95 results about "Joint cavity" patented technology

The invention provides an artificial intelligence auxiliary diagnosis method and system for a knee joint, and the method comprises the steps: synchronously collecting a multi-angle dynamic X-ray image and six-degree-of-freedom contact force distribution data in an articular cavity, dynamically tracking a patella sliding track, and generating a mechanical phase track; a personalized knee joint model is constructed in combination with the biological parameters of the lower limbs of the patient, the mechanical phase trajectory and the contact force data vector are superposed to generate a dynamic mechanical fingerprint, and then the dynamic mechanical fingerprint is mapped into a biomechanical attribute map; electromyographic signal time-frequency characteristics and tibia rotation angles in the movement process are collected, an electromyographic activation mode is constructed, and the electromyographic activation mode and a biomechanical attribute map are subjected to characteristic fusion to form a joint dynamics comprehensive contour; analyzing a stress wave conduction path by using a joint anomaly dynamic propagation model to identify a compensatory injury mode; a diagnosis map is generated according to the recognition result, a preset biomechanical constraint condition is matched to correct the diagnosis map, and an individualized rehabilitation strategy is formulated. The treatment effect is improved, and the recovery speed of a patient is increased.

The present application relates to the technical field of joint cavity positioning, and specifically provides a joint cavity positioning method and device based on a deep learning model, the method comprising the steps of: S1, acquiring an arthroscopic image, and preprocessing the arthroscopic image to obtain an enhanced image; S2, acquiring joint cavity position information based on a pre-trained joint cavity positioning model and the enhanced image; the pre-training of the joint cavity positioning model comprises: A1, training a pre-built deep learning model using a pre-collected general medical image dataset to obtain a preliminary positioning model; A2, expanding a pre-collected arthroscopic image dataset of rare bone and joint diseases to obtain an expanded image dataset, and then dynamically adjusting the regularization strength of the preliminary positioning model based on an adaptive regularization coefficient function according to the joint cavity morphological diversity index of the expanded image dataset to obtain a joint cavity positioning model; the method can accurately locate the joint cavity of rare bone and joint diseases.

The present invention relates to a pharmaceutical composition with joint repair efficacy, which is composed of collagen, chitosan and a pharmaceutically acceptable carrier, wherein the weight ratio of collagen to chitosan in the composition is 11:1-1:11, the average molecular weight of collagen is 3kDa-500kDa, and the weight average molecular weight of chitosan is 10000-200000. The pharmaceutical composition of the present invention is used to treat and relieve pain caused by joint cavity stenosis and bone wear, effectively prevent and treat traumatic or degenerative osteoarthritis, and has the advantages of good water solubility, good biocompatibility, fast onset, good repair effect, good stability, good re-dissolution stability, long effective period, easy storage, etc.

The utility model relates to the field of medical instruments, and discloses an arthroscopic bone grafting positioner which is accurate in positioning and not prone to dislocation, the arthroscopic bone grafting positioner comprises a positioning structure, a threading structure and two sleeves, the positioning structure is provided with a guide sliding groove structure, and the guide sliding groove structure comprises a guide sliding groove handle. An arc-shaped plate is fixedly connected to the position, close to the lower end, of the center of the front side wall of the guide sliding groove handle, a sliding groove is formed in the center of the lower end face of the arc-shaped plate, the threading structure comprises a sleeve rod, a side plate is fixedly connected to the center of one side wall of the sleeve rod, and wire holes are formed in the centers of the rear side walls of the sleeve rod and the side plate respectively. According to the utility model, the guide chute structure is arranged, so that before use, the guide chute structure can extend into the joint cavity, the subsequent installation of the positioning structure is facilitated, the installation is convenient, and the damage to the soft tissue of a patient can be reduced.

The invention discloses a knee osteoarthritis dynamic grading prediction and intervention system and method based on a large model, and relates to the field of medical image analysis, and the method comprises the steps: obtaining a knee joint MRI image sequence and knee joint angle time sequence data of a patient; processing the MRI image sequence by using a pre-trained articular cavity segmentation model to obtain a joint fluid volume quantized value; aligning the knee joint angle time sequence to an image frame acquisition time point to generate a synchronous angle sequence; whether the average value of the liquid amount change rate sequence is lower than a preset stable threshold value or not is judged by calculating the liquid amount change rate sequence and the angle change quantity sequence, and if yes, a low-risk signal is output; otherwise, calculating a correlation coefficient between the liquid amount change rate and the angle change amount, outputting a moderate or severe gonitis prediction signal according to the value of the correlation coefficient, and further judging the mild or moderate risk of the gonitis according to the amplitude characteristics of the liquid amount change rate sequence; according to the invention, early gonitis lesion features can be identified, and the accuracy of grading prediction is improved.

