190 results about "Joint cavity" patented technology

The present invention relates to a method and a device for alleviating and / or preventing conditions relating to damaged joints involving articulating surfaces. In a first aspect the present invention relates to a prosthetic device for insertion into a joint cavity of a joint of a vertebrate, such as a human, said device consisting of a biocompatible material comprising at least a first polymeric component and a second polymeric component, wherein the chain length of the first polymeric component is longer than the chain length of the second polymeric component, the polymeric components in particular being polyethylene, polypropylene and / or polyvinylpyrrolidone. A further aspect of invention relates to a method for introducing the prosthetic device into a joint, such as a method comprising locking the device to an intro-articular component, thereby fixing or retaining the device in the joint cavity in a manner which is substantially non-invasive with respect to cartilage and bone natively present in the joint cavity. Also the invention relates to an instrument for inserting a prosthetic device according to the invention, comprising means for deforming the prosthetic device into a reduced volume or a slender shape and means for grasping the intra-articular component to which the device is capable of interlocking.

The present invention relates to a method and a device for alleviating and / or preventing conditions relating to damaged joints involving articulating surfaces. In a first aspect the present invention relates to a prosthetic device for insertion into a joint cavity of a joint of a vertebrate, such as a human, said device consisting of a biocompatible material comprising at least a first polymeric component and a second polymeric component, wherein the chain length of the first polymeric component is longer than the chain length of the second polymeric component, the polymeric components in particular being polyethylene, polypropylene and / or polyvinylpyrrolidone. The device may be used for establishing slidability and / or distributing pressure in a joint of a vertebrate such as a human, by inserting into the joint cavity of the joint a prosthetic device, preferably a prosthetic device as defined in this invention, capable of locking itself to an intra-articular component and thereby being fixed or retained in the joint cavity in a manner which is substantially non-invasive with respect to cartilage and bone natively present in the joint cavity. The device may be formed by moulding, whereby it is possible to adapt the form of the device to the joint needing alleviation. Also the device may be formed with a hole or a slit to fit into the joint and lock the device around intra-articular components. A further aspect of invention relates to a method for introducing the prosthetic device into a joint, such as a method comprising locking the device to an intro-articular component, thereby fixing or retaining the device in the joint cavity in a manner which is substantially non-invasive with respect to cartilage and bone natively present in the joint cavity. Also the invention relates to an instrument for inserting a prosthetic device according to the invention, comprising means for deforming the prosthetic device into a reduced volume or a slender shape and means for grasping the intra-articular component to which the device is capable of interlocking.

A vent valve for use in a constant velocity joint having a vent aperture in communication with a joint chamber comprises a body having a first end and a second end and at least one flat extending therebetween; and an umbrella shaped flexible retention cap disposed adjacent the first end of the body and the at least one flat. The retention cap is operative in a normally closed position to cover the at least one flat and seal the joint from external contaminants, and in response to internal pressure created in the joint cavity, functions to bellow outward and expose the at least one flat to permit air to escape from the chamber. The at least one flat includes a straight-line vent to clean the grease off and away from the vent valve. The vent valve can be made from single or multiple materials, having porous and non-porous properties.

The invention provides a cell preparation for treating osteoarthritis and a preparation method thereof. The cell preparation mainly comprises mesenchymal stem cells, differentiation-induced stem cells, platelet-rich plasma and dispersion media thereof. Compared with the prior art, the cell preparation for treating osteoarthritis has the advantages that the mesenchymal stem cells are mixed with the differentiation-induced stem cells and compounded with the platelet-rich plasma and can be dispersed in the joint cavity, so that the immune regulation function of the mesenchymal stem cells can be exerted, the microenvironment of the whole joint cavity can be improved, and inflammation remission and injury repair are facilitated; tissues can be repaired after the differentiated mesenchymal stem cells are implanted into the body, so that the repair process is shortened.

