38 results about "Weakness" patented technology

The invention features polypeptides that include an extracellular ActRIIa variant. In some embodiments, a polypeptide of the invention includes an extracellular ActRIIa variant fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving weakness and atrophy of muscles, e.g., Duchenne muscular dystrophy, facioscapulohumeral muscular dystrophy, inclusion body myositis, amyotrophic lateral sclerosis, sarcopenia; or cancer cachexia; or metabolic diseases, e.g., obesity, Type-1 diabetes, or Type-2 diabetes.

The invention features polypeptides that include an extracellular ActRIIB variant. In some embodiments, a polypeptide of the invention includes an extracellular ActRIIB variant fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving weakness and atrophy of muscles, bone damage, low red blood cell levels (e.g., anemia or blood loss), fibrosis, and / or pulmonary hypertension.

A closed-loop neuromodulation system includes at least one implantable neurostimulator configured to deliver electrical stimulation to a target nerve innervating a muscle; at least one biosignal sensor configured to detect a physiological signal associated with the target muscle, wherein the physiological signal may include an electromyographic (EMG) or electroneurographic (ENG) signal; and a controller operatively coupled to the neurostimulator and the sensor. The controller is configured to receive the physiological signal from the sensor, determine whether the signal satisfies a predefined condition indicative of weakness, strength, fatigue, muscle underactivity, or overstimulation, and, in response to detecting that the condition is satisfied, automatically adjust one or more stimulation parameters selected from amplitude, frequency, pulse width, train duration, or train count.

The invention features polypeptides that include an extracellular ActRIIa variant. In some embodiments, a polypeptide of the invention includes an extracellular ActRIIa variant fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving weakness and atrophy of muscles, e.g., Duchenne muscular dystrophy, facioscapulohumeral muscular dystrophy, inclusion body myositis, amyotrophic lateral sclerosis, sarcopenia; or cancer cachexia; or metabolic diseases, e.g., obesity, Type-1 diabetes, or Type-2 diabetes.

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a kidney-tonifying and liver-nourishing compound preparation and a preparation method thereof. The compound preparation comprises 5-15 parts of roasted herba epimedii, 5-15 parts of fructus cnidii, 50-70 parts of roasted radix astragali and 10-30 parts of pulp of dogwood fruit. The traditional Chinese medicine composition has remarkable curative effects on various diseases and chronic strain caused by deficiency of liver and kidney and deficiency of blood and essence, such as dizziness, blurred vision, fatigue, swelling and pain of waist, back and limbs, dry mouth and eyes, limb ache and weakness, irregular menstruation, incapability of holding weight or hemiplegia and the like, and has a very good application prospect.

Myotonic Dystrophy type 1 (DM1) is an inherited disease characterized by multi-systemic symptoms, particularly in skeletal muscles (progressive weakness and atrophy, myotonia). The inventors screened 7 500 bioactive compounds for their ability to improve the myogenic fusion and reduce the molecular hallmarks of DM1 skeletal muscle cells. The inventors found that five compounds, all inhibiting HDAC6, a cytoplasmic histone deacetylase, were effective at the micromolar range in normalizing the myogenic fusion, reducing the number of nuclear foci of mutant DMPK mRNA, decreasing the expression level of DMPK mRNA, restoring the splicing of several genes, and increasing the acetylation of SMAD3, a transcription factor involved in muscle development. The effects of HDAC6 inhibitors were observed both in immortalized and hiPSC-derived skeletal muscle cells from DM1 patients, and in different stages of differentiation. Thus, the present invention relates to the use of selective HDAC6 inhibitors for the treatment of DM1.

In MRI examinations of patients with acute ischemic stroke, it is often difficult for patients to fix and hold their heads due to impaired consciousness or limb weakness. Therefore, this invention provides a tool that is structurally rational, easy to operate, and effectively enhances the head fixation effect. [Solution] A tool to support MRI examination, comprising a base 1, a head rest member 2 with adjustable anterior-posterior position, a lateral limiting member 3 with an elastic buffer layer, and an adjustment mechanism 4. The head rest member slides relative to the base to adapt to the length of the patient's neck. The lateral limiting member is biased inward by a compression coil spring and flexibly holds both sides of the head with an elastic buffer layer, absorbing and suppressing involuntary movements. The adjustment mechanism uses a single reverse-threaded adjustment rod to synchronously and symmetrically move the left and right limiting plates, enabling precise adjustment according to the head circumference. This effectively limits multi-directional micro-movements of the head during imaging and improves image stability.

