64 results about "Bone damage" patented technology

The invention belongs to the technical field of biological medicine, and discloses a probiotic agent capable of improving the physiological activity function of vitamin D and maintaining bone health and application of the probiotic agent. The invention provides a probiotic agent composed of bifidobacterium adolescentis and bifidobacterium longum, the probiotic agent can significantly improve the bone mineral density, the bone trabecula thickness, the bone trabecula number, the bone trabecula connectivity and the bone volume fraction of an osteoporosis mouse, and meanwhile, the bone trabecula separation degree of the osteoporosis-removed mouse is significantly reduced; the level of vitamin D metabolites such as 25-hydroxy vitamin D and 1, 25-dihydroxy vitamin D in mouse serum is improved; the content of serum calcium and alkaline phosphatase in serum of mice is reduced, and the level of osteocalcin and type I procollagen amino terminal peptide in the serum is improved. The probiotic agent can relieve bone calcium loss, maintain bone health, repair bone injury, increase osteoblasts and reduce the osteoporosis degree, and can be used for preparing drugs for preventing and / or treating osteoporosis or preparing health care products or food beneficial to improving bone mineral density.

The invention relates to the technical field of medical image processing, in particular to a method and system for identifying odontogenic jaw cyst and tumor based on deep learning, and the method comprises the steps: obtaining original jaw CBCT image data, carrying out the preprocessing, and generating a combined annotation data set containing lesion types, tooth root absorption form annotations and CT value annotations; constructing a multi-branch neural network model, and training the multi-branch neural network model by using the joint labeling data set to obtain an odontogenic jaw lesion recognition model; and obtaining jaw CBCT image data of a target patient, inputting the jaw CBCT image data into the odontogenic jaw lesion recognition model, and outputting lesion type classification results, tooth root absorption forms and bone destruction volumes. The diagnosis capability of minimal lesions can be improved, missed diagnosis is reduced, whole-process auxiliary diagnosis from qualitative diagnosis to quantitative analysis is realized, and the diagnosis speed is increased.

The invention features polypeptides that include an extracellular ActRIIB variant. In some embodiments, a polypeptide of the invention includes an extracellular ActRIIB variant fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving weakness and atrophy of muscles, bone damage, low red blood cell levels (e.g., anemia or blood loss), fibrosis, and / or pulmonary hypertension.

The invention relates to the technical field of medicines, in particular to application of an active ingredient xanthohumol (XAN) derived from a traditional Chinese medicine humulus lupulus in preparation of medicines for reducing uric acid and resisting gout, and the xanthohumol (XAN) can be prepared into various oral preparations, injection preparations and external preparations with the assistance of pharmaceutically acceptable auxiliary materials and has good development and application prospects. The inventor finds that the xanthohumol has relatively strong effects of reducing blood uric acid, resisting inflammation, resisting bone damage and the like, and the mechanism of the effect of reducing the blood uric acid is that the activity of xanthine oxidase is inhibited so as to reduce the generation of uric acid, and the renal function of an organism is improved so as to enhance uric acid excretion; according to the anti-inflammatory effect, the inflammatory reaction is relieved mainly by down-regulating the levels of inflammatory factors such as IL-1beta, IL-6, TNF alpha and PEG2; the mechanism for resisting gout bone damage is realized through the fact that RANKL / OPG / RANK signal pathway participates in bone metabolism regulation.

There are provided polypeptides that include an Activin receptor type IIB (ActRIIB) ectodomain (ECD) variant. In some embodiments, a polypeptide of the disclosure includes an ActRIIB-ECD variant fused to an Fc domain moiety. The disclosure also provides pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions associated with TGFβ superfamily ligand signaling, such as pulmonary hypertension, fibrosis, muscle weakness and atrophy, metabolic disorders and / or cardiometabolic disease, bone damage, and / or low red blood cell levels (such as anemia).

