergistic compatibility of the ergothioneine, the sodium hyaluronate and the tromethamine is utilized, so that the moisturizing effect and the eye protection effect of the composition can be remarkably improved. The ergothioneine-containing multi-effect composition provided by the invention has the effect of preventing cataract through specific components and proportions, and has the advantages of long-acting eye moistening and good stability.

The invention discloses an oral joint protection composition containing ergothioneine and a preparation method thereof, and relates to the technical field of joint protection compositions. The oral joint protection composition containing the ergothioneine is prepared from the following components in parts by mass: 0.05 to 5 parts of the ergothioneine, 20 to 50 parts of glucosamine salt, 10 to 30 parts of chondroitin sulfate, 2 to 10 parts of curcumin, 30 to 70 parts of a diluent, 1 to 10 parts of an adhesive, 0.5 to 5 parts of a lubricant, 2 to 10 parts of a disintegrating agent and 0.1 to 0.5 part of an antioxidant stabilizer. Through synergistic compatibility of active ingredients such as ergothioneine, curcumin and the like, a multi-dimensional action network of oxidation resistance, inflammation resistance and cartilage metabolism regulation is formed, the inhibition effect on joint inflammation is remarkably improved, and the limitation of a single ingredient is broken through.

The invention belongs to the technical field of nutritional compositions and cosmetics, and particularly relates to an anti-aging composition and application and a product thereof. The composition provided by the invention is composed of L-ergothioneine and alpha-ketoglutaric acid, or L-ergothioneine and alpha-ketoglutaric acid salt, or L-ergothioneine and alpha-ketoglutaric acid salt. Through the synergistic effect of the L-ergothioneine and the alpha-ketoglutaric acid or the alpha-ketoglutarate, the contents of Col I and hydroxyproline in skin tissues can be remarkably increased, the expression of TGF-beta1 is up-regulated and converted, the activity of MMP-1 is inhibited, meanwhile, the malondialdehyde level is reduced to enhance the oxidation resistance, the synthesis of hyaluronic acid is promoted, and the water content of the skin is increased. The composition is simple in component and simple and convenient in preparation process, can be prepared into various products such as cosmetics, health care products or medicines, is used for achieving the effects of resisting aging, moisturizing, resisting inflammation or resisting oxidation, particularly has an excellent improvement effect on skin photoaging induced by ultraviolet rays, and is wide in application prospect.

The invention aims to disclose a special dietary preparation based on alpha-ketoglutaric acid as well as a preparation process and application thereof, and relates to the technical field of dietary supplements. Every 800 mg of the dietary preparation comprises 50 mg to 100 mg of alpha-ketoglutaric acid or alpha-ketoglutaric acid salt, 5 mg to 12 mg of N-acetylneuraminic acid or N-acetylneuraminic acid salt, 30 mg to 60 mg of ergothioneine, 100 mg to 150 mg of a desert cistanche deserticola water extract or 50 mg to 80 mg of desert cistanche deserticola total glycosides, and auxiliary materials. The alpha-ketoglutaric acid salt is any one or more of alpha-ketoglutaric acid calcium, alpha-ketoglutaric acid sodium and alpha-ketoglutaric acid magnesium; the N-acetylneuraminic acid salt is any one or more of N-acetylneuraminic acid calcium, N-acetylneuraminic acid sodium and N-acetylneuraminic acid magnesium; the special dietary preparation has the beneficial effects that the special dietary preparation simultaneously contains alpha-ketoglutaric acid or alpha-ketoglutaric acid salt, N-acetylneuraminic acid or N-acetylneuraminic acid salt, ergothioneine and the cistanche deserticola aqueous extract, and has the effects of delaying senescence, resisting fatigue, improving the symptom of kidney-yang deficiency and enhancing immunity for males aged more than 45 years old.

The invention provides an anti-aging composition and application thereof, the composition at least contains pyrroloquinoline quinone disodium salt, ergothioneine and 5-aminolevulinic acid or salt thereof in physiologically acceptable media, the composition contains PQQ, ergothioneine and 5-aminolevulinic acid (5-ALA) or salt thereof, the three components are compounded to achieve a synergistic effect, and the anti-aging effect is achieved. The dyeing intensity of beta-galactosidase is reduced, and the anti-aging effect is achieved.

