40 results about "Bone damage" patented technology

The invention belongs to the technical field of biological medicine, and discloses a probiotic agent capable of improving the physiological activity function of vitamin D and maintaining bone health and application of the probiotic agent. The invention provides a probiotic agent composed of bifidobacterium adolescentis and bifidobacterium longum, the probiotic agent can significantly improve the bone mineral density, the bone trabecula thickness, the bone trabecula number, the bone trabecula connectivity and the bone volume fraction of an osteoporosis mouse, and meanwhile, the bone trabecula separation degree of the osteoporosis-removed mouse is significantly reduced; the level of vitamin D metabolites such as 25-hydroxy vitamin D and 1, 25-dihydroxy vitamin D in mouse serum is improved; the content of serum calcium and alkaline phosphatase in serum of mice is reduced, and the level of osteocalcin and type I procollagen amino terminal peptide in the serum is improved. The probiotic agent can relieve bone calcium loss, maintain bone health, repair bone injury, increase osteoblasts and reduce the osteoporosis degree, and can be used for preparing drugs for preventing and / or treating osteoporosis or preparing health care products or food beneficial to improving bone mineral density.

The invention discloses an orthodontic appliance design method and system based on biomechanics and an orthodontic appliance, and relates to the technical field of orthodontics, the method comprises the following steps: obtaining oral cavity information of a target object, and constructing an initial dental digital model according to the oral cavity information; determining a target dental digital model for optimizing an occlusion relationship according to the initial dental digital model, and generating an orthodontic appliance model according to the target dental digital model; respectively calculating the movement track of each tooth according to the initial dental digital model and the target dental digital model; and correcting the orthodontic appliance model according to the movement track so as to form extruding parts and avoiding parts which are alternately arranged in a tooth socket of the orthodontic appliance model. According to the invention, the teeth can be naturally aligned, the risk of tooth root absorption or alveolar bone injury is reduced, and the orthodontic effect on the teeth is ensured.

According to the novel osteotomy fixator, a plurality of through holes and positioning holes are formed in a connecting plate and are accurately matched with connecting holes in a supporting plate, so that a multi-point fixing system is formed, and it is ensured that the supporting plate and the connecting plate are stressed in a balanced and stable mode in any direction. In addition, mounting rings are arranged at the two ends of the supporting plate, and a third screw is arranged in each mounting ring to serve as an auxiliary fixing point. By means of the design, the fixing strength is improved, concentrated pressure generated by the device on the sclerotin is further dispersed, stress is more uniform, and therefore the risk of sclerotin injury is effectively reduced. The mechanical stability of the device is greatly improved through combination of the mounting ring and the multiple screws, and displacement or looseness caused by external force or movement of the patient is prevented.

There remains a need for effective therapeutic agents for the treatment of TGFβ superfamily-associated disorders. [Solution] Polypeptides comprising an activin receptor type IIB (ActRIIB) ectodomain (ECD) variant are provided. In some embodiments, the polypeptides of the present disclosure comprise an ActRIIB-ECD variant fused to an Fc domain portion. The present disclosure also provides pharmaceutical compositions and methods using the polypeptides to treat diseases and conditions associated with TGF-β superfamily ligand signaling, such as metabolic disorders, diabetes, obesity, cardiometabolic disease, pulmonary hypertension, fibrosis, muscle weakness and atrophy, bone damage, and / or low red blood cell levels (e.g., anemia).

The invention discloses an antibacterial and antioxidant multifunctional composite scaffold material and a preparation method thereof, the scaffold material is a gelatin-polylactic acid composite scaffold containing functional particles, the functional particles are curcumin-coated manganese ferrite particles, and arginine is loaded on a coating layer of the functional particles. According to the invention, the antibacterial effect of Mn < 2 + > released by the functional particles is utilized, and the excellent antioxidant effect of curcumin and arginine is utilized, so that excessive active oxygen generated by a bone tissue injury part is removed, the purpose of regulating and controlling the microenvironment of a bone injury area is achieved, and bone tissue regeneration is promoted.