The present invention provides a safe hyaluronic acid base material that is suitable for use in practical hyaluronic acid pharmaceutical preparations capable of distribution at room temperature and having such a low viscosity that injection is easy. The hyaluronic acid pharmaceutical preparations can reside in a joint cavity for a prolonged period of time while exhibiting analgesic effects. More specfically, there is provide a hyaluronic acid modification product in which hyaluronic acid and / or a pharmaceutically acceptable salt thereof is bounded to a block polymer selected from PEO-PPO-PEO, PPO-PEO-PPO, PEO-PLGA-PEO, PLGA-PEO-PLGA, PEO-PLA-PEO and PLA-PEO-PLA. The hyaluronic acid modification product, despite capability of distribution at room temperature and ease in handling because of the low viscosity, can have its viscoelasticity rapidly increased after injection into a living body, so that it is highly useful in treatment of joint diseases, aid in surgical operation, repair of tissue, etc. as a main ingredient of novel and practical hyaluronic acid pharmaceutical preparations.

The present invention includes methods of bonding two or more components to form a unitary article. The methods involve placing the components in their final assembled position to create a joint cavity, filling the cavity with an adhesive, and curing the adhesive so that it can be handled without dissociating the components. The invention also relates to articles formed by the disclosed methods.

The present invention provides a safe hyaluronic acid base material that is suitable for use in practical hyaluronic acid pharmaceutical preparations capable of distribution at room temperature and having such a low viscosity that injection is easy. The hyaluronic acid pharmaceutical preparations can reside in a joint cavity for a prolonged period of time while exhibiting analgesic effects. More specfically, there is provide a hyaluronic acid modification product in which hyaluronic acid and / or a pharmaceutically acceptable salt thereof is bounded to a block polymer selected from PEO-PPO-PEO, PPO-PEO-PPO, PEO-PLGA-PEO, PLGA-PEO-PLGA, PEO-PLA-PEO and PLA-PEO-PLA. The hyaluronic acid modification product, despite capability of distribution at room temperature and ease in handling because of the low viscosity, can have its viscoelasticity rapidly increased after injection into a living body, so that it is highly useful in treatment of joint diseases, aid in surgical operation, repair of tissue, etc. as a main ingredient of novel and practical hyaluronic acid pharmaceutical preparations.

The invention discloses a method for testing the interface shear resistant strength of the sample bonded by sealant and base material. The method comprises: forming the base material into to T-shaped samples with a joint cavity of a certain size reserved therebetween; filling sealant to bond the base material and the sealant into an integral bonded sample body; maintaining in the environment with temperature of 20+ / -2 degrees centigrade and relative humidity of 65+ / -5% for 28 days; fixing the two ends of the sample in the chucks; connecting two ends of the chuck respectively with a pulling force machine; running the pulling force machine in 5mm / min to pull the bonded base material to opposite directions untile the sealant and the base material are detached completely; defining the maximum pulling force value as the shearing force value of the interface of sealant and base material; and obtaining the shearing strength by dividing the shearing force by the shear area. The method can be used for test the interface shear resistant strength of the sample bonded by sealant and base material, achieves the advantages of simple operation and convenient using, need not adding other equipments, is convenient for popularization; it can test the shearing strength of any composite material structure, has good instructiveness to engineering practice.

Disclosed herein are systems and methods for securing a glenoid baseplate to a resected glenoid cavity in a preoperatively planned position. Image information obtained from the glenoid cavity and surrounding scapula is analyzed to determine the location of optimal bone stock. A guide is designed based on the image information, the guide having a patient specific contact surface that contacts a surface of the bone in a preoperatively planned position. The guide is designed to have a cannulated portion including a specific length. A marking pin having at least one reference feature is drilled into the glenoid cavity. The length of the cannulated portion of the guide is based on a location of the at least one reference feature on an outer surface of the marking pin. A cannulated reamer guided by the marking pin is then used to resect the glenoid cavity until a stop surface of the cannulated reamer contacts an end of the marking pin.

