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207 results about "Ergothioneine" patented technology

Ergothioneine is a naturally occurring amino acid and is a thiourea derivative of histidine, containing a sulfur atom on the imidazole ring. This compound is made in relatively few organisms, notably Actinobacteria, Cyanobacteria, and certain fungi. Ergothioneine was discovered in 1909 and named after the ergot fungus from which it was first purified, with its structure being determined in 1911.

Bacterial strain producing L-erythrothioneine and method of preparing the L-erythrothioneine

The invention relates to a strain Pleurotus ostreatus TIB.BPE.10010 with the accession number being CGMCC No.6232. The invention also relates to a method of preparing L-erythrothioneine. The method comprises steps of culturing and fermenting the Pleurotus ostreatus CGMCC No.6232 to perform biosynthesis to form the L-erythrothioneine and extracting the L-erythrothioneine from mycelium cells.
Owner:TIANJIN INST OF IND BIOTECH CHINESE ACADEMY OF SCI

Personal Care Compositions Comprising Alpha-Glucans and/or Beta-Glucans

Personal care compositions containing at an alpha-glucan and / or beta-glucan; at least one additional skin and / or hair care active selected from the group consisting of sugar amine, vitamin B3, retinoids, peptides, phytosterol, dialkanoyl hydroxyproline, hexamidine, salicylic acid, n-acyl amino acid compounds, sunscreen actives, water soluble vitamins, oil soluble vitamins, hesperedin, mustard seed extract, glycyrrhizic acid, glycyrrhetinic acid, carnosine, Butylated Hydroxytoluene (BHT) and Butylated Hydroxyanisole (BHA), menthyl anthranilate, cetyl pyridinium chloride, ergothioneine, vanillin or its derivatives, diethylhexyl syrinylidene malonate, melanostatine, sterol esters, tetrahydrocurcumin, their derivatives, their precursors, and combinations thereof; and a dermatologically acceptable carrier.
Owner:THE PROCTER & GAMBLE COMPANY

Methods and compositions using ergothioneine to treat a variety of health related factors

In one embodiment, a composition containing ergothioneine and / or synthesized l-ergothioneine and one or more compounds selected from the group consisting of vitamin B-12, glucosamine sulfate, calcium ascorbate, turmeric extract, black pepper extract, hyaluronic acid, collagen, glycosaminoglycans, cat's claw extract, acai berry; and white willow bark extract is provided to a mammal to improve a variety of health related factors, including but not limited to brain health, joint health, eye health, mitondchorial optimization / improvement and reduction of inflammation and pain in a mammal.
Owner:OXIS INT

Method for preparing ergothioneine

The invention provides a method for preparing ergothioneine. The method takes mushrooms or leftovers as raw materials and comprises the following steps: extracting the raw materials in water or an ethanol water solution with the volume percent concentration of 5 percent to 30 percent at the temperature of 70 DEG C to 95 DEG C; sequentially separating and purifying an extracted product through macroporous resin and polyamide resin; collecting an eluting solution and concentrating to obtain ergothioneine extract. Compared with the prior art, the extract with the ergothioneine content of 20 percent to 98 percent can be obtained and the content is much higher than 1 percent to 5 percent in the prior art. The ergothioneine prepared by the invention can reach requirements of industrialized production and lays a foundation for further development and utilization of the ergothioneine extract.
Owner:天津华泰至成医药科技发展有限公司

Anti-inflammatory approach to prevention and suppression of post-traumatic stress disorder, traumatic brain injury, depression and associated disease states

A composition and methods of use are disclosed for prevention and control of inflammation and oxidative stress and various associated medical conditions, including PTSD, chronic depression and traumatic brain injury. A composition providing a phytonutrient and enriched mushrooms having enhanced Vitamin D and ergothioneine are disclosed. The combined use of an enriched mushroom and phytonutrient provide a synergistic effect on cellular longevity and / or cellular rejuvenation of subjects with both a normal and nutritionally deficient diets, improved tolerance to oxidative and / or inflammatory stress, and increased cellular longevity and / or cellular rejuvenation as a result of the neutralization of free radicals and prevention of chronic inflammation.
Owner:TOTAL NUTRACEUTICAL SOLUTIONS

Biosynthesis preparation method for ergothioneine, and fermentation culture medium

