25 results about "Joint damage" patented technology

The present application belongs to the technical field of medicine, and particularly relates to the use of tetrahydrojatrorrhizine or a pharmaceutically acceptable salt thereof in the preparation of a medicament for treating rheumatoid arthritis. Experimental results show that tetrahydrojatrorrhizine can effectively alleviate the foot swelling level of CIA rats, reduce the arthritis score, and inhibit the progression of rheumatoid arthritis. Blood routine analysis shows that the administration of tetrahydrojatrorrhizine reduces the number of immune cells in the blood and weakens the immune level of the body. In addition, the experimental results also show that tetrahydrojatrorrhizine can inhibit synovial hyperplasia and relieve joint damage. Therefore, tetrahydrojatrorrhizine has the prospect of being developed into an oral medicament for treating rheumatoid arthritis, provides more treatment options for clinically treating rheumatoid arthritis, and has important social and economic values.

The application provides a composition containing curcuma and type II collagen-containing cartilage powder and application thereof in joint maintenance, and relates to the field of food technology. The application provides a composition containing milk mineral salt, curcuma, type II collagen-containing cartilage powder, enzymatic bone powder, N-acetyl glucosamine and black pepper extract, which can significantly repair joint damage, significantly reduce cartilage damage indexes such as CTX-II and COMP, and can be used for preparing a joint maintenance medicine.

The present invention relates to a hydrogel composition for intra-articular administration, which is easily injected into the human body, and use thereof for supplementing joint synovial fluid, supplementing viscosity, and preventing or treating intra-articular lesions. The hydrogel composition according to the present invention can improve the gelation temperature, viscosity, biodegradability, and tissue support capability of hyaluronic acid and, at the same time, can improve practitioner convenience and patient compliance due to the reduced injection pressure thereof. In addition, the hydrogel composition can increase the effect of ameliorating intra-articular lesions when co-administered with stem cells or exosomes, and thus can have various applications in medical devices and pharmaceutical fields for the purpose of cartilage regeneration and intra-articular lesion treatment.

The application discloses a joint cavity filling preparation of precisely proportioned carboxymethyl chitosan and sodium glycerophosphate and a preparation method and application thereof, and the effective component of the filling preparation is carboxymethyl chitosan with a concentration of 25 mg / mL and sodium glycerophosphate with a concentration of 15 mg / mL, and the balance is a sterile isotonic physiological buffer aqueous solution. The application forms component synergy by relying on the lubrication and long-acting stability characteristics of carboxymethyl chitosan and combining the structure reinforcement, ion regulation and cartilage repair promoting characteristics of sodium glycerophosphate, and effectively solves the defects of short in-vivo retention time, poor mechanical stability, lack of biological repair activity and easy dilution and collapse of the traditional joint filling material in the joint cavity fluid. The application overcomes the problem that a high-concentration viscous solution cannot be filtered and sterilized, can effectively buffer the joint mechanical load, optimize the joint microenvironment and promote the repair of degenerative cartilage, is suitable for clinical scenes such as mild and moderate osteoarthritis, sports joint injury and postoperative joint function repair, and has good clinical application value and industrialization prospect.

The application discloses a kind of food relieving bone joint damage evaluation method, it is related to food efficacy evaluation technical field, for solving the problem of single dimension of existing evaluation method, unstable model leads to poor reliability of conclusion.The application builds composite modeling and multi-modal analysis mechanism, first, a stable animal model is established by using chemical injury combined with forced exercise training, a two-stage increasing dosing regimen is set, and behavior dynamic trend data and histology, imaging multi-modal results are collected synchronously.Then, based on the weight assigned to osteoarthritis stage, a weighted composite score is generated, and a perturbation sensitivity index is calculated, a multi-index collaborative influence map is constructed, a key evaluation node is located, a graded evaluation conclusion is generated based on the food action characteristics and efficacy determination threshold, and false positives caused by single index fluctuations are avoided.Finally, a full-cycle closed-loop evaluation process is formed, which improves the scientificity, reproducibility and self-adaptive ability of efficacy determination in complex biological systems.

The invention relates to the technical field of functional food, in particular to an electrolyte composition beneficial to joint injury repair after exercise and a preparation method of the electrolyte composition. The electrolyte composition is mainly prepared from the following raw materials in parts by mass: 0.1 to 2 percent of N-acetylglucosamine, 0.05 to 0.5 percent of cartilage extract, 0.05 to 0.5 percent of enzymolysis bone meal, 0.01 to 0.05 percent of milk mineral salt, 0.1 to 1 percent of collagen peptide, 0.01 to 0.3 percent of vitamin and 0.03 to 0.3 percent of electrolyte. The nano hydrated milk mineral salt is adopted, the absorption efficiency of elements such as calcium and phosphorus in a body is improved, and the electrolyte composition is prepared by combining components such as N-acetylglucosamine and the cartilage extract, so that joint inflammation and cartilage injury caused by exercise are effectively improved while water and electrolyte are supplemented, and the activity of joints and exercises is improved. The electrolyte composition is good in taste, high in stability and suitable for joint protection and nutrition supplement after exercise.

