41 results about "Joint damage" patented technology

The invention discloses a hip and knee joint replacement postoperative rehabilitation method and system based on mobile medical treatment, relates to the technical field of medical rehabilitation, and discloses the hip and knee joint replacement postoperative rehabilitation method and system based on mobile medical treatment. The training plan is dynamically adjusted in combination with multi-dimensional indexes, the problems of compensation recognition deficiency, feedback lag and plan stiffness in a traditional rehabilitation scheme are effectively solved, the rehabilitation effect can be improved, and the injury risk of adjacent joints can be reduced.

The present application belongs to the technical field of medicine, and particularly relates to the use of tetrahydrojatrorrhizine or a pharmaceutically acceptable salt thereof in the preparation of a medicament for treating rheumatoid arthritis. Experimental results show that tetrahydrojatrorrhizine can effectively alleviate the foot swelling level of CIA rats, reduce the arthritis score, and inhibit the progression of rheumatoid arthritis. Blood routine analysis shows that the administration of tetrahydrojatrorrhizine reduces the number of immune cells in the blood and weakens the immune level of the body. In addition, the experimental results also show that tetrahydrojatrorrhizine can inhibit synovial hyperplasia and relieve joint damage. Therefore, tetrahydrojatrorrhizine has the prospect of being developed into an oral medicament for treating rheumatoid arthritis, provides more treatment options for clinically treating rheumatoid arthritis, and has important social and economic values.

The application provides a composition containing curcuma and type II collagen-containing cartilage powder and application thereof in joint maintenance, and relates to the field of food technology. The application provides a composition containing milk mineral salt, curcuma, type II collagen-containing cartilage powder, enzymatic bone powder, N-acetyl glucosamine and black pepper extract, which can significantly repair joint damage, significantly reduce cartilage damage indexes such as CTX-II and COMP, and can be used for preparing a joint maintenance medicine.

The present invention relates to a hydrogel composition for intra-articular administration, which is easily injected into the human body, and use thereof for supplementing joint synovial fluid, supplementing viscosity, and preventing or treating intra-articular lesions. The hydrogel composition according to the present invention can improve the gelation temperature, viscosity, biodegradability, and tissue support capability of hyaluronic acid and, at the same time, can improve practitioner convenience and patient compliance due to the reduced injection pressure thereof. In addition, the hydrogel composition can increase the effect of ameliorating intra-articular lesions when co-administered with stem cells or exosomes, and thus can have various applications in medical devices and pharmaceutical fields for the purpose of cartilage regeneration and intra-articular lesion treatment.

The application discloses a joint cavity filling preparation of precisely proportioned carboxymethyl chitosan and sodium glycerophosphate and a preparation method and application thereof, and the effective component of the filling preparation is carboxymethyl chitosan with a concentration of 25 mg / mL and sodium glycerophosphate with a concentration of 15 mg / mL, and the balance is a sterile isotonic physiological buffer aqueous solution. The application forms component synergy by relying on the lubrication and long-acting stability characteristics of carboxymethyl chitosan and combining the structure reinforcement, ion regulation and cartilage repair promoting characteristics of sodium glycerophosphate, and effectively solves the defects of short in-vivo retention time, poor mechanical stability, lack of biological repair activity and easy dilution and collapse of the traditional joint filling material in the joint cavity fluid. The application overcomes the problem that a high-concentration viscous solution cannot be filtered and sterilized, can effectively buffer the joint mechanical load, optimize the joint microenvironment and promote the repair of degenerative cartilage, is suitable for clinical scenes such as mild and moderate osteoarthritis, sports joint injury and postoperative joint function repair, and has good clinical application value and industrialization prospect.

The application discloses a kind of food relieving bone joint damage evaluation method, it is related to food efficacy evaluation technical field, for solving the problem of single dimension of existing evaluation method, unstable model leads to poor reliability of conclusion.The application builds composite modeling and multi-modal analysis mechanism, first, a stable animal model is established by using chemical injury combined with forced exercise training, a two-stage increasing dosing regimen is set, and behavior dynamic trend data and histology, imaging multi-modal results are collected synchronously.Then, based on the weight assigned to osteoarthritis stage, a weighted composite score is generated, and a perturbation sensitivity index is calculated, a multi-index collaborative influence map is constructed, a key evaluation node is located, a graded evaluation conclusion is generated based on the food action characteristics and efficacy determination threshold, and false positives caused by single index fluctuations are avoided.Finally, a full-cycle closed-loop evaluation process is formed, which improves the scientificity, reproducibility and self-adaptive ability of efficacy determination in complex biological systems.

