158 results about "Bone damage" patented technology

A bone graft substitute using magnesium substituted calcium phosphate compounds and a method of manufacturing the same is provided in which the bone graft substitute is used for recovering bones damaged due to a bone fracture. The method of manufacturing a bone graft substitute includes the steps of mixing powdered calcium pyrophosphate and a magnesium included compound to thereby obtain a composition, pressure-forming the compositions to obtain a plastic body; and sintering the plastic body.

A reamer for preparing a spinal upper facet to facilitate insertion of combined screw/washer implant, preventing bone damage and facet weakening, and also allowing possibility to place grafting so as to maximize implant stabilization. The reamer has shallow outer cutting surfaces to cut a groove for spike insertion; deep inner cutting surfaces to cut a cortical-penetrating bore for insertion of the screw, and a flat therebetween to limit penetration of these cutting surfaces.

Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), abdominal adiposity, metabolic syndrome, type II diabetes, cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Disclosed is a method for forming carbonated calcium hydroxyapatite. The disclosed method can be used for forming bone cements or optionally cast, cured scaffolds such as may be used in many medical applications, including as implants for bone damage caused by, for instance, trauma, disease, or surgical excision due to disease. The cured materials include an interconnected network including both microporosity and macroporosity. The disclosed materials can be very similar in both chemical and physical make-up to natural bone mineral. The invention is also directed to systems that can be used for conveniently carrying out the disclosed methods.

Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), abdominal adiposity, metabolic syndrome, type II diabetes, cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Compounds of structural formula (I) are disclosed as useful for modulating the androgen receptor (AR) in a tissue selective manner in a patient in need of such modulation, and in particular for antagonizing AR in the prostate of a male patient or in the uterus of a female patient and agonizing AR in bone and/or muscle tissue. These compounds are useful in the treating conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including: osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, female sexual dysfunction, post-menopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, aplastic anemia and other hematopoietic disorders, pancreatic cancer, renal cancer, prostate cancer, arthritis and joint repair, alone or in combination with other active agents. In addition, these compounds are useful as pharmaceutical composition ingredients alone and in combination with other active agents.

Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of the androgen receptor in bone and/or muscle tissue while antagonizing the AR in the prostate of a male patient or in the uterus of a female patient. These compounds are therefore useful in the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, cancer cachexia, muscular dystrophies, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

The invention discloses a 3D printing template for surgical puncture. The 3D printing template includes a plate body and several cylinders with puncture holes; the cylinders are divided by seams passing through the puncture holes; the outside of the cylinders An outer ring is provided; the board body is constructed with a positioning ring. Also disclosed is a method for preparing a 3D printing template for surgical puncture. The use of this puncture template can significantly reduce the operation time, and more importantly, it can significantly reduce the radiation exposure time of the operator and the patient; at the same time, according to the precise positioning before the operation, the number of punctures can be reduced, the puncture angle can be accurately determined, and the occurrence of complications can be avoided. curative effect. Especially for patients with congenital deformities or bone injuries, the feasibility of surgery can be clarified before surgery and the accuracy of puncture can be improved.

The invention discloses an orthopedic nail removing device, which includes a bottom plate, Both sides of the top of the bottom plate are fixedly connected with bottom boxes, and the tops of the two bottom boxes are fixedly connected with horizontal boxes, the tops of the horizontal boxes are fixedly connected with top boxes, and sliding plates are slidably connected between opposite sides of the two bottom boxes, and the bottoms of the sliding plates are fixedly connected with motor boxes and fixed boxes, which relate to the technical field of medical instruments. As that orthopedic nail takedevice, through which the bottom of both moving plates penetrate and extend to the bottom of the stationary box, the screw which is corroded with the steel plate can be taken out smoothly, take out that steel plate, The screw can be fixed first, and then moved upward, and the screw is taken out slowly, so that the pain of the patient can be alleviated, the operation efficiency is improved, and thetime is saved. The invention has the advantages of simple operation, no need to increase the slot area, small bone damage surface, and effectively avoiding secondary injury to the patient.

The invention discloses an implant system based on titanium-zirconium alloys. The implant system comprises an implant, an artificial tooth base table and a center screw, two ends of the artificial tooth base table are provided with a dental crown connecting section and an implant inserting section respectively, the implant inserting section comprises a first frustum, a plum blossom-shaped column and a second frustum, the dental crown connecting section is connected with a large-diameter end of the first frustum, a small-diameter end of the first frustum is connected with one end of the plum blossom-shaped column, and the other end of the plum blossom-shaped column is connected with a large-diameter end of the second frustum. According to the implant system based on the titanium-zirconium alloys, the implant is of a double-threaded structure of a primary thread and a secondary thread, alveolar bone damage can be effectively reduced, generated cutting resistance is small, and the implant system effectively solves the problems of bone burn, stress concentration, micro-cracks of notching positions and the like.