The invention discloses an orthodontic appliance design method and system based on biomechanics and an orthodontic appliance, and relates to the technical field of orthodontics, the method comprises the following steps: obtaining oral cavity information of a target object, and constructing an initial dental digital model according to the oral cavity information; determining a target dental digital model for optimizing an occlusion relationship according to the initial dental digital model, and generating an orthodontic appliance model according to the target dental digital model; respectively calculating the movement track of each tooth according to the initial dental digital model and the target dental digital model; and correcting the orthodontic appliance model according to the movement track so as to form extruding parts and avoiding parts which are alternately arranged in a tooth socket of the orthodontic appliance model. According to the invention, the teeth can be naturally aligned, the risk of tooth root absorption or alveolar bone injury is reduced, and the orthodontic effect on the teeth is ensured.

The invention discloses bifidobacterium longum subsp.longum capable of improving the physiological activity function of vitamin D and maintaining bone health and application of the bifidobacterium longum subsp.longum, and belongs to the technical field of biological medicine. The bifidobacterium longum subsp. Longum CCFM1448 provided by the invention can obviously improve the total bone mineral density, the bone mineral density of distal femur bone trabecula, the thickness of the bone trabecula, the number of the bone trabecula, the connectivity of the bone trabecula and the bone volume fraction of an osteoporosis mouse, and obviously reduce the separation degree of the bone trabecula of the osteoporosis mouse; the content of a vitamin D metabolite 1, 25-dihydroxy vitamin D in serum of a mouse with osteoporosis is remarkably increased, the content of serum calcium and alkaline phosphatase in the serum of the mouse with osteoporosis is reduced, and the level of osteocalcin and I-type procollagen amino-terminal original peptide in the serum is increased. Therefore, the bifidobacterium longum subsp. Longum CCFM1448 has the effects of relieving bone calcium loss, maintaining bone health, repairing bone injury, increasing osteoblasts and reducing osteoporosis degree.

According to the novel osteotomy fixator, a plurality of through holes and positioning holes are formed in a connecting plate and are accurately matched with connecting holes in a supporting plate, so that a multi-point fixing system is formed, and it is ensured that the supporting plate and the connecting plate are stressed in a balanced and stable mode in any direction. In addition, mounting rings are arranged at the two ends of the supporting plate, and a third screw is arranged in each mounting ring to serve as an auxiliary fixing point. By means of the design, the fixing strength is improved, concentrated pressure generated by the device on the sclerotin is further dispersed, stress is more uniform, and therefore the risk of sclerotin injury is effectively reduced. The mechanical stability of the device is greatly improved through combination of the mounting ring and the multiple screws, and displacement or looseness caused by external force or movement of the patient is prevented.

Compositions including metformin and their use for inhibiting or treating soft tissue musculoskeletal injuries, such as tendinopathy, and / or treating or inhibiting scar tissue are disclosed.

To provide a method for producing a myokine producing promotor supported by evidence; and to provide various agents exhibiting excellent effects on skeletal muscles and immunization by promoting production of myokine in a body (skeletal muscles, etc.).SOLUTION: There is provided a method of producing a myokine producing promotor, in which, while a temperature of an object to be separated into solid and liquid in a vessel is maintained at 45°C or lower, a pressure inside the vessel is reduced to separate the object into solid and liquid without using both extraction liquid and extraction steam which are extraction media, and the liquid contained in the object is recovered as an active ingredient, the object being an undried product which is cypress not completely dried in the method of producing a myokine producing promotor. There are provided a myokine producing promotor produced by the method, and an anti-inflammatory agent for skeletal muscles, a skeletal muscle formation promoter, a repair agent for damaged skeletal muscles, an enlargement agent for skeletal muscles, and a post-movement immunosuppressant, which contain the myokine producing promotor.SELECTED DRAWING: Figure 4

There remains a need for effective therapeutic agents for the treatment of TGFβ superfamily-associated disorders. [Solution] Polypeptides comprising an activin receptor type IIB (ActRIIB) ectodomain (ECD) variant are provided. In some embodiments, the polypeptides of the present disclosure comprise an ActRIIB-ECD variant fused to an Fc domain portion. The present disclosure also provides pharmaceutical compositions and methods using the polypeptides to treat diseases and conditions associated with TGF-β superfamily ligand signaling, such as metabolic disorders, diabetes, obesity, cardiometabolic disease, pulmonary hypertension, fibrosis, muscle weakness and atrophy, bone damage, and / or low red blood cell levels (e.g., anemia).