The invention relates to a knee joint anterior and posterior cruciate ligament femoral tunnel positioner. The positioner comprises a hook body, wherein the hook head of the hook body extends in the knee joint cavity and points to the anterior and posterior cruciate ligament femoral insertion; the long stem of the hook head is upward and above the front of the femur of knee joint and is connected with an arc chute which is arranged laterally; a curved lever which can slide relatively to the arc chute is embedded in the arc chute; and the movable end of the curved lever is provided with a drillstem guide sleeve which directly points to the tip of the ligament hook head. By adopting the positioner of the invention, the problem that the previous arthroscope can perform observation only through the lateral approach and the visual blind area is caused, can be solved; and the reconstruction of femoral tunnel can be better performed from the physical point of the ligament, thus the reconstruction of femoral tunnel in clinic has higher repeatability and operability, the accuracy degree of operations is greatly increased, the operating time is reduced, and the positioner has great use value and wide market space.

This preparation set comprises a drill guide (31) comprising a bearing surface (33) intended to bear against a glenoid cavity, a passage orifice (35) intended for the passage of a guide pin (36) implanted in the glenoid cavity, and first and second guide orifices (37, 38) each opening into the bearing surface (33) and each intended to guide a drill bit (38) capable of realizing a bone bore in the glenoid cavity, the first and second guide orifices (37, 38) being inclined with respect to the extension axis of the passage orifice (35) and converging in the direction of the bearing surface (33); and a compactor (42) comprising a compaction portion (45) having a generally trapezoidal shape and intended to be impacted against the glenoid cavity so as to form a bone housing in the glenoid cavity, the compactor (42) further including a passage hole (49) extending at least partially in the compaction portion (45) and intended for the passage of the guide pin (36) implanted in the glenoid cavity.

A method for displaying, in the field of medical technology, an orientation of an object on a ball joint, includes: defining a zero angle projecting out of a joint cavity on the ball joint, wherein directions are defined as anatomical directions; defining a preferred direction of the object, wherein the preferred direction is to be oriented in relation to the zero angle; and graphically displaying the object orientation, wherein a deviation between the preferred direction and the zero angle is displayed as a magnitude, and the relative orientation between the preferred direction and at least one anatomical direction is displayed as a circumferential representation having a proportional value corresponding to the at least one anatomical direction.

The invention provides a xanthan-gum-containing pharmaceutical preparation for joint intracavity injection, which is characterized by containing xanthan gum. In the preparation, xanthan gum used as a pharmaceutical component for joint cavity injection has the advantages of favorable viscoelasticity and favorable lubricating property, has particular thixotropy, can be used as an excellent pharmaceutical release-control carrier, and can act in the joint cavity for a long time. The pharmaceutical preparation can improve and treat rheumatism, rheumatoid arthritis, osteoarthritis, synovitis and / or cartilage injury, and effectively relieve pain of patients.

A tool for scrubbing, removing tissue from the medullary cavity or joint cavity of a bone or removing cartilage and / or cortical bone from a joint cavity has a proximal end, a distal end, and a cannula extending therethrough. The distal end includes at least one scraping surface and / or cutting surface to soften marrow in the medullary cavity or joint cavity as the scraping and / or cutting surface(s) are rotated or otherwise moved relative to the medullary cavity or joint cavity. When used, the tool may be attached to a drill and the cannula receives a K-wire previously inserted into the medullary or joint cavity. The drill rotates the tool around the K-wire and pushes the tool over the K-wire into the medullary cavity or joint cavity.

A vent valve for use in a constant velocity joint having a vent aperture in communication with a joint chamber comprises a body having a first end and a second end and at least one flat extending therebetween; and an umbrella shaped flexible retention cap disposed adjacent the first end of the body and the at least one flat. The retention cap is operative in a normally closed position to cover the at least one flat and seal the joint from external contaminants, and in response to internal pressure created in the joint cavity, functions to bellow outward and expose the at least one flat to permit air to escape from the chamber. The at least one flat includes a straight-line vent to clean the grease off and away from the vent valve. The vent valve can be made from single or multiple materials, having porous and non-porous properties.