The invention discloses a preparation method and an application of laponite (LAP) bioceramics. The method comprises a first step of tabletting LAP powder in a mold through a uniaxial pressing method to obtain LAP sheets; and a second step of sintering the LAP sheets in a muffle furnace to obtain the LAP bioceramics. The preparation method and application provided by the invention are simple in process; products are easily available; cost of LAP is relatively low; the prepared LAP bioceramics have good blood compatibility and good capacity for accelerating bone healing, and have wide application prospects in the fields of tissue engineering scaffold materials, particularly the field of bone damage repair.

The invention provides a medicament for treating bone damage and relates to a Chinese medicinal medicament for treating the bone damage, which is prepared from the following raw materials in part by weight: 20 to 28 parts of ground beetle, 55 to 65 parts of processed frankincense, 43 to 53 parts of processed myrrh, 25 to 35 parts of arisaema cum bile, 25 to 35 parts of dahurian angelica root, 25 to 35 parts of dragon's bones, 25 to 35 parts of processed nux vomica, 25 to 35 parts of largetrifoliolious bugbane rhizome, 14 to 22 parts of incised notopterygium rhizome, 14 to 22 parts of crab shell, 14 to 22 parts of grassleaf sweelflag rhizome, 25 to 35 parts of safflower, 25 to 35 parts of dragon's blood, 25 to 35 parts of divaricate saposhnikovia root, 20 to 28 parts of szechuan lovage rhizome and 14 to 22 parts of Chinese angelica. The medicament has the advantages that: clinical repeated practices prove that the medicament has the effects of quickening blood and dispelling stasis, dispersing swelling and relieving pain, soothing sinews and quickening blood, and dispelling wind and dissipating cold; and clinical repeated practices also prove that the medicament has high cure rate, concentrated medicinal strength, rapid action, no toxic or side effects, long duration of medicament effect, low cost, no pain of patients and wide application. The medicament also has the advantages of addressing of symptoms and root causes, quick response, safety, reliability and better curative effect. 278 clinical trials show that the total effective rate of the medicament reaches 96.4 percent.

Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of the androgen receptor in bone and/or muscle tissue while antagonizing the AR in the prostate of a male patient or in the uterus of a female patient. These compounds are therefore useful in the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, cancer cachexia, Alzheimer s disease, muscular dystrophies, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

The present invention relates to applications of a bionic silicon-calcium hybrid collagen scaffold material within fiber, specifically to the osteoclastogenesis inhibition application of the bionic silicon-calcium hybrid collagen scaffold material within fiber, and the application of the bionic silicon-calcium hybrid collagen scaffold material within fiber as the bone defect repair material. According to the present invention, calcium ions and silicic acid released by the bionic silicon-calcium hybrid collagen scaffold material within fiber under the body fluid environment can promote osteogenic differentiation of the mesenchymal stem cells and induce the mesenchymal stem cells to secrete a large number of osteoprotegerin so as to provide effects of osteoclast activation inhibiting and bone damage function inhibiting, and in the late stage of implantation, the secretion of the osteoprotegerin returns to the normal level, and the activation of the osteoclasts is beneficial to the normal processing of the bone remodeling process.

Compounds of structural formula I as herein defined are disclosed as useful in a method for modulating the androgen receptor in a tissue selective manner in a patient in need of such modulation, as well as in a method of activating the function of the androgen receptor in a patient, and in particular the method wherein the function of the androgen receptor is blocked in the prostate of a male patient or in the uterus of a female patient and activated in bone and/or muscle tissue. These compounds are useful in the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporesis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, female sexual dysfunction, post-menopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, pancreatic cancer, renal cancer, prostate cancer, arthritis and joint repair, alone or in combination with other active agents.

Aqueous based tile etching solutions are disclosed containing hydrofluoric acid along with additives that can be used to reveal exposure. The exposure revealing additives of the present invention may have irritant properties so that an exposed individual can feel that skin contact has occurred and/or alternatively may dye the skin to reveal a colored or fluorescent stain where contact has taken place. The result is a hydrofluoric acid containing tile etching solution having improved overall safety by revealing when and where exposure has taken place. This becomes very important owing to the fact that skin contact with solutions containing hydrofluoric acid often go unnoticed for some time and may therefore result in substantial chemical injury including bone damage. The hydrofluoric acid employed in the present invention may be formed in situ by the interaction of a strong acid with a water soluble fluoride salt.

The invention relates to a preparation method of a customizable, degradable and encircling nano-porous structure material 3D printing bone connector. The preparation method comprises the following steps of designing a reasonable bone connector conforming to the ulna size according to the image data of the ulna middle end obtained by CT scanning, and proportionally mixing a metal nano-mixed material and a hydroxyapatite-polylactic acid compound to obtain a bone connector matrix material; and reloading polylactic acid/osteogenic inducer fibers on the matrix. According to the printed bone connector, a sectional encircling mode is adopted, bone connectors of different lengths can be flexibly arranged according to the fracture situation, and the printed bone connector is suitable for fractures of different degrees; meanwhile, a good stress buffering and protecting effect is achieved on the bone damage position, and the bone cement also has the advantages of being degradable, promoting the formation of bone cells and improving the drug loading performance.