The present invention relates to the technical field of patient rehabilitation training, and discloses a rehabilitation training auxiliary device for critically ill patients and a working method thereof, comprising a bed body, a leg support portion being provided on the right side of the bed body, a driven portion for controlling the leg support portion being provided inside and on the top of the bed body, a swinging portion being provided on the right side of the bed body, the leg support portion comprising a main support and a secondary support, the driven portion comprising an arc plate, a connecting rod being fixed to the bottom of the arc plate, the connecting rod passing through the top of the bed body and being slidably connected to the bed body, a spring being fixed on the inner wall of the bed body, the rehabilitation training auxiliary device for critically ill patients and a working method thereof, through the provided leg support portion, the swinging portion and the driven portion, the patient can lie on the bed body and place his legs on the leg support portion, and the leg support portion can support the patient's legs to perform back and forth and up and down swinging training, thereby assisting the patient in leg muscle exercise and avoiding the phenomenon of weakness caused by the patient not exercising.

The application discloses a medical nursing pressure injury prevention device and belongs to the technical field of medical auxiliary devices. The device comprises a bed frame, the inside of the bed frame is fixedly connected with a first lying plate, one side of the first lying plate is provided with a second lying plate, the inside of the second lying plate is provided with a rotating roller, the lower end of the bed frame is provided with an adjusting assembly, and the lower end of the first lying plate is provided with a lower limb massage assembly. The adjusting assembly is arranged to adjust the angle of the second lying plate, so that the risk of exacerbation of the illness of the patient due to forced getting up is reduced. The handle structure is arranged to facilitate the patient to hold, so that the patient is prevented from falling due to the weakness of the upper limbs. The lower limb massage assembly is arranged to massage the lower limbs of the patient, so that the pressure injury of the patient due to long-time prohibition of the lower limbs is avoided. The practicality of the device is improved. The limiting mechanism is arranged to limit the massage block, so that the massage block is prevented from being separated from the inside of the first lying plate due to gravity.

This utility model provides an anti-tipping osteoporosis treatment chair, including: a headrest, an adjustment component, and a water pipe. The lower end of the headrest is provided with a set of lifting rods for controlling the up-and-down movement of the headrest. The lower end of the lifting rods is provided with a backrest for supporting the patient's back. The lower front side of the backrest is provided with a seat. The lower end of the seat is provided with a connecting seat for supporting its lower end. The support plate and the connecting seat are connected and fixed by several sets of bolts. Compared with the prior art, this utility model has the following beneficial effects: by using the adjustment component to adjust the height and tilt of the seat, it prevents the patient from tipping over due to unsuitable height. Osteoporosis patients often experience weakness, bone pain, spinal deformities, and fractures, thus reducing the need for self-adjustment and decreasing the likelihood of tipping due to self-adjustment.

The apelin receptor modulator can improve the physical performance of a human patient, slow the progression of age-related weakness, and can reduce age-related muscle weakness. The present disclosure provides methods of treating muscle disorders using specific classes of apelin receptor modulators (e.g., agonists). The muscle condition may be an age-related muscle condition. Also provided is a method of maintaining and / or increasing muscle mass, muscle function, and / or muscle strength in an elderly subject by administering an apelin receptor modulator. In some embodiments, an apelin receptor modulator (e.g., an agonist) is BGE-105 or a pharmaceutically acceptable salt thereof.

The utility model provides a body position frame. The body position frame comprises a hoop, an inverted-L-shaped rod arranged on the hoop, a vertical rod arranged at the upper end of a transverse rod of the inverted-L-shaped rod and an arm support arranged at the upper end of the vertical rod. The lower end of the side, close to the elbow, of the arm support is connected with a T-shaped fixing band, and the two wing parts of the T-shaped fixing band are bonded to the outer walls of the two sides of the arm support respectively. A headstock installation assembly is further arranged on the side, away from the operating bed, of the transverse rod. According to the utility model, the elbow is wrapped by the T-shaped fixing band, so that the elbow can be supported, the numbness and weakness of the elbow caused by long-time operation can be avoided, the elbow can be limited, the fixing effect is improved, and the phenomenon that the arm slips off can be effectively avoided; the head frame for supporting the sterile towel can be conveniently connected to one side of the body position frame, the head frame and the arm supporting frame can be used at the same time, the practicability of the device is improved, the operation space of a doctor on the side of an operation bed is saved, the operation view is expanded, and convenience is provided for operation of the doctor.