The invention relates to the technical field of functional food, in particular to an electrolyte composition beneficial to joint injury repair after exercise and a preparation method of the electrolyte composition. The electrolyte composition is mainly prepared from the following raw materials in parts by mass: 0.1 to 2 percent of N-acetylglucosamine, 0.05 to 0.5 percent of cartilage extract, 0.05 to 0.5 percent of enzymolysis bone meal, 0.01 to 0.05 percent of milk mineral salt, 0.1 to 1 percent of collagen peptide, 0.01 to 0.3 percent of vitamin and 0.03 to 0.3 percent of electrolyte. The nano hydrated milk mineral salt is adopted, the absorption efficiency of elements such as calcium and phosphorus in a body is improved, and the electrolyte composition is prepared by combining components such as N-acetylglucosamine and the cartilage extract, so that joint inflammation and cartilage injury caused by exercise are effectively improved while water and electrolyte are supplemented, and the activity of joints and exercises is improved. The electrolyte composition is good in taste, high in stability and suitable for joint protection and nutrition supplement after exercise.

The invention discloses a small-molecule chondroitin sulfate group effect compound for interventional treatment of joint inflammation and application, relates to the technical field of joint inflammation improvement, and aims to solve the problems that small-molecule chondroitin sulfate obtained by an existing single degradation method is single in action way and difficult to comprehensively cope with the complex pathological process of joint inflammation. The composition is composed of an oxidative degradation product LMCSO, an acid degradation product LMCSA and an alkali degradation product LMCSB according to the weight ratio of 6: 3: 1, the number-average molecular weight of the three products is smaller than 10 kDa, and the composition is prepared through specific oxidative degradation, acid degradation and microwave-assisted alkali degradation methods containing a phase transfer catalyst. The small-molecular chondroitin sulfate combined-effect compound can be used for preparing medicines beneficial to repairing bone joint injuries and relieving arthralgia or stiffness.

The invention relates to the technical field of specific therapeutic activity of pharmaceutical preparations, in particular to a PRP administration concentration evaluation method for joint movement injury repair, which comprises the following steps: obtaining an inflammation comprehensive repair expression according to the change condition of multiple C-reactive protein levels before the last PRP administration; according to the change condition of the joint swelling degree in a time period between two adjacent C-reactive protein levels, joint swelling repair characteristics are obtained; determining the change correlation between the arthrocele repair characteristics and the C-reactive protein level, and combining the arthrocele repair characteristics and the inflammation comprehensive repair expression to obtain comprehensive repair effect characteristics; obtaining hormone level deviation characteristics according to multiple abnormal conditions of cortisol hormone levels; according to the comprehensive repair effect characteristics and the hormone level deviation characteristics, the next PRP administration concentration is adjusted, the accuracy and reliability of determining the PRP administration concentration are effectively improved, and therefore the overall effect of joint injury repair is improved.

The present disclosure provides biomaterials and methods for preventing and minimizing progression of cartilage and / or connective tissue damage. Also provided herein are biomaterials and methods for alleviating and / or reducing the risk for developing arthritis (e.g., osteoarthritis) associated with joint injury and / or joint surgery.

The present invention relates to the field of medical equipment technology, specifically an intra-articular perfusion device, comprising a perfusion shell, the outer wall of the perfusion shell is fixedly connected to a liquid extraction mechanism, the inner wall of the perfusion shell is slidably connected to a cleaning mechanism, the inner wall of the cleaning mechanism is slidably connected to the outer wall of the liquid extraction mechanism, the inner wall of the perfusion shell is clamped with a quantitative shell, and the inner wall of the quantitative shell is clamped with an injection head. In the prior art, when there is a lot of joint effusion, it is necessary to frequently remove the syringe to extract it. During the extraction process, it may cause sealing problems caused by the misalignment of the syringe and the needle. At the same time, the efficiency is not high, and when there is less joint effusion in the subsequent process, precise extraction operations are required to avoid human tissue being sucked into the joint cavity due to low pressure during extraction, thereby causing damage. When encountering effusion caused by joint damage, slow extraction is also required to prevent secondary damage to the patient. After the extraction of the intra-articular effusion is completed, the interior needs to be cleaned and disinfected to prevent recurrence of the disease.

