64 results about "Joint cavity" patented technology

The invention discloses a knee osteoarthritis dynamic grading prediction and intervention system and method based on a large model, and relates to the field of medical image analysis, and the method comprises the steps: obtaining a knee joint MRI image sequence and knee joint angle time sequence data of a patient; processing the MRI image sequence by using a pre-trained articular cavity segmentation model to obtain a joint fluid volume quantized value; aligning the knee joint angle time sequence to an image frame acquisition time point to generate a synchronous angle sequence; whether the average value of the liquid amount change rate sequence is lower than a preset stable threshold value or not is judged by calculating the liquid amount change rate sequence and the angle change quantity sequence, and if yes, a low-risk signal is output; otherwise, calculating a correlation coefficient between the liquid amount change rate and the angle change amount, outputting a moderate or severe gonitis prediction signal according to the value of the correlation coefficient, and further judging the mild or moderate risk of the gonitis according to the amplitude characteristics of the liquid amount change rate sequence; according to the invention, early gonitis lesion features can be identified, and the accuracy of grading prediction is improved.

An intraoperative surgical system for knee arthroplasty may be configured and / or reconfigurable to allow the surgical system to be inserted into different sized joint spaces during a surgical procedure. For example, the surgical system may include a sensor support body defining a platform, a force sensor, and a plurality of sensor covers each being configured to be detachably attached to the sensor support body. Each of the sensor covers can vary from each other in at least one characteristic. A selected one of the sensor covers can be placed over the platform, sandwiching the force sensor between the platform and sensor cover, to define a joint insertion block configured to be inserted into a tibiofemoral joint for measuring a force between a tibia and a femur defining the tibiofemoral joint.

The invention discloses an organic framework microgel for relieving osteoarthritis and application thereof.The organic framework microgel takes a cross-linked HAMA hydrogel network as a matrix and a skeleton of the whole microgel, and HAMA inherits and strengthens inherent excellent lubricating performance and biocompatibility of hyaluronic acid; according to the present invention, the HAMA matrix and the TA-ZIF-8 nano-particles are uniformly dispersed in the lubrication matrix so as to directly and enduringly improve the lubrication state of the joint, and the TA-ZIF-8 nano-particles are adopted as the treatment unit to be uniformly dispersed in the lubrication matrix, such that the matrix-wrapping structure ensures that the lubrication function (provided by the HAMA matrix) and the treatment function (provided by the TA-ZIF-8) can synchronously and continuously act in the whole period of the microgel retention in the joint cavity.

The present invention relates to a composition for intra-articular injection in dogs or cats, which is used to treat or ameliorate arthritis or reduce mechanical friction at joint sites by physical repair when injected into the joint cavity of dogs or cats. The present invention also relates to a method for administering a composition for intra-articular injection in dogs or cats, which is used to treat or ameliorate arthritis or reduce mechanical friction at joint sites by physical repair when injected into the joint cavity of dogs or cats. The composition of the present invention is administered so that the dosage of polynucleotide sodium is 2 to 3 mg, preferably 2.5 to 3 mg, per kg of body weight of the dog or cat.

The application discloses application of mesenchymal stem cell spheroids in preparation of a preparation for treating osteoarthritis, and relates to the technical field of cell therapy and osteoarthritis treatment, and specifically comprises mesenchymal stem cell spheroids with an average diameter of 120-180 mu m and a solution containing 0.5%-10% human serum albumin. The cells are prepared into 120-180 mu m cell spheroids, and the solution containing specific concentration human serum albumin is used as a carrier, so that the cell survival rate is stabilized at more than 90%, and high-activity delivery is realized; the optimized size ensures smooth injection and long-term retention in the joint cavity, and overcomes the shortcoming that single cells are easily removed; after joint cavity injection, the preparation can synergistically promote bone reconstruction and cartilage repair, and produces clear curative effects such as bone mass increase of more than 30%, cartilage degeneration score reduction of more than 50%, and the like, which are quantifiable and verifiable, so that a stable, long-acting and curative drug preparation and application scheme are provided for osteoarthritis treatment.

