25 results about "Bone damage" patented technology

The invention discloses an orthodontic appliance design method and system based on biomechanics and an orthodontic appliance, and relates to the technical field of orthodontics, the method comprises the following steps: obtaining oral cavity information of a target object, and constructing an initial dental digital model according to the oral cavity information; determining a target dental digital model for optimizing an occlusion relationship according to the initial dental digital model, and generating an orthodontic appliance model according to the target dental digital model; respectively calculating the movement track of each tooth according to the initial dental digital model and the target dental digital model; and correcting the orthodontic appliance model according to the movement track so as to form extruding parts and avoiding parts which are alternately arranged in a tooth socket of the orthodontic appliance model. According to the invention, the teeth can be naturally aligned, the risk of tooth root absorption or alveolar bone injury is reduced, and the orthodontic effect on the teeth is ensured.

There remains a need for effective therapeutic agents for the treatment of TGFβ superfamily-associated disorders. [Solution] Polypeptides comprising an activin receptor type IIB (ActRIIB) ectodomain (ECD) variant are provided. In some embodiments, the polypeptides of the present disclosure comprise an ActRIIB-ECD variant fused to an Fc domain portion. The present disclosure also provides pharmaceutical compositions and methods using the polypeptides to treat diseases and conditions associated with TGF-β superfamily ligand signaling, such as metabolic disorders, diabetes, obesity, cardiometabolic disease, pulmonary hypertension, fibrosis, muscle weakness and atrophy, bone damage, and / or low red blood cell levels (e.g., anemia).

The invention provides a dental implant which comprises an implant body, and an implant thread matched with an alveolar bone is formed on the outer side wall of the implant body. The implant thread is made of a non-absorbable material and has good mechanical strength and biocompatibility. The surface of the implant thread is covered with the absorbable alloy layer, and the absorbable alloy layer is designed to be in a sharp thread form, so that bone injury in the implanting process is reduced. The absorbable alloy layer can be slowly absorbed by the alveolar bone after being implanted, so that the pressure on the cancellous bone is slowly reduced, the bone tissue healing is promoted, the stability of the dental implant is gradually consolidated and maintained, the reduction of peripheral inflammatory response or foreign body response is facilitated, and the long-term stability of the dental implant after being implanted is finally improved.

The invention features polypeptides that include an extracellular ActRII chimera. In some embodiments, a polypeptide of the invention includes an extracellular ActRII chimera fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving weakness and atrophy of muscles, bone damage, low red blood cell levels (e.g., anemia or blood loss), low platelet levels (e.g., thrombocytopenia), low neutrophil levels (e.g., neutropenia), fibrosis, metabolic disorders, and / or pulmonary hypertension.

The invention features polypeptides that include an extracellular ActRIIB variant. In some embodiments, a polypeptide of the invention includes an extracellular ActRIIB variant fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving weakness and atrophy of muscles, bone damage, low red blood cell levels (e.g., anemia or blood loss), fibrosis, and / or pulmonary hypertension. 20 24 20 43 42 25 J un 2 02 4 A B S T R A C T 2 0 2 4 2 0 4 3 4 2 2 5 J u n 2 0 2 4

The invention features polypeptides that include an extracellular ActRII chimera. In some embodiments, a polypeptide of the invention includes an extracellular ActRII chimera fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving weakness and atrophy of muscles, bone damage, low red blood cell levels (e.g., anemia or blood loss), low platelet levels (e.g., thrombocytopenia), low neutrophil levels (e.g., neutropenia), fibrosis, metabolic disorders, and / or pulmonary hypertension.

There are provided polypeptides that include an Activin receptor type IIB (ActRIIB) ectodomain (ECD) variant. In some embodiments, a polypeptide of the disclosure includes an ActRIIB-ECD variant fused to an Fc domain moiety. The disclosure also provides pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions associated with TGFβ superfamily ligand signaling, such as metabolic disorders, diabetes, obesity, cardiometabolic disease, pulmonary hypertension, fibrosis, muscle weakness and atrophy, bone damage, and / or low red blood cell levels (such as anemia).

The invention relates to the technical field of exercise devices, in particular to an exercise device for obese patients, which comprises a treadmill body, a console is arranged at the upper end of the treadmill body, and an anti-gravity exercise mechanism for reducing the weight of the patients and avoiding bone damage is arranged on the treadmill body. An upward stretching mechanism used for exercising arms of a patient is movably installed on the side face of the treadmill body, the anti-gravity exercising mechanism comprises a high-pressure air bag fixedly installed on the treadmill body, and an inflation pump assembly for continuously supplying air to the high-pressure air bag is arranged on the control table. A standing relaxing mechanism for massaging the shanks of the patient to avoid muscle strain is arranged in the high-pressure air bag. By arranging the standing relaxing mechanism and utilizing mutual cooperation between the rotating support and the hammering rubber block, calf muscles of a patient can be automatically massaged and relaxed when the patient has a rest during exercise, the exercise comfort of the patient can be effectively improved, and meanwhile, the muscles of the patient can be prevented from being strained to a certain extent.

