71results about How to "Improve outcome" patented technology

A movement augmentation system that provides various forms of feedback, including real-time and post-performance for training and rehabilitation is disclosed. The systems, devices and methods provide augmentation to human movement behavior in order to accelerate acquisition of complex movement skills by a user and to mitigate injuries from poor movement technique (e.g., joint damage or muscle fatigue). An environment is provided that enables systematic and comprehensive capabilities through integration of its components.

A modular prosthetic valve device for implantation in a patient is disclosed. The valve device is designed as two or more modules to be delivered unassembled and combined into an assembled valve device in the body—e.g., in the body at or near the site where implantation occurs. The two or more modules may be a support structure and a valve assembly. The valve assembly may be formed from two or more valve sections. Because the valve device of the invention is deliverable as modules, it may have a smaller delivery diameter than pre-assembled percutaneous valves and permits use of a delivery device of reduced diameter. Delivering the valve device as modules increases the flexibility of the valve device during delivery, compared to percutaneous valve devices in the art. The invention further provides a system for and method of delivering such a modular valve device and assembling it in vivo. The modules of the valve device may be connected by pull wires for delivery sequentially to or near the implantation site in the body lumen, and then assembled by remote manipulation using the pull wires. The system may further include a temporary valve that may be deployed to maintain valvular function while the device modules are assembled. The temporary valve may be attached to the delivery device and deployed either before or after the support structure is expanded, or the temporary valve may be attached to the support structure and deployed when the support structure is expanded. Various locking mechanisms are provided for attaching the device modules together.

A system and method for analyzing images to optimize orthopaedic functionality at a site within a patient, including obtaining at least a first, reference image of the site, or a corresponding contralateral site, the first image including at least a first anatomical region or a corresponding anatomical region. At least a second, intra-operative results image of the site is obtained. At least one stationary base with at least two base points is selected to serve as a reference for both images during analysis including at least one of scaling, calculations, and image comparisons.

An assembly for guiding resection of a femur and tibia of a knee joint in preparation for installing a femoral and tibial knee components. For example, the assembly can include tibial and femoral IM rods to which are connected through a tensioning bolt that allows controlled adjustment of the distraction of the tibia and femur during cut positioning in a range of flexion angles. Also, the assembly is usable with relatively small, noninvasive approaches to the knee joint by way of relatively narrow, low profile components that attach to tibial and femoral IM rods. Further, the assembly includes several quick-release components to allow fast assembly and disassembly in a surgical setting. Each of these aspects, along with the ability of the assembly to accurately guide initial reference cuts to the tibia and femur, promotes an improved outcome for the patient.

A method, system, and computer software product for correlating medical images, comprising: obtaining first image data representative of a first medical image including a first abnormality; obtaining second image data representative of a second medical image including a second abnormality; determining at least one feature value for each of the first and second abnormalities using the first and second image data; calculating, based on the determined feature values, a likelihood value indicative of a likelihood that the first and second abnormalities are a same abnormality; and outputting the determined likelihood value.

A system and method that acquire (i) at least a reference image including one of a preoperative image of a surgical site with skeletal and articulating bones and a contralateral image on an opposite side of the patient from the surgical site, and (ii) at least an intraoperative image of the site after an implant has been affixed to the articulating bone. The system preferably generates at least one reference stationary point on at least the skeletal bone in the reference image and at least one intraoperative stationary point on at least the skeletal bone in the intraoperative image. The location of the implant is identified in the intraoperative image, preferably including the position of first and second centers of rotation, which are digitally represented and copied into the reference image to analyze at least one of offset and length differential.

A temporary percutaneous valve-filter device having valve portions non-porous to blood and filter portions non-porous to emboli but at least in part porous to blood. In one embodiment, the device has a substantially flat valve unit and a substantially flat filter unit. In another embodiment, the device has at least one open umbrella deployed configuration. In one aspect, the device has a unitary construction with one umbrella canopy with one or more filter areas with flaps allowing unidirectional blood flow. In another aspect, the device has a valve unit and filter unit, the umbrella canopies oriented in opposite directions, and the valve unit “closes” and opens to allow blood to flow to one direction. Also provided is a temporary valve system, including a core having an inverted delivery configuration and everted deployed configuration, that may be used with or without a filter unit, and a method of deployment.

The invention relates to methods of diagnosing or monitoring a psychotic disorder in a subject comprising providing a test biological sample from the subject, performing spectral analysis on said test biological sample to provide one or more spectra, and, comparing the one or more spectra with one or more control spectra. The invention also relates to methods for diagnosing or monitoring psychotic disorders such as schizophrenic or bipolar disorders, comprising measuring the level of one or more biomarkers present in a biological sample taken from a test subject, said biomarkers being selected from the group consisting of transthyretin, ApoA1: VLDL, LDL and aromatic species such as plasma proteins. The invention also relates to sensors, biosensors, multi-analyte panels, arrays, assays and kits for performing methods of the invention.

An apparatus is provided for applying a restrictive fiber matrix to a conduit to create a graft device. A rotating assembly rotates the conduit, and a polymer delivery assembly delivers the restrictive fiber matrix. A controller controls the polymer deliver assembly and the rotating assembly.