The invention relates to the technical field of skin care products, and discloses an anti-aging and whitening composition and a preparation method thereof.The anti-aging and whitening composition comprises anti-aging and whitening components, whitening synergistic components, moisturizing and repairing components and deionized water, and the anti-aging and whitening components comprise botryine, ergothioneine and Ectoine; wherein the mass ratio of the glassine to the ergothioneine to the ectoine is (1.2 to 2.0) to (0.4 to 0.7) to (1.0 to 1.5); the whitening synergistic component comprises one or more of nicotinamide, glabridin and tranexamic acid; the moisturizing and repairing component is prepared from one or more of sodium hyaluronate, ceramide NP, glycerol and 1, 3-butanediol. Experiments show that the mass ratio of the glassine to the ergothioneine to the ectoine is (1.2-2.0): (0.4-0.7): (1.0-1.5), so that the glassine, the ergothioneine and the ectoine show a remarkable synergistic effect (in some cases, the synergistic index CIlt is 0.85), and the anti-aging and whitening functions of the composition containing the glassine, the ergothioneine and the ectoine are improved.

The invention provides a composition for delaying senescence by activating telomerase activity. The composition is prepared from the following raw materials in parts by weight: 12.5 parts of wheat germ concentrated powder, 0.25 to 5 parts of ergothioneine, 0.25 to 5 parts of pyrroloquinoline quinone disodium salt and 0.25 to 5 parts of alpha-ketoglutaric acid. The invention further provides a preparation method and application of the composition for delaying senescence by activating telomerase activity. Through the synergistic effect of the ergothioneine and the pyrroloquinoline quinone disodium salt, the telomerase activity can be activated, the telomerase expression can be improved, the telomere length can be maintained, and the effect of delaying senescence can be achieved, so that the functional metabolism of a human body can be promoted, and the health state of the body can be improved; through the synergistic effect of the wheat germ concentrated powder and alpha-ketoglutaric acid, cell aging can be delayed; through the multi-target synergistic effect of'telomerase activation + mitochondrial repair + autophagy enhancement ', the anti-aging effect is delayed, the metabolic capability is high, the anti-aging effect is good, and safety and high efficiency are achieved; belongs to the technical field of food and health care product processing.

The invention provides a method for separating and purifying ergothioneine by simulated moving bed chromatography, which comprises the following steps: step 1, carrying out pretreatment, sterilization and ultrafiltration on fermentation liquor to obtain ultrafiltrate; 2, separating and purifying the ultrafiltrate by adopting a simulated moving bed chromatography system, and collecting a target component containing ergothioneine; and step 3, carrying out deep desalination, decoloration, concentration, cooling crystallization, centrifugation and drying on the target component to obtain a pure ergothioneine product. According to the method for separating and purifying the ergothioneine through the simulated moving bed chromatography, in the ergothioneine preparation process, the ergothioneine is purified from fermentation liquor through the simulated moving bed technology, and the method is high in efficiency and capable of achieving automatic and continuous large-scale production.

The invention belongs to the technical field of health care products or daily chemical products, and particularly relates to a composition with anti-wrinkle, firming, whitening and brightening effects and application. The composition is prepared from the following components in parts by weight: 72 to 180 parts of fisetin, 120 to 180 parts of urolithin A and 5 to 15 parts of ergothioneine. Through precise component compounding, the synergistic interaction among fisetin, urolithin A and ergothioneine is brought into full play, the skin care composition integrating anti-wrinkle, firming, whitening and brightening functions is successfully developed, and the natural components of the skin care composition ensure the use safety of the product, so that the skin care composition has a good application prospect. The requirements of consumers on efficient skin care are effectively met.

The invention provides a bolete concentrated powder composition lipid carrier with an anti-aging effect as well as a preparation method and application of the bolete concentrated powder composition lipid carrier. The lipid carrier is prepared from the following substances in percentage by mass: 10 to 40 percent of bolete extract, 0.2 to 0.8 percent of antioxidant, 45 to 66 percent of solid lipid, 10 to 16 percent of liquid lipid and 4.2 to 7.8 percent of surfactant. According to the bolete concentrated powder composition lipid carrier provided by the invention, liquid lipid with anti-oxidation and light protection effects is mixed into solid lipid to construct a nano carrier matrix with a light protection function. Plant active ingredients with a light protection effect and an anti-oxidation effect and ergothioneine in the bolete extract are jointly loaded in a nano-structure lipid carrier, so that synergistic interaction of multiple effects is realized. The synergistic delivery system of the nanostructured lipid carrier can inhibit the photodegradation reaction of the ergothioneine and the generation of peculiar smell, improve the photostability of the ergothioneine, enhance the oxidation resistance of the ergothioneine in an acid environment, and improve the anti-aging effect.

The application provides a preparation method of ergothioneine and application of a mercapto compound in the method. The method comprises the following steps: in the presence of a catalyst system, a sulfur oxide is reacted to generate ergothioneine. The catalyst system comprises a first catalyst and a second catalyst. The first catalyst is ergothioneine synthase, and the second catalyst is one or more of a mercapto-containing amino acid and a mercapto-containing polypeptide. The preparation method of ergothioneine provided by the application does not need to use a large amount of a chemical mercaptan reagent with a foul smell, has the advantages of high efficiency, green environmental protection, and friendly production scene, and is beneficial to industrial production of ergothioneine.