The utility model discloses an orthopedic joint rehabilitation training device, which is applied to the technical field of medical instruments and can effectively improve the movement range of elbow joints, enhance the coordination of elbow and forearm muscles and promote blood circulation around the joints through controllable bending and unbending actions. Joint stiffness and soft tissue adhesion can be prevented through regular movement, and meanwhile the hand grabbing capacity is enhanced in combination with the holding action; due to the design of adjustable holding distance, arm lengths of different patients can be accurately adapted, and it is ensured that a hand holding point is aligned with the axis of a shoulder and wrist joint during elbow joint flexion and extension training; muscle strength levels of different rehabilitation stages of a patient cannot be matched due to fixed training intensity, so that joint injury is caused by overlarge early load or muscle activation is delayed due to insufficient later load.

1. The name of the design product: muscle paste (water drop type). 2. The use of the design product: for human waist joint injury protection. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: design 1 front view. 5. The rear view of designs 1-3 is symmetrical with the front view, and the rear view of designs 1-3 is omitted; the design product is a thin product, and the left view, right view, top view and bottom view of designs 1-3 are omitted. 6. Design 1 is designated as the basic design.

The invention provides a breathable casual shoe imitating the shape of a human foot bone and a preparation method of the breathable casual shoe. The breathable casual shoe imitating the shape of the foot bone of the human body comprises a sole; the supporting bottom is arranged at the top of the sole and is used for increasing the supporting force of the sole; the vamp is sewn on the supporting bottom through a sewing line and is used for protecting the instep. According to the breathable casual shoe imitating the human foot bone shape and the preparation method thereof, the breathable holes are formed in the vamp to assist in breathability, air circulation is improved, stuffiness is reduced, the supporting bag is arranged at the top of the insole to be attached to the arch curve, plantar pressure is dispersed, arch fatigue is relieved, and the comfort level of the shoe is improved. The sole and heel support is intensified in a targeted manner by sticking the wear-resistant pad, so that the sole and heel support fits the human leg and foot bone form, pressure can be dispersed, impact force can be absorbed, joint injury can be reduced, and the service life can be prolonged.

In a first aspect, the present invention is related to lactic acid or a pharmaceutically acceptable salt thereof for use in the prevention and / or treatment of a musculoskeletal injury in a subject. In a second aspect, the present invention is related to an injectable composition for use in the treatment of a musculoskeletal injury in a subject characterized in that it comprises lactic acid or a pharmaceutically acceptable salt thereof and a suitable solvent. In a preferred embodiment, the musculoskeletal injury is selected from the group consisting of tendon injury, joint injury, cartilage injury and muscle injury.

The present disclosure provides biomaterials and methods for preventing and minimizing the progression of cartilage and / or connective tissue damage. Also provided herein are biomaterials and methods for mitigating and / or reducing the risk of developing arthritis (e.g., osteoarthritis) associated with joint injury and / or joint surgery.

The application discloses a composition for promoting joint health, a preparation method and application, and relates to the field of food.The composition comprises the following components in parts by weight: animal protein: 20-80; non-denatured type II collagen: 0.2-1; sodium hyaluronate: 0.5-2; proteoglycan: 0.5-2; sour cherry extract: 3-10; and calcium beta-hydroxy-beta-methylbutyrate: 5-20.The application takes non-denatured type II collagen as a main efficacy component, and additionally adds animal protein, sodium hyaluronate, proteoglycan, sour cherry extract and calcium beta-hydroxy-beta-methylbutyrate, synergistically acts through the multiple efficacy components, relieves joint discomfort through multiple pathways, maintains muscle health, and enables the product to have the optimal effect of repairing joint damage, improving joint and skeletal muscle health.

The present invention discloses a wearable stroke rehabilitation device based on flexible tactile sensation. A bionic artificial muscle and a sliding block are arranged on one side of the palm body, and a palm tactile massage ball is arranged on the other side. The bionic artificial muscle and the sliding block are spaced apart, and at least three bionic artificial muscles are arranged on the five fingers of the palm body. The palm body and the bionic upper limb are connected by a wrist rotating ring. An air power source supplies air to the bionic artificial muscle. The present invention uses a highly safe alcohol vapor drive device to promote the regeneration of nerve fiber endings through repeated self-training by the patient. The flexible bionic artificial pneumatic muscle drive prevents secondary joint damage, achieving rehabilitation while protecting the patient both physically and psychologically.