To provide polypeptides and pharmaceutical compositions comprising activin type IIB receptor variants.SOLUTION: The polypeptide of the present invention comprises an extracellular activin type IIB receptor (ActRIIB) mutant comprising an amino acid sequence consisting of a specific sequence, wherein the C-terminus of the ActRIIB mutant is fused to a human IgG1Fc domain monomer. The invention also features pharmaceutical compositions and methods of using the same to treat diseases and conditions involving muscle weakness and atrophy, bone damage, low red blood cell levels (e.g., anemia or blood loss), fibrosis, and / or pulmonary hypertension.SELECTED DRAWING: Figure 2

The invention provides a multi-target bone rehabilitation physiotherapy patch based on yin-yang balance compatibility and magnetoelectric infiltration promotion and a preparation method of the multi-target bone rehabilitation physiotherapy patch. The bone rehabilitation physiotherapy patch integrates a traditional Chinese medicine yin-yang balance compatibility theory and a modern magnetoelectric infiltration promotion technology; the obtained rehabilitation physical therapy patch is suitable for prevention, control and rehabilitation treatment of bone diseases such as neck, shoulder and lumbar vertebra pain, arthritis, osteonecrosis and fracture later rehabilitation as well as chronic diseases related to bone injuries.

The application discloses an angle-adjustable guiding reset device for tibiofibular syndesmosis, which comprises an adjusting mechanism, a first guiding reset mechanism, a second guiding reset mechanism and a positioning mechanism; the two guiding reset mechanisms are symmetrically arranged on the two sides of tibia and fibula and are connected through the adjusting mechanism; the positioning mechanism comprises a positioning plate and a positioning rod, the positioning plate is attached to the posterolateral surface of the fibula, and the positioning plate is connected with the adjusting mechanism through the positioning rod; the adjusting mechanism adjusts the position and axial direction of the two guiding reset mechanisms clamping the tibia and the fibula with the positioning plate as the reference. The posterolateral surface of the fibula is used as the reference datum of the guiding reset device to accurately correspond the axial direction of the guiding reset mechanism in the three-dimensional space to the reset axis planned in the CT image, so that the reset effect of the tibia and the fibula is closer to the ideal reset state. Especially, the reset mode of the two guiding reset mechanisms clamping the two bones in opposite directions can further enhance the stability in the reset process and reduce the risk of bone damage.

This invention provides a partially detachable orthopedic splint, belonging to the field of medical device technology. It includes a positioning and adjustment structure, and splint fixing structures located at both ends of the positioning and adjustment structure. Auxiliary positioning structures are provided on both sides of the splint fixing structure. By using the splint fixing structure in conjunction with the auxiliary positioning structures, during dressing changes, rotating the telescopic ring causes the two splints to move away from each other through the adjustment frame and support arm. This exposes the wound surface at the splint-covered area of ​​the fracture. Simultaneously, as the two adjustment frames move continuously, the two longitudinal sleeves move closer together, causing the positioning ring frames on both sides to move closer together, fixing the upper and lower sides of the limb fracture site. This ensures that while the wound surface is being cleaned and dressing changed, the ends of the fractured limb still have fixing structures supporting the original fixation position, greatly reducing the problem of secondary bone damage during debridement.

The invention relates to the field of application of tea leaves, in particular to application of catechin in preparation of a reagent for repairing bone injury caused by obesity. In order to solve the problem that in existing research, the action mechanism of main catechin monomers for repairing the bone injury caused by obesity is not clear, four catechin monomers EC, ECG, EGC and EGCG are screened and applied to repairing the bone injury caused by obesity, and it is found through determination of related indexes of mouse skeletal muscles that the function mechanism of the main catechin monomers for repairing the bone injury caused by obesity is not clear. ECG has the strongest ability of repairing skeletal muscle injury caused by obesity, and the ECG regulates skeletal muscle injury by means of inflammation expression of obesity, skeletal muscle lesion, muscle homeostasis and the like; by adjusting fatty acid, blood fat is reduced, and adipogenesis is inhibited; glutamic acid is adjusted, muscle strength, endurance and quality are increased, and a protection effect on bone damage is achieved. The method is an important supplement in the field of scientific research of tea leaves, and provides a scientific basis for application of functional components of the tea leaves.