The invention discloses an oral sleep-aiding composition containing ergothioneine and a preparation method of the oral sleep-aiding composition, and relates to the technical field of sleep-aiding compositions. The oral sleep-aiding composition containing the ergothioneine is prepared from the following components in parts by mass: 0.01 to 3 parts of the ergothioneine, 0.1 to 10 parts of melatonin, 10 to 40 parts of glycine, 2 to 15 parts of magnesium salt, 30 to 70 parts of a diluent, 1 to 10 parts of an adhesive, 0.5 to 5 parts of a lubricant, 2 to 10 parts of a disintegrating agent and 0.1 to 0.5 part of an antioxidant preservative. Through the synergistic compatibility of ergothioneine, melatonin, glycine and magnesium salt, a multi-dimensional action network of oxidation resistance, neuromodulation and receptor inhibition is formed, the limitation of single-component sleep aiding is broken through, and the sleeping efficiency and the sleep maintenance capability are remarkably improved. Based on the scientific proportion of endogenous substances (ergothioneine and glycine), the metabolic burden of traditional sleep-aiding components is avoided, and in combination with the design of a sustained-release preparation, the dose-dependent side effects are reduced, and the safety of long-term taking is improved.

The invention relates to a natural plant functional component based on cell function regulation, a natural plant composition and application thereof. The natural plant composition is prepared from the following raw material components in parts by weight: 1000 to 1600 parts of phospholipid, 200 to 400 parts of cholesterol, 200 to 400 parts of prinsepia utilis royle oil, 100 to 300 parts of ergothioneine and 200 to 500 parts of nicotinamide mononucleotide. Compared with the prior art, the composition not only can cover multi-target composite components with ROS removal, mitochondrial autophagy activation and NAD + level improvement, but also can improve the component permeability by optimizing the delivery technology, thereby effectively improving the skin anti-aging effect and the like.

The invention relates to the technical field of biology, in particular to a purification method of ergothioneine. The invention provides a method for purifying high-purity ergothioneine from an enzyme catalytic reaction. According to the method, high-purity ergothioneine is purified from the enzyme catalysis reaction liquid, so that the purification steps are greatly simplified, and the total purification yield is increased; and only a single organic solvent ethanol is used for crystallization, so that the ergothioneine product with high purity and uniform and thick particles is obtained, and the method is suitable for large-scale production of ergothioneine.

The invention relates to the technical field of active ingredient extraction, in particular to an ergothioneine-hydroxytyrosol mixture and a preparation method and application thereof, and optimizes a culture medium formula for producing ergothioneine through submerged liquid fermentation of pleurotus citrinopileatus mycelium. In the later stage of the process of producing ergothioneine by mycelium fermentation, a culture medium formula is designed according to nutritional ingredients required by hydroxytyrosol biosynthesis to supplement a sterile culture medium, and meanwhile, secondary metabolites and residual nutritional ingredients generated by fermentation of pleurotus citrinopileatus mycelium are fully utilized; the ergothioneine-hydroxytyrosol mixture is obtained through biosynthesis fermentation of hydroxytyrosol, the production period is short, the efficiency is high, the energy consumption is low, the ergothioneine-hydroxytyrosol mixture is green and safe, nutritional ingredients of a culture solution can be fully utilized, the overall production cost is reduced, the comprehensive production efficiency and productivity are improved, no waste liquid is discharged, and the subsequent application requirements are better met.

The invention discloses an efficient extraction and compounding method of ergothioneine, and relates to the technical field of ergothioneine preparation, the efficient extraction and compounding method comprises the steps of raw material pretreatment, extraction, purification, compounding and embedding, raw material pretreatment adopts an enzymolysis and chelation synergistic technology, extraction adopts a pH response type aqueous two-phase system and is combined with ultrasonic microwave synergistic enhancement, and the compounding and embedding are carried out. A nanofiltration membrane separation and vacuum freeze drying combined process is adopted for purification, a targeted compounding system is adopted for compounding, and a composite wall material microcapsule embedding technology is adopted for embedding. According to the method, the cell wall structure of the raw material is destroyed and the oxidation of active ingredients is inhibited through an enzymolysis and chelation synergistic pretreatment technology, the ergothioneine distribution behavior is regulated and controlled and the mass transfer process is accelerated by matching with a pH response type aqueous two-phase system and ultrasonic microwave synergistic enhanced extraction, and then a nanofiltration membrane separation and vacuum freeze drying combined purification process is combined; impurities are effectively removed, the activity of components is reserved, and the problems of low extraction rate and insufficient purity of a traditional method are solved.