The invention discloses a small-molecule chondroitin sulfate group effect compound for interventional treatment of joint inflammation and application, relates to the technical field of joint inflammation improvement, and aims to solve the problems that small-molecule chondroitin sulfate obtained by an existing single degradation method is single in action way and difficult to comprehensively cope with the complex pathological process of joint inflammation. The composition is composed of an oxidative degradation product LMCSO, an acid degradation product LMCSA and an alkali degradation product LMCSB according to the weight ratio of 6: 3: 1, the number-average molecular weight of the three products is smaller than 10 kDa, and the composition is prepared through specific oxidative degradation, acid degradation and microwave-assisted alkali degradation methods containing a phase transfer catalyst. The small-molecular chondroitin sulfate combined-effect compound can be used for preparing medicines beneficial to repairing bone joint injuries and relieving arthralgia or stiffness.

The invention relates to the technical field of specific therapeutic activity of pharmaceutical preparations, in particular to a PRP administration concentration evaluation method for joint movement injury repair, which comprises the following steps: obtaining an inflammation comprehensive repair expression according to the change condition of multiple C-reactive protein levels before the last PRP administration; according to the change condition of the joint swelling degree in a time period between two adjacent C-reactive protein levels, joint swelling repair characteristics are obtained; determining the change correlation between the arthrocele repair characteristics and the C-reactive protein level, and combining the arthrocele repair characteristics and the inflammation comprehensive repair expression to obtain comprehensive repair effect characteristics; obtaining hormone level deviation characteristics according to multiple abnormal conditions of cortisol hormone levels; according to the comprehensive repair effect characteristics and the hormone level deviation characteristics, the next PRP administration concentration is adjusted, the accuracy and reliability of determining the PRP administration concentration are effectively improved, and therefore the overall effect of joint injury repair is improved.

The present disclosure provides biomaterials and methods for preventing and minimizing progression of cartilage and / or connective tissue damage. Also provided herein are biomaterials and methods for alleviating and / or reducing the risk for developing arthritis (e.g., osteoarthritis) associated with joint injury and / or joint surgery.

The utility model discloses an orthopedic joint rehabilitation training device, which is applied to the technical field of medical instruments and can effectively improve the movement range of elbow joints, enhance the coordination of elbow and forearm muscles and promote blood circulation around the joints through controllable bending and unbending actions. Joint stiffness and soft tissue adhesion can be prevented through regular movement, and meanwhile the hand grabbing capacity is enhanced in combination with the holding action; due to the design of adjustable holding distance, arm lengths of different patients can be accurately adapted, and it is ensured that a hand holding point is aligned with the axis of a shoulder and wrist joint during elbow joint flexion and extension training; muscle strength levels of different rehabilitation stages of a patient cannot be matched due to fixed training intensity, so that joint injury is caused by overlarge early load or muscle activation is delayed due to insufficient later load.

1. The name of the design product: muscle paste (water drop type). 2. The use of the design product: for human waist joint injury protection. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: design 1 front view. 5. The rear view of designs 1-3 is symmetrical with the front view, and the rear view of designs 1-3 is omitted; the design product is a thin product, and the left view, right view, top view and bottom view of designs 1-3 are omitted. 6. Design 1 is designated as the basic design.

The invention provides a breathable casual shoe imitating the shape of a human foot bone and a preparation method of the breathable casual shoe. The breathable casual shoe imitating the shape of the foot bone of the human body comprises a sole; the supporting bottom is arranged at the top of the sole and is used for increasing the supporting force of the sole; the vamp is sewn on the supporting bottom through a sewing line and is used for protecting the instep. According to the breathable casual shoe imitating the human foot bone shape and the preparation method thereof, the breathable holes are formed in the vamp to assist in breathability, air circulation is improved, stuffiness is reduced, the supporting bag is arranged at the top of the insole to be attached to the arch curve, plantar pressure is dispersed, arch fatigue is relieved, and the comfort level of the shoe is improved. The sole and heel support is intensified in a targeted manner by sticking the wear-resistant pad, so that the sole and heel support fits the human leg and foot bone form, pressure can be dispersed, impact force can be absorbed, joint injury can be reduced, and the service life can be prolonged.

The application belongs to the technical field of microorganisms and particularly relates to application of heat-inactivated Bifidobacterium longum ZFML0012 in relieving rheumatoid arthritis. TNF-α 、 iNOS 、 IL-1β The mRNA expression level of the heat-inactivated Bifidobacterium longum ZFML0012 bacterial liquid can be lowered, and the mRNA expression level of the heat-inactivated Bifidobacterium longum ZFML0012 bacterial liquid can be raised. IL-10 The taxonomic name of the Bifidobacterium longum ZFML0012 is Bifidobacterium longum ( Bifidobacterium longum ) ZFML0012, and the preservation number is CCTCC NO: M 20252539. The heat-inactivated Bifidobacterium longum ZFML0012 bacterial liquid has anti-inflammatory activity on inflammation induced by lipopolysaccharide, and the heat-inactivated Bifidobacterium longum ZFML0012 bacterial liquid can improve joint injury and immune imbalance.

