36 results about "Premature ageing" patented technology

A comprehensive dietary supplement of bioavailable minerals, vitamins, phytonutrients, herbs, antioxidants, and enzymes for ameliorating the effects of stress and premature aging, for enhancing natural cellular rejuvenation and regeneration, and for fortifying the immune system of a warm-blooded animal or human, comprises, in parts by weight (a) about 100–500×10−3 of a blend of vitamins, (b) about 200–800×10−3 of blend of minerals wherein said minerals are present as amino acid chelates formed from an amino acid ligand and said minerals, wherein the mole ratio of amino acid ligand to mineral in said chelate is at least 1:1, (c) about 250–750×10−3 of a blend of phytonutrients, (d) about 50–500×10−3 of a blend of herbs, and (e) about 30–500×10−3 of a blend of enzymes.

The invention provides for methods for predicting age of a subject based on the epigenome of the subject.

A diagnostic plot derived from the measurement of 82 assays which characterize two key parameters which significantly contribute to an individual's health status. These two parameters are oxidative stress profile (OSP) and antioxidant profile. Each of the assays which constitute the 82 assays are complimentary with other assays of the profile, thus providing either confirmation information or the synthesis of new information. The diagnostic plot, developed to interpret the assay data which provides information about oxidative damage and antioxidant protection, consists of four quadrants, each with noticeable characteristics. By visually assessing the position of a patient's OSP status, in comparison to reference OSP values in the four quadrants constituting the diagnostic plot, physicians and other health care professionals can provide sound advice to their patients regarding dietary and life style changes one need to adhere for prevention of oxidative stress-related diseases as well as postponing premature aging processes.

A sleeping or resting device designed to prevent improper sleeping and / or resting that leads to the damage of facial tissues, wrinkles and premature aging. The pillow's design adjusts the sleeper's body position to prevent the face from supporting the weight of the sleeper's head by supporting the user's head primarily behind the temple. The novel design prevents wrinkling of the face that occurs during the sleeping process caused by a traditional pillow. The novel design can be generally described as an elongated foam box, having an upper concavity, an integrated coaxial cylindrical member at the leading edge, with laterally tapering triangular ends of various design.

The present invention is directed to a System characterization of NASH that combines Modeling and Biomarkers, enabling pharmaceutical compositions and methods of treatment that relate to the inhibition, resolution and / or prevention of Non Alcoholic Fatty Liver Disease (NAFLD) and Non Alcoholic Steatohepatitis (NASH). Said conditions are Liver related complications among the array of manifestations of metabolic syndromes, including Type 2 diabetes, hyperlipidemia, weight gain, abdominal obesity, insulin resistance, hypertension, atherosclerosis, fatty liver diseases and certain chronic inflammatory states that lead to these manifestations, among others. In additional aspects, the present invention relates to compositions and methods which may be used to treat, inhibit or reduce the likelihood of NASH and NAFLD complications in patients with hepatitis viral infections, including Hepatitis B and Hepatitis C viral infections, as well as the secondary disease states and / or conditions which are often associated with such viral infections, including hepatic steatosis (steatohepatitis), cirrhosis, fatty liver and hepatocellular cancer, metabolic syndrome complications including cardiovascular diseases, neurodegenerative diseases and premature ageing, among other disease states or conditions.

The present invention relates to a composition containing peptide of SEQ ID No. 1 linked to oleanolic acid and a method of treating skin aging. The composition effectively reduces signs of ageing due to oxidation, collagen insufficiency and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin, fine expression lines, reduced skin thickness, hyperpigmentation, under eye dark circles, and premature ageing.