The invention provides a dental implant which comprises an implant body, and an implant thread matched with an alveolar bone is formed on the outer side wall of the implant body. The implant thread is made of a non-absorbable material and has good mechanical strength and biocompatibility. The surface of the implant thread is covered with the absorbable alloy layer, and the absorbable alloy layer is designed to be in a sharp thread form, so that bone injury in the implanting process is reduced. The absorbable alloy layer can be slowly absorbed by the alveolar bone after being implanted, so that the pressure on the cancellous bone is slowly reduced, the bone tissue healing is promoted, the stability of the dental implant is gradually consolidated and maintained, the reduction of peripheral inflammatory response or foreign body response is facilitated, and the long-term stability of the dental implant after being implanted is finally improved.

The invention features polypeptides that include an extracellular ActRII chimera. In some embodiments, a polypeptide of the invention includes an extracellular ActRII chimera fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving weakness and atrophy of muscles, bone damage, low red blood cell levels (e.g., anemia or blood loss), low platelet levels (e.g., thrombocytopenia), low neutrophil levels (e.g., neutropenia), fibrosis, metabolic disorders, and / or pulmonary hypertension.

There are provided polypeptides that include an Activin receptor type IIB (ActRIIB) ectodomain (ECD) variant. In some embodiments, a polypeptide of the disclosure includes an ActRIIB-ECD variant fused to an Fc domain moiety. The disclosure also provides pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions associated with TGFβ superfamily ligand signaling, such as pulmonary hypertension, fibrosis, muscle weakness and atrophy, metabolic disorders and / or cardiometabolic disease, bone damage, and / or low red blood cell levels (such as anemia).

The invention features polypeptides that include an extracellular ActRIIB variant. In some embodiments, a polypeptide of the invention includes an extracellular ActRIIB variant fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving weakness and atrophy of muscles, bone damage, low red blood cell levels (e.g., anemia or blood loss), fibrosis, and / or pulmonary hypertension. 20 24 20 43 42 25 J un 2 02 4 A B S T R A C T 2 0 2 4 2 0 4 3 4 2 2 5 J u n 2 0 2 4

The invention features polypeptides that include an extracellular ActRII chimera. In some embodiments, a polypeptide of the invention includes an extracellular ActRII chimera fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving weakness and atrophy of muscles, bone damage, low red blood cell levels (e.g., anemia or blood loss), low platelet levels (e.g., thrombocytopenia), low neutrophil levels (e.g., neutropenia), fibrosis, metabolic disorders, and / or pulmonary hypertension.

There are provided polypeptides that include an Activin receptor type IIB (ActRIIB) ectodomain (ECD) variant. In some embodiments, a polypeptide of the disclosure includes an ActRIIB-ECD variant fused to an Fc domain moiety. The disclosure also provides pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions associated with TGFβ superfamily ligand signaling, such as metabolic disorders, diabetes, obesity, cardiometabolic disease, pulmonary hypertension, fibrosis, muscle weakness and atrophy, bone damage, and / or low red blood cell levels (such as anemia).

The invention relates to the technical field of exercise devices, in particular to an exercise device for obese patients, which comprises a treadmill body, a console is arranged at the upper end of the treadmill body, and an anti-gravity exercise mechanism for reducing the weight of the patients and avoiding bone damage is arranged on the treadmill body. An upward stretching mechanism used for exercising arms of a patient is movably installed on the side face of the treadmill body, the anti-gravity exercising mechanism comprises a high-pressure air bag fixedly installed on the treadmill body, and an inflation pump assembly for continuously supplying air to the high-pressure air bag is arranged on the control table. A standing relaxing mechanism for massaging the shanks of the patient to avoid muscle strain is arranged in the high-pressure air bag. By arranging the standing relaxing mechanism and utilizing mutual cooperation between the rotating support and the hammering rubber block, calf muscles of a patient can be automatically massaged and relaxed when the patient has a rest during exercise, the exercise comfort of the patient can be effectively improved, and meanwhile, the muscles of the patient can be prevented from being strained to a certain extent.