The invention features polypeptides that include an extracellular ActRII chimera. In some embodiments, a polypeptide of the invention includes an extracellular ActRII chimera fused to an Fc domain or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving weakness or atrophy of muscles, bone damage, low red blood cell levels (e.g., anemia or blood loss), low platelet levels (e.g., thrombocytopenia), low neutrophil levels (e.g., neutropenia), fibrosis, metabolic disorders, pulmonary hypertension, and / or diseases and conditions that can be treated with erythropoietin or an erythropoiesis-stimulating agent.

The invention discloses an antibacterial and antioxidant multifunctional composite scaffold material and a preparation method thereof, the scaffold material is a gelatin-polylactic acid composite scaffold containing functional particles, the functional particles are curcumin-coated manganese ferrite particles, and arginine is loaded on a coating layer of the functional particles. According to the invention, the antibacterial effect of Mn < 2 + > released by the functional particles is utilized, and the excellent antioxidant effect of curcumin and arginine is utilized, so that excessive active oxygen generated by a bone tissue injury part is removed, the purpose of regulating and controlling the microenvironment of a bone injury area is achieved, and bone tissue regeneration is promoted.

The invention provides a dental implant which comprises an implant body, and an implant thread matched with an alveolar bone is formed on the outer side wall of the implant body. The implant thread is made of a non-absorbable material and has good mechanical strength and biocompatibility. The surface of the implant thread is covered with the absorbable alloy layer, and the absorbable alloy layer is designed to be in a sharp thread form, so that bone injury in the implanting process is reduced. The absorbable alloy layer can be slowly absorbed by the alveolar bone after being implanted, so that the pressure on the cancellous bone is slowly reduced, the bone tissue healing is promoted, the stability of the dental implant is gradually consolidated and maintained, the reduction of peripheral inflammatory response or foreign body response is facilitated, and the long-term stability of the dental implant after being implanted is finally improved.

The invention features polypeptides that include an extracellular ActRII chimera. In some embodiments, a polypeptide of the invention includes an extracellular ActRII chimera fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving weakness and atrophy of muscles, bone damage, low red blood cell levels (e.g., anemia or blood loss), low platelet levels (e.g., thrombocytopenia), low neutrophil levels (e.g., neutropenia), fibrosis, metabolic disorders, and / or pulmonary hypertension.

There are provided polypeptides that include an Activin receptor type IIB (ActRIIB) ectodomain (ECD) variant. In some embodiments, a polypeptide of the disclosure includes an ActRIIB-ECD variant fused to an Fc domain moiety. The disclosure also provides pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions associated with TGFβ superfamily ligand signaling, such as pulmonary hypertension, fibrosis, muscle weakness and atrophy, metabolic disorders and / or cardiometabolic disease, bone damage, and / or low red blood cell levels (such as anemia).

The invention features polypeptides that include an extracellular ActRIIB variant. In some embodiments, a polypeptide of the invention includes an extracellular ActRIIB variant fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving weakness and atrophy of muscles, bone damage, low red blood cell levels (e.g., anemia or blood loss), fibrosis, and / or pulmonary hypertension. 20 24 20 43 42 25 J un 2 02 4 A B S T R A C T 2 0 2 4 2 0 4 3 4 2 2 5 J u n 2 0 2 4

The invention features polypeptides that include an extracellular ActRII chimera. In some embodiments, a polypeptide of the invention includes an extracellular ActRII chimera fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving weakness and atrophy of muscles, bone damage, low red blood cell levels (e.g., anemia or blood loss), low platelet levels (e.g., thrombocytopenia), low neutrophil levels (e.g., neutropenia), fibrosis, metabolic disorders, and / or pulmonary hypertension.

There are provided polypeptides that include an Activin receptor type IIB (ActRIIB) ectodomain (ECD) variant. In some embodiments, a polypeptide of the disclosure includes an ActRIIB-ECD variant fused to an Fc domain moiety. The disclosure also provides pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions associated with TGFβ superfamily ligand signaling, such as metabolic disorders, diabetes, obesity, cardiometabolic disease, pulmonary hypertension, fibrosis, muscle weakness and atrophy, bone damage, and / or low red blood cell levels (such as anemia).