The invention relates to a grape seed polyphenol compound chewable tablet and a preparation method thereof and belongs to the technical field of food processing. The grape seed polyphenol compound chewable tablet comprises the main components of 40 parts of grape seed polyphenol, 8-10 parts of licorice, 10-15 parts of strawberries and 5-10 parts of waxberries, wherein the strawberries and strawberries are of 20 parts in total. The grape seed polyphenol compound chewable tablet is nutritious and rich in amino acids, vitamins, polyphenols and trace elements such as calcium and iron, has effects of antioxidation, free radical scavenging and preventing free radicals from damaging to human cells so as to protect human organs and tissues and prevent diseases such as heart disease, cancer, premature aging, diabetes and arteriosclerosis which are caused by free radicals, is good in flavor, moderate in sweet and sour, bitter free and fresh and puckery taste free and sweet after-taste available after chewing, is not added with sweeteners to be healthy, simultaneously has effects of prevention and treatment of oral ulcer and anti-inflammation, and long in storage period. The preparation method is simple in process and suitable for industrial production.

The invention relates to a skin care product, in particular to an A-Fib aloe extract composition, which belongs to the field of cosmetics. The aloe extract comprises aloe ferox miller extract, paeoniflorin, fresh water pearl solution, grape seed oil, beta-glucosan, pollen, leucine and lysine. The skin care product can be used every day as a cream, facial cleaner, facial essence or lotion. The skin care product has the double functions of surface layer moistening and dermis water replenishing, and can replenish the skin deep layer with water, promote skin water metabolism, effectively prevent the electromagnetic radiation of a computer and the like from damaging the skin, effectively improve skin elasticity while moistening the skin, and avoid skid premature aging. The skin care product is particularly suitable for the daily use of people living in the environments of computer radiation and air conditioning. The aloe extract composition can prevent skin dryness and winkles, and the long-term use of the aloe extract composition can achieve whitening effect.

The invention relates to a peanut growing control medical fertilizer wettable powder and a method for controlling growth and increasing yield of peanut plants, wherein the peanut growing control medical fertilizer wettable powder comprises plant growth regulator adjustable ring acid calcium, brassinolide, bactericide azoxystrobin, macroelement water-soluble fertilizers, microelements and assistants. The peanut growing control medical fertilizer wettable powder and the method for controlling growth and increasing yield of the peanut plants solve a premature aging phenomenon of peanuts because a large amount of growth control agents such as paclobutrazol are used, effectively prevent and control fungal diseases such as leaf spot diseases and the like and supplies nutrient substances required by legumes, and achieves to solve many problems by spraying at one time. Stem leaves are sprayed with the peanut growing control medical fertilizer wettable powder in full-bloom stages and legumes stages, thereby increasing yield 15%-20%. The peanut growing control medical fertilizer wettable powder and the method for controlling growth and increasing yield of the peanut plants are simple to prepare, save labor in operation, are obvious to control growth and increase yield, and are suitable for industrial production and application.

The manufacture and use of compounds of formula (Ia) or a pharmaceutically acceptable salt thereof for preventing, inhibiting or treating cancer, AIDS and / or premature aging. The compounds of formula (Ia) being:where:R independently represents a hydrogen atom, a halogen atom, a (C1-C3)alkyl group, a —CN group, a hydroxyl group, a —COOR1 group, a (C1-C3)fluoroalkyl group, a —NO2 group, a —NR1R2 group, or a (C1-C3)alkoxy group;R′ is a hydrogen atom, a halogen atom, a (C1-C3)alkyl group, a —NO2 group, a (C1-C3)alkoxy group, or a —NR1R2 group; andR1 and R2 are a hydrogen atom or a (C1-C3) alkyl group.

The invention relates to compounds in the treatment or prevention of disorders associated with Lamin A and / or Lamin C depletion or LMNA mutations, such as laminopathy, premature ageing disorders, normal ageing and cancer(such as a cancer characterised by low levels of LMNA expression).

The nonenzymatic glycation and crosslinking of proteins is a part of the aging process with the glycation endproducts and crosslinking of long-lived proteins increasing with age. This process is increased at elevated concentrations of reducing sugars in the blood and in the intracellular environment such as occurs with diabetes. The structural and functional integrity of the affected molecules become disturbed by these modifications and can result in severe consequences. The compounds of the present invention can be used to inhibit this process of nonenzymatic glycation and therefore to inhibit some of the ill effects caused by diabetes or by aging. The compounds are also useful for preventing premature aging, spoilage of proteins in food and can prevent discoloration of teeth.