The utility model relates to an anterior column intramedullary nail for pelvis percutaneous internal fixation, which belongs to the technical field of orthopedic medical instruments and is characterized in that the front end of the anterior column intramedullary nail is cut to form a cut surface to form a tip; the anterior column intramedullary nail is arc-shaped, so that the anterior column intramedullary nail can conveniently penetrate along the suprapubis ramus and part of the ilium; the surface of the anterior column intramedullary nail is smooth so as to be prevented from penetrating into an articular cavity; a hollow channel is formed in the anterior column intramedullary nail, penetrates through the two ends of the anterior column intramedullary nail and is used for allowing an anterior column nail guide pin to penetrate through so that the anterior column intramedullary nail can penetrate into the suprapubis ramus and part of the ilium. The anterior column intramedullary nail for percutaneous internal fixation of the pelvis disclosed by the utility model can be matched with an in-vitro guide frame for percutaneous internal fixation and reinforcement of the intramedullary nail around the acetabulum for use, assists the anterior column intramedullary nail to be percutaneously fixed around the acetabulum, and is suitable for penetrating through an anterior column nail guide tube of the in-vitro guide frame and only penetrating into suprapubic ramus and part of ilium; and popularization and application of pelvic metastatic carcinoma surgery are facilitated.

An intraoperative surgical system for knee arthroplasty may be configured and / or reconfigurable to allow the surgical system to be inserted into different sized joint spaces during a surgical procedure. For example, the surgical system may include a sensor support body defining a platform, a force sensor, and a plurality of sensor covers each being configured to be detachably attached to the sensor support body. Each of the sensor covers can vary from each other in at least one characteristic. A selected one of the sensor covers can be placed over the platform, sandwiching the force sensor between the platform and sensor cover, to define a joint insertion block configured to be inserted into a tibiofemoral joint for measuring a force between a tibia and a femur defining the tibiofemoral joint.

The invention relates to a wrist joint, a minimally invasive surgery robot and a knee joint endoscopic surgery robot. The knee joint endoscopic surgery robot comprises a far-end two-degree-of-freedom wrist joint, a one-degree-of-freedom bent flexible mechanical arm, a rigid insertion sheath tube, a wire transmission device, a bending driving device and a gear transmission device. Wherein the endoscope module is integrated at the tail end of the wrist joint, so that flexible exploration in a knee joint cavity is realized; through two-degree-of-freedom movement of the wrist joint, local flexible adjustment of the visual field of the endoscope is achieved; large-range bending movement and safe interaction of the endoscope are realized through one-degree-of-freedom bending movement of the flexible mechanical arm; by controlling extension and retraction of the rigid insertion sheathing canal, a doctor can conveniently control the endoscope to smoothly enter a knee joint cavity from a knee joint incision, the bending radius of the flexible joint in the flexible mechanical arm can be changed by regulating and controlling the extension amount of the rigid insertion sheathing canal, and then flexible adjustment of the visual field of the endoscope in a large range and a small range is achieved.

The invention discloses an organic framework microgel for relieving osteoarthritis and application thereof.The organic framework microgel takes a cross-linked HAMA hydrogel network as a matrix and a skeleton of the whole microgel, and HAMA inherits and strengthens inherent excellent lubricating performance and biocompatibility of hyaluronic acid; according to the present invention, the HAMA matrix and the TA-ZIF-8 nano-particles are uniformly dispersed in the lubrication matrix so as to directly and enduringly improve the lubrication state of the joint, and the TA-ZIF-8 nano-particles are adopted as the treatment unit to be uniformly dispersed in the lubrication matrix, such that the matrix-wrapping structure ensures that the lubrication function (provided by the HAMA matrix) and the treatment function (provided by the TA-ZIF-8) can synchronously and continuously act in the whole period of the microgel retention in the joint cavity.