The invention relates to a biosynthesis preparation method for ergothioneine, and a fermentation culture medium. The method comprises the following steps of S1: inoculating Hericium erinaceus myceliumslant cultures to a liquid seed culture medium to be cultured to obtain seed liquid; S2: inoculating the obtained seed liquid to the fermentation culture medium to be fermented, adding precusor substances for culturing, and fermenting to a fermentation destination through pH (Potential of Hydrogen) judging a fermentation liquor; S3: after fermentation finishes, adding enzyme, carrying out enzymolysis to the destination, raising the temperature to kill enzyme, and lixiviating the ergothioneine in the cell of the mycelium to the fermentation liquor out of the cell. By use of the method disclosed by the invention, the yield of the ergothioneine can be improved, the fermentation destination can be quickly and simply judged, fermentation byproducts are reduced, the enzyme is used for breakingmycelium cells, and ergothioneine is safe to be lixiviated.
Owner:BLOOMAGE BIOTECHNOLOGY CORP LTD

Extraction and purification method of ergothioneine

A method for extracting and purifying L-ergothioneine comprises the following steps: (1) soaking and extracting a mushroom mycelium fermentation liquid by using hot water, so as to obtain a mushroom and L-ergothioneine water solution; (2) performing ultrafiltration of the mushroom and L-ergothioneine water solution by using an ultrafiltration membrane with a molecular weight cut-off of 1kDa to 30kDa, and collecting an ultrafiltration liquid; and (3) performing chromatographic purification of the ultrafiltration permeation liquid, the chromatographic purification conditions being: a chromatographic filler being an HILIC filler, a mobile phase forming acetonitrile-water with a volume ratio of 80: 20 to 88: 12, and a quantity of feed of L-ergothioneine being 0.01g to 0.323 per 100g.
Owner:TIANJIN INST OF IND BIOTECH CHINESE ACADEMY OF SCI

Refreshing agent and method for inhibiting blackening of prawns

The invention provides a refreshing agent and method for inhibiting blackening of prawns. The refreshing agent comprises ergothioneine, kelp polyphenols, laminarin, and glacial acetic acid. The refreshing method comprises the following steps: extracting kelp polyphenols and laminarin; then adding ergothioneine, the extracted kelp polyphenols and the extracted laminarin to deionized water; uniformly agitating; and then adding glacial acetic acid to obtain the refreshing agent, wherein the prepared refreshing agent comprises 0.2 to 0.9% of ergothioneine in mass percent concentration, 0.3 to 0.9% of kelp polyphenols in mass percent concentration, 0.3 to 1% of laminarin in mass percent concentration, and 0.6 to 1% of glacial acetic acid in mass percent concentration. The refreshing agent is used for refreshing prawns. The refreshing method has the advantages of being few in steps and convenient in operation; the refreshing agent can remain the original color and luster of the prawns, shows a good blackening inhibiting effect and great antibacterial effect, keeps the prawns fresh, and also can prolong the shelf life of prawn products.
Owner:BOHAI UNIV

Ergothioneine production through metabolic engineering

The present disclosure relates to the production of ergothioneine through either in vitro enzymatic transformations or fermentations using microbials created by metabolic engineering. Also disclosed are transformed cells useful in such methods and ergothioneine produced by such methods. Transformed cells of the disclosure are capable of converting histidine and cysteine or hercynine and cysteine into ergothioneine in greater efficiency than the untransformed wild-type cells.
Owner:刘平华 +2

Transformed fungus having enhanced ergothioneine productivity and method for producing ergothioneine

The purpose of the present invention is to provide an organism having an ergothioneine productivity that is capable of easily producing ergothioneine within a short period of time at a high yield, as compared with a conventional technology, and, therefore, enables ergothioneine production on an industrial scale. This purpose can be achieved by a transformed fungus into which a gene encoding enzyme (1) or genes encoding enzymes (1) and (2) have been inserted and in which the inserted gene(s) are overexpressed. (1) An enzyme catalyzing a reaction of synthesizing hercynyl cysteine sulfoxide from histidine and cysteine in the presence of S-adenosyl methionine, iron (II) and oxygen. (2) An enzyme catalyzing a reaction of synthesizing ergothioneine from hercynyl cysteine sulfoxide using pyridoxal 5'-phosphate as a coenzyme.
Owner:KIKKOMAN CORP

