The invention discloses a degradable, asymmetric-adhesion and non-swelling Janus hydrogel
adhesive as well as a preparation method and application thereof, and belongs to the technical field of
functional composite materials and preparation thereof. The problems that an existing Janus hydrogel cannot be degraded, is weak in
adhesive force, adheres and is high in swelling are solved.
Polyethylene glycol with double bonds,
sodium alginate and
chitosan are used for physical and covalent cross-linking, a degradable hydrogel substrate is constructed and then soaked in a
phosphate buffer solution for swelling equilibrium, then a solution containing
chitosan is used for preparing an adhesion
coating, and the degradable and asymmetrically-adhered non-swelling Janus hydrogel
adhesive is obtained. The adhesive can be applied to the biomedical fields of
wound healing anti-adhesion, in-vivo degradability, intestinal repair and the like, and can also be used for adhesion of
bioelectronics, epidermal physiological
signal monitoring sensors, epidermal
muscle fatigue monitoring sensors, rat subcutaneous
muscle physiological
signal monitoring sensors and
muscle fatigue monitoring sensors.