70 results about "Joint damage" patented technology

The invention discloses a hip and knee joint replacement postoperative rehabilitation method and system based on mobile medical treatment, relates to the technical field of medical rehabilitation, and discloses the hip and knee joint replacement postoperative rehabilitation method and system based on mobile medical treatment. The training plan is dynamically adjusted in combination with multi-dimensional indexes, the problems of compensation recognition deficiency, feedback lag and plan stiffness in a traditional rehabilitation scheme are effectively solved, the rehabilitation effect can be improved, and the injury risk of adjacent joints can be reduced.

The invention relates to the technical field of image data processing, in particular to a rheumatism immune disease joint injury assessment system based on image recognition. The system comprises a joint image preprocessing module, an image segmentation and injury characteristic analysis module, a bone erosion and synovial thickening evaluation module and a joint injury evaluation and injury visualization module, can obtain joint image data of the rheumatism immune disease, perform size scaling and image denoising processing, and perform joint part image segmentation at the same time. Image data of the joint part region of the rheumatism immune disease is obtained; and performing joint injury structural feature analysis and joint image injury quantitative evaluation on the joint partial region image data of the rheumatism immune disease to obtain a joint image injury score corresponding to the rheumatism immune disease patient, and performing evaluation to obtain a joint image injury type to perform joint injury visualization so as to obtain a joint injury visual image result. The joint injury degree corresponding to the joint image of the rheumatism immune disease can be more accurately detected.

The present application belongs to the technical field of medicine, and particularly relates to the use of tetrahydrojatrorrhizine or a pharmaceutically acceptable salt thereof in the preparation of a medicament for treating rheumatoid arthritis. Experimental results show that tetrahydrojatrorrhizine can effectively alleviate the foot swelling level of CIA rats, reduce the arthritis score, and inhibit the progression of rheumatoid arthritis. Blood routine analysis shows that the administration of tetrahydrojatrorrhizine reduces the number of immune cells in the blood and weakens the immune level of the body. In addition, the experimental results also show that tetrahydrojatrorrhizine can inhibit synovial hyperplasia and relieve joint damage. Therefore, tetrahydrojatrorrhizine has the prospect of being developed into an oral medicament for treating rheumatoid arthritis, provides more treatment options for clinically treating rheumatoid arthritis, and has important social and economic values.

Whole blood is mixed with one or more coagulators to produce coagulated blood which is then introduced into a site of bone or joint damage or disease and allowed to coagulate at the site. The aim is to promote healing or amelioration of a disease, disorder or lesion at the site, such as healing and regeneration-6623 of damaged bone, damaged joint, cartilage lesion, and the like.

The invention discloses an application of rare ginsenoside in preparation of a medicine for improving intestinal dysbacteriosis and inhibiting rheumatoid arthritis, including an application of rare ginsenoside Rk3 in preparation of a medicine for improving intestinal dysbacteriosis and an application of rare ginsenoside Rk3 in preparation of a medicine for inhibiting rheumatoid arthritis. Rare ginsenoside Rk3 can improve the richness and diversity of intestinal flora of mice with rheumatoid arthritis, enrich probiotics and regulate bile acid metabolism, so that intestinal flora imbalance caused by rheumatoid arthritis is effectively relieved, and intestinal barrier function damage is repaired; the generation of inflammatory factors can be reduced, a TLR4-NF-kappa B signal channel is inhibited, and joint injury in an RA model is treated. Based on investigation of causal association among ginsenoside Rk3, intestinal flora and rheumatoid arthritis, clinical application of rare ginsenoside Rk3 in rheumatoid arthritis is provided, and new strategies and candidate drugs are provided for treatment of rheumatoid arthritis.

The application provides a composition containing curcuma and type II collagen-containing cartilage powder and application thereof in joint maintenance, and relates to the field of food technology. The application provides a composition containing milk mineral salt, curcuma, type II collagen-containing cartilage powder, enzymatic bone powder, N-acetyl glucosamine and black pepper extract, which can significantly repair joint damage, significantly reduce cartilage damage indexes such as CTX-II and COMP, and can be used for preparing a joint maintenance medicine.