Composition containing L-Ergothioneine extract, brown rice fermentation filtrate and acetylchitosamine and application of composition

The invention discloses a composition containing L-Ergothioneine extract, brown rice fermentation filtrate and acetylchitosamine and application of the composition. The composition includes 0.1-2.0 parts of L-Ergothione extract, 0.1-4.0 parts of brown rice fermentation filtrate and 0.1-2.0 parts of acetylchitosamine. Since the three natural fermentation source components which include the L-Ergothioneine extract, brown rice fermentation filtrate and acetylchitosamine are selected, the composition has the advantages of naturalness, high activity, easy absorption and high safety, an obvious synergistic effect is achieved through sieving of the dosage of the components, meanwhile, the effects of regulating the biological rhythm of skin, delaying skin aging and improving pigmentation are achieved, and damage of blue light to the skin is prevented from the three aspects, so that comprehensiveness is achieved, and the blue light resistant effect is achieved.
Owner:BLOOMAGE BIOTECHNOLOGY CORP LTD +1

Regulation of mammalian keratinous tissue using personal care compositions comprising cetyl pyridinium chloride

Personal care composition including a first skin and / or hair care active cetyl pyridinium chloride; and at least one additional skin and / or hair care active selected from the group consisting of tetrahydrocurcumin, sugar amine, vitamin B3, retinoids, hydroquinone, peptides, phytosterol, dialkanoyl hydroxyproline, hexamidine, salicylic acid, n-acyl amino acid compounds, sunscreen actives, water soluble vitamins, oil soluble vitamins, hesperedin, mustard seed extract, glycyrrhizic acid, glycyrrhetinic acid, carnosine, Butylated Hydroxytoluene (BHT) and Butylated Hydroxyanisole (BHA), ergothioneine, vanillin or its derivatives, diethylhexyl syrinylidene malonate, melanostatine, sterol esters, idebenone, dehydroacetic acid, Licohalcone A, creatine, creatinine, feverfew extract, yeast extract, beta glucans, alpha glucans, their salts, their derivatives, their precursors, and / or combinations thereof; and a dermatologically acceptable carrier. The invention further relates to methods for regulating the condition of mammalian keratinous tissue wherein the methods each comprise the step of topically applying to the keratinous tissue of a mammal needing such treatment, a safe and effective amount of the personal care composition of the invention.
Owner:THE PROCTER & GAMBLE COMPANY

Neuroprotectant methods, compositions, and screening methods thereof

The present invention relates in general to methods of protecting a mammalian central nervous system cell from damage, and to methods of treating or ameliorating neurodegenerative diseases. The invention further relates to screening for neuro-protective agents that may alone, or in combination with other neuroprotective agents, aid in protecting cells of the central nervous system from damage attributed to neurotoxic compounds, free radicals, or neurodegenerative diseases. The invention further relates to pharmaceutical compositions comprising L-ergothioneine or other newly identified compounds and pharmaceutically acceptable carriers for administration to a mammal in need of neuroprotection.
Owner:OXIS INT

Cosmetic or skin composition with function of delaying skin aging

The invention relates to the field of cosmetic or skin compositions, and provides a cosmetic or skin composition with the function of delaying skin aging. The composition comprises ectoin, hydroxypropyl tetrahydropyrantriol and ergothioneine in certain proportion. The composition internally improves the self-healing capability of cells and the immunity of the skin; the composition externally increases the thickness of the epidermis and repairs the skin barrier, so that the damaged skin gets healthier and healthier through self-regulation to achieve skin repair. The composition can be applied to masks, emulsions, essences and the like, and has important application value and broad market prospects.
Owner:SHANGHAI COACHCHEM TECH

Application of high-temperature-resistant pleurotus ostreatus in production of ergothioneine