A cartilage fragment removal device and method permits the removal of articular cartilage fragments, without undue risk of harm to the healthy cartilage surface. The device consists of a brush attachment located at the end of a shaft, which shaft is in turn coupled to a drive mechanism. The drive mechanism imparts a desired brushing motion to the brush attachment, the bristles of which are brought into contact with the articular cartilage fragment during an arthroscopic procedure so as to cause the fragment's removal. The removed fragment is then suctioned from the joint cavity, preferably using a suction tube that is integral to the cartilage fragment removal device.

The present invention includes methods of bonding two or more components to form a unitary article. The methods involve placing the components in their final assembled position to create a joint cavity, filling the cavity with an adhesive, and curing the adhesive so that it can be handled without dissociating the components. The invention also relates to articles formed by the disclosed methods.

An apparatus for in vivo intracellular transfection of gene, siRNA, shRNA vectors, and other biomedical diagnostic and therapeutic drugs and molecules for the treatment of arthritis and other orthopedic diseases in large animals and humans includes: a source of low voltage, short duration pulses in long duration bursts (LSEN); an electrode mesh system coupled to the source for generating distributed electric field network into a joint, including bones, cartilages, and related tissues; and means for transfecting the gene, siRNA, shRNA vectors, and other biomedical diagnostic and therapeutic drugs and molecules into a joint. The electrode mesh system includes alternatively arranged negative and positive electrodes in a first array which is capable of being inserted into a joint cavity, and either an alternatively arranged negative and positive or an all negative second electrode array which is positioned outside of the joint and in directly contact with overlying skin.

The invention provides a stem cell injection for treating osteoarthritis cartilage defect and preparation and application thereof. The injection comprises fifth-generation umbilical cord mesenchymal stem cells and a liquid solvent, wherein the fifth generation umbilical cord mesenchymal stem cells are suspended in the liquid solvent, and the concentration is (2.0-3.0)x10<7> cells / 4.5-5.0ml of the liquid solvent. The liquid solvent is normal saline, or autologous platelet-rich plasma, or a mixed solution of normal saline and human albumin, or a mixed solution of normal saline and autologous platelet-rich plasma. The human albumin accounts for 5-8% in volume by percentage. The normal saline accounts for 10% or below in volume by percentage. The injection is administered by intravenous injection or bone joint cavity local injection or the combination of the two, the cell injection amount of the intravenous injection is (1.0-1.5)x10<8> cells / one time, and the cell injection amount of the bone joint cavity injection is (2.0-3.0)x10<7> cells / one time / one knee. The effect of the stem cell injection for treating the integrity degree of osteoarthritis cartilage is obviously superior to that of a traditional hyaluronic acid (HA) method.

The invention discloses a minimally invasive collective integral acupotomy scope, which comprises a light microscope assembly of a scope-acupotomy integral body, a tube core assembly of the scope-acupotomy integral body and a hard sleeve assembly of the scope-acupotomy integral body. The light microscope assembly of the scope-acupotomy integral body comprises a lens, a lens base and a light guide tube. The tube core assembly of the scope-acupotomy integral body comprises a knife tube core. The hard sleeve assembly of the scope-acupotomy integral body comprises a knife tube. The light guide tube is inserted in the knife tube core. The knife tube core is inserted in the knife tube. An operation method of the minimally invasive collective integral acupotomy scope disclosed by the invention comprises the following steps of: (1) holding the acupotomy scope, and inserting the acupotomy scope into a knee joint through front external approach; (2) opening a water inlet channel to full a joint cavity; and (3) sequentially searching suprapatellar bursa, patellofemoral joint, internal tibia clearance, fossa intercondyloidea, external tibia clearance, knee lateralis sulci, rear internal clearance and rear external clearance, wherein the scope surface angle of the whole acupotomy scope is correspondingly adjusted according to searched specific parts in the searching process.