The invention relates to a skin anti-ageing composition, in particular to a skin care product containing kinds of biological factors, and belongs to the fields of cosmetics and biotechnologies. Every10 ml of composition is composed of, by content, 5-40 mg of transparent hyaluronic acid, 50-400 mg of hydrolyzed collagen, 1-5 ml of mesenchymal stem cell secretion, 1-5 ng of EGF, 1-8 ng of b-FGF1 and 10 ml of sufficiently-supplemented purified water. The skin anti-ageing composition has the advantages that a formula is safe and effective, there are no allergic substances and preservative, ageingresistance and wrinkle removal are effective, the premature ageing of the skin is improved greatly, meanwhile, it is avoided that nutrition excess makes the skin burdened, and new skin problems appear, and the skin anti-ageing composition is particularly suitable for allergic skin.

The invention provides for methods for predicting age of a subject based on the epigenome of the subject.

The current invention provides new methods and means for the prevention and treatment of ageing-related symptoms and diseases. The invention discloses mannitol 5 and / or proline containing compositions that are particularly useful for the treatment of premature ageing related symptoms in mammalian subjects suffering from genetic defects in DNA damage response and genome maintenance pathways. Humans suffering from Cockayne syndrome (CS), Xeroderma pigmentosum (XP), combined XPCS, trichothiodystrophy (TTD), COFS (cerebro-oculo-facio-skeletal syndrome), 10 XFE disorder (Xpf-Erccl syndrome), Bloom Syndrome (BS), Werner Syndrome (WS), Ataxia telangiectasia (AT), Fanconi Anemia (FA), Hutchinson Guilford Progeria (HGP) may be treated with pharmaceutical compositions comprising mannitol and / or proline according to this invention.

The invention provides for methods for predicting age of a subject based on the epigenome of the subject.

The present invention is directed to combination pharmacological treatments that induce a prolonged, modest decrease in core body temperature, to the range of ˜95° F. to ˜98.5° F. (˜35° C. to ˜36.7° C.) to mitigate and delay the early onset and progression of fatal disease processes associated with premature aging, such as those characteristic of progeria (Hutchinson-Gilford Progeria Syndrome, HGPS), Wiedemann-Rautenstrauch syndrome (neonatal progeroid syndrome), Werner syndrome, and other rare disorders characterized by premature aging, and to prolong the shortened lifespan of children afflicted with these diseases. Short-term chronic administration of the pharmaceutical treatments to a person suffering from mild concussion may also have value in ameliorating neurological damage / symptoms associated with mild concussion. Chronic administration of the pharmacological treatments may also have value in normal human populations or in high-risk human populations. Similar benefits may be realized in other mammals such as canines, felines and other non-human species.

The invention relates to a composition for use in the treatment of the effects of environmental pollution on the skin or for the prevention of premature ageing of the skin associated with the effectsof environmental pollution. Said composition comprises diterpenes, oleuropein, verbascoside, quercetin and hydroxytyrosol. In a preferred embodiment, the composition contains approx. 32 wt.% of rosemary extract with a minimum content of 15 wt.% of diterpenes, approx. 30 wt.% of olive leaf or fruit extract with a minimum content of 16 wt.% of oleuropein and a minimum content of 5 wt.% of hydroxytyrosol, approx. 28 wt.% of Lippia citriodora extract with a minimum content of 25 wt.% of verbascoside, and approx. 10 wt.% of Sophora japonica extract with a minimum content of 40 wt.% of quercetin.

The present invention relates to a composition containing peptide of SEQ ID NO: 1 linked to oleanolic acid and a method of treating skin aging. The composition effectively reduces signs of ageing due to oxidation, collagen insufficiency and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin, fine expression lines, reduced skin thickness, hyperpigmentation, under eye dark circles, and premature ageing.