The application belongs to the technical field of microorganisms and particularly relates to application of heat-inactivated Bifidobacterium longum ZFML0012 in relieving rheumatoid arthritis. TNF-α 、 iNOS 、 IL-1β The mRNA expression level of the heat-inactivated Bifidobacterium longum ZFML0012 bacterial liquid can be lowered, and the mRNA expression level of the heat-inactivated Bifidobacterium longum ZFML0012 bacterial liquid can be raised. IL-10 The taxonomic name of the Bifidobacterium longum ZFML0012 is Bifidobacterium longum ( Bifidobacterium longum ) ZFML0012, and the preservation number is CCTCC NO: M 20252539. The heat-inactivated Bifidobacterium longum ZFML0012 bacterial liquid has anti-inflammatory activity on inflammation induced by lipopolysaccharide, and the heat-inactivated Bifidobacterium longum ZFML0012 bacterial liquid can improve joint injury and immune imbalance.

Disclosed in the present invention are a chondroitin sulfate biological polyamine compound, a preparation method therefor and use thereof. The present invention provides a chondroitin sulfate biological polyamine compound, which is a compound of chondroitin sulfate and biological polyamine. The chondroitin sulfate is non-covalently linked to the biological polyamine, and the biological polyamine comprises one, two, three or more of combinations of spermine, spermidine, putrescine and cadaverine. The chondroitin sulfate biological polyamine compound provided by the present invention has the anti-inflammatory activity remarkably superior to that of common chondroitin sulfate sodium, can be used in the prevention and treatment of inflammatory diseases, especially arthritis and joint damage, as well as the repair of bone tissues, and has the effects of reducing blood fat, anti-oxidation, slowing down aging, prolonging life span and the like.

The invention belongs to the technical field of bridge hinge joint damage detection, and discloses a hinge joint damage identification and detection method based on ensemble learning and deep clustering, and the specific technical scheme is as follows: obtaining a displacement time sequence of downwarping of hollow slabs at two sides of a hinge joint, calculating a displacement difference of downwarping at two sides of each hinge joint, and obtaining a displacement difference sequence; carrying out anomaly detection on the displacement difference sequence, distinguishing anomaly types, executing corresponding anomaly correction processing, dividing a down-warping displacement time sequence into subsequences, capturing time characteristics of the sequences, judging the damage degree of the hinge joint, and identifying the damage degree of the hinge joint by utilizing a clustering analysis method based on division and a clustering analysis method based on hierarchy; according to the method, an integrated classifier is constructed, model evaluation is carried out on sequence data sets before and after clustering, weighted voting operation is carried out on a prediction result of each basic classifier, the accuracy and reliability of hollow slab girder bridge hinge joint damage detection are improved, and powerful technical support is provided for bridge health monitoring and maintenance decision making.

The application provides a collagen composite material for joint injury repair and a preparation method and application thereof, wherein the collagen composite material comprises collagen and chitosan; the chitosan is water-soluble chitosan which is treated by one or more than two ways of carboxylation, hydroxylation, phosphatization and quaternary ammonium saltization; and the weight ratio of the collagen to the water-soluble chitosan is 1:15-1:3. The application adopts scientific screening of the composition and ratio of the collagen and the water-soluble chitosan, forms the collagen composite material which is more close to natural joint fluid in composition, provides physical blocking inflammatory factors and lubrication for the cartilage gap by the water-soluble chitosan, and the collagen has a porous structure, is more conducive to the adhesion and nutrition acquisition of chondrocytes, promotes chondrocyte proliferation and realizes the repair of damaged cartilage.

The external medicinal liquor is prepared from the following components in parts by weight: 10 to 28 parts of rhizoma sparganii, 10 to 25 parts of rhizoma curcumae, 10 to 30 parts of sappan wood, 10 to 20 parts of radix dipsaci asperoidis, 10 to 22 parts of native copper, 10 to 26 parts of herba lycopi, 10 to 25 parts of cortex eucommiae, 10 to 27 parts of rhizoma drynariae, 10 to 23 parts of ground beetle, 10 to 32 parts of radix gentianae macrophyllae, 10 to 40 parts of radix notoginseng, 10 to 30 parts of rhizoma chuanxiong, 10 to 22 parts of radix angelicae lateralis preparata, 10 to 25 parts of flos carthami, 10 to 20 parts of amber, 10 to 50 parts of radix achyranthis bidentatae and 10 to 36 parts of dragon's blood. A plurality of traditional Chinese medicinal materials are scientifically combined, and the raw materials form a synergistic effect in a specific weight part range, so that the problem of blood stasis can be improved, and the repair of injured tissues can be promoted; the raw materials are strictly and normatively pretreated in the preparation process, and plant medicinal materials are selected, cleaned and dried at low temperature, so that effective components are prevented from being lost due to high temperature; the traditional Chinese medicine composition can be correspondingly selected for slight sprain, muscle strain, severe blood stasis swelling and pain and joint injury, is externally applied, sprayed or applied and does not need to be orally taken.