The invention discloses an application of high-temperature-resistant pleurotus ostreatus in production of ergothioneine. The pleurotus ostreatus is collected in the CGMCC (China General Microbiological Culture Collection Center) of the CCCCM (China Committee for Culture Collection of Microorganism) on October 18, 2018, with the collection number of CGMCC:16378. When applied to production of ergothioneine, the high-temperature-resistant pleurotus ostreatus has the advantages as follows: 1, the high-temperature-resistant pleurotus ostreatus shortens the fermentation time of the ergothioneine; 2, the highest culture temperature of the ergothioneine in the fermentation production process can reach 32 DEG C, energy consumption caused by culture temperature decrease can be reduced, and the production cost can be reduced; 3, the yield of the ergothioneine is higher, the production and preparation costs of the ergothioneine are reduced, and a solid foundation is laid for industrial production and commercial application of the ergothioneine.
Owner:弘恒泰(天津)科技发展有限公司

Regulation of mammalian keratinous tissue using personal care compositions comprising ergothioneine

Personal care compositions containing ergothioneine are provided. Methods for regulating the condition of mammalian keratinous tissue by topically applying the personal care compositions are also provided.
Owner:THE PROCTER & GAMBLE COMPANY

Process for synthesizing ergothioneine and related compounds

The invention provides a process for synthesising a compound of formula (V) wherein: formula (z) or a physiologically acceptable salt, tautomer, stereoisomer or mixture of stereoisomers thereof. The process utilizes a / V-benzyl protected histidine rather than the unprotected form of histidine. The process of the invention comprises the steps of: (a) deprotecting a / V-benzyl protected histidine of formula 11 to form A / -benzyl histidine of formula 12; (b) converting compound 12 to (S)-3-(1 -benzyl-1 H-imidazol-4-yl)-2-(dimethylamino)propanoic acid of formula 13; (c) converting compound 13 to (2S)-N,N,N-2-trimethylethanaminium-3-(1 -benzyl- 1H-imidazol-4-yl)propanoic acid of formula 14; (d) brominating the imidazole ring of the compound of formula 14 to form 5-bromohercynine lactone (reactive intermediate); and (e) converting the 5-bromohercynine lactone of step (d) to (p-amino-p- carboxyethyl)ergothioneine sulfide of formula 15. The process optionally further includes one of steps (f) to (h): (f) converting the compound of formula 15 to a sulfoxide; (g) converting the compound of formula 15 to a sulfone; or (h) converting the compound of formula 15 to ergothioneine (ESH).
Owner:UNIVERSITY OF CAPE TOWN

Method for inhibiting photodegradation of ergothioneine and application of method

The invention provides a method for inhibiting photodegradation of ergothioneine and application of the method. The method comprises the following steps: adding hyaluronate into a solution containingergothioneine; the content of the ergothioneine is 0.0005-0.01% by weight; and the content of the hyaluronate is more than 0.1% by weight. According to the present invention, the combination of hyaluronate and ergothioneine can effectively inhibit the photodegradation of ergothioneine, and the composition can be use in food health products or cosmetics, with good moisturizing effect and stable efficacy.
Owner:BLOOMAGE BIOTECHNOLOGY CORP LTD +1

Application of needle mushroom genes Fvegt1, Fvegt2 and Fvegt3 to synthesis of ergothioneine

The invention discloses an application of needle mushroom genes Fvegt1, Fvegt2 and Fvegt3 to synthesis of ergothioneine, and belongs to the field of biosynthesis. By a homologous clone method and a gene synthesis method, 3 genes in an ergothioneine synthesis way are cloned from a needle mushroom mycelium, expression in vitro is performed, and in vitro biosynthesis of the needle mushroom ergothioneine is realized. The FvEgt1 can catalyze substrates of His, Cys, SAM, FeSO4 and the like to form AdoHcy and HerSul; FvEgt2 can be combined with the Cys, so that SH of cysteine is activated to form sulfur anions; the FvEgt3 can catalyze PLP and HerSul to form a ketimine compound; and the sulfur anions activated by the SH of the cysteine perform nucleophillic attack on the ketimine compound to obtain the ergothioneine. The invention firstly clarifies a biosynthesis way of the ergothioneine in basidiomycetes needle mushrooms except bacteria, ascomycetes and the like.
Owner:SOUTH CHINA AGRI UNIV