The invention relates to the technical field of skin care products. The invention aims to provide a split storage type novel skin-brightening skin-care product combined by oligopeptide freeze-dried powder and essence. The split storage type novel skin-brightening skin-care product comprises multiple oligopeptide freeze-dried powder and solvent essence, the multi-oligopeptide freeze-dried powder is prepared from the following raw materials in parts by weight: 90 to 95 parts of water, 1 to 2 parts of glutathione, 1 to 2 parts of mannitol, 1 to 2 parts of carnosine, 0.5 to 1 part of ergothioneine, 0.5 to 1 part of vitamin C and 0.0005 to 0.001 part of a multi-peptide-zinc chelate. The multi-peptide-zinc chelate is prepared from the following raw materials in parts by weight: 1-2 parts of hexapeptide-2, 1-2 parts of nonapeptide-1, 1-2 parts of dipeptide-2, 1-2 parts of tripeptide-10 and 2-3 parts of zinc oxide. According to the invention, various peptides with small molecular weights are chelated with zinc, the characteristics of good permeability and strong skin affinity of the small molecular peptides are fully played, the effects of zinc and other components are effectively played, and the overall use effect is greatly improved. Through compounding of multiple components, the moisturizing and brightening mask has multiple effects of moisturizing, good permeability, whitening, brightening and the like.

The invention discloses an anti-aging composition which comprises the following components or consists of the following components in parts by weight: 10-20 parts of pyrroloquinoline quinone or derivatives thereof; 2 to 30 parts by weight of ergothioneine; 0.2 to 10 parts by weight of spermidine; and 10-650 parts by weight of a pomegranate extract. The invention also discloses an application of the anti-aging composition. According to the anti-aging composition disclosed by the invention, the pyrroloquinoline quinone or the derivative thereof, the ergothioneine, the spermidine and the pomegranate extract contained in the anti-aging composition can generate a synergistic effect, so that the anti-aging composition has good anti-oxidation and anti-aging effects. The anti-aging composition can be applied to food, health care products and medicines, and has the effects of resisting skin oxidation and delaying aging.

The invention discloses a method for producing ergothioneine by fermentation of a mixed strain. The method comprises a step of performing mixed fermentation on a high-yield histidine EGT strain and a histidine defect type EGT strain to obtain ergothioneine, the high-yield histidine EGT strain and the histidine defect type EGT strain both comprise fusion proteins with EgtD, Egt1 and EgtE catalytic functions. According to the present invention, the fermentation is performed by using the method, such that the yield of the ergothioneine is high, the histidine does not need to be added during the fermentation process so as to save the cost, and the method is suitable for the industrial production of the ergothioneine.

Among others, the present disclosure provides methods for extending lifespan or improving healthspan in a mammal, which includes administration to the mammal of a composition containing an effective amount of ergothioneine, or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof.

The invention discloses a composition containing achillea millefolium extract, which is prepared from the following ingredients in percentage by weight: 45 to 55 percent of glycerol, 4 to 6 percent of hydrogenated lecithin, 3 to 5 percent of caprylic / capric triglyceride, 1 to 3 percent of 1, 2-hexanediol, 0.8 to 1.2 percent of achillea millefolium extract, 0.4 to 0.6 percent of ergothioneine and the balance of water. Through precise compounding of the achillea millefolium extract and the ergothioneine, the dual effects of anti-inflammation and skin repair are achieved, flavonoid and organic acid components in the achillea millefolium extract can effectively inhibit release of inflammatory mediators such as IL-6 and TNF-alpha, and sensitive symptoms such as red and swollen and pruritus are relieved.

The invention provides a beautifying composition and application thereof in whitening, anti-inflammatory and anti-aging products, and belongs to the technical field of cosmetics. The beautifying composition is prepared from collagen peptide, sodium hyaluronate and ergothioneine, wherein the mass concentration ratio of the collagen peptide to the sodium hyaluronate to the ergothioneine is (75 to 85) to (3.5 to 10) to (0.4 to 3.5); the beautifying composition shows remarkable advantages in the aspects of collagen regeneration and skin improvement, the collagen content can be remarkably increased, and multi-effect collagen regeneration promotion is achieved by inhibiting collagen degrading enzyme MMP-1 and up-regulating TGF-beta1; the content of AQP3 and HA can be increased, and water locking and moisturizing of the skin are enhanced; by activating an Nrf2 pathway, the SOD2 level is improved, IL-6 and IL-1alpha are inhibited, and the antioxidant, anti-inflammatory and whitening effects are achieved; the thickness of an epidermal layer and the density of dermal fibroblasts can be remarkably improved, wrinkle resistance and repairing are effectively achieved, and the skin structure is improved.