The present invention relates to a hydrogel composition for intra-articular administration, which is easily injected into the human body, and use thereof for supplementing joint synovial fluid, supplementing viscosity, and preventing or treating intra-articular lesions. The hydrogel composition according to the present invention can improve the gelation temperature, viscosity, biodegradability, and tissue support capability of hyaluronic acid and, at the same time, can improve practitioner convenience and patient compliance due to the reduced injection pressure thereof. In addition, the hydrogel composition can increase the effect of ameliorating intra-articular lesions when co-administered with stem cells or exosomes, and thus can have various applications in medical devices and pharmaceutical fields for the purpose of cartilage regeneration and intra-articular lesion treatment.

The application discloses a joint cavity filling preparation of precisely proportioned carboxymethyl chitosan and sodium glycerophosphate and a preparation method and application thereof, and the effective component of the filling preparation is carboxymethyl chitosan with a concentration of 25 mg / mL and sodium glycerophosphate with a concentration of 15 mg / mL, and the balance is a sterile isotonic physiological buffer aqueous solution. The application forms component synergy by relying on the lubrication and long-acting stability characteristics of carboxymethyl chitosan and combining the structure reinforcement, ion regulation and cartilage repair promoting characteristics of sodium glycerophosphate, and effectively solves the defects of short in-vivo retention time, poor mechanical stability, lack of biological repair activity and easy dilution and collapse of the traditional joint filling material in the joint cavity fluid. The application overcomes the problem that a high-concentration viscous solution cannot be filtered and sterilized, can effectively buffer the joint mechanical load, optimize the joint microenvironment and promote the repair of degenerative cartilage, is suitable for clinical scenes such as mild and moderate osteoarthritis, sports joint injury and postoperative joint function repair, and has good clinical application value and industrialization prospect.

The utility model relates to the technical field of rehabilitation equipment, and discloses an auxiliary instrument suitable for resistance exercise of obese children, which comprises a base with a first direction and a second direction; the damping structure comprises a resistance plate and an elastic piece, and the bottom end of the resistance plate is hinged to the base; the sliding plate is assembled on the base in a guiding mode in the first direction, the resistance plate is arranged on the moving route of the sliding plate, and the resistance plate is used for providing resistance for the sliding plate in the reciprocating movement process of the sliding plate; the foot stool is arranged at one end of the base in the first direction; one end of the pull rope is fixedly assembled on the base or the foot stool, and the other end of the pull rope forms a traction end for an obese child to pull. According to the auxiliary instrument, the weight of a child patient serves as resistance, back-and-forth resistance movement is conducted in a lying posture, resistance movement participated by muscle groups of the whole body is utilized, movement without gravity is achieved, the joint burden is reduced, muscle and joint damage related to movement of obese people is reduced, and continuous movement training of the child patient is achieved.

The application discloses a kind of food relieving bone joint damage evaluation method, it is related to food efficacy evaluation technical field, for solving the problem of single dimension of existing evaluation method, unstable model leads to poor reliability of conclusion.The application builds composite modeling and multi-modal analysis mechanism, first, a stable animal model is established by using chemical injury combined with forced exercise training, a two-stage increasing dosing regimen is set, and behavior dynamic trend data and histology, imaging multi-modal results are collected synchronously.Then, based on the weight assigned to osteoarthritis stage, a weighted composite score is generated, and a perturbation sensitivity index is calculated, a multi-index collaborative influence map is constructed, a key evaluation node is located, a graded evaluation conclusion is generated based on the food action characteristics and efficacy determination threshold, and false positives caused by single index fluctuations are avoided.Finally, a full-cycle closed-loop evaluation process is formed, which improves the scientificity, reproducibility and self-adaptive ability of efficacy determination in complex biological systems.

The invention relates to the technical field of functional food, in particular to an electrolyte composition beneficial to joint injury repair after exercise and a preparation method of the electrolyte composition. The electrolyte composition is mainly prepared from the following raw materials in parts by mass: 0.1 to 2 percent of N-acetylglucosamine, 0.05 to 0.5 percent of cartilage extract, 0.05 to 0.5 percent of enzymolysis bone meal, 0.01 to 0.05 percent of milk mineral salt, 0.1 to 1 percent of collagen peptide, 0.01 to 0.3 percent of vitamin and 0.03 to 0.3 percent of electrolyte. The nano hydrated milk mineral salt is adopted, the absorption efficiency of elements such as calcium and phosphorus in a body is improved, and the electrolyte composition is prepared by combining components such as N-acetylglucosamine and the cartilage extract, so that joint inflammation and cartilage injury caused by exercise are effectively improved while water and electrolyte are supplemented, and the activity of joints and exercises is improved. The electrolyte composition is good in taste, high in stability and suitable for joint protection and nutrition supplement after exercise.