The application provides a 3D printing guide plate positioning system and method for posterior cruciate ligament reconstruction, and belongs to the technical field of ligament surgical instruments in sports medicine. The system comprises a positioning guide plate, a guide plate supporting frame and a drilling guide arm. The positioning guide plate is shaped according to a three-dimensional reconstruction model of a tibia, is manufactured through 3D printing, and is connected to the guide plate supporting frame. One side of the positioning guide plate is attached with a flexible sensor to detect the attached stress. The drilling guide arm is fixedly connected to the guide plate supporting frame after the positioning guide plate is placed at a set position to realize the positioning of drilling. The method is realized based on the system. Through the positioning system, the influence of human factors in surgery is reduced, the establishment of the tibial tunnel is more scientific and accurate by combining with the sensing technology, the problems of possible reconstruction and healing failure, bone damage and the like are solved, and the recovery of the movement ability of the patient is accelerated.

To provide polypeptides and pharmaceutical compositions comprising activin type IIB receptor variants.SOLUTION: The polypeptide of the present invention comprises an extracellular activin type IIB receptor (ActRIIB) mutant comprising an amino acid sequence consisting of a specific sequence, wherein the C-terminus of the ActRIIB mutant is fused to a human IgG1Fc domain monomer. The invention also features pharmaceutical compositions and methods of using the same to treat diseases and conditions involving muscle weakness and atrophy, bone damage, low red blood cell levels (e.g., anemia or blood loss), fibrosis, and / or pulmonary hypertension.SELECTED DRAWING: Figure 2

The invention provides a multi-target bone rehabilitation physiotherapy patch based on yin-yang balance compatibility and magnetoelectric infiltration promotion and a preparation method of the multi-target bone rehabilitation physiotherapy patch. The bone rehabilitation physiotherapy patch integrates a traditional Chinese medicine yin-yang balance compatibility theory and a modern magnetoelectric infiltration promotion technology; the obtained rehabilitation physical therapy patch is suitable for prevention, control and rehabilitation treatment of bone diseases such as neck, shoulder and lumbar vertebra pain, arthritis, osteonecrosis and fracture later rehabilitation as well as chronic diseases related to bone injuries.

The application discloses an angle-adjustable guiding reset device for tibiofibular syndesmosis, which comprises an adjusting mechanism, a first guiding reset mechanism, a second guiding reset mechanism and a positioning mechanism; the two guiding reset mechanisms are symmetrically arranged on the two sides of tibia and fibula and are connected through the adjusting mechanism; the positioning mechanism comprises a positioning plate and a positioning rod, the positioning plate is attached to the posterolateral surface of the fibula, and the positioning plate is connected with the adjusting mechanism through the positioning rod; the adjusting mechanism adjusts the position and axial direction of the two guiding reset mechanisms clamping the tibia and the fibula with the positioning plate as the reference. The posterolateral surface of the fibula is used as the reference datum of the guiding reset device to accurately correspond the axial direction of the guiding reset mechanism in the three-dimensional space to the reset axis planned in the CT image, so that the reset effect of the tibia and the fibula is closer to the ideal reset state. Especially, the reset mode of the two guiding reset mechanisms clamping the two bones in opposite directions can further enhance the stability in the reset process and reduce the risk of bone damage.

This invention provides a partially detachable orthopedic splint, belonging to the field of medical device technology. It includes a positioning and adjustment structure, and splint fixing structures located at both ends of the positioning and adjustment structure. Auxiliary positioning structures are provided on both sides of the splint fixing structure. By using the splint fixing structure in conjunction with the auxiliary positioning structures, during dressing changes, rotating the telescopic ring causes the two splints to move away from each other through the adjustment frame and support arm. This exposes the wound surface at the splint-covered area of ​​the fracture. Simultaneously, as the two adjustment frames move continuously, the two longitudinal sleeves move closer together, causing the positioning ring frames on both sides to move closer together, fixing the upper and lower sides of the limb fracture site. This ensures that while the wound surface is being cleaned and dressing changed, the ends of the fractured limb still have fixing structures supporting the original fixation position, greatly reducing the problem of secondary bone damage during debridement.