The present application relates to a kind of wrist joint and minimally invasive surgery robot and knee arthroscopy surgery robot, the knee arthroscopy surgery robot includes remote end 2 degrees of freedom wrist joint, 1 degree of freedom flexible mechanical arm, rigid insertion sheath, wire transmission device, bending drive device and gear transmission device;Wherein, by integrating endoscope module in wrist joint terminal, to realize the intelligent exploration in knee joint cavity;By the 2 degrees of freedom movement of wrist joint, realize the local intelligent adjustment of endoscope field of view;By the 1 degree of freedom bending movement of flexible mechanical arm, realize the large range bending movement and safety interaction of endoscope;By controlling the extension and retraction of rigid insertion sheath, it is convenient for doctor to control endoscope to enter knee joint cavity from knee joint incision smoothly, also can change the bending radius of flexible joint in flexible mechanical arm by regulating the extension amount of rigid insertion sheath, to realize the intelligent adjustment of endoscope field of view in large range and small range.

The present invention relates to a composition for injection into the joint cavity of dogs or cats, which is used to treat or ameliorate arthritis by injection into the joint cavity of dogs or cats, or to reduce mechanical friction in the joint region through physical restoration. The present invention also relates to a method for administering a composition for injection into the joint cavity of dogs or cats, the composition being used to treat or ameliorate arthritis by injection into the joint cavity of dogs or cats, or to reduce mechanical friction in the joint region through physical restoration. When the composition of the present invention is administered, the dose of sodium polynucleotide is 2-3 mg, preferably 2.5-3 mg, per body weight (kg) of a dog or a cat.

Provided are an injectable joint cavity hydrogel pharmaceutical composition and a method for preparing same. The hydrogel pharmaceutical composition comprises a gel particle and a drug loaded in the gel particle. The gel particle is formed by cross-linking hyaluronic acid or a salt thereof with fibroin via a cross-linking agent. The drug comprises an anti-inflammatory agent and / or a growth factor. The hydrogel pharmaceutical composition can treat a bone and joint-related disease by means of intra-articular injection.

The invention discloses an injectable hydrogel pharmaceutical composition for an articular cavity as well as a preparation method and application of the injectable hydrogel pharmaceutical composition. The hydrogel pharmaceutical composition comprises gel particles and a medicine loaded in the gel particles, the gel particles are formed by cross-linking hyaluronic acid or salt thereof and silk fibroin through a cross-linking agent; the medicine comprises an anti-inflammatory drug and / or a growth factor. The preparation method is simple, good in safety and beneficial to industrial production. The uniform porous structure of the hydrogel is beneficial to adhesion and growth of bone cells, meanwhile, the double-load hydrogel loaded with the anti-inflammatory drug and the growth factor has good viscoelasticity and injectability and has the effects of synergistically resisting inflammation and promoting cartilage repair, and bone joint related diseases are treated in a bone joint intracavity injection mode; the drug residence time can be prolonged, and the bioavailability is improved.

The invention relates to the technical field of medical image reconstruction, and discloses a bone joint three-dimensional reconstruction method and system based on deep learning. The method comprises the steps that a bone joint tomography image set is input, and multi-scale density slices and edge contour information are analyzed; deducing the two types of information space structures, and establishing an initial space field containing a bone tissue main body frame and a joint lacuna form; separating articular surface structure details and bone surface texture veins from the initial field; generating a network by using the three-dimensional structure which is obtained through separation and input and is trained to obtain a grid body with anatomical topological connection; and performing curved surface iterative smoothing based on biomechanical characteristics on the grid body, and outputting a final bone joint three-dimensional model.