The invention relates to the technical field of medical instruments, and discloses a torsion type anatomical locking steel plate for sternoclavicular joint dislocation and a using method thereof.The torsion type anatomical locking steel plate comprises a plate body section, a transition section and a hook body section, the plate body section is an arc-shaped plate suitable for being attached to the anatomical contour of the front side of the near end of the clavicle, and a plurality of locking holes are formed in the plate body section to serve as fixing holes; the far end of the hook body section is provided with a flat hook body used for being hooked behind a sternum handle. The transition section is connected between the plate body section and the hook body section and is of a space torsion structure which smoothly extends from the plate body section to the hook body section. The plate body section is in arc fit with the contour of the near end of the clavicle, the fixing holes are distributed in a staggered mode and are spherical countersunk head taper threaded holes, the composite holes integrate the locking and pressurizing functions, the hook body section is provided with anti-slip barbs, the transition section is in spatial torsion connection, all the parts cooperate to improve the dissection suitability and stability, stress is dispersed, screw loosening and bone damage are reduced, and the fracture resistance is improved. Reliable support is provided for dislocation reduction of the sternoclavicular joint, and fracture around the sternoclavicular joint and healing of the sternoclavicular joint are guaranteed.

The application provides a ROS response 3D printing shape memory material loaded with camel milk derived exosomes and a preparation method and application thereof, and belongs to the technical field of bone repair materials. The application utilizes 3D printing technology to prepare a porous channel bone scaffold material ISO-PUs-SMP from isosorbide long-chain hard segment polyurethane ISO-PUs, uniformly blends drug-loaded nanofiber microcrystalline beta-C-C-CM-Exo containing camel milk derived exosomes and a gelatin solution, and fills the channel of the ISO-PUs-SMP, so as to prepare the ROS response 3D printing shape memory material through freeze drying. The ROS response 3D printing shape memory material provided by the application has the effects of promoting blood vessels, resisting oxidation and resisting inflammation, can promote angiogenesis at a large bone damage site, reduce the oxidative stress reaction caused by hypoxia, reduce the inflammatory reaction and hypoxic damage, and finally promote the repair and reconstruction of bone tissue at the large bone defect site.

There are provided polypeptides that include an Activin receptor type IIB (ActRIIB) ectodomain (ECD) variant. In some embodiments, a polypeptide of the disclosure includes an ActRIIB-ECD variant fused to an Fc domain moiety. The disclosure also provides pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions associated with TGFβ superfamily ligand signaling, such as metabolic disorders, diabetes, obesity, cardiometabolic disease, pulmonary hypertension, fibrosis, muscle weakness and atrophy, bone damage, and / or low red blood cell levels (such as anemia).

The application provides a 2.5D medical image osteoporosis prediction method and system based on double fusion of a Transformer and stacking, and belongs to the field of artificial intelligence and medical image analysis. First, deep features are extracted in parallel from a 2.5D pelvic CT slice group by using a plurality of pre-training convolutional neural networks; then multi-head self-attention pre-fusion is performed by using a Transformer encoder to generate a unified image feature vector; then the unified image feature vector is spliced with key clinical features such as age and radiotherapy dose to form a multi-modal feature, and the multi-modal feature is input into a plurality of base classifiers to obtain preliminary prediction probabilities; finally, a stacking strategy is used for post-fusion to obtain a final osteoporosis risk probability. Experiments show that the method has excellent prediction performance, the external validation AUC reaches 0.964, and individualized bone damage risk assessment before radiotherapy can be realized.

An implanted bone bandage comprises a bandlet part and a transition guide part, the bandlet part is connected with the transition guide part so that the bandlet part and the transition guide part can form a surrounding state, the bandlet part comprises a plurality of warp yarns and a plurality of weft yarns, and the warp yarns and the weft yarns are arranged in a staggered mode. The warp yarns and the weft yarns are connected in a staggered manner so as to form the flat belt part with a preset size. Compared with a traditional metal cable, the bone implanting bandage has the advantages that fracture fixation is more fit, bone damage is small, tissue growth is faster and safer, the bone implanting bandage is friendly to metal allergy persons, secondary taking-out is not needed, the fracture risk is avoided, the pressure borne by the fracture is more uniform through the flat bandage part, patient recovery is faster, the elastic coefficient is large, and the stability after binding is good.

This invention belongs to the field of traditional Chinese medicine. It relates to a Tonglaga-5 poultice, its preparation process, and its application in treating rheumatoid arthritis. Tonglaga-5 powder is extracted with ethanol to prepare a concentrated Tonglaga-5 solution. The concentrated solution is then freeze-dried to obtain a lyophilized Tonglaga-5 powder, which is further used to prepare a Tonglaga-5 gel ointment and a Tonglaga-5 poultice. Specifically, the optimal extraction process for the Tonglaga-5 concentrate is 77% ethanol (volume fraction), a material-to-liquid ratio of 1:20, and an extraction time of 1 hour. The optimal formulation for the Tonglaga-5 gel is a ratio of carbomer-941: Tonglaga-5 lyophilized powder: sodium polyacrylate: glycerin: aluminum hydroxyl group of 1:2:4:20:5. Pharmacological experiments show that the prepared Tonglaga-5 gel ointment has a uniform and fine appearance, and the Tonglaga-5 poultice prepared using this as a matrix can effectively inhibit the inflammatory response in CIA rats and delay the progression of bone damage.