The invention discloses a power supply connector component, which consists of a plug connector (1) and a socket connector (2) which are mutually matched, wherein the plug connector comprises a plug insulating body (11) and a male terminal set (12) which is assembled on the plug insulating body; the socket connector comprises a socket insulating body (21) and a female terminal set (22) which is assembled on the socket insulating body; the front part of a socket of the plug insulating body is inserted in an abut-joint cavity (215) of the socket insulating body; a positioning rib (118) on the front part of the plug insulating body is higher than an opposite wall surface so as to form a height fall; and the inner side, not playing a role in guidance, of a guide post (1111) of the plug insulating body is concave, and clearances are reserved between ribs (218) on the top wall of the abut-joint cavity of the plug insulating body. The structures ensure that matching parts of the plug insulating body and the socket insulating body form convection channels to dissipate heat generated by high-voltage and high-current electricity transmitted in the terminal.

The invention relates to a surface finishing method of an artificial ligament. The surface finishing method mainly comprises the following steps: (1) a deep cleaning procedure of an artificial ligament fabric, (2) a peroxidation procedure of a fiber surface, (3) a graft polymerization procedure of the fiber surface, (4) a rewashing procedure and (5) a sectional coating procedure. The surface finishing method is characterized in that by utilizing a multi-step ultrasonic / lotion cooperative treatment manner, a relatively good surface can be obtained; by utilizing an ozone / ultraviolet combined oxidation method, the grafting efficiency is beneficially improved, and the generation of homopolymers is reduced; a grafted hydrophilic polymer layer is of a three-dimensional network-shaped gellike structure, so that a relatively good environment is provided for the development of cells; by carrying out rewashing, the surface of the ligament fabric is relatively clean, and the adhesion, growth and proliferation of the cells are promoted; by sectionally coating a biochemical reagent and a mineralization coating layer, the growth of autologous synovial tissues is easily induced by a ligament joint cavity segment, and the ligament autogeny is beneficially carried out; and the osteogenic property of a bone tunnel segment is enhanced, and the healing of the ligament and bones is relatively good.

A fluid management system includes a pump connectable to a fluid source. An inflow line removably connects to a cannula for delivering a fluid flow from the pump into a surgical site, such as a joint cavity. A flow pressure sensor is coupled to measure flow pressure in the inflow line and produce a measured pressure value, A controller is connected to the pump and the flow pressure sensor, and the controller maintains a pressure set point by controlling a pump speed based on a backpressure-adjusted pressure value calculated by subtracting a backpressure value selected from a backpressure table from the measured pressure value. The BAPV is monitored to determine whether the BAPV deviates outside an initial BAPV range, and corrective measure are taken should such deviations occur.

Method and pharmaceutical compositions for enhancing osteochondral tissue, so that osteochondral defects may be repaired by the body and / or prevented or lessened. The methods primarily include administering into a joint cavity, in doses not more frequently than daily for up to 13 days, an effective amount of anti-inflammatory cell growth pharmaceutical composition including cell secretory microvesicles derived from placental cotyledon derived mesenchymal stem cells that secrete growth factors; and administering into the joint cavity on day 14 (and as appropriate thereafter) an effective amount of pharmaceutical composition for cell differentiation and growth including chondrocyte derived exosomes.

The invention discloses a segmented and gradient functional tendon sleeve implanting device and a preparation method thereof. The preparation method includes the steps: (1) firstly, a three-dimensional bracket structure containing a bone tunnel part and a joint cavity part and having a porous hollow cylindrical structure shape is prepared through an electrostatic spinning or textile weaving method; (2) surface modification is conducted on wefts of the joint cavity part through a physical or chemical method, and surface modification comprises protein and small molecular compound modification; (3) gradient modification is conducted on the bone tunnel part through a physical or chemical method, and gradient modification comprises bone material, protein and small molecular compound modification; and (4) a needle threading marker hole is reserved in the outer surface of the bone tunnel part, a traction line is arranged, and thus the segmented and gradient functional tendon sleeve implantingdevice is obtained. The segmented and gradient functional tendon sleeve implanting device can achieve a promoting enhancement effect on clinical ACL repair through autograft tendon and allogenic tendon grafts and artificial grafts and ligament regeneration and tendon-bone healing of other ligament and tendon injuries, and provide mechanical protection without forming of stress shielding.