The application discloses a joint cavity filling preparation of precisely proportioned carboxymethyl chitosan and sodium glycerophosphate and a preparation method and application thereof, and the effective component of the filling preparation is carboxymethyl chitosan with a concentration of 25 mg / mL and sodium glycerophosphate with a concentration of 15 mg / mL, and the balance is a sterile isotonic physiological buffer aqueous solution. The application forms component synergy by relying on the lubrication and long-acting stability characteristics of carboxymethyl chitosan and combining the structure reinforcement, ion regulation and cartilage repair promoting characteristics of sodium glycerophosphate, and effectively solves the defects of short in-vivo retention time, poor mechanical stability, lack of biological repair activity and easy dilution and collapse of the traditional joint filling material in the joint cavity fluid. The application overcomes the problem that a high-concentration viscous solution cannot be filtered and sterilized, can effectively buffer the joint mechanical load, optimize the joint microenvironment and promote the repair of degenerative cartilage, is suitable for clinical scenes such as mild and moderate osteoarthritis, sports joint injury and postoperative joint function repair, and has good clinical application value and industrialization prospect.

The utility model relates to a knee joint cavity injection training device. Comprising an upper simulation joint and a lower simulation joint which are connected in a hinged mode, an upper connecting rod is installed on the rear portion of the upper simulation joint, a lower connecting rod is installed on the lower portion of the lower simulation joint, a sliding rail is installed on the top of the front portion of the lower simulation joint, and a simulation patella capable of sliding left and right is installed on the sliding rail. The elastic jacket seals the front part of the upper connecting rod, the simulated upper joint, the simulated lower joint, the upper part of the lower connecting rod and the simulated patella inside; the device further comprises an adjusting type supporting frame capable of adjusting the angle between the simulation upper joint and the simulation lower joint. The utility model provides a knee joint cavity injection practical training device and provides a simulated knee joint model, so that a practical trainee operates an injector to complete the injection operation of a knee joint cavity on the knee joint model and master the operation skill of knee joint injection in the practical training process, and the problem that the skill cannot be really mastered in the existing teaching mode is solved.

This invention relates to the field of artificial ligament technology, specifically disclosing a method for securing the distal end of an artificial ligament. This method is mainly used for securing the traction suture to the distal fixation segment of the artificial ligament. The artificial ligament includes a free wire segment within the joint cavity, two braided segments located at both ends of the free wire segment, and two distal fixation segments located on opposite sides of the two braided segments. The fixation method mainly includes the following steps: placing the traction suture outside the distal fixation segment, and using a portion of the traction suture to create a covering portion, wherein the covering portion covers a portion of the two free strands of the traction suture outside the distal fixation segment. This invention ensures the structural integrity of the artificial ligament, the reliability of its function, and reduces the risk of inflammation in the patient.

The application discloses a kind of for repairing cartilage decellularized cartilage matrix support and apoptotic corpuscle composition and its preparation method, composition includes: microporous support, support includes decellularized cartilage outer matrix and crosslinked organic polymer;Apoptotic corpuscle, apoptotic corpuscle exists in microporous support;Wherein, based on the volume 3.14mm 3 Microporous support, 0.01-0.02ug of apoptotic corpuscle is included.The combined support of the application can improve the activity of apoptotic corpuscle, prolong the action time of apoptotic corpuscle, achieve the effect of slow release, also can regulate joint cavity microenvironment, effectively promote joint cartilage repair, improve the repair effect of loss cartilage, avoid the security risks brought by traditional exogenous cell transplantation.