The application discloses a medical image key point detection method, device, equipment and medium, and is based on the skeleton anatomy prior information and the deep neural network for the detection of the hip joint key point in the medical CT image. The method considers the common bone structure missing or damage situation in the clinical image data, introduces the anatomy prior information to realize the key point detection for the bone damage part. And the commonly used detection deep neural network structure is improved, the balance between the detection precision and the detection efficiency is realized. In addition, the loss function of the detection network is improved, the skeleton region mask is used to correct the predicted key point position, so that the position result of the key point prediction is more consistent with the normal cognition.

The application discloses a kind of photodynamic bone stable balloon and system, belong to medical instrument technical field, including outer balloon and inner balloon;Between outer balloon and inner balloon, there is injection liquid outer cavity;Injection liquid outer cavity is used to inject the photosensitive liquid containing initiator;Inner balloon has operating inner cavity, and operating inner cavity is used to make optical fiber enter;Optical fiber is used to transmit light energy, to activate initiator to initiate photosensitive liquid polymerization;Outer balloon has non-compliant balloon section and compliant balloon section in axial direction, at least one non-compliant balloon section is used to correspond the fracture crack in medullary cavity, and compliant balloon section is used to adaptive expansion at the variable diameter area in medullary cavity, solve the contradiction of " over-compliance leads to uncontrolled expansion, bone injury " and " insufficient compliance leads to poor fit, axial sliding ".

The invention discloses a targeted MACF1 protein phase separation polypeptide and application thereof, and relates to the technical field of biological medicines. The polypeptide can be specifically combined with stress particle core protein G3BP1, formation of stress particles is promoted under the mechanical stress condition, and mechanical sensitive proteins PIEZO1, PXN and beta-Catenin are selectively recruited to enter the stress particles, so that the steady state of the stress particles is maintained, the mechanical signal transduction capacity of osteoblasts is enhanced, and osteogenic differentiation is promoted. In a mouse osteoporosis model, bone mineral density and bone mechanical properties can be remarkably improved by adopting bone targeted delivery of the polypeptide, and osteoporosis-related bone injuries can be effectively improved. The polypeptide contains 200 amino acids, is high in safety, and provides a brand new strategy for osteoporosis treatment based on a cell phase separation mechanism.

The invention discloses a first-aid shaping and fixing device for limb bone injury, and relates to the technical field of bone injury fixing.The first-aid shaping and fixing device comprises a shaping plate which can be rolled and bent in multiple directions and is provided with a plurality of through holes; the flexible cushion layer is wrapped on the shaping plate; a limiting hole is formed in the flexible cushion layer corresponding to the through hole; the clamping piece is rotationally arranged in the through hole and the limiting hole; the tightening belt is connected to the clamping piece and rotates along with the clamping piece; and the protective sleeve is arranged on the flexible cushion layer in a sliding manner. A shaping plate capable of being rolled and bent in multiple directions is wrapped with a double-layer flexible cushion layer, the shaping plate is shaped according to the shape of the limb with the bone loss, the limb with the bone loss is shaped, positioned and fixed, the shaping plate and the flexible cushion layer are tightened on the limb through a tightening belt capable of rotating at multiple angles, and therefore the limb with the bone loss can be shaped, positioned and fixed. The device is portable and is integrally operated, so that daily first aid of limb skeleton injury is facilitated; and by arranging the protective sleeve, the limbs can be prevented from being scratched by sharp parts generated in the cutting process of the shaping plate.

This invention relates to the field of oral medical technology, specifically to a conical bone compressor for dental implants. It includes a gripping part, a connecting seat fixedly connected to the top of the gripping part, a rod fixedly connected to the top of the connecting seat, a connecting transition rod fixedly connected to the end of the rod, and a bone compressing rod fixedly connected to the top of the connecting transition rod. The bone compressing rod is conical in shape. A connecting rod is fixedly connected to the bottom of the gripping part, and a spherical part is fixedly connected to the bottom of the connecting rod. Grip rods are fixedly connected to both sides of the gripping part. An anti-slip layer is fixedly connected to the outer ring of the gripping part, and the rod is bent. By using a conical bone compressing rod, the tip is precisely positioned, the compressing force is evenly distributed, and the channel is formed smoothly and regularly, significantly reducing the risk of bone damage. The conical structure allows for progressive compressing from fine to coarse using a single instrument, reducing instrument changes, simplifying the operation process, and shortening the surgical time.