A PTC heater for an air conditioner belongs to the technical field of electric heaters. Including the PTC heater body, there are more than two parallel to each other and spaced apart from each other; the tailstock has a tailstock socket cavity on the tailstock; the electrical connection seat has an electrical connection socket socket cavity; The connecting seat is buckled and fixed, and features: there is a tailstock support on the tailstock, and the tailstock support has a tailstock support cavity; the left end surface of the front and rear walls of the electrical connection seat is extended with a support, and the support has a support cavity. There is an electrode sheet insulating partition wall in the socket cavity of the electrical connection seat, and the right side of the electrode sheet insulating partition wall is joined to the right wall of the electrical connection seat of the electrical connection seat, and is located between the electrode sheet insulating partition walls in two adjacent electrical connection seat cavities The space constituted as an electrical protection component housing cavity. Good heat dissipation efficiency and effect; prevent cracking, deformation and premature aging of tailstock and electrical connection seat; meet installation requirements; save material consumption and increase assembly speed.

The invention provides a rice wheat full mechanical high-yield high-efficiency planting method. The method adopts a rice wheat two-cropping planting mode and full mechanical production. The planting method includes: performing preparation before wheat sowing, selecting and air-drying seeds, mixing the seeds with a farm chemical agent, performing fine-sowing, stabilizing moisture in soil, allowingseedlings to grow orderly, and strengthening the seedlings; promoting rooting and tillering, and cultivating strong seedlings; performing adjustment and control at suitable time, promoting growth of weak seedlings, controlling vigorous growth, allowing strong seedlings to safely overwinter, lifting the seedlings, stabilizing growth, hardening the seedlings, and strengthening tillers; consolidatingvalid tillers, and ensuring full and big ears; applying an elongation booting fertilizer; rearing roots, protecting leaves, preventing green retaining and premature aging, increasing grains and the weight, performing watering to resist drought, performing drainage to reduce the moisture and prevent premature aging, and performing rice sowing preparation and rice sowing at the same time; performing high-quality mechanical rice transplanting, performing quick reviving, finely preparing a large field, and applying a sufficient base fertilizer; ensuring full ears during a valid tillering stage ofthe rice; controlling invalid tillering during an invalid tillering stage of the rice; strengthening roots and stems so as to promote big ears; rearing roots, protecting leaves, increasing grains andthe weight, and improving the quality. The planting method is supported by a matching intercropping technology adapting to mechanical operations, is scientific in planting, and can achieve increase in grain yield and income.

The invention discloses a formula having anti-fatigue, anti-premature decrepitude and anti-coagulation effects and a preparation method thereof. The components of the formula include sea perch fish sperms, urechis unicinctus, shelled oysters, antler blood, chaga mushroom, radix ginseng, solomonseal rhizome, cassia bark, lepidium meyenii and Chinese chive seeds. The formula is rich in protein, vitamin A, B vitamins, calcium, magnesium, zinc, selenium, phospholipids, minerals, collagen, proteoglycan, hyaluronic acid, nucleotide, ganglioside, growth hormone and various amino acids required by human bodies, therefore, blood circulation can be promoted, intravascular waste can be timely removed, anti-fatigue, anti-premature decrepitude, anti-coagulant and anti-thrombotic effects can be achieved, unblocked microcirculation can be ensured, and premature ageing can be effectively prevented.

The invention relates to the technical field of medicine, and provides a method of screening and identifying small molecule with anti-aging properties. The method comprises cellular models, namely premature aging mouse embryonic fibroblasts and human HGPS mesenchymal stem cells and animal models, namely premature aging progeroid mice and Caenorhabditis elegans. The method successfully screened and identified Cannabidiol (CBD), which had senolytic effects. The invention also determined that the optimal concentration of CBD treatment is 10-20 μM.