The invention discloses a small-molecule chondroitin sulfate group effect compound for interventional treatment of joint inflammation and application, relates to the technical field of joint inflammation improvement, and aims to solve the problems that small-molecule chondroitin sulfate obtained by an existing single degradation method is single in action way and difficult to comprehensively cope with the complex pathological process of joint inflammation. The composition is composed of an oxidative degradation product LMCSO, an acid degradation product LMCSA and an alkali degradation product LMCSB according to the weight ratio of 6: 3: 1, the number-average molecular weight of the three products is smaller than 10 kDa, and the composition is prepared through specific oxidative degradation, acid degradation and microwave-assisted alkali degradation methods containing a phase transfer catalyst. The small-molecular chondroitin sulfate combined-effect compound can be used for preparing medicines beneficial to repairing bone joint injuries and relieving arthralgia or stiffness.

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof;or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds; and methods of using such compounds for treating joint damage or injury in a mammal, for inducing hyaline cartilage production or for inducing differentiation of chondrogenic progenitor cells into mature chondrocytes.

The invention relates to the technical field of specific therapeutic activity of pharmaceutical preparations, in particular to a PRP administration concentration evaluation method for joint movement injury repair, which comprises the following steps: obtaining an inflammation comprehensive repair expression according to the change condition of multiple C-reactive protein levels before the last PRP administration; according to the change condition of the joint swelling degree in a time period between two adjacent C-reactive protein levels, joint swelling repair characteristics are obtained; determining the change correlation between the arthrocele repair characteristics and the C-reactive protein level, and combining the arthrocele repair characteristics and the inflammation comprehensive repair expression to obtain comprehensive repair effect characteristics; obtaining hormone level deviation characteristics according to multiple abnormal conditions of cortisol hormone levels; according to the comprehensive repair effect characteristics and the hormone level deviation characteristics, the next PRP administration concentration is adjusted, the accuracy and reliability of determining the PRP administration concentration are effectively improved, and therefore the overall effect of joint injury repair is improved.

The present disclosure provides biomaterials and methods for preventing and minimizing progression of cartilage and / or connective tissue damage. Also provided herein are biomaterials and methods for alleviating and / or reducing the risk for developing arthritis (e.g., osteoarthritis) associated with joint injury and / or joint surgery.

The present invention relates to the field of medical equipment technology, specifically an intra-articular perfusion device, comprising a perfusion shell, the outer wall of the perfusion shell is fixedly connected to a liquid extraction mechanism, the inner wall of the perfusion shell is slidably connected to a cleaning mechanism, the inner wall of the cleaning mechanism is slidably connected to the outer wall of the liquid extraction mechanism, the inner wall of the perfusion shell is clamped with a quantitative shell, and the inner wall of the quantitative shell is clamped with an injection head. In the prior art, when there is a lot of joint effusion, it is necessary to frequently remove the syringe to extract it. During the extraction process, it may cause sealing problems caused by the misalignment of the syringe and the needle. At the same time, the efficiency is not high, and when there is less joint effusion in the subsequent process, precise extraction operations are required to avoid human tissue being sucked into the joint cavity due to low pressure during extraction, thereby causing damage. When encountering effusion caused by joint damage, slow extraction is also required to prevent secondary damage to the patient. After the extraction of the intra-articular effusion is completed, the interior needs to be cleaned and disinfected to prevent recurrence of the disease.

The utility model discloses an orthopedic joint rehabilitation training device, which is applied to the technical field of medical instruments and can effectively improve the movement range of elbow joints, enhance the coordination of elbow and forearm muscles and promote blood circulation around the joints through controllable bending and unbending actions. Joint stiffness and soft tissue adhesion can be prevented through regular movement, and meanwhile the hand grabbing capacity is enhanced in combination with the holding action; due to the design of adjustable holding distance, arm lengths of different patients can be accurately adapted, and it is ensured that a hand holding point is aligned with the axis of a shoulder and wrist joint during elbow joint flexion and extension training; muscle strength levels of different rehabilitation stages of a patient cannot be matched due to fixed training intensity, so that joint injury is caused by overlarge early load or muscle activation is delayed due to insufficient later load.