The utility model relates to a hip and knee joint cavity perfusion drainage device. The device comprises a drug delivery mechanism and a suction mechanism which are arranged in vitro; the drug feeding mechanism is connected with a drug injection header pipe, the suction mechanism is connected with a drainage header pipe, and the drug injection header pipe and the drainage header pipe enter a human body through a skin incision; the medicine injection header pipe is arranged in a forked mode after entering a human body to form medicine injection branch pipes used for being placed in a hip joint cavity or a knee joint cavity, and medicine injection holes are evenly distributed in the medicine injection branch pipes. The main drainage pipe is arranged in a forked mode after entering the body, and a suction branch pipe used for being placed in a hip joint cavity or a knee joint cavity is formed. According to the utility model, a self-made simple medicine injection drainage tube commonly used in clinic at present can be replaced, so that the local part of an articular cavity is continuously, stably and uniformly dosed, the optimal effect of locally applying antibiotics is achieved, and the stable high-concentration state of the antibiotics is maintained. Meanwhile, skin incisions can be reduced, and the risks of incision infection and reverse infection are avoided.

The present application provides a method of preventing or treating joint periprosthetic infection (PJI), or alleviating a PJI-related condition, the method comprising administering to an articular cavity of a patient in need thereof a therapeutic agent comprising a compound represented by formula (I) and / or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, metabolite, or deuterated substance thereof.

The application belongs to the technical field of biotechnology, and discloses application of a new sialyloligosaccharide and astaxanthin composition in preparation of a transdermal drug for treating osteoarthritis and a composite gel preparation. The composition provided by the application comprises new sialyloligosaccharide, astaxanthin, carbomer and alginate with a mass ratio of (1-10):(1-10):(0.01-0.5):(0.1-1). The composition can realize efficient enrichment of the new sialyloligosaccharide and astaxanthin in the joint cavity through a diffusion pathway of skin penetration, deep tissue diffusion, joint capsule penetration and joint cavity enrichment of the substance, and the new sialyloligosaccharide and astaxanthin have excellent synergistic effects, can efficiently relieve acute inflammatory symptoms of gouty osteoarthritis, block the disease progression and repair the joint tissue pathological changes, and have excellent application prospects in preparation of the transdermal drug for treating osteoarthritis.

The invention relates to the technical field of biomedical gel material preparation, and discloses medicine mineralized gel as well as a preparation method and application thereof. The preparation method of the medicine mineralization type gel comprises the following steps: dropwise adding a NaOH aqueous solution into an alendronate sodium aqueous solution to obtain a mixture; mixing the mixture with sodium hyaluronate to obtain a viscous liquid; dropwise adding the viscous liquid into a CaCl2 aqueous solution, and stirring and mixing to obtain hydrogel; and incubating the hydrogel to obtain the drug mineralization type gel. The medicine mineralized gel prepared by the invention has excellent injectability, lubricating property, long-acting medicine slow release capacity and good biocompatibility, can quickly form gel after being injected into an articular cavity, not only plays roles in lubricating joints and reducing friction, but also can relieve joint inflammation and effectively improve joint functions, and can be used for treating joint inflammation. The application value in the field of osteoarthritis treatment is extremely high.

The invention discloses a medical composite material for synergistically regulating cholesterol and oxidative stress. The material comprises a Fe2-N6 / NC carrier, cholesterol oxidase loaded on the Fe2-N6 / NC carrier and a hyaluronic acid targeting layer modified on the surface, the carrier is a nitrogen-doped carbon material loaded with iron double-atom active sites, the distance between adjacent iron atoms is 0.311 + / -0.009 nm, and the iron content is 0.393 wt%; the average particle size of the composite material is 242.5 nm, and the Zeta potential of the composite material is-23.71 mV; the preparation method comprises the following steps: synthesizing Fe2-N6 / NC through mechanochemical-assisted in-situ MOF packaging, ultrasonically loading cholesterol oxidase and modifying with hyaluronic acid. The material has cholesterol degradation activity (the degradation rate is 33.94%) and active oxygen scavenging activity (the scavenging rate is 78.8%), and can be used for preparing an implant material for joint repair or a medical material for articular cavity injection so as to realize coordinated regulation of osteoarthritis cholesterol metabolism disorder and oxidative stress.