A kind of flexion-extension mechanism for rotating center adaptive hip exoskeleton, adaptive elastic module is slidably connected on L-shaped support module, thigh lever swing module is fixedly connected on L-shaped support module;In the adaptive elastic module, two symmetrical stand column pipes are equipped on the front surface of fixed platform, two through holes are opened on the side surface of stand column pipe, through hole is opened in adaptive rod middle, round pipe is installed at both ends, two through holes are opened on the side surface of round pipe;Four hook springs are respectively connected with one end of fixed platform stand column pipe hole, and the other end is connected with adaptive rod round pipe hole;The back surface of fixed platform is equipped with convex shaft, convex shaft can slide on the L-shaped support module, convex shaft terminal is equipped with locking nut, and fixed platform can be fixed using locking nut.There is provided a kind of rotating center adaptive hip exoskeleton.The present application has the advantages of compact structure, wearing comfort, suitable for multi-position rehabilitation training, etc., and can provide three free rehabilitation training for patients with hip joint damage.

The present invention primarily relates to a combination agent for reducing appetite and / or for providing a feeling of satiety and / or for reducing energy intake and / or for reducing body weight. In addition, the present invention relates to a medical use of the combination agent, in particular for the treatment of overweight and obesity and for the prevention of cardiovascular disease, stroke, diabetes, and joint damage and wear of the spine, and to a non-therapeutic use of the combination agent. In particular, the focus of the present invention is on the use of the combination agent to provide a feeling of satiety and / or to reduce energy intake and / or to reduce body weight. Finally, the present invention relates to the use of the combination agent for the preparation of an orally consumable preparation or food ingredient and an orally consumable preparation or food ingredient prepared therefrom.

The present invention belongs to the field of medical technology, and specifically relates to the use of corydaline or a pharmaceutically acceptable salt thereof in the preparation of a medicament for treating rheumatoid arthritis. Experimental results show that corydaline can effectively alleviate the level of paw swelling in CIA rats, reduce arthritis scores, and inhibit the progression of rheumatoid arthritis. Routine blood analysis shows that administration of corydaline reduces the number of immune cells in the blood and weakens the body's immune level. In addition, experimental results also show that corydaline can inhibit synovial hyperplasia and alleviate joint damage. Therefore, corydaline has the prospect of being developed into an oral medication for treating rheumatoid arthritis, providing more treatment options for the clinical treatment of rheumatoid arthritis, and has important social benefits and economic value.

Whole blood is mixed with one or more coagulating agents to yield a coagulating blood that is then introduced into a site of bone or join injury or disease and permitted to coagulate in said site. The purpose is to facilitates healing or amelioration of a disease, disorder or injury at said site. For example, healing and regeneration of damaged bones, damaged joints, cartilage lesions, etc.

The application discloses a traditional Chinese medicine composition for nourishing blood and regulating marrow and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. In view of the defects of hemophilia arthritis treatment in western medicine, such as inhibitor production, frequent injection, high cost and unknown safety of gene therapy, the application provides a traditional Chinese medicine composition for nourishing blood and regulating marrow. Through the synergistic effect of eight Chinese herbal medicine materials, namely, herba agrimoniae, panax notoginseng, poria cocos, bletilla striata, cornus officinalis, angelica sinensis, radix clematidis and radix paeoniae alba, the traditional Chinese medicine composition can achieve the effects of kidney-tonifying, marrow-regulating and yin-yang balancing, can promote the generation of bone marrow hematopoietic materials, and can improve joint microcirculation through blood-nourishing and blood-stasis-removing, so as to repair hemophilia joint damage. The traditional Chinese medicine composition integrates three links of kidney-tonifying, blood-nourishing and meridian-dredging, is suitable for the pathogenesis of marrow deficiency and blood stasis of hemophilia arthritis, provides a new treatment scheme for the treatment of hemophilia arthritis, and the treatment effect of the traditional Chinese medicine composition on hemophilia arthritis is proved through clinical experiments.

The application belongs to the technical field of health food, and provides a composition for improving osteoarthritis and increasing bone density and application thereof.The composition comprises, in terms of weight fraction, 1-600 parts of eggshell membrane, 1-80 parts of non-denatured type II collagen, 1-900 parts of mangosteen fruit powder and 1-1000 parts of sophora fruit powder.The composition of the application has reasonable compatibility, and each component has clear efficacy, and has remarkable effect in improving bone and joint damage, such as improving osteoarthritis and increasing bone density.