The present invention provides a pharmaceutical composition containing Scrophularia or its extract and its use. Compared with the prescription composed of honeysuckle, Scrophularia, angelica and liquorice, the single drug or its active component of the present invention can effectively alleviate joint damage in acute gouty arthritis (AGA) model mice, collagen antibody-induced arthritis (CAIA) model mice and collagen-induced arthritis (CIA) model mice by regulating neutrophil activity, reducing neutrophil migration, and alleviating immune damage caused by inappropriately activated neutrophils. It further confirms that the new strategy of treating diseases related to abnormal neutrophil activation by targeting neutrophils is feasible.

Systems and related methods for preparing and treating damage in an ankle joint. The system may include one or more of a reamer, a surgical device, a tibial implant, a placement tool, and a talar implant. The reamer may prepare an intramedullary canal for implantation of an implant. The reamer may include a plurality of nested reamer elements that may be expanded into the intramedullary canal. The surgical device may include a housing containing the reamer and be configured to orient the reamer with the intramedullary canal. The tibial implant may include a plurality of stem components. The placement tool may be configured to combine the plurality of stem components. The talar implant may be configured to be implanted in a talus.

1. The name of the design product: muscle paste (water drop type). 2. The use of the design product: for human waist joint injury protection. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: design 1 front view. 5. The rear view of designs 1-3 is symmetrical with the front view, and the rear view of designs 1-3 is omitted; the design product is a thin product, and the left view, right view, top view and bottom view of designs 1-3 are omitted. 6. Design 1 is designated as the basic design.

The invention provides a breathable casual shoe imitating the shape of a human foot bone and a preparation method of the breathable casual shoe. The breathable casual shoe imitating the shape of the foot bone of the human body comprises a sole; the supporting bottom is arranged at the top of the sole and is used for increasing the supporting force of the sole; the vamp is sewn on the supporting bottom through a sewing line and is used for protecting the instep. According to the breathable casual shoe imitating the human foot bone shape and the preparation method thereof, the breathable holes are formed in the vamp to assist in breathability, air circulation is improved, stuffiness is reduced, the supporting bag is arranged at the top of the insole to be attached to the arch curve, plantar pressure is dispersed, arch fatigue is relieved, and the comfort level of the shoe is improved. The sole and heel support is intensified in a targeted manner by sticking the wear-resistant pad, so that the sole and heel support fits the human leg and foot bone form, pressure can be dispersed, impact force can be absorbed, joint injury can be reduced, and the service life can be prolonged.

In a first aspect, the present invention is related to lactic acid or a pharmaceutically acceptable salt thereof for use in the prevention and / or treatment of a musculoskeletal injury in a subject. In a second aspect, the present invention is related to an injectable composition for use in the treatment of a musculoskeletal injury in a subject characterized in that it comprises lactic acid or a pharmaceutically acceptable salt thereof and a suitable solvent. In a preferred embodiment, the musculoskeletal injury is selected from the group consisting of tendon injury, joint injury, cartilage injury and muscle injury.

The present disclosure provides biomaterials and methods for preventing and minimizing the progression of cartilage and / or connective tissue damage. Also provided herein are biomaterials and methods for mitigating and / or reducing the risk of developing arthritis (e.g., osteoarthritis) associated with joint injury and / or joint surgery.

The application discloses a composition for promoting joint health, a preparation method and application, and relates to the field of food.The composition comprises the following components in parts by weight: animal protein: 20-80; non-denatured type II collagen: 0.2-1; sodium hyaluronate: 0.5-2; proteoglycan: 0.5-2; sour cherry extract: 3-10; and calcium beta-hydroxy-beta-methylbutyrate: 5-20.The application takes non-denatured type II collagen as a main efficacy component, and additionally adds animal protein, sodium hyaluronate, proteoglycan, sour cherry extract and calcium beta-hydroxy-beta-methylbutyrate, synergistically acts through the multiple efficacy components, relieves joint discomfort through multiple pathways, maintains muscle health, and enables the product to have the optimal effect of repairing joint damage, improving joint and skeletal muscle health.

The present invention relates to a joint repair protein composition, and its preparation comprises the following steps: adding 20U / mL-35U / mL of any one or combination of nuclease or universal nuclease to a cell protein extract, placing it under 37°C±1°C for enzymolysis for 15min-40min, and separating and purifying the obtained enzymolysis solution. The cell protein composition obtained by the present invention has the effects of cell repair, joint repair, and cartilage repair, and is used for preventing and treating any one or complications of joint traumatic lesions, degenerative osteoarthritis, joint injuries, refractory wound lesions, knee osteoarthritis, and cartilage damage.