The invention relates to a preparation method of a multilayer sustained-release drug-loaded microsphere for articular cavity injection, and belongs to the field of biomedical materials and sustained-release preparations. The microsphere aims at solving the problems that traditional articular cavity lubricating gel is short in acting time and uncontrollable in drug release, and common drug-loaded microspheres are remarkable in burst release and insufficient in lubricity. The microsphere is constructed by adopting a natural material with good biocompatibility, collagen is taken as a core to load a drug, and a chitosan controlled release layer and a sodium hyaluronate lubricating layer are sequentially coated through electrostatic adsorption and covalent crosslinking to form the composite microsphere with a'core-shell-lubrication 'multilayer structure. The preparation method is based on a technical path technology of combining'crosslinking agent premixing emulsification-in-situ reaction curing 'and'layer-by-layer self-assembly-covalent crosslinking', and effective entrapment of drugs, stable construction of a controlled release structure and regulation and control of a degradation period are realized by optimizing process conditions. The microsphere can realize long-acting release of a medicine in a simulated environment, and the sodium hyaluronate on the outer layer of the microsphere material can improve the injection and pushing smoothness and is beneficial to the instant lubricity of the microsphere and retention of the microsphere in an articular cavity; all layers of materials are biodegradable, and degradation products have a potential nutrition support effect on joint tissues. The invention provides a microsphere delivery system with comprehensive performance for local treatment of joint diseases such as osteoarthritis.

This invention provides a stress-triggered selective targeting hydrogel microsphere, its preparation method, and its application, belonging to the field of biomedical technology. The core of this invention is the "stress-triggered charge reversal" mechanism. It utilizes the interaction between weakly cross-linked disulfide bonds broken under stress and "charge reversal" messenger molecules to achieve "charge reversal" of nanoparticles under stress. A dual-network hydrogel microsphere system is prepared using microfluidic technology to achieve bearing lubrication and stress relaxation within the joint cavity. Stress-triggered charge reversal is achieved at stress-overloaded cartilage lesions, imparting a positive charge to the drug-loaded nanoparticles within the hydrogel microspheres. This significantly enhances the ability of the drug-loaded nanoparticles to penetrate deep into the cartilage matrix and target chondrocytes for drug release under the guidance of the charge. This enables the selective and targeted release of appropriate drug concentrations to deep-seated chondrocytes in pathological microenvironments induced by different stress intensities, achieving highly effective and low-toxicity treatment of osteoarthritis.

The invention relates to a biological lubricant, in particular to a bone joint biological lubricant as well as a preparation method and application thereof. The bone joint biological lubricant comprises a component A and a component B, wherein the component A comprises the following raw materials in parts by volume: 4-6 parts of a 4% (w / v) sodium alginate solution, 0.3-0.5 part of a 1M calcium nitrate tetrahydrate solution, 0.4-0.6 part of a 2M beta-sodium glycerophosphate solution and 4-4.5 parts of normal saline; wherein the component B comprises the following raw materials in parts by volume: 3-5 parts of a 1M sodium citrate solution; after an ice-cold component A solution is injected into an articular cavity through an injector, and the solution enters an in-vivo environment at 37 DEG C, the temperature triggers Ca to be slowly released from a complex, the released Ca begins to be crosslinked with a G unit on a sodium alginate molecular chain, and finally stable hydrogel is formed in the articular cavity and has a good supporting effect when a patient is static; when the patient walks, a lubricating effect is achieved; when the gel needs to be removed, the component B can be injected into the gel part to convert the gel into a liquid state.

Provided is a biocompatible composition or the like that assists cells in the repair of a damaged tissue in a joint cavity. The biocompatible composition or the like according to the disclosure includes a biocompatible polymer having a substituent that adheres or binds to cells and / or a soft tissue in a joint cavity.