The invention relates to the field of application of tea leaves, in particular to application of catechin in preparation of a reagent for repairing bone injury caused by obesity. In order to solve the problem that in existing research, the action mechanism of main catechin monomers for repairing the bone injury caused by obesity is not clear, four catechin monomers EC, ECG, EGC and EGCG are screened and applied to repairing the bone injury caused by obesity, and it is found through determination of related indexes of mouse skeletal muscles that the function mechanism of the main catechin monomers for repairing the bone injury caused by obesity is not clear. ECG has the strongest ability of repairing skeletal muscle injury caused by obesity, and the ECG regulates skeletal muscle injury by means of inflammation expression of obesity, skeletal muscle lesion, muscle homeostasis and the like; by adjusting fatty acid, blood fat is reduced, and adipogenesis is inhibited; glutamic acid is adjusted, muscle strength, endurance and quality are increased, and a protection effect on bone damage is achieved. The method is an important supplement in the field of scientific research of tea leaves, and provides a scientific basis for application of functional components of the tea leaves.

The present invention discloses a small nucleic acid targeting the RANKL gene and its use in the treatment of orthopedic diseases. The present invention designs a small nucleic acid drug targeting the RANKL gene and further optimizes the sequence and chemical modification to provide an effective treatment strategy for diseases with high RANKL expression. The small nucleic acid drug targeting the RANKL gene provided by the present invention has great application value in the treatment of orthopedic diseases, especially for the treatment of osteoarthritis, rheumatoid arthritis, psoriatic arthritis, bone damage, osteoporosis, bone destruction, and synovitis, which are closely related to the RANKL gene in orthopedic diseases.

The invention relates to the technical field of medical instruments, and discloses a torsion type anatomical locking steel plate for sternoclavicular joint dislocation and a using method thereof.The torsion type anatomical locking steel plate comprises a plate body section, a transition section and a hook body section, the plate body section is an arc-shaped plate suitable for being attached to the anatomical contour of the front side of the near end of the clavicle, and a plurality of locking holes are formed in the plate body section to serve as fixing holes; the far end of the hook body section is provided with a flat hook body used for being hooked behind a sternum handle. The transition section is connected between the plate body section and the hook body section and is of a space torsion structure which smoothly extends from the plate body section to the hook body section. The plate body section is in arc fit with the contour of the near end of the clavicle, the fixing holes are distributed in a staggered mode and are spherical countersunk head taper threaded holes, the composite holes integrate the locking and pressurizing functions, the hook body section is provided with anti-slip barbs, the transition section is in spatial torsion connection, all the parts cooperate to improve the dissection suitability and stability, stress is dispersed, screw loosening and bone damage are reduced, and the fracture resistance is improved. Reliable support is provided for dislocation reduction of the sternoclavicular joint, and fracture around the sternoclavicular joint and healing of the sternoclavicular joint are guaranteed.

The invention provides a self-tapping anti-pulling anchor used in a loose bone bed, and relates to the technical field of medical apparatus and instruments, the self-tapping anti-pulling anchor comprises an anchor which is set to be of a self-tapping structure and is suitable for being placed in the bone bed; the multiple anti-pulling assemblies are all arranged at the near end of the anchor nail; the nail feeding rod is of a hollow structure, and the nail feeding rod is arranged on the outer sides of the multiple anti-pulling assemblies in a sleeving mode; the invention provides a self-tapping anti-pulling anchor for a loose bone bed. The self-tapping anti-pulling anchor is provided with a self-tapping anchor body, a plurality of anti-pulling assemblies and a nail feeding rod. The anchor is automatically drilled and fixed by virtue of a self-tapping structure, so that bone loss caused by pre-operation is avoided; the rivet feeding rod is arranged on the outer side of the anti-pulling assembly in a sleeving mode, and the anti-pulling assembly can be prevented from colliding with sclerotin when the rivet is placed into a bone bed. The anti-pulling assembly expands outwards by virtue of self elasticity and pierces into a bone bed; when the anchor is subjected to pulling-out force, the pulling-resistant assembly can go deep into a bone bed and resist pulling by means of elastic force so as to adapt to a loose bone bed scene, bone damage in the anchor placement process is reduced, and the pulling-resistant performance of the anchor is improved.