The present invention relates to a composition for intra-articular injection in dogs or cats, which is used to treat or ameliorate arthritis or reduce mechanical friction at joint sites by physical repair when injected into the joint cavity of dogs or cats. The present invention also relates to a method for administering a composition for intra-articular injection in dogs or cats, which is used to treat or ameliorate arthritis or reduce mechanical friction at joint sites by physical repair when injected into the joint cavity of dogs or cats. The composition of the present invention is administered so that the dosage of polynucleotide sodium is 2 to 3 mg, preferably 2.5 to 3 mg, per kg of body weight of the dog or cat.

The application discloses application of mesenchymal stem cell spheroids in preparation of a preparation for treating osteoarthritis, and relates to the technical field of cell therapy and osteoarthritis treatment, and specifically comprises mesenchymal stem cell spheroids with an average diameter of 120-180 mu m and a solution containing 0.5%-10% human serum albumin. The cells are prepared into 120-180 mu m cell spheroids, and the solution containing specific concentration human serum albumin is used as a carrier, so that the cell survival rate is stabilized at more than 90%, and high-activity delivery is realized; the optimized size ensures smooth injection and long-term retention in the joint cavity, and overcomes the shortcoming that single cells are easily removed; after joint cavity injection, the preparation can synergistically promote bone reconstruction and cartilage repair, and produces clear curative effects such as bone mass increase of more than 30%, cartilage degeneration score reduction of more than 50%, and the like, which are quantifiable and verifiable, so that a stable, long-acting and curative drug preparation and application scheme are provided for osteoarthritis treatment.

The present application relates to a kind of wrist joint and minimally invasive surgery robot and knee arthroscopy surgery robot, the knee arthroscopy surgery robot includes remote end 2 degrees of freedom wrist joint, 1 degree of freedom flexible mechanical arm, rigid insertion sheath, wire transmission device, bending drive device and gear transmission device;Wherein, by integrating endoscope module in wrist joint terminal, to realize the intelligent exploration in knee joint cavity;By the 2 degrees of freedom movement of wrist joint, realize the local intelligent adjustment of endoscope field of view;By the 1 degree of freedom bending movement of flexible mechanical arm, realize the large range bending movement and safety interaction of endoscope;By controlling the extension and retraction of rigid insertion sheath, it is convenient for doctor to control endoscope to enter knee joint cavity from knee joint incision smoothly, also can change the bending radius of flexible joint in flexible mechanical arm by regulating the extension amount of rigid insertion sheath, to realize the intelligent adjustment of endoscope field of view in large range and small range.

The present invention relates to a composition for injection into the joint cavity of dogs or cats, which is used to treat or ameliorate arthritis by injection into the joint cavity of dogs or cats, or to reduce mechanical friction in the joint region through physical restoration. The present invention also relates to a method for administering a composition for injection into the joint cavity of dogs or cats, the composition being used to treat or ameliorate arthritis by injection into the joint cavity of dogs or cats, or to reduce mechanical friction in the joint region through physical restoration. When the composition of the present invention is administered, the dose of sodium polynucleotide is 2-3 mg, preferably 2.5-3 mg, per body weight (kg) of a dog or a cat.

Provided are an injectable joint cavity hydrogel pharmaceutical composition and a method for preparing same. The hydrogel pharmaceutical composition comprises a gel particle and a drug loaded in the gel particle. The gel particle is formed by cross-linking hyaluronic acid or a salt thereof with fibroin via a cross-linking agent. The drug comprises an anti-inflammatory agent and / or a growth factor. The hydrogel pharmaceutical composition can treat a bone and joint-related disease by means of intra-articular injection.

The present invention relates to a composition for injection into the articular cavity of a dog or cat for treating or ameliorating arthritis by injection into the articular cavity of a dog or cat, or for reducing mechanical friction in the articular region via body repair. The invention also relates to a method for administering a composition for injection into the articular cavity of a dog or cat for treating or ameliorating arthritis by injection into the articular cavity of a dog or cat, or for reducing mechanical friction in the articular region by body repair. When the composition of the invention is administered, the dosage of the polynucleotide sodium is 2 to 3 mg per kilogram of body weight of dogs or cats, preferably 2.5 to 3 mg.

The invention discloses an injectable hydrogel pharmaceutical composition for an articular cavity as well as a preparation method and application of the injectable hydrogel pharmaceutical composition. The hydrogel pharmaceutical composition comprises gel particles and a medicine loaded in the gel particles, the gel particles are formed by cross-linking hyaluronic acid or salt thereof and silk fibroin through a cross-linking agent; the medicine comprises an anti-inflammatory drug and / or a growth factor. The preparation method is simple, good in safety and beneficial to industrial production. The uniform porous structure of the hydrogel is beneficial to adhesion and growth of bone cells, meanwhile, the double-load hydrogel loaded with the anti-inflammatory drug and the growth factor has good viscoelasticity and injectability and has the effects of synergistically resisting inflammation and promoting cartilage repair, and bone joint related diseases are treated in a bone joint intracavity injection mode; the drug residence time can be prolonged, and the bioavailability is improved.