The auxiliary device comprises a base, an upper rod, a lower rod, an anti-return height adjusting mechanism and an arc-shaped fixing piece, the upper rod is arranged above the lower rod, the anti-return height adjusting mechanism is arranged between the upper rod and the lower rod, the base is arranged at the bottom of the lower rod, and the arc-shaped fixing piece is arranged above the upper rod. The arc-shaped fixing piece is placed below the knee joint, a knee joint cavity is fully opened, medicine injection can be conveniently and better conducted, meanwhile, through the anti-back-off height adjusting mechanism, the device adapts to different patient body types, puncture accuracy is improved, the joint cavity opening degree is optimized, and meanwhile the defect that traditional injection depends on manual fixing of the legs of a patient by a doctor, and the operation is not convenient can be overcome. The auxiliary device with the adjustable height can stably support limbs, a doctor can operate the auxiliary device with two hands, and the puncture stability is improved.

The application discloses application of Tiki2 as a target point in preparation of a drug for treating osteoarthritis, and relates to the technical field of osteoarthritis treatment. The drug can promote expression of Tiki2 protein. The drug developed for the Tiki2 protein will be possible to fundamentally slow down and reverse the osteoarthritis course. Especially, the Tiki2 protein in the joint cavity is supplemented by injecting the joint cavity with the gene therapy drug prepared by using the adeno-associated virus, and the gene therapy drug is expected to become a new treatment method for changing the osteoarthritis course.

A chitosan thermosensitive glue composition for treating osteoarthritis and a preparation method thereof. The composition comprises 0.5-5% chitosan thermosensitive glue and 10 6 -10 7 / mL stem cells. After mixing mesenchymal stem cells with chitosan thermosensitive glue, the mixture is injected into the joint cavity, which can not only play the effect of chitosan gel in lubricating the joint, but also inhibit inflammatory factors secreted by mesenchymal stem cells, and at the same time, mesenchymal stem cells can promote the regeneration of chondrocytes, effectively treating osteoarthritis.

The invention discloses a knee joint cavity puncturing and flushing device, and relates to the technical field of knee joint cavity puncturing. The device comprises a supporting block, the top of the supporting block is bent, the top of the supporting block is attached to a knee bend, a fixing mechanism is fixedly connected with the surface of the supporting block, the output end of a driving mechanism is fixedly connected with the surface of a puncture mechanism, the outer side face of a flushing assembly is slidably connected with a mounting plate, and the mounting plate is fixedly connected with the output end of the driving mechanism. The outer puncture needle is fixedly connected to one end of the flushing assembly, the inner puncture needle is arranged inside the outer puncture needle, the inner puncture needle is fixedly connected with the end, close to the outer puncture needle, of the flushing assembly, the top of the supporting block attached to the knee bend can support popliteal fossa, the joint is in a relaxed state, the puncture needle is easy to penetrate, and the intra-articular structure is not prone to being damaged. The inner puncture needle and the outer puncture needle can achieve the dual effects of extracting and flushing joint fluid through one-time puncture, and the environment in a knee joint cavity is improved to the maximum extent.

The application provides an anti-osteoarthritis nanometer radionuclide gel and a preparation method and application thereof 177 Lu and adenosine monophosphate coordination self-assembly 177 Lu-labeled metal organic framework, chitosan forms a temperature-sensitive gel in the case of glycerophosphate sodium as a crosslinking agent. The temperature-sensitive gel encapsulates 177 Lu-labeled metal organic framework not only helps to prolong the retention time of radionuclide in the local joint cavity, and by utilizing the temperature response performance of the high molecular material in the temperature-sensitive gel, a semi-solid gel is formed in situ in the joint, which not only has good viscoelasticity, lubrication and buffering of the joint, but also can play a barrier effect to prevent the diffusion of inflammatory substances in the joint cavity, and the degradation components of chitosan can stimulate the production of collagen and glycosaminoglycan of chondrocytes, and play a role in protecting and repairing cartilage. Therefore, the nanometer radionuclide gel is an excellent RSO drug delivery system, and has good biocompatibility and