The invention features polypeptides that include an extracellular ActRII chimera. In some embodiments, a polypeptide of the invention includes an extracellular ActRII chimera fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving weakness and atrophy of muscles, bone damage, low red blood cell levels (e.g., anemia or blood loss), low platelet levels (e.g., thrombocytopenia), low neutrophil levels (e.g., neutropenia), fibrosis, metabolic disorders, and / or pulmonary hypertension.

The invention provides a traditional Chinese medicine composition for strengthening spleen and building muscle, a medicinal preparation and a preparation method thereof, and belongs to the technical field of medicines. The traditional Chinese medicine composition comprises the following components: Chinese yam, bighead atractylodes rhizome, sun-dried ginseng, hyacinth bean and malt. The traditional Chinese medicine composition and the pharmaceutical preparation provided by the invention have the effects of tonifying spleen and qi, promoting digestion and resolving dampness, and regulating middle warmer and increasing muscle, and can be used for treating senile sarcopenia and improving symptoms such as weakness of spleen and stomach, reduction of muscle strength, deficiency of qi and blood and the like.

1. The name of the design product: rehabilitation grip ball. 2. The use of the design product: for wrist weakness patients rehabilitation training. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view. 5. The content of the rear view has been fully embodied in the left view, right view, top view and bottom view, and the rear view is omitted.

The present disclosure provides methods for preventing loss of muscle mass and function and bone loss in patients via gene therapy, administration of therapeutics, and combinations thereof. Methods to prevent loss of muscle mass and function in patients with cancer or any other condition that causes muscle wasting conditions such as sarcopenia, aging, immobilization, and any other cause of muscle loss, include inhibiting or depleting skeletal muscle of FNDC5 / irisin. More particularly, the present disclosure provides antibody antagonists or other small molecules directed against FNDC5 / irisin, for example, to reduce weakness in the patient and allow them to recover strength more quickly after eradication of the tumor.

The invention features polypeptides that include an extracellular ActRII chimera. In some embodiments, a polypeptide of the invention includes an extracellular ActRII chimera fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving weakness and atrophy of muscles, bone damage, low red blood cell levels (e.g., anemia or blood loss), low platelet levels (e.g., thrombocytopenia), low neutrophil levels (e.g., neutropenia), fibrosis, metabolic disorders, and / or pulmonary hypertension.

The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration for urinary incontinence and other urinary tract pathologies.

The invention relates to the technical field of maxillofacial muscle group function evaluation, in particular to a maxillofacial muscle group function dynamic capturing method for a patient with dysphagia, which comprises the following steps: acquiring a rate slow expression based on age, weakness degree obtained by body data evaluation and a displacement rate of a monitoring point; acquiring displacement shrinkage performance based on the volume and the spacing of the tongue bones and the displacement of the monitoring points; acquiring a muscle movement sequence expression based on the actual movement sequence number of the muscle movement event corresponding to each monitoring point and the actual time interval of the adjacent muscle movement event; on the basis of the rate slow expression and the displacement shrinkage expression, obtaining the overall movement expression of the single-swallowing monitoring point; and acquiring swallowing ability expression based on the integral movement expression of the single swallowing monitoring point and the muscle movement sequence expression so as to acquire the maxillofacial muscle group function expression of the patient. According to the invention, accurate evaluation of the maxillofacial muscle group function of the patient can be realized.

The invention belongs to the technical field of rehabilitation instruments, and particularly relates to a spinal pelvic unbalance correction device which comprises a seat surface module, a waist supporting module, a sacrum supporting module and a control module. The multi-dimensional linkage adjustment specifically comprises the steps that 10-15 minutes serve as a cycle, the seat surface module is controlled to execute left-right alternate lifting actions, the lifting angle is 0.5-1 degree, the side wing tension of the waist supporting module and the supporting point position of the sacrum supporting module are synchronously adjusted, spiral muscle groups such as trapezius muscle chains and oblique abdominal muscles are specifically activated, the excessively-nervous erector spinae muscles are restrained, and the sacrum supporting function is achieved. The spinal intervertebral disc pressure is reduced. According to the correction equipment for spinal pelvic imbalance, a seat is converted into a dynamic rehabilitation tool from a static supporting tool, deep stable muscles are actively activated through multi-dimensional linkage rhythmic mechanical stimulation on the basis of the SPS spiral stable muscle chain theory, muscle strength imbalance is fundamentally improved, muscle disuse weakening caused by passive supporting is avoided, and the rehabilitation effect of spinal pelvic imbalance is improved. The correction effect is longer.

