46 results about "Joint cavity" patented technology

An intraoperative surgical system for knee arthroplasty may be configured and / or reconfigurable to allow the surgical system to be inserted into different sized joint spaces during a surgical procedure. For example, the surgical system may include a sensor support body defining a platform, a force sensor, and a plurality of sensor covers each being configured to be detachably attached to the sensor support body. Each of the sensor covers can vary from each other in at least one characteristic. A selected one of the sensor covers can be placed over the platform, sandwiching the force sensor between the platform and sensor cover, to define a joint insertion block configured to be inserted into a tibiofemoral joint for measuring a force between a tibia and a femur defining the tibiofemoral joint.

The invention discloses an organic framework microgel for relieving osteoarthritis and application thereof.The organic framework microgel takes a cross-linked HAMA hydrogel network as a matrix and a skeleton of the whole microgel, and HAMA inherits and strengthens inherent excellent lubricating performance and biocompatibility of hyaluronic acid; according to the present invention, the HAMA matrix and the TA-ZIF-8 nano-particles are uniformly dispersed in the lubrication matrix so as to directly and enduringly improve the lubrication state of the joint, and the TA-ZIF-8 nano-particles are adopted as the treatment unit to be uniformly dispersed in the lubrication matrix, such that the matrix-wrapping structure ensures that the lubrication function (provided by the HAMA matrix) and the treatment function (provided by the TA-ZIF-8) can synchronously and continuously act in the whole period of the microgel retention in the joint cavity.

The application discloses application of mesenchymal stem cell spheroids in preparation of a preparation for treating osteoarthritis, and relates to the technical field of cell therapy and osteoarthritis treatment, and specifically comprises mesenchymal stem cell spheroids with an average diameter of 120-180 mu m and a solution containing 0.5%-10% human serum albumin. The cells are prepared into 120-180 mu m cell spheroids, and the solution containing specific concentration human serum albumin is used as a carrier, so that the cell survival rate is stabilized at more than 90%, and high-activity delivery is realized; the optimized size ensures smooth injection and long-term retention in the joint cavity, and overcomes the shortcoming that single cells are easily removed; after joint cavity injection, the preparation can synergistically promote bone reconstruction and cartilage repair, and produces clear curative effects such as bone mass increase of more than 30%, cartilage degeneration score reduction of more than 50%, and the like, which are quantifiable and verifiable, so that a stable, long-acting and curative drug preparation and application scheme are provided for osteoarthritis treatment.

The present invention relates to a composition for injection into the joint cavity of dogs or cats, which is used to treat or ameliorate arthritis by injection into the joint cavity of dogs or cats, or to reduce mechanical friction in the joint region through physical restoration. The present invention also relates to a method for administering a composition for injection into the joint cavity of dogs or cats, the composition being used to treat or ameliorate arthritis by injection into the joint cavity of dogs or cats, or to reduce mechanical friction in the joint region through physical restoration. When the composition of the present invention is administered, the dose of sodium polynucleotide is 2-3 mg, preferably 2.5-3 mg, per body weight (kg) of a dog or a cat.

Provided are an injectable joint cavity hydrogel pharmaceutical composition and a method for preparing same. The hydrogel pharmaceutical composition comprises a gel particle and a drug loaded in the gel particle. The gel particle is formed by cross-linking hyaluronic acid or a salt thereof with fibroin via a cross-linking agent. The drug comprises an anti-inflammatory agent and / or a growth factor. The hydrogel pharmaceutical composition can treat a bone and joint-related disease by means of intra-articular injection.

The invention discloses an injectable hydrogel pharmaceutical composition for an articular cavity as well as a preparation method and application of the injectable hydrogel pharmaceutical composition. The hydrogel pharmaceutical composition comprises gel particles and a medicine loaded in the gel particles, the gel particles are formed by cross-linking hyaluronic acid or salt thereof and silk fibroin through a cross-linking agent; the medicine comprises an anti-inflammatory drug and / or a growth factor. The preparation method is simple, good in safety and beneficial to industrial production. The uniform porous structure of the hydrogel is beneficial to adhesion and growth of bone cells, meanwhile, the double-load hydrogel loaded with the anti-inflammatory drug and the growth factor has good viscoelasticity and injectability and has the effects of synergistically resisting inflammation and promoting cartilage repair, and bone joint related diseases are treated in a bone joint intracavity injection mode; the drug residence time can be prolonged, and the bioavailability is improved.

The invention relates to the technical field of medical image reconstruction, and discloses a bone joint three-dimensional reconstruction method and system based on deep learning. The method comprises the steps that a bone joint tomography image set is input, and multi-scale density slices and edge contour information are analyzed; deducing the two types of information space structures, and establishing an initial space field containing a bone tissue main body frame and a joint lacuna form; separating articular surface structure details and bone surface texture veins from the initial field; generating a network by using the three-dimensional structure which is obtained through separation and input and is trained to obtain a grid body with anatomical topological connection; and performing curved surface iterative smoothing based on biomechanical characteristics on the grid body, and outputting a final bone joint three-dimensional model.

This invention relates to the field of artificial ligament technology, specifically disclosing a method for securing the distal end of an artificial ligament. This method is mainly used for securing the traction suture to the distal fixation segment of the artificial ligament. The artificial ligament includes a free wire segment within the joint cavity, two braided segments located at both ends of the free wire segment, and two distal fixation segments located on opposite sides of the two braided segments. The fixation method mainly includes the following steps: placing the traction suture outside the distal fixation segment, and using a portion of the traction suture to create a covering portion, wherein the covering portion covers a portion of the two free strands of the traction suture outside the distal fixation segment. This invention ensures the structural integrity of the artificial ligament, the reliability of its function, and reduces the risk of inflammation in the patient.

The utility model relates to a hip and knee joint cavity perfusion drainage device. The device comprises a drug delivery mechanism and a suction mechanism which are arranged in vitro; the drug feeding mechanism is connected with a drug injection header pipe, the suction mechanism is connected with a drainage header pipe, and the drug injection header pipe and the drainage header pipe enter a human body through a skin incision; the medicine injection header pipe is arranged in a forked mode after entering a human body to form medicine injection branch pipes used for being placed in a hip joint cavity or a knee joint cavity, and medicine injection holes are evenly distributed in the medicine injection branch pipes. The main drainage pipe is arranged in a forked mode after entering the body, and a suction branch pipe used for being placed in a hip joint cavity or a knee joint cavity is formed. According to the utility model, a self-made simple medicine injection drainage tube commonly used in clinic at present can be replaced, so that the local part of an articular cavity is continuously, stably and uniformly dosed, the optimal effect of locally applying antibiotics is achieved, and the stable high-concentration state of the antibiotics is maintained. Meanwhile, skin incisions can be reduced, and the risks of incision infection and reverse infection are avoided.

The present application provides a method of preventing or treating joint periprosthetic infection (PJI), or alleviating a PJI-related condition, the method comprising administering to an articular cavity of a patient in need thereof a therapeutic agent comprising a compound represented by formula (I) and / or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, metabolite, or deuterated substance thereof.

The application belongs to the technical field of biotechnology, and discloses application of a new sialyloligosaccharide and astaxanthin composition in preparation of a transdermal drug for treating osteoarthritis and a composite gel preparation. The composition provided by the application comprises new sialyloligosaccharide, astaxanthin, carbomer and alginate with a mass ratio of (1-10):(1-10):(0.01-0.5):(0.1-1). The composition can realize efficient enrichment of the new sialyloligosaccharide and astaxanthin in the joint cavity through a diffusion pathway of skin penetration, deep tissue diffusion, joint capsule penetration and joint cavity enrichment of the substance, and the new sialyloligosaccharide and astaxanthin have excellent synergistic effects, can efficiently relieve acute inflammatory symptoms of gouty osteoarthritis, block the disease progression and repair the joint tissue pathological changes, and have excellent application prospects in preparation of the transdermal drug for treating osteoarthritis.

The invention relates to the technical field of biomedical gel material preparation, and discloses medicine mineralized gel as well as a preparation method and application thereof. The preparation method of the medicine mineralization type gel comprises the following steps: dropwise adding a NaOH aqueous solution into an alendronate sodium aqueous solution to obtain a mixture; mixing the mixture with sodium hyaluronate to obtain a viscous liquid; dropwise adding the viscous liquid into a CaCl2 aqueous solution, and stirring and mixing to obtain hydrogel; and incubating the hydrogel to obtain the drug mineralization type gel. The medicine mineralized gel prepared by the invention has excellent injectability, lubricating property, long-acting medicine slow release capacity and good biocompatibility, can quickly form gel after being injected into an articular cavity, not only plays roles in lubricating joints and reducing friction, but also can relieve joint inflammation and effectively improve joint functions, and can be used for treating joint inflammation. The application value in the field of osteoarthritis treatment is extremely high.

The invention discloses a medical composite material for synergistically regulating cholesterol and oxidative stress. The material comprises a Fe2-N6 / NC carrier, cholesterol oxidase loaded on the Fe2-N6 / NC carrier and a hyaluronic acid targeting layer modified on the surface, the carrier is a nitrogen-doped carbon material loaded with iron double-atom active sites, the distance between adjacent iron atoms is 0.311 + / -0.009 nm, and the iron content is 0.393 wt%; the average particle size of the composite material is 242.5 nm, and the Zeta potential of the composite material is-23.71 mV; the preparation method comprises the following steps: synthesizing Fe2-N6 / NC through mechanochemical-assisted in-situ MOF packaging, ultrasonically loading cholesterol oxidase and modifying with hyaluronic acid. The material has cholesterol degradation activity (the degradation rate is 33.94%) and active oxygen scavenging activity (the scavenging rate is 78.8%), and can be used for preparing an implant material for joint repair or a medical material for articular cavity injection so as to realize coordinated regulation of osteoarthritis cholesterol metabolism disorder and oxidative stress.

The invention relates to a preparation method of a multilayer sustained-release drug-loaded microsphere for articular cavity injection, and belongs to the field of biomedical materials and sustained-release preparations. The microsphere aims at solving the problems that traditional articular cavity lubricating gel is short in acting time and uncontrollable in drug release, and common drug-loaded microspheres are remarkable in burst release and insufficient in lubricity. The microsphere is constructed by adopting a natural material with good biocompatibility, collagen is taken as a core to load a drug, and a chitosan controlled release layer and a sodium hyaluronate lubricating layer are sequentially coated through electrostatic adsorption and covalent crosslinking to form the composite microsphere with a'core-shell-lubrication 'multilayer structure. The preparation method is based on a technical path technology of combining'crosslinking agent premixing emulsification-in-situ reaction curing 'and'layer-by-layer self-assembly-covalent crosslinking', and effective entrapment of drugs, stable construction of a controlled release structure and regulation and control of a degradation period are realized by optimizing process conditions. The microsphere can realize long-acting release of a medicine in a simulated environment, and the sodium hyaluronate on the outer layer of the microsphere material can improve the injection and pushing smoothness and is beneficial to the instant lubricity of the microsphere and retention of the microsphere in an articular cavity; all layers of materials are biodegradable, and degradation products have a potential nutrition support effect on joint tissues. The invention provides a microsphere delivery system with comprehensive performance for local treatment of joint diseases such as osteoarthritis.

This invention provides a stress-triggered selective targeting hydrogel microsphere, its preparation method, and its application, belonging to the field of biomedical technology. The core of this invention is the "stress-triggered charge reversal" mechanism. It utilizes the interaction between weakly cross-linked disulfide bonds broken under stress and "charge reversal" messenger molecules to achieve "charge reversal" of nanoparticles under stress. A dual-network hydrogel microsphere system is prepared using microfluidic technology to achieve bearing lubrication and stress relaxation within the joint cavity. Stress-triggered charge reversal is achieved at stress-overloaded cartilage lesions, imparting a positive charge to the drug-loaded nanoparticles within the hydrogel microspheres. This significantly enhances the ability of the drug-loaded nanoparticles to penetrate deep into the cartilage matrix and target chondrocytes for drug release under the guidance of the charge. This enables the selective and targeted release of appropriate drug concentrations to deep-seated chondrocytes in pathological microenvironments induced by different stress intensities, achieving highly effective and low-toxicity treatment of osteoarthritis.

The invention relates to a biological lubricant, in particular to a bone joint biological lubricant as well as a preparation method and application thereof. The bone joint biological lubricant comprises a component A and a component B, wherein the component A comprises the following raw materials in parts by volume: 4-6 parts of a 4% (w / v) sodium alginate solution, 0.3-0.5 part of a 1M calcium nitrate tetrahydrate solution, 0.4-0.6 part of a 2M beta-sodium glycerophosphate solution and 4-4.5 parts of normal saline; wherein the component B comprises the following raw materials in parts by volume: 3-5 parts of a 1M sodium citrate solution; after an ice-cold component A solution is injected into an articular cavity through an injector, and the solution enters an in-vivo environment at 37 DEG C, the temperature triggers Ca to be slowly released from a complex, the released Ca begins to be crosslinked with a G unit on a sodium alginate molecular chain, and finally stable hydrogel is formed in the articular cavity and has a good supporting effect when a patient is static; when the patient walks, a lubricating effect is achieved; when the gel needs to be removed, the component B can be injected into the gel part to convert the gel into a liquid state.

Provided is a biocompatible composition or the like that assists cells in the repair of a damaged tissue in a joint cavity. The biocompatible composition or the like according to the disclosure includes a biocompatible polymer having a substituent that adheres or binds to cells and / or a soft tissue in a joint cavity.

The application discloses application of Tiki2 as a target point in preparation of a drug for treating osteoarthritis, and relates to the technical field of osteoarthritis treatment. The drug can promote expression of Tiki2 protein. The drug developed for the Tiki2 protein will be possible to fundamentally slow down and reverse the osteoarthritis course. Especially, the Tiki2 protein in the joint cavity is supplemented by injecting the joint cavity with the gene therapy drug prepared by using the adeno-associated virus, and the gene therapy drug is expected to become a new treatment method for changing the osteoarthritis course.

A chitosan thermosensitive glue composition for treating osteoarthritis and a preparation method thereof. The composition comprises 0.5-5% chitosan thermosensitive glue and 10 6 -10 7 / mL stem cells. After mixing mesenchymal stem cells with chitosan thermosensitive glue, the mixture is injected into the joint cavity, which can not only play the effect of chitosan gel in lubricating the joint, but also inhibit inflammatory factors secreted by mesenchymal stem cells, and at the same time, mesenchymal stem cells can promote the regeneration of chondrocytes, effectively treating osteoarthritis.

The invention discloses a knee joint cavity puncturing and flushing device, and relates to the technical field of knee joint cavity puncturing. The device comprises a supporting block, the top of the supporting block is bent, the top of the supporting block is attached to a knee bend, a fixing mechanism is fixedly connected with the surface of the supporting block, the output end of a driving mechanism is fixedly connected with the surface of a puncture mechanism, the outer side face of a flushing assembly is slidably connected with a mounting plate, and the mounting plate is fixedly connected with the output end of the driving mechanism. The outer puncture needle is fixedly connected to one end of the flushing assembly, the inner puncture needle is arranged inside the outer puncture needle, the inner puncture needle is fixedly connected with the end, close to the outer puncture needle, of the flushing assembly, the top of the supporting block attached to the knee bend can support popliteal fossa, the joint is in a relaxed state, the puncture needle is easy to penetrate, and the intra-articular structure is not prone to being damaged. The inner puncture needle and the outer puncture needle can achieve the dual effects of extracting and flushing joint fluid through one-time puncture, and the environment in a knee joint cavity is improved to the maximum extent.

This invention relates to a portable arthroscopy, comprising a cable connecting the lens, a traction unit for driving the lens to swing, a steering unit behind the lens, and a scope tube. When the steering unit rotates around its axis of rotation, pulling one of the traction units connected to it backward causes the lens to swing toward the side where the traction unit is located. The arthroscopy lens can swing at various angles to introduce light into the joint cavity; the acquired images can be transmitted to a matching terminal device for display. The arthroscopy of this invention has a simple structure and can be used only once to avoid or reduce sterilization work; the small diameter of the scope tube results in smaller incisions and easier handling; the arthroscopy can also have a surgical tool intervention channel, and is equipped with various surgical tools, any one of which can be selected and installed at the intervention channel for joint examination or treatment.

The invention discloses a pharmaceutical composition for targeted removal of osteoarthritis articular cavity apoptotic cells and application, and belongs to the technical field of biological medicines. The pharmaceutical composition comprises a targeting ligand, an apoptotic cell scavenger and a drug carrier, the targeting ligand is selected from an anti-phosphatidylserine monoclonal antibody or Annexin V protein, and can be specifically combined with phosphatidylserine on the surface of an apoptotic cell; the apoptotic cell scavenger is selected from demethoxycurcumin, andrographolide and the like, and can promote apoptotic cell phagocytosis and inhibit inflammatory factor release; and the drug carrier is hyaluronic acid-polylactic acid copolymer nanoparticles, and has good articular cavity retention property and drug sustained release effect. The pharmaceutical composition disclosed by the invention can be used for accurately targeting apoptotic cells in osteoarthritis articular cavities, efficiently removing the apoptotic cells, inhibiting inflammatory response and delaying cartilage degeneration, is good in biological safety and provides a new effective means for treating osteoarthritis.

The invention discloses a tunnel deformation joint cavity treatment method and structure, the treatment structure comprises a primary support structure layer, a secondary lining structure layer is arranged below the primary support structure layer, a first waterproof layer is arranged between the primary support structure layer and the secondary lining structure layer, a cavity is formed in the secondary lining structure layer, and a second waterproof layer is arranged between the primary support structure layer and the secondary lining structure layer. A plurality of pressure relief holes are formed in the second lining structure layer and located in the outer side of the cavity, and plugging layers are arranged in the pressure relief holes. According to the method, before the cavity at the tunnel deformation joint is treated, the pressure relief holes are drilled in the periphery of the cavity, so that seepage water in the stratum can be discharged through the pressure relief holes, the situation that grout is flushed out by water or the strength is reduced due to the fact that the water enters the cavity during repairing is avoided, and the repairing effect of the cavity can be enhanced.

The application provides application of SEMA3E protein in preparation of a drug for treating rheumatoid arthritis and promoting cartilage regeneration, and belongs to the technical field of biological medicine. The amino acid sequence of the SEMA3E protein is shown as SEQ ID No. 1. Research results show that one month after injection of the SEMA3E protein solution, the joint swelling degree of the double hind limbs of an animal model is reduced, the joint space and integrity are restored to normal, the cartilage thickness is increased, and the phenomenon of synovial cell infiltration and invasion into the cartilage is eliminated. That is, the SEMA3E protein can well reduce joint cavity inflammation and improve damaged joints.

The invention discloses a lipid composition and application thereof in nucleic acid delivery. The lipid composition can be used for delivery of siRNA through intraarticular administration or subcutaneous administration, and aims to achieve arthritis treatment effects superior to those of existing commercialized proportions of lipid compositions. The lipid composition provided by the invention can be used for delivering nucleic acid drugs, and compared with a marketed LNP formula, the lipid composition has the advantages that the proportion of ionizable cationic lipid is reduced, and the proportion of PEG lipid is increased. When siRNA for treating autoimmune diseases is delivered, the lipid composition is administered through articular cavity injection or subcutaneous injection, especially has a good effect in treatment of collagen-induced rat arthritis (CIA), and remarkably reduces the arthritis score and the foot volume.

The invention provides a medicine for preventing and / or treating sterile looseness. The medicine is a proteasome inhibitor, and the proteasome inhibitor comprises a broad-spectrum inhibitor (such as bortezomib, carfilzomib and ixazomib) and an immune proteasome selective inhibitor (such as ONX-0914, KZR-616 and analogues thereof). The drug can be in a dosage form suitable for modes of articular cavity injection, bone cement slow release, prosthesis surface coating or systemic drug delivery and the like. The invention not only can be used for preparing the medicine for treating or preventing the sterile looseness, but also can be expanded to the development of a medicine carrying delivery system and an anti-rejection prosthesis material, and provides a new thought and a feasible way for preventing and treating the sterile looseness.

This invention provides a joint cavity expansion device for shoulder arthroscopic surgery, comprising a main tube, an injection balloon, supporting blades, an injection line, a drainage line, and a sealing structure. In use, the main tube is first inserted into the established channel in the shoulder joint. Water is injected into the injection line through a one-way valve using a syringe. The liquid enters the injection balloon through the injection channel, causing it to expand and deploy the supporting blades to support the bottom of the balloon. The main tube is then screwed outwards, fixing its position via spiral protrusions on the tube wall. Simultaneously, the injection balloon compresses the surrounding soft tissue, effectively increasing the operating space within the joint cavity. This joint cavity expansion device significantly expands the operating space within the joint cavity by compressing soft tissue with the injection balloon, ensuring flexible operation of surgical instruments without restricting the surgical field of view. The supporting blades provide stable support when the balloon expands, preventing deformation during soft tissue compression, thus achieving stable compression of the soft tissue.

The utility model relates to the technical field of medical treatment, and provides a balloon for treating a frozen shoulder by directionally expanding an articular cavity under ultrasound, which comprises a puncture guide needle, a first balloon main body and a second balloon main body, the first balloon and the second balloon are designed, the first balloon is used for expanding a thickened articular cavity, and the second balloon is used for expanding the articular cavity. The design and the size of the balloon are different from those of the first balloon, so that the balloon can be accurately matched with different parts, and effective dilation is achieved. In the aspect of design of the puncture guide needle, two needle stem design schemes are provided, the needle stem is made of a fiber soft lens material or provided with a movable joint to achieve a bending function, and the front end of the needle stem can be subjected to arc molding, so that the guide needle can enter an articular cavity conveniently, the risk of damage to surrounding tissues is greatly reduced, and treatment safety is guaranteed. According to the internal structural design of the guide needle, pipelines with different functions are arranged and comprise the two balloon inflation cavities with different lengths and the medicine injection cavity, all the pipelines are clear in division of labor, and inflation operation of the balloon and supply of medicine liquid are facilitated.

The application discloses application of UFM1 protein or a coding gene thereof in preparation of a medicine for treating osteoarthritis, and belongs to the technical field of biotechnology.The application proves that knockout of UFM1 accelerates aging of human chondrocytes, overexpression of specific UFM1 protein or a coding gene thereof can relieve aging of human chondrocytes, and specific knockout of UFM1 in a mouse experimental model can accelerate osteoarthritis of the mouse, and injection of UFM1 recombinant protein into a joint cavity of the mouse can relieve osteoarthritis of the mouse.Therefore, the UFM1 protein or the coding gene thereof can be used as a drug target, and has a good prospect in screening and preparation of the medicine for treating osteoarthritis.

This invention discloses the application of cPGES as a target in the development, screening, or preparation of drugs for the prevention and / or treatment of osteoarthritis. This invention is the first to propose cPGES as a drug target for osteoarthritis. Experiments show that intra-articular injection of cPGES knockdown virus significantly reduces joint pain in mice, protects against cartilage wear, improves bone metabolic imbalance, and inhibits the release of inflammatory factors. These results demonstrate that cPGES has a significant effect on improving osteoarthritis and can serve as a target for the treatment of osteoarthritis, which is of great significance for the future development and prevention of this type of disease.