The application belongs to the technical field of genetic engineering, and specifically relates to the application of Arabidopsis thaliana ACS2 gene (AtACS2) gene in drought resistance and early maturity of cotton. The gene number is At1g01480, its CDS length is 1491bp, and it encodes 496 amino acids. The encoded protein belongs to an isoenzyme of ACC synthetase; after the enhanced expression of the gene, the transfected cotton can obtain drought-resistant, precocious and non-premature transgenic cotton new strain or variety. Planting experiments show that when encountering extreme water shortage and drought, compared with non-transgenic cotton, transgenic cotton has a well-developed root system, significantly increased lateral roots, and shortened internodes of cotton plants, which is conducive to water acquisition, transportation and utilization, and enhances the ability of cotton to tolerate drought At the same time, the transgenic cotton blooms and opens bolls in advance, without premature senescence, cotton fiber yield and quality are slightly improved, and has the excellent trait of "early maturity and no premature senility", which has good popularization and application value.

The invention relates to a pure traditional Chinese medicine preparation, especially Yangshou oral liquid which has a good therapeutic effect on patients with kidney yin deficiency. It is composed of Morinda officinalis, Lycium barbarum, Rehmannia glutinosa, Polygonum multiflorum, Cistanche, Dodder, raspberry, Atractylodes macrocephala, Dipsacus, Achyranthes bidentata, Poria cocos, Asarum, Plantago seed, Polygala, Shichangpu, chrysanthemum, Digu Oral liquid made from leather has the functions of nourishing five viscera, strengthening muscles and bones, blackening beard and black hair, and dredging veins. It is used for preventing and treating premature aging, promoting longevity, anti-fatigue and anti-aging. . It is suitable for middle-aged and elderly people to take for a long time. It has a good therapeutic effect on patients with kidney yin deficiency. According to the clinical test on 300 patients, the total effective rate is 88.3%, and the curative effect is remarkable and definite.

The invention relates to the technical field of biological medicines, provides a live bifidobacterium capsule and applications of the live bifidobacterium capsule in preparing medicines for preventing premature ovarian failure, and relates to the live bifidobacterium capsule and applications of the live bifidobacterium capsule in preparing the medicines for preventing premature ovarian failure. With the technology provided by the invention, the clinical applications of the live bifidobacterium capsule are expanded, and meanwhile, a novel medication choice and a novel clinical diagnosis and treatment scheme are provided for preventing premature ovarian failure.

The invention relates to a grape seed polyphenol compound chewable tablet and a preparation method thereof and belongs to the technical field of food processing. The grape seed polyphenol compound chewable tablet comprises the main components of 40 parts of grape seed polyphenol, 8-10 parts of licorice, 10-15 parts of strawberries and 5-10 parts of waxberries, wherein the strawberries and strawberries are of 20 parts in total. The grape seed polyphenol compound chewable tablet is nutritious and rich in amino acids, vitamins, polyphenols and trace elements such as calcium and iron, has effects of antioxidation, free radical scavenging and preventing free radicals from damaging to human cells so as to protect human organs and tissues and prevent diseases such as heart disease, cancer, premature aging, diabetes and arteriosclerosis which are caused by free radicals, is good in flavor, moderate in sweet and sour, bitter free and fresh and puckery taste free and sweet after-taste available after chewing, is not added with sweeteners to be healthy, simultaneously has effects of prevention and treatment of oral ulcer and anti-inflammation, and long in storage period. The preparation method is simple in process and suitable for industrial production.

The present invention provides a biological inoculant for cotton growth-promoting, anti-premature senescence, and anti-boll fall. The biological inoculum includes the following substances: strain ACCC30352, strain ACCC30334 and strain ACCC31052. The biological bacterial agent produced by the invention can promote the growth of cotton, solve the problem of slow growth of cotton seedlings in the early stage, and can resist premature senescence of cotton, improve the resistance and disease resistance of cotton, and can also protect flowers and protect It can prevent the shedding of cotton buds and bolls and significantly increase the yield of cotton. The biological inoculum of the present invention can be continuously sprayed (dropped) applied after the cotton emerges, and applied once every 7-10 days, and the effect of continuous use more than 5 times is remarkable. The biological bacterial agent of the invention is simple to use, convenient, low in cost, safe and environmentally friendly, and has high cost performance.