The application provides a preparation method of an anti-infection bone repair promoting preparation for sequentially regulating a macrophage immune microenvironment, which comprises the following steps: uniformly mixing 1-10% flavone modified hydroxyapatite, 2-10% sodium alginate hydrogel, 0.1-1% hydrogen sulfide sustained release carrier and 79-96.9% tricalcium phosphate in proportion by weight percentage, adding a calcium chloride aqueous solution, uniformly stirring, and freeze-drying. The flavone tricalcium phosphate, the calcium phosphate cement of the light crosslinking alginate hydrogel containing the hydrogen sulfide sustained release carrier, exhibits the function of regulating the macrophage immune microenvironment, and the preparation itself can better realize the function of sequentially inducing the macrophages in a bone damage microenvironment to be induced to M1 type polarization and then to M2 type polarization.

The application provides a ROS response 3D printing shape memory material loaded with camel milk derived exosomes and a preparation method and application thereof, and belongs to the technical field of bone repair materials. The application utilizes 3D printing technology to prepare a porous channel bone scaffold material ISO-PUs-SMP from isosorbide long-chain hard segment polyurethane ISO-PUs, uniformly blends drug-loaded nanofiber microcrystalline beta-C-C-CM-Exo containing camel milk derived exosomes and a gelatin solution, and fills the channel of the ISO-PUs-SMP, so as to prepare the ROS response 3D printing shape memory material through freeze drying. The ROS response 3D printing shape memory material provided by the application has the effects of promoting blood vessels, resisting oxidation and resisting inflammation, can promote angiogenesis at a large bone damage site, reduce the oxidative stress reaction caused by hypoxia, reduce the inflammatory reaction and hypoxic damage, and finally promote the repair and reconstruction of bone tissue at the large bone defect site.

The invention relates to the technical field of medical information, in particular to a chronic osteomyelitis prediction model training method, prediction method and device based on radiomics, electronic equipment and a storage medium, and the method comprises the steps: obtaining a first sample set, a second sample set and a third sample set, carrying out the training of a plurality of machine learning algorithms, obtaining a corresponding original ROI training model set, a first external expansion ROI training model set and a second external expansion ROI training model set, respectively testing each training model set, and selecting a model with the best evaluation result as an original ROI prediction model, a first external expansion ROI prediction model and a second external expansion ROI prediction model. According to the method, effective chronic osteomyelitis debridement auxiliary decisions can be obtained during application by utilizing a step-by-step expansion strategy and algorithm optimization, and more comprehensive focus evaluation and clearer operation edge selection are provided for surgeons; accurate and effective auxiliary data support is provided for finding a relatively safe balance point between'thorough debridement 'and'minimization of bone injury'.

There are provided polypeptides that include an Activin receptor type IIB (ActRIIB) ectodomain (ECD) variant. In some embodiments, a polypeptide of the disclosure includes an ActRIIB-ECD variant fused to an Fc domain moiety. The disclosure also provides pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions associated with TGFβ superfamily ligand signaling, such as metabolic disorders, diabetes, obesity, cardiometabolic disease, pulmonary hypertension, fibrosis, muscle weakness and atrophy, bone damage, and / or low red blood cell levels (such as anemia).