Efficacy promoting composition and application thereof

The invention provides an efficacy promoting composition, which is characterized by comprising polymer hyaluronic acid or salt thereof, hydrolyzed hyaluronic acid or salt thereof, acetylated hyaluronic acid or salt thereof, tetrahydropyrimidine or derivative thereof, ergothioneine, yeast / rice fermentation product filtrate and aminobutyric acid. When the efficacy promoting composition provided by the invention is used for moisturizing and repairing the skin, on one hand, the stability of macromolecular functional components can be improved, and the contact time with the skin is prolonged, so that the utilization rate of the macromolecular functional components is increased, the dosage of the functional components is reduced, the cost is saved, and skin irritation caused by excessive dosageof some functional components is reduced; on the other hand, the transdermal absorption effect of the micromolecular functional components can be improved, and the utilization rate of the micromolecular functional components is increased.
Owner:BLOOMAGE BIOTECHNOLOGY CORP LTD

Method of synthesizing ergothioneine and analogs

The present disclosure relates to a method for synthesizing ergothioneine or one of the derivatives thereof of following formula (I):or a physiologically acceptable salt, a tautomer, a stereoisomer or a mixture of stereoisomers in all proportions thereof,from a compound of betaine type of following formula (II):or a physiologically acceptable salt, a tautomer, a stereoisomer or a mixture of stereoisomers in all proportions thereof,by cleavage reaction in the presence of a thiol, at a temperature above or equal to 60° C.The present disclosure also relates to compounds of formula (II) and the method of synthesis thereof.
Owner:TETRAHEDRON SAS

Moisturizing, repairing, anti-aging and anti-saccharificationcomposition and application thereof

The invention belongs to the technical field of skin care products, and particularly relates to a moisturizing, repairing, anti-aging and anti-saccharification composition and application thereof. The moisturizing, repairing, anti-aging and anti-saccharification composition is characterized by being prepared from the following raw materials in parts by weight: 0.1-8 parts of vitamin palmitates, 1-6 parts of vitamine, 1-20 parts of a plant extract, 0.1-4 parts of ergothioneine, 0.01-0.5 part of astaxanthin, 1-13 parts of argireline, 0.5-6 parts of fullerene, 0.1-6 parts of a peptide compound, 0.1-7 parts of hydrolyzed collagen, 0.01-0.2 part of an antioxidant active enzyme and 0.1-4 parts of a coenzyme. The composition in the technical scheme is applied to moisturizers, emulsions, creams, essence stock solutions and masks to keep the moisture and elasticity of cells, promote regeneration of damaged tissues, improve the repairing capacity of the skin, delay aging of the cells and improve the anti-aging capacity and anti-saccharification capacity of the skin.
Owner:皓雨(广州)化妆品制造有限公司

Deep moisturizing compound and preparation method thereof

The invention relates to a deep moisturizing compound and a preparation method thereof. The deep moisturizing compound consists of the following components in parts by weight: 0.05-1 part of hyaluronic acid, 0.04-2 parts of transdermal fibronectin, 0.06-4 parts of ergothioneine, 4-40 parts of a dispersing agent and 5-60 parts of a solvent. The preparation method of the deep moisturizing compound comprises the following steps: dispersing the sodium hyaluronate and the ergothioneine by using the dispersing agent according to the ratio, then adding the material into the solvent, stirring the materials until the sodium hyaluronate and the ergothioneine are completely dissolved, finally adding the transdermal fibronectin, and completely stirring the material to obtain the deep moisturizing compound. According to the deep moisturizing compound provided by the invention, hyaluronic acid is used as a main functional substance for skin moisturizing, meanwhile, transdermal fibronectin is added to promote permeation and realize deep moisturizing, and finally ergothioneine is used as an auxiliary material to improve and repair a skin barrier and lock moisture in skin, so that comfortable skinfeeling can be provided, and skin health is facilitated.
Owner:广东科盈科技有限公司

Engineering strain for fermented synthesis of ergothioneine and construction method thereof

ActiveCN110358719ABiosynthesis of ergothioneineBacteriaMicroorganism based processesEscherichia coliHeterologous
The invention discloses an engineering strain for fermented synthesis of ergothioneine and a construction method thereof, and belongs to the technical field of bioengineering. With escherichia coli and bacillus subtilis as the host and three shuttle plasmids pEBS of bacillus subtilis, escherichia coli and saccharomyces cerevisiae as the expression vector, egtABCDE gene clusters from different sources are introduced into the escherichia coli and the bacillus subtilis for heterologous expression; biosynthesis of the ergothioneine is realized; then, the egtABCDE gene clusters are subjected to optimized expression, including codon optimization, promoter optimization and expression of different combinations, and meanwhile a culture medium and added methionine, hercynine, histidine and cysteineare optimized. Through the optimized expression and optimized culture conditions, efficient biosynthesis of the ergothione is realized. The engineering strain lays a foundation for efficient fermentedpreparation of ergothione by a microbial system and is suitable for industrial production and application.
Owner:JIANGNAN UNIV