Provided herein is a magnetic apparatus for collecting superparamagnetic particles from a subject. The superparamagnetic particles are previously injected into the subject and have ligands bound thereto that are specific for one or more non-cell biomarkers. In one embodiment, the superparamagnetic particles are injected into and retrieved from a cavity such as a joint cavity. These compositions and methods allow for the sequestration and removal of inflammatory mediators, as both a diagnostic of the local immune response and a therapeutic that can reduce inflammation in the local disease environment.

A vehicle roof frame includes an adhering structure having an adhesive carrier and an expanding structural adhesive coupled to at least a portion of an outer surface of the adhesive carrier. The expanding structural adhesive includes an installation state and a structural state, and the structural state has a larger volume than the installation state. The vehicle roof frame also includes a plurality of vehicle frame members that cooperate to form a frame joint and a joint cavity defined within the frame joint. The adhering structure is disposed within the joint cavity and the adhesive carrier and the expanding structural adhesive in the structural state substantially occupies the joint cavity and fixably couples the plurality of framing members such that the frame joint is free of supplemental mechanical connections proximate the joint cavity.

The invention relates to a transverse filtering mask, and belongs to the technical field of hygienic products. According to the technical scheme, the transverse filtering mask comprises a mask body, inspiration cavities and an expiration cavity and is characterized in that a hollow nasal prong is installed on a nasal prong base, and a joint cavity is formed below the nasal prong base. The inspiration cavities are formed in the left side and the right side of a core cavity, an inspiration valve is installed in each inspiration cavity, and the expiration cavity is formed in the middle of the core cavity and internally provided with an expiration valve. A gas purifying element is connected with the inspiration cavities, and various sterilizing and filtering materials are placed in the gas purifying element. The transverse filtering mask has the advantages that closure is tight without leakage, the inspiration cavities and the expiration cavity are partitioned, the inspiration cavities effectively block bacterial viruses and haze, and expiration waste gas is not sucked back; the inspiration cavities are formed transversely and are large in capacity, so that a wearer does not feel stuffy in summer; the transverse filtering mask will replace a traditional mask with respiration at the same position and an old-fashioned protrusive filtering antigas mask and is wide in market prospect.

The invention discloses a complex salt rock underground and water dissolution joint cavity construction method. The method comprises the following steps of: 1) selecting a site for a rock salt deposit; 2) enabling a water dissolution drilled well to drill through a target rock salt layer; 3) arranging an underground vertical shaft at the center of a regular hexagon; 4) excavating in the underground vertical shaft till the bottom of the target rock salt layer; 5) excavating a communicating laneway to the bottom of the water dissolution drilled well; 6) constructing a groove in the rock salt layer at the bottom of the water dissolution drilled well; 7) cutting off rock salt and transporting to the ground; 8) mounting a sealing valve at the vertical shaft end of the communicating laneway after the end of groove construction; 9) closing the valve and continuously constructing a cavern in rock salt; 10) opening the sealing valve of the communicating laneway and discharging insoluble matters at the bottom of the cavern in rock salt to the bottom of the vertical shaft; 11) discharging the insoluble matters to the ground surface; and 12) sealing the communicating laneway after the end of construction of the cavern in rock salt. According to the method disclosed by the invention, the problem that the groove construction is difficult to perform in the rock salt with high content of the insoluble matters by water dissolution-process cavity construction can be solved; by adopting the method, the usable volume of a cavity can be improved by above 90% under the same geological conditions; and the overall economy is higher than that of a pure water dissolution cavity construction method.