The present invention relates to an assembly configured for insertion of medical objects in need for protection into soft tissue, such as nervous tissue, the assembly comprising a water-resistant sleeve, accommodating an oblong device comprising at least one rigidity imparting element, the oblong device having an overall diameter of less than about 5 mm, preferably less than 2 mm, the he sleeve wall having an average thickness of less than 100 µm and comprising a weakness at least in the distal section, said weakness enabling the distal section to rupture when an axial force is exerted on the distal section, such as the region of the distal end, by the oblong device.

The present invention relates to an assembly configured for insertion of medical objects in need for protection into soft tissue, such as nervous tissue, the assembly comprising a water-resistant sleeve, accommodating an oblong device comprising at least one rigidity imparting element, the oblong device having an overall diameter of less than about 5 mm, preferably less than 2 mm, the he sleeve wall having an average thickness of less than 100 µm and comprising a weakness at least in the distal section, said weakness enabling the distal section to rupture when an axial force is exerted on the distal section, such as the region of the distal end, by the oblong device.

The invention provides a rehabilitation training device which comprises a back plate, a fixing belt, a support and a table top, the fixing belt is arranged on the back plate, the fixing belt is adjusted within a certain range according to the size of a human trunk and fixes the human trunk to the back plate, the back plate is detachably installed on the support or the table top, and the table top has a certain supporting area in the horizontal direction. The table top is installed on the support, the support is provided with a transverse rod extending in the horizontal direction, the transverse rod is close to the ground and can be inserted below the bed, and a fulcrum is arranged below the end of the transverse rod so that the fulcrum of the support can be away from the gravity center of the support. For a critical patient who lies in bed for a long time or is weak, the rehabilitation training device can be used for achieving sitting and simple rehabilitation training more conveniently, medical staff can transfer the patient more conveniently, participation of multiple medical staff is not needed, turning around is not needed compared with a wheelchair, the transferring difficulty is reduced, and the medical staff can carry out rehabilitation training more conveniently. And for patients with limited activities or paralyzed patients, the device is relatively practical.

The invention discloses a construction method and application of an acute toxic rhabdomyolysis syndrome animal model. According to the method, maduramicin is applied to an experimental animal through an intragastric administration way, and non-equal-dose intragastric administration is performed twice within 24 hours by adopting a specific scheme. The method is simple and convenient to operate, the modeling rate is up to 85% or above, and a typical disease model can be successfully established within 48 hours. Model animals show typical symptoms such as limb weakness, soy sauce color and urine, serum creatine kinase and lactic dehydrogenase are remarkably increased, and skeletal muscles have characteristic pathological changes. The model established by the invention is highly consistent with a human oral poisoning way, and an ideal experimental platform is provided for studying rhabdomyolysis pathogenesis, screening drugs and preventing and treating complications.

A closed-loop neuromodulation system includes at least one implantable neurostimulator configured to deliver electrical stimulation to a target nerve innervating a muscle; at least one biosignal sensor configured to detect a physiological signal associated with the target muscle, wherein the physiological signal may include an electromyographic (EMG) or electroneurographic (ENG) signal; and a controller operatively coupled to the neurostimulator and the sensor. The controller is configured to receive the physiological signal from the sensor, determine whether the signal satisfies a predefined condition indicative of weakness, strength, fatigue, muscle underactivity, or overstimulation, and, in response to detecting that the condition is satisfied, automatically adjust one or more stimulation parameters selected from amplitude, frequency, pulse width, train duration, or train count.

The utility model discloses a wound flushing device for orthopedic nursing, and aims to solve the technical problems that in the prior art, an orthopedic patient usually has difficulty in sitting for a long time and easily has the risk of falling down due to unstable center of gravity when the wound of the upper limb is flushed along with physical weakness. The flushing device comprises a supporting base, a cleaning box, a medicine mixing box, flushing heads and a water filtering plate, the cleaning box is installed at the top of the supporting base, the medicine mixing box is installed on the upper surface of the cleaning box, the flushing heads are connected to the side surface of the medicine mixing box, and the water filtering plate is connected to the inner wall of the cleaning box; a support is connected between the supporting base and the side surface of the cleaning box. According to the flushing device, when the hand wheel rotates, the threaded rod can be driven to rotate, the threaded rod rotates to drive the movable block to longitudinally move, the movable block longitudinally moves to drive the soft pillow to longitudinally move through the supporting rod, supporting force can be provided after the soft pillow moves to the proper height, and therefore the situation that an orthopedic patient falls down due to weakness can be avoided.