The invention relates to the technical field of medical image reconstruction, and discloses a bone joint three-dimensional reconstruction method and system based on deep learning. The method comprises the steps that a bone joint tomography image set is input, and multi-scale density slices and edge contour information are analyzed; deducing the two types of information space structures, and establishing an initial space field containing a bone tissue main body frame and a joint lacuna form; separating articular surface structure details and bone surface texture veins from the initial field; generating a network by using the three-dimensional structure which is obtained through separation and input and is trained to obtain a grid body with anatomical topological connection; and performing curved surface iterative smoothing based on biomechanical characteristics on the grid body, and outputting a final bone joint three-dimensional model.

The application discloses a joint cavity filling preparation of precisely proportioned carboxymethyl chitosan and sodium glycerophosphate and a preparation method and application thereof, and the effective component of the filling preparation is carboxymethyl chitosan with a concentration of 25 mg / mL and sodium glycerophosphate with a concentration of 15 mg / mL, and the balance is a sterile isotonic physiological buffer aqueous solution. The application forms component synergy by relying on the lubrication and long-acting stability characteristics of carboxymethyl chitosan and combining the structure reinforcement, ion regulation and cartilage repair promoting characteristics of sodium glycerophosphate, and effectively solves the defects of short in-vivo retention time, poor mechanical stability, lack of biological repair activity and easy dilution and collapse of the traditional joint filling material in the joint cavity fluid. The application overcomes the problem that a high-concentration viscous solution cannot be filtered and sterilized, can effectively buffer the joint mechanical load, optimize the joint microenvironment and promote the repair of degenerative cartilage, is suitable for clinical scenes such as mild and moderate osteoarthritis, sports joint injury and postoperative joint function repair, and has good clinical application value and industrialization prospect.

The utility model relates to a knee joint cavity injection training device. Comprising an upper simulation joint and a lower simulation joint which are connected in a hinged mode, an upper connecting rod is installed on the rear portion of the upper simulation joint, a lower connecting rod is installed on the lower portion of the lower simulation joint, a sliding rail is installed on the top of the front portion of the lower simulation joint, and a simulation patella capable of sliding left and right is installed on the sliding rail. The elastic jacket seals the front part of the upper connecting rod, the simulated upper joint, the simulated lower joint, the upper part of the lower connecting rod and the simulated patella inside; the device further comprises an adjusting type supporting frame capable of adjusting the angle between the simulation upper joint and the simulation lower joint. The utility model provides a knee joint cavity injection practical training device and provides a simulated knee joint model, so that a practical trainee operates an injector to complete the injection operation of a knee joint cavity on the knee joint model and master the operation skill of knee joint injection in the practical training process, and the problem that the skill cannot be really mastered in the existing teaching mode is solved.

This invention relates to the field of artificial ligament technology, specifically disclosing a method for securing the distal end of an artificial ligament. This method is mainly used for securing the traction suture to the distal fixation segment of the artificial ligament. The artificial ligament includes a free wire segment within the joint cavity, two braided segments located at both ends of the free wire segment, and two distal fixation segments located on opposite sides of the two braided segments. The fixation method mainly includes the following steps: placing the traction suture outside the distal fixation segment, and using a portion of the traction suture to create a covering portion, wherein the covering portion covers a portion of the two free strands of the traction suture outside the distal fixation segment. This invention ensures the structural integrity of the artificial ligament, the reliability of its function, and reduces the risk of inflammation in the patient.

The application discloses a kind of for repairing cartilage decellularized cartilage matrix support and apoptotic corpuscle composition and its preparation method, composition includes: microporous support, support includes decellularized cartilage outer matrix and crosslinked organic polymer;Apoptotic corpuscle, apoptotic corpuscle exists in microporous support;Wherein, based on the volume 3.14mm 3 Microporous support, 0.01-0.02ug of apoptotic corpuscle is included.The combined support of the application can improve the activity of apoptotic corpuscle, prolong the action time of apoptotic corpuscle, achieve the effect of slow release, also can regulate joint cavity microenvironment, effectively promote joint cartilage repair, improve the repair effect of loss cartilage, avoid the security risks brought by traditional exogenous cell transplantation.