The invention relates to the technical field of exercise devices, in particular to an exercise device for obese patients, which comprises a treadmill body, a console is arranged at the upper end of the treadmill body, and an anti-gravity exercise mechanism for reducing the weight of the patients and avoiding bone damage is arranged on the treadmill body. An upward stretching mechanism used for exercising arms of a patient is movably installed on the side face of the treadmill body, the anti-gravity exercising mechanism comprises a high-pressure air bag fixedly installed on the treadmill body, and an inflation pump assembly for continuously supplying air to the high-pressure air bag is arranged on the control table. A standing relaxing mechanism for massaging the shanks of the patient to avoid muscle strain is arranged in the high-pressure air bag. By arranging the standing relaxing mechanism and utilizing mutual cooperation between the rotating support and the hammering rubber block, calf muscles of a patient can be automatically massaged and relaxed when the patient has a rest during exercise, the exercise comfort of the patient can be effectively improved, and meanwhile, the muscles of the patient can be prevented from being strained to a certain extent.

Compositions including metformin and their use for inhibiting or treating soft tissue musculoskeletal injuries, such as tendinopathy, and / or treating or inhibiting scar tissue are disclosed.

The invention features methods of treating a disease or condition that can be treated with an ALK2 or ALK3 inhibitor including a bone disease or bone damage, low red blood cell levels (e.g., anemia or blood loss), heterotopic ossification (e.g., heterotopic ossification resulting from fibrodysplasia ossificans progressiva), Sjogren's syndrome (e.g., dry eye associated with Sjogren's syndrome), multiple osteochondroma, diffuse intrinsic pontine glioma, posterior capsule opacification, or cardiac hypertrophy and / or cardiac fibrosis by administering to a subject an isolated ALK2 or ALK3 antibody, or antigen binding fragment thereof, in an amount of 0.002 mg / kg to 3 mg / kg.

The application provides a 3D printing guide plate positioning system and method for posterior cruciate ligament reconstruction, and belongs to the technical field of ligament surgical instruments in sports medicine. The system comprises a positioning guide plate, a guide plate supporting frame and a drilling guide arm. The positioning guide plate is shaped according to a three-dimensional reconstruction model of a tibia, is manufactured through 3D printing, and is connected to the guide plate supporting frame. One side of the positioning guide plate is attached with a flexible sensor to detect the attached stress. The drilling guide arm is fixedly connected to the guide plate supporting frame after the positioning guide plate is placed at a set position to realize the positioning of drilling. The method is realized based on the system. Through the positioning system, the influence of human factors in surgery is reduced, the establishment of the tibial tunnel is more scientific and accurate by combining with the sensing technology, the problems of possible reconstruction and healing failure, bone damage and the like are solved, and the recovery of the movement ability of the patient is accelerated.

To provide polypeptides and pharmaceutical compositions comprising activin type IIB receptor variants.SOLUTION: The polypeptide of the present invention comprises an extracellular activin type IIB receptor (ActRIIB) mutant comprising an amino acid sequence consisting of a specific sequence, wherein the C-terminus of the ActRIIB mutant is fused to a human IgG1Fc domain monomer. The invention also features pharmaceutical compositions and methods of using the same to treat diseases and conditions involving muscle weakness and atrophy, bone damage, low red blood cell levels (e.g., anemia or blood loss), fibrosis, and / or pulmonary hypertension.SELECTED DRAWING: Figure 2

The invention provides a multi-target bone rehabilitation physiotherapy patch based on yin-yang balance compatibility and magnetoelectric infiltration promotion and a preparation method of the multi-target bone rehabilitation physiotherapy patch. The bone rehabilitation physiotherapy patch integrates a traditional Chinese medicine yin-yang balance compatibility theory and a modern magnetoelectric infiltration promotion technology; the obtained rehabilitation physical therapy patch is suitable for prevention, control and rehabilitation treatment of bone diseases such as neck, shoulder and lumbar vertebra pain, arthritis, osteonecrosis and fracture later rehabilitation as well as chronic diseases related to bone injuries.