The application provides a 2.5D medical image osteoporosis prediction method and system based on double fusion of a Transformer and stacking, and belongs to the field of artificial intelligence and medical image analysis. First, deep features are extracted in parallel from a 2.5D pelvic CT slice group by using a plurality of pre-training convolutional neural networks; then multi-head self-attention pre-fusion is performed by using a Transformer encoder to generate a unified image feature vector; then the unified image feature vector is spliced with key clinical features such as age and radiotherapy dose to form a multi-modal feature, and the multi-modal feature is input into a plurality of base classifiers to obtain preliminary prediction probabilities; finally, a stacking strategy is used for post-fusion to obtain a final osteoporosis risk probability. Experiments show that the method has excellent prediction performance, the external validation AUC reaches 0.964, and individualized bone damage risk assessment before radiotherapy can be realized.

The present invention provides a highly filling porous granular biomaterial and a preparation method thereof. The outer wall surface of the particles of the porous granular biomaterial is a continuous curved surface or a closed body composed of a curved surface and a flat surface. The pore structure inside the particles is a completely or partially connected porous network. The particle shape and internal porous structure are three-dimensionally modeled by a computer. A mixed slurry containing inorganic powder and photosensitive resin is added to a printing tank and photocured according to the model. The mixed slurry is then washed to remove uncured residual slurry, and then dried and sintered to obtain a highly filling porous granular biomaterial. The porous granular biomaterial of the present invention is designed through coordinated optimization of chemical composition, internal structure and particle shape, effectively ensuring that the material directly fills various bone defects, promotes rapid regeneration and repair of bone damage, and prevents complications. The porous granular biomaterial has clinical application value in the field of promoting bone defect repair.

An implanted bone bandage comprises a bandlet part and a transition guide part, the bandlet part is connected with the transition guide part so that the bandlet part and the transition guide part can form a surrounding state, the bandlet part comprises a plurality of warp yarns and a plurality of weft yarns, and the warp yarns and the weft yarns are arranged in a staggered mode. The warp yarns and the weft yarns are connected in a staggered manner so as to form the flat belt part with a preset size. Compared with a traditional metal cable, the bone implanting bandage has the advantages that fracture fixation is more fit, bone damage is small, tissue growth is faster and safer, the bone implanting bandage is friendly to metal allergy persons, secondary taking-out is not needed, the fracture risk is avoided, the pressure borne by the fracture is more uniform through the flat bandage part, patient recovery is faster, the elastic coefficient is large, and the stability after binding is good.

The present disclosure provides polypeptides comprising an activin type IIB receptor (ActRIIB) extracellular domain (ECD) variant. In some embodiments, the polypeptides of the present disclosure include an ActRIIB-ECD variant fused to an Fc domain moiety. The disclosure also provides pharmaceutical compositions and methods of using the polypeptides in the treatment of diseases and conditions associated with TGF [beta] superfamily ligand signaling, such as metabolic disorders, diabetes, obesity, cardiac metabolic disease, pulmonary hypertension, fibrosis, muscle weakness and atrophy, bone injury, and / or low red blood cell levels, such as anemia.

This invention belongs to the field of traditional Chinese medicine. It relates to a Tonglaga-5 poultice, its preparation process, and its application in treating rheumatoid arthritis. Tonglaga-5 powder is extracted with ethanol to prepare a concentrated Tonglaga-5 solution. The concentrated solution is then freeze-dried to obtain a lyophilized Tonglaga-5 powder, which is further used to prepare a Tonglaga-5 gel ointment and a Tonglaga-5 poultice. Specifically, the optimal extraction process for the Tonglaga-5 concentrate is 77% ethanol (volume fraction), a material-to-liquid ratio of 1:20, and an extraction time of 1 hour. The optimal formulation for the Tonglaga-5 gel is a ratio of carbomer-941: Tonglaga-5 lyophilized powder: sodium polyacrylate: glycerin: aluminum hydroxyl group of 1:2:4:20:5. Pharmacological experiments show that the prepared Tonglaga-5 gel ointment has a uniform and fine appearance, and the Tonglaga-5 poultice prepared using this as a matrix can effectively inhibit the inflammatory response in CIA rats and delay the progression of bone damage.