The invention provides a collagen composite material for joint injury repair and a preparation method and application thereof.The collagen composite material comprises collagen and chitosan, the chitosan is water-soluble chitosan subjected to one or two or more combined treatment of carboxylation, hydroxylation, phosphatization and quaternization, and the chitosan is water-soluble chitosan subjected to one or two or more combined treatment of carboxylation, hydroxylation, phosphatization and quaternization. The weight ratio of the collagen to the water-soluble chitosan is (1: 15)-(1: 3). The composition and proportion of the collagen and the water-soluble chitosan are scientifically screened, the collagen composite material which is closer to natural synovial fluid in composition is formed, the water-soluble chitosan provides physical blocking inflammatory factors and a lubricating effect between cartilages, and the collagen has a pore structure, so that the cartilages have a good anti-inflammatory effect on the cartilages, and the cartilages have a good anti-inflammatory effect on the cartilages. Adhesion of cartilage cells is facilitated, nutrition is obtained, proliferation of the cartilage cells is promoted, and repair of damaged cartilage is achieved.

The invention discloses an application of rotigotine microspheres in preparation of medicines for preventing or treating rheumatic arthritis, the rotigotine microspheres can directly act on joint parts, joint synovial hyperplasia, joint injury and bone erosion are effectively reduced, and the curative effect of the rotigotine microspheres is improved. The rotigotine microspheres can be independently used or matched with other known medicines, compounds or carriers to be prepared into various forms of medicaments or pharmaceutical compositions for prevention or treatment, and the dopamine receptor can be continuously excited for 4-8 weeks by injecting once during administration, so that the'on-off 'phenomenon caused by fluctuation of blood concentration is remarkably improved, and the bioavailability of the rotigotine microspheres is improved. Therefore, the curative effect can be effectively improved, and the compliance of a patient is greatly improved.

The present invention discloses a wearable stroke rehabilitation device based on flexible tactile sensation. A bionic artificial muscle and a sliding block are arranged on one side of the palm body, and a palm tactile massage ball is arranged on the other side. The bionic artificial muscle and the sliding block are spaced apart, and at least three bionic artificial muscles are arranged on the five fingers of the palm body. The palm body and the bionic upper limb are connected by a wrist rotating ring. An air power source supplies air to the bionic artificial muscle. The present invention uses a highly safe alcohol vapor drive device to promote the regeneration of nerve fiber endings through repeated self-training by the patient. The flexible bionic artificial pneumatic muscle drive prevents secondary joint damage, achieving rehabilitation while protecting the patient both physically and psychologically.

The application belongs to the technical field of microorganisms and particularly relates to application of heat-inactivated Bifidobacterium longum ZFML0012 in relieving rheumatoid arthritis. TNF-α 、 iNOS 、 IL-1β The mRNA expression level of the heat-inactivated Bifidobacterium longum ZFML0012 bacterial liquid can be lowered, and the mRNA expression level of the heat-inactivated Bifidobacterium longum ZFML0012 bacterial liquid can be raised. IL-10 The taxonomic name of the Bifidobacterium longum ZFML0012 is Bifidobacterium longum ( Bifidobacterium longum ) ZFML0012, and the preservation number is CCTCC NO: M 20252539. The heat-inactivated Bifidobacterium longum ZFML0012 bacterial liquid has anti-inflammatory activity on inflammation induced by lipopolysaccharide, and the heat-inactivated Bifidobacterium longum ZFML0012 bacterial liquid can improve joint injury and immune imbalance.

The invention provides a bony hammer finger clamp which comprises a joint bearing assembly and a pressure applying assembly, the pressure applying assembly is rotationally arranged on one side of the upper portion of the joint bearing assembly, the joint bearing assembly is used for placing a finger, and one end of the pressure applying assembly abuts against a fracture block. The device is simple in structure, convenient to manufacture and low in cost. The bone block fixing needle is utilized to pressurize a reset fracture block and maintain normal alignment, so that the operation difficulty can be reduced, the risk that the bone block is broken due to internal fixation is reduced, the success rate of one-time reset fixation is improved, the operation time is shortened, and the dependence on the skill and experience of an operator is reduced; and meanwhile, the soft joint supporting bracket can maintain the straightening position fixation of the distal interphalangeal joint under the condition of not damaging skin soft tissues, so that the joint surface injury caused by the use of a kirschner wire for threading and fixing is avoided, and the later joint function exercise is facilitated.