The present invention relates to the field of Chinese medicine preparations, and discloses a bone rehabilitation promoting pill based on Chinese medicine extracts and a preparation method thereof, wherein the components of the bone rehabilitation promoting pills include: a Chinese medicine extract, wherein the Chinese medicine extract is one or more of Rhizoma Drynariae, Eucommia ulmoides, Rhizoma Chuanxiong, and Radix Angelicae Sinensis, and the content thereof is 40% to 60% of the total weight of the bone rehabilitation promoting pills; a drug carrier, wherein the drug carrier is polylactic acid, polylactic-co-glycolic acid copolymer, or a complex thereof with nano-calcium phosphate, and the content thereof is 20% to 30% of the total weight of the bone rehabilitation promoting pills; and a cosolvent, wherein the cosolvent is cyclodextrin or phospholipids. By combining Chinese medicine extracts such as Rhizoma Drynariae, Eucommia ulmoides, Rhizoma Chuanxiong, and Radix Angelicae Sinensis with drug carriers such as polylactic acid and polylactic-co-glycolic acid copolymer, the effect of continuous release of drugs and targeting bone tissue when treating diseases such as bone injury and osteoporosis is achieved, and the solution solves the problem of excessively fast release of drugs in vivo, and ensures a long-term effective concentration of drugs in bone tissue.

The invention provides a traditional Chinese medicine composition for repairing muscle, tendon and skeleton injuries and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition for repairing muscle, tendon and skeleton injuries is prepared from the following traditional Chinese medicines in parts by weight: 5-10 parts of garden balsam stem, 1-3 parts of raw semen strychni, 3-5 parts of radix aconiti agrestis, 5-10 parts of sambucus chinensis, 5-10 parts of paris polyphylla, 1-3 parts of radix zanthoxyli, 5-10 parts of angelica sinensis, 5-10 parts of safflower, 3-5 parts of notopterygium root, 3-5 parts of willow bark and 5-10 parts of peach kernel. , 3-5 parts of ligusticum wallichii, 5-10 parts of eucommia ulmoides, 5-10 parts of rhizoma cibotii, 3-5 parts of dipsacus root and 5-10 parts of liquorice. The traditional Chinese medicine composition disclosed by the invention can play a role in continuously treating and repairing diseases, assists muscles, tendons and bones to gradually repair and recover, and prevents relapse.

The application discloses an angle-adjustable guiding reset device for tibiofibular syndesmosis, which comprises an adjusting mechanism, a first guiding reset mechanism, a second guiding reset mechanism and a positioning mechanism; the two guiding reset mechanisms are symmetrically arranged on the two sides of tibia and fibula and are connected through the adjusting mechanism; the positioning mechanism comprises a positioning plate and a positioning rod, the positioning plate is attached to the posterolateral surface of the fibula, and the positioning plate is connected with the adjusting mechanism through the positioning rod; the adjusting mechanism adjusts the position and axial direction of the two guiding reset mechanisms clamping the tibia and the fibula with the positioning plate as the reference. The posterolateral surface of the fibula is used as the reference datum of the guiding reset device to accurately correspond the axial direction of the guiding reset mechanism in the three-dimensional space to the reset axis planned in the CT image, so that the reset effect of the tibia and the fibula is closer to the ideal reset state. Especially, the reset mode of the two guiding reset mechanisms clamping the two bones in opposite directions can further enhance the stability in the reset process and reduce the risk of bone damage.

This invention provides a partially detachable orthopedic splint, belonging to the field of medical device technology. It includes a positioning and adjustment structure, and splint fixing structures located at both ends of the positioning and adjustment structure. Auxiliary positioning structures are provided on both sides of the splint fixing structure. By using the splint fixing structure in conjunction with the auxiliary positioning structures, during dressing changes, rotating the telescopic ring causes the two splints to move away from each other through the adjustment frame and support arm. This exposes the wound surface at the splint-covered area of ​​the fracture. Simultaneously, as the two adjustment frames move continuously, the two longitudinal sleeves move closer together, causing the positioning ring frames on both sides to move closer together, fixing the upper and lower sides of the limb fracture site. This ensures that while the wound surface is being cleaned and dressing changed, the ends of the fractured limb still have fixing structures supporting the original fixation position, greatly reducing the problem of secondary bone damage during debridement.