The present disclosure relates to the field of joint micro-motion technology, and in particular to a joint micro-motion structure and a lumbar auxiliary device. The present disclosure provides a joint micro-motion structure, comprising a first joint part and a second joint part, wherein one end of the first joint part has a joint cavity opening toward the second joint part, and the second joint part comprises a joint head and a joint rod part, the joint rod part is connected to the joint head part, the joint head part is adapted to the joint cavity and can rotate in the joint cavity, and a limiting member is provided at the opening of the joint cavity, and the limiting member is used to prevent the joint head from falling out of the joint cavity; the joint head part comprises a first joint head and a second joint head connected thereto, the diameter of the first joint head is smaller than the diameter of the second joint head, and the second joint head is connected to the joint rod part. By implementing the technical solution of the present disclosure, it is possible to avoid metal fatigue caused by long-term use of the connection between the joint rod part and the joint head part, thereby avoiding affecting the use effect of the micro-motion structure.

The utility model relates to a hip and knee joint cavity perfusion drainage device. The device comprises a drug delivery mechanism and a suction mechanism which are arranged in vitro; the drug feeding mechanism is connected with a drug injection header pipe, the suction mechanism is connected with a drainage header pipe, and the drug injection header pipe and the drainage header pipe enter a human body through a skin incision; the medicine injection header pipe is arranged in a forked mode after entering a human body to form medicine injection branch pipes used for being placed in a hip joint cavity or a knee joint cavity, and medicine injection holes are evenly distributed in the medicine injection branch pipes. The main drainage pipe is arranged in a forked mode after entering the body, and a suction branch pipe used for being placed in a hip joint cavity or a knee joint cavity is formed. According to the utility model, a self-made simple medicine injection drainage tube commonly used in clinic at present can be replaced, so that the local part of an articular cavity is continuously, stably and uniformly dosed, the optimal effect of locally applying antibiotics is achieved, and the stable high-concentration state of the antibiotics is maintained. Meanwhile, skin incisions can be reduced, and the risks of incision infection and reverse infection are avoided.

The present application provides a method of preventing or treating joint periprosthetic infection (PJI), or alleviating a PJI-related condition, the method comprising administering to an articular cavity of a patient in need thereof a therapeutic agent comprising a compound represented by formula (I) and / or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, metabolite, or deuterated substance thereof.

The present invention relates to the field of medical equipment technology, specifically an intra-articular perfusion device, comprising a perfusion shell, the outer wall of the perfusion shell is fixedly connected to a liquid extraction mechanism, the inner wall of the perfusion shell is slidably connected to a cleaning mechanism, the inner wall of the cleaning mechanism is slidably connected to the outer wall of the liquid extraction mechanism, the inner wall of the perfusion shell is clamped with a quantitative shell, and the inner wall of the quantitative shell is clamped with an injection head. In the prior art, when there is a lot of joint effusion, it is necessary to frequently remove the syringe to extract it. During the extraction process, it may cause sealing problems caused by the misalignment of the syringe and the needle. At the same time, the efficiency is not high, and when there is less joint effusion in the subsequent process, precise extraction operations are required to avoid human tissue being sucked into the joint cavity due to low pressure during extraction, thereby causing damage. When encountering effusion caused by joint damage, slow extraction is also required to prevent secondary damage to the patient. After the extraction of the intra-articular effusion is completed, the interior needs to be cleaned and disinfected to prevent recurrence of the disease.

The application belongs to the technical field of biotechnology, and discloses application of a new sialyloligosaccharide and astaxanthin composition in preparation of a transdermal drug for treating osteoarthritis and a composite gel preparation. The composition provided by the application comprises new sialyloligosaccharide, astaxanthin, carbomer and alginate with a mass ratio of (1-10):(1-10):(0.01-0.5):(0.1-1). The composition can realize efficient enrichment of the new sialyloligosaccharide and astaxanthin in the joint cavity through a diffusion pathway of skin penetration, deep tissue diffusion, joint capsule penetration and joint cavity enrichment of the substance, and the new sialyloligosaccharide and astaxanthin have excellent synergistic effects, can efficiently relieve acute inflammatory symptoms of gouty osteoarthritis, block the disease progression and repair the joint tissue pathological changes, and have excellent application prospects in preparation of the transdermal drug for treating osteoarthritis.