Yeast repairing micro essence and preparation method thereof

PendingCN113648260AImprove the efficacy of repairing the skin barrierIncreasing the thicknessCosmetic preparationsToilet preparationsPyrrolidinonesTrehalose
The invention relates to the technical field of cosmetics, in particular to yeast repairing micro essence and a preparation method thereof. The yeast repairing micro essence comprises a phase A, a phase B, a phase C, a phase D and a phase E. The phase A comprises water, allantoin and a chelating agent; the phase B comprises a humectant, xanthan gum, Arabic gum and methylparaben; the phase C is prepared from a humectant and p-hydroxyacetophenone; the phase D comprises nicotinamide and trehalose; the phase E is prepared from a plant extract, a humectant, compound amino acid, dipotassium glycyrrhizinate, sodium pyrrolidone carboxylate, ergothioneine, a soluble collagen cross-linked polymer, hexapeptide-1, oligopeptide-1, saccharomycetes polypeptides, beta-glucan, palmitoyl pentapeptide-4, grease, a bifidus yeast fermentation product sporolysate, maltodextrin, a lactobacillus fermentation product and inulin. The yeast repairing micro essence disclosed by the invention has the effects of replenishing water, preserving moisture, tightening skin, resisting aging, whitening and repairing skin barrier.
Owner:广东瀚森生物科技有限公司

Anti-aging composition and anti-aging cosmetic containing same

The invention discloses an anti-aging composition, which is prepared from the following components in parts by weight: 0.04 to 0.4 part of cordyceps sinensis extract; 0.0001 to 0.003 part of palmitoyl hexapeptide-12, 0.0001 to 0.003 0.002 to 0.01 part of a mulberry root extract; 0.001 to 0.01 part of beta-alanyl hydroxyprolyl diaminobutyric acid benzylamine, and 0.001 to 0.01 part of beta-alanyl 0.07 to 0.21 part of a chrysanthemum indicum extract; 0.002 to 0.1 part of a peony root bark extract; 0.004 to 0.01 part of ergothioneine and 0.056 to 0.168 part of kappaphycus alvarezii extract. The anti-aging composition disclosed by the invention is designed in the directions of epidermal barrier repair, dermis repair, nuclear gene telomere protection and mitochondrial ROS (reactive oxygen species) removal, anti-aging at epidermal, dermis and muscle levels is considered in the aspect of dermatology, and a strong-effect active matter with irritation to skin is not used, so that the safety of the product is ensured. The invention further discloses an anti-aging cosmetic containing the anti-aging composition.
Owner:YUNNAN BOTANEE BIO TECH GRP CO LTD +2

Efficient moisturizing and allergy-relieving repairing composition and application thereof

InactiveCN111265420AEfficient moisturizing, soothing and repairingResist external stimuliCosmetic preparationsToilet preparationsAllergyBULK ACTIVE INGREDIENT
The invention relates to the field of protection of injuries from environmental stress factors, in particular to an efficient moisturizing and allergy-relieving repairing composition and application thereof. The high-efficiency moisturizing and allergy-relieving repair composition comprises the following components in percentage by mass: a) ectoin; b) ergothioneine or a pharmaceutically acceptablesalt or ester thereof; and c) cannabinoid as an active ingredient, wherein the content of the active ingredient in the composition is 0.5-5%. The composition has the effects of relieving sensitivity,repairing skin micro-damage and repairing after sun exposure, and can also be used for repairing a skin barrier after household acid brushing; by matching with 4D hyaluronic acid, the skin can be moistened immediately, an invisible protection film is established, external stimulation is resisted, a skin protective layer is built, the active ingredient is locked, and the purposes of efficiently moisturizing, relieving allergy and repairing are achieved.
Owner:深圳市知趣生物科技有限公司
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