The invention features polypeptides that include an extracellular ActRIIa variant. In some embodiments, a polypeptide of the invention includes an extracellular ActRIIa variant fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving weakness and atrophy of muscles, e.g., Duchenne muscular dystrophy, facioscapulohumeral muscular dystrophy, inclusion body myositis, amyotrophic lateral sclerosis, sarcopenia; or cancer cachexia; or metabolic diseases, e.g., obesity, Type-1 diabetes, or Type-2 diabetes.

The invention relates to the technical field of traditional Chinese medicine moxibustion therapy conditioning, in particular to a conditioning method for activating the self-healing capacity of a human body through three-dimensional balanced moxibustion multi-acupoint linkage. The three-dimensional moxibustion therapy network is composed of a core shaft system, four-major-jiao acupoints and abdominal and dorsal reflection area acupoints. Vertical shafts (Tiansheng three-jiao axis) comprise the Baihui acupoint, the perineum acupoint (between the rear joint and the anus) and the Yongquan acupoint, and a vertical Tai Chi and three-jiao energy through channel is formed. A two-axis three-jiao three-dimensional moxibustion network is constructed, full coverage of acupuncture points of the head, the trunk, the feet, the front side and the rear side is achieved, the limitation of traditional single-point moxibustion is broken through, the overall view of traditional Chinese medicine and the multi-acupuncture-point linkage synergistic effect are truly embodied, meridians and collaterals are rapidly penetrated, yin and yang are harmonized, qi and blood circulation is activated, and harmful substances in the body are discharged in a targeted mode in stages; after the three stages, the symptoms of dark complexion, limb weakness, poor sleep, digestion disorder and the like can be obviously improved.

Our squat toilet represents a long-overdue expansion of the existing portable toilet market, enabling users to perform two of the most natural bodily functions in a simple, practical, convenient, hygienic, and healthy way, safely and physiologically correctly. It offers all age groups and genders an unprecedented opportunity for hygienically safe, location-independent, and physiologically correct bowel and bladder emptying. Its unique design allows for a fully natural squatting position, enabling complete bowel emptying without artificial straining and its associated risks. This helps prevent typical health problems caused by excessive straining, including digestive issues such as diarrhea or constipation, gastrointestinal cramps, incontinence, erectile dysfunction, pelvic floor weakness, and spikes in blood pressure. Furthermore, daily squatting maintains both the natural mobility of the lower extremities (ankle, knee, and hip joints) and leg strength (for standing up). Even in cases of pre-existing health problems such as hemorrhoids, erectile dysfunction, incontinence, digestive problems, high blood pressure and much more, the squat toilet could support the recovery process in addition to conventional, mainstream medical therapies by avoiding unnecessary strain. The buttocks, which hover freely over the edge of the squat toilet, avoid direct contact with germs or bodily fluids in a simple and natural way. Its globally unique design allows for splash-free defecation and urination. Our squat toilet is designed for user-friendliness. It is easy to handle, intuitive to use, easy to transport, easy to clean, yet sturdy, stable, and natural.

The utility model relates to the field of exercise devices, in particular to a Parkinson's patient exercise device which comprises a transverse plate, a vertical plate is fixedly connected to the right side of the top of the transverse plate, an adjusting mechanism is connected to the front side of the top of the transverse plate in a penetrating and threaded mode, and limiting mechanisms are fixedly connected to the bottom and the front side of the right side of the vertical plate; by arranging the limiting mechanism, balancing weights with different weights can be limited, a user can feel the balancing weights by inserting the inserting rods into the inserting grooves in the two sides of the balancing weights with the light weight, if weight needs to be increased, the inserting rods can be inserted into the inserting grooves of the balancing weights with the heavy weight, and the situation that when the user uses the device, the weight of the balancing weights can not be increased due to the fact that the inserting rods are inserted into the inserting grooves of the balancing weights with the heavy weight is avoided. When a Parkinson's disease patient exercises the arm, the arm is injured due to the fact that the balancing weight is too heavy, so that the user can be protected, the problem that the weight cannot be limited and adjusted in the existing process that the Parkinson's disease patient exercises the arm is solved, and the safety of the patient can be guaranteed.