The invention relates to a whole-nutritive formula food, and discloses a whole-nutritive special medical emulsion and a preparation method thereof. The emulsion contains protein, carbohydrate, fat, a compound stabilizing agent, an acidity adjusting agent, vitamin A, vitamin D3, vitamin E, vitamin K1, vitamin B1, vitamin B2, vitamin B6, vitamin B12, nicotinamide, D-calcium pantothenate, folic acid, biotin, vitamin C, myo-inositol, L-carnitine tartrate, calcium, iodine, magnesium, ferrum, zinc, sodium, manganese, copper, potassium, phosphorus, L-glutamine, yeast beta-glucan and the like, is reasonable in compounding ratio, and can meet nutritional requirements of crowds with food and drink limitation, metabolic disturbance, postoperative restoration and weak constitutions. The compound stabilizing agent is used, so that the emulsion has favorable stability; other nutrient substances beneficial for human bodies are added, so that the nutrients are improved; the medical care effect is improved, and comprehensive expense is reduced; and in the preparation process, different raw materials are separately treated, so that the utilization rate of the raw materials is high, the raw materials are sufficient to dissolve, and finished products are uniform and stable.

A multi-functional medical facility permits emergent diagnostic imaging assessment, image guided therapeutic interventions, and open surgical procedures within the complex. The concept of bringing diagnostic and therapeutic imaging and operative equipment to the critically ill patient or the patient undergoing non-emergency, elective surgery, instead of bringing the patient to the equipment is a major clinical advantage that should improve efficiency, outcome and survival. An important economic advantage is that the components can be used separately and independently of each other, thus enabling them to also be used for routine emergency room (ER) work.

An image data correction apparatus has a motion information acquisition section, a correction section, and a composition section. The motion information acquisition section acquires motion information indicating spatial distribution of the magnitude of motion, in actual space, of a to-be-imaged portion of a subject. Based on the motion information, the correction section performs correction, which is different from correction in a second region, in a first region of image data collected by a scan by magnetic resonance imaging. The composition section composes individual image data of the first region and the second region that are corrected by the correction section.

A system is provided that includes a processor configured to access a catalog of a plurality of medical services spanning a plurality of one or more of clinicians responsible for diagnoses of respective patients, facilities responsible for performing medical services with respect to respective patients, or paying entities responsible for the coverage of respective patients. The clinicians, facilities or paying entities have a respective plurality of nomenclatures for identifying the medical services, with at least some of the nomenclatures differing in identifying similar medical services. The processor is therefore configured to receive identification of a medical service in the nomenclature of one clinician, facility or paying entity, and from the catalog, translate the identification to the nomenclature of another clinician, facility or paying entity for transmission thereto.

The present invention includes compositions and methods of reducing the glycosylation of proteins comprising: obtaining a cell that expresses one or more proteins that comprise one or more glycosylation sites and are glycosylated; expressing in the cell one or more glycosidases that cleaves one or more glycosyl groups from the one or more proteins; and isolating the one or more proteins with reduced glycosylation from the cell.

The invention relates to data searching and translation. In particular, the invention relates to searching documents from the Internet or databases. Even further, the invention also relates to translating words in documents, WebPages, images or speech from one language to the next. A computer implemented method including at least one computer in accordance with the invention is characterised by the following steps:

• • receiving a search query including at least one search term, deriving at least one synonym for at least one search term, expanding the received search query with the at least one synonym, searching at least one document using the expanded search query, retrieving the search results obtained with the expanded query, ranking the search results based on context of occurrence of at least one search term. The best mode of the invention is considered to be an Internet search engine that delivers better search results.

The present invention relates to methods of alleviating pain with the administration of norketamine with a narcotic. More particularly, the invention provides a method of alleviating pain through the administration of a dose of norketamine, which, if administered alone would provide sub-optimal analgesic relief, yet provides analgesic relief when combined with a narcotic. In some embodiments, the combination of norketamine with a narcotic, further allows for the administration of a dose narcotic, which would be sub-optimal if used alone, but provides adequate pain relief in combination with norketamine. The invention relates to self-management of pain on an outpatient basis comprising administering via conventional routes, including transdermal, nasal, rectal, oral, transmucosal, intravenous, intramuscular, and other routes, one or more doses of norketamine/opioid compositions effective to alleviate pain to a subject suffering from pain. Uses of norketamine/opioid compositions would also apply, to treating headaches, drug abuse, mood and anxiety disorders, as well as other, neuropsychiatric disorders, both motoric and cognitive, such as Alzheimer's disease, Parkinson's syndrome, which are thought to be caused by neurodegeneration.

The invention discloses an immunity-related biomarker and an application of the biomarker to prognosis diagnosis of head and neck squamous cell carcinoma. The biomarker comprises four immune-related genes PVR, TNFRSF12A, IL-21R and SOCS1, and the biomarker and Path_N jointly form a head and neck squamous cell carcinoma prediction prognosis model. A group of new high-sensitivity and specific immunity-related molecular markers are developed for HNSCC prediction prognosis diagnosis to improve the outcome of a patient, which meets the current urgent demands. A model detection method is simple andeasy to operate, helps to better identify HNSCC patients, and can be used as a guidance basis for HNSCC immunotherapy decisions.

A device having a biocompatible polymer as a body and regularly spaced radiation seeds and regularly spaced magnetic materials disposed of within the body of the biocompatible polymer, or uniformly distributed liquid radiation and magnetic fluid materials within a polymer slab, hollow thick wall polymer shell, or thin wall polymer balloon, as suitable for surgical placement within a resection cavity for treatment of at-risk tissue in the tumor margin with local hyperthermia in combination with radiation and potentially also with chemotherapy and/or immunotherapy that is slowly released from the biocompatible polymer.