The present invention primarily relates to a combination agent for reducing appetite and / or for providing a feeling of satiety and / or for reducing energy intake and / or for reducing body weight. In addition, the present invention relates to a medical use of the combination agent, in particular for the treatment of overweight and obesity and for the prevention of cardiovascular disease, stroke, diabetes, and joint damage and wear of the spine, and to a non-therapeutic use of the combination agent. In particular, the focus of the present invention is on the use of the combination agent to provide a feeling of satiety and / or to reduce energy intake and / or to reduce body weight. Finally, the present invention relates to the use of the combination agent for the preparation of an orally consumable preparation or food ingredient and an orally consumable preparation or food ingredient prepared therefrom.

Whole blood is mixed with one or more coagulating agents to yield a coagulating blood that is then introduced into a site of bone or join injury or disease and permitted to coagulate in said site. The purpose is to facilitates healing or amelioration of a disease, disorder or injury at said site. For example, healing and regeneration of damaged bones, damaged joints, cartilage lesions, etc.

The application belongs to the technical field of health food, and provides a composition for improving osteoarthritis and increasing bone density and application thereof.The composition comprises, in terms of weight fraction, 1-600 parts of eggshell membrane, 1-80 parts of non-denatured type II collagen, 1-900 parts of mangosteen fruit powder and 1-1000 parts of sophora fruit powder.The composition of the application has reasonable compatibility, and each component has clear efficacy, and has remarkable effect in improving bone and joint damage, such as improving osteoarthritis and increasing bone density.

The invention relates to the technical field of health food, in particular to a composite bioactive peptide composition for improving joint injury and a preparation method thereof, and the composition comprises the following raw materials: yak bone oligopeptide, yak bone marrow, whole milk, bovine brain peptide, hyaluronic acid, tea polyphenol and a sweetening agent.

The present invention provides new protease resistant polypeptides, as well as compositions and methods for treating, ameliorating or preventing conditions related to joint damage, including acute joint injury and arthritis.

This invention discloses a non-denatured cartilage nutrient ultrafine powder with joint injury repair and inflammation suppression effects, its preparation method, and its applications, relating to the fields of joint repair and medical and health care technology. The non-denatured cartilage nutrient ultrafine powder comprises the following raw materials in the indicated mass fractions: 35-50% functionalized non-denatured cartilage micropowder, 10-20% oligochitosan, 5-10% chondroitin sulfate, 5-10% glucosamine, 3-8% calcium supplement, and the remainder being excipients. The surface of the functionalized non-denatured cartilage micropowder is coated with modified hyaluronic acid, and the core layer includes plant glycogen-curcumin nanoparticles and composite particles of non-denatured cartilage micropowder. The modified hyaluronic acid contains thioether bonds. The non-denatured cartilage micropowder can effectively retain bioactive substances, providing a comprehensive nutritional substrate. The stability of curcumin after encapsulation is also improved, and the outer coating with modified hyaluronic acid can enhance targeting, enabling a highly efficient treatment step of first reducing inflammation and then repairing.

The invention relates to the technical field of medicines, in particular to application of mulberry total flavonoids in preparation of a preparation for treating rheumatoid arthritis. The medicine mulberry total flavonoids have definite anti-inflammatory and protective effects on the histology level. After intervention of the medicine mulberry general flavone, the autophagy function of the synovial cells can be recovered. The medicine mulberry general flavone can also be used for synchronously down-regulating the expression of p-PI3K, p-AKT and p-mTOR, up-regulating Beclin-1 and LC3-II, and remarkably reducing the levels of TNF-alpha, IL-6 and IL-17 in serum. Therefore, the medicine mulberry general flavone can restore autophagy activity and relieve synovitis and joint injury by inhibiting a PI3K / AKT / mTOR axis.

The invention provides a rheumatoid arthritis assessment method, a rheumatoid arthritis assessment device, a computer readable medium and electronic equipment, and relates to the technical field of image processing. The method comprises the following steps: acquiring a tongue image and clinical data corresponding to a patient; performing target task learning based on the tongue body image and the clinical data, and constructing a rheumatoid arthritis assessment model; and inputting the to-be-detected tongue image and the to-be-detected clinical data of the to-be-detected patient into the rheumatoid arthritis evaluation model, and outputting the rheumatoid arthritis course corresponding to the to-be-detected patient. According to the method, the model is constructed through the obtained tongue body image of the patient and the clinical data, and the core tongue body features of traditional Chinese medicine tongue diagnosis are combined with the objective clinical data, so that the objectivity of RA disease course evaluation is improved; according to the method, assessment is carried out through the constructed rheumatoid arthritis assessment model, the illness state of the to-be-detected patient can be accurately reflected, a reliable diagnosis and treatment basis is provided for clinicians, and then the joint damage risk caused by inaccurate assessment is reduced.

A bone fixation apparatus is used in the treatment of bone and joint damage as well as the correction of skeletal deformities with an externally applied device that provides stabilization of damaged limbs. The bone fixation apparatus provides the operator with the speed and ease of application during the procedure, as well as the opportunity to continue the daily life of the applied living thing without any difficulty with the help of its geometric structure.