The invention relates to the technical field of biomedical gel material preparation, and discloses medicine mineralized gel as well as a preparation method and application thereof. The preparation method of the medicine mineralization type gel comprises the following steps: dropwise adding a NaOH aqueous solution into an alendronate sodium aqueous solution to obtain a mixture; mixing the mixture with sodium hyaluronate to obtain a viscous liquid; dropwise adding the viscous liquid into a CaCl2 aqueous solution, and stirring and mixing to obtain hydrogel; and incubating the hydrogel to obtain the drug mineralization type gel. The medicine mineralized gel prepared by the invention has excellent injectability, lubricating property, long-acting medicine slow release capacity and good biocompatibility, can quickly form gel after being injected into an articular cavity, not only plays roles in lubricating joints and reducing friction, but also can relieve joint inflammation and effectively improve joint functions, and can be used for treating joint inflammation. The application value in the field of osteoarthritis treatment is extremely high.

The invention discloses multi-degree-of-freedom angle-rigidity-adjustable handheld release forceps for arthroscopic surgery, which comprise a handheld operating device, a continuous body section and release forceps, the handheld operating device and the release forceps are respectively mounted at the head end and the tail end of the continuous body section, and the handheld operating device comprises a shell, a connecting rod and a connecting rod, the up-down bending driving assembly is mounted in the shell; the left-right bending driving assembly is mounted in the shell; the jaw opening and closing driving assembly is installed at the bottom of the shell, and the jaw opening and closing driving assembly is used for controlling the opening and closing angle of the loosening pliers; wherein a locking assembly is installed in the shell, and the locking assembly is in limiting fit with the up-down bending driving assembly and the left-right bending driving assembly. The device can adapt to a complex anatomical structure of an articular cavity, flexibly reach the position of a view blind area and keep precision and stability in surgical operation, so that the surgical efficiency is improved, and wounds of a patient are reduced.

The invention discloses a medical composite material for synergistically regulating cholesterol and oxidative stress. The material comprises a Fe2-N6 / NC carrier, cholesterol oxidase loaded on the Fe2-N6 / NC carrier and a hyaluronic acid targeting layer modified on the surface, the carrier is a nitrogen-doped carbon material loaded with iron double-atom active sites, the distance between adjacent iron atoms is 0.311 + / -0.009 nm, and the iron content is 0.393 wt%; the average particle size of the composite material is 242.5 nm, and the Zeta potential of the composite material is-23.71 mV; the preparation method comprises the following steps: synthesizing Fe2-N6 / NC through mechanochemical-assisted in-situ MOF packaging, ultrasonically loading cholesterol oxidase and modifying with hyaluronic acid. The material has cholesterol degradation activity (the degradation rate is 33.94%) and active oxygen scavenging activity (the scavenging rate is 78.8%), and can be used for preparing an implant material for joint repair or a medical material for articular cavity injection so as to realize coordinated regulation of osteoarthritis cholesterol metabolism disorder and oxidative stress.

The invention relates to a preparation method of a multilayer sustained-release drug-loaded microsphere for articular cavity injection, and belongs to the field of biomedical materials and sustained-release preparations. The microsphere aims at solving the problems that traditional articular cavity lubricating gel is short in acting time and uncontrollable in drug release, and common drug-loaded microspheres are remarkable in burst release and insufficient in lubricity. The microsphere is constructed by adopting a natural material with good biocompatibility, collagen is taken as a core to load a drug, and a chitosan controlled release layer and a sodium hyaluronate lubricating layer are sequentially coated through electrostatic adsorption and covalent crosslinking to form the composite microsphere with a'core-shell-lubrication 'multilayer structure. The preparation method is based on a technical path technology of combining'crosslinking agent premixing emulsification-in-situ reaction curing 'and'layer-by-layer self-assembly-covalent crosslinking', and effective entrapment of drugs, stable construction of a controlled release structure and regulation and control of a degradation period are realized by optimizing process conditions. The microsphere can realize long-acting release of a medicine in a simulated environment, and the sodium hyaluronate on the outer layer of the microsphere material can improve the injection and pushing smoothness and is beneficial to the instant lubricity of the microsphere and retention of the microsphere in an articular cavity; all layers of materials are biodegradable, and degradation products have a potential nutrition support effect on joint tissues. The invention provides a microsphere delivery system with comprehensive performance for local treatment of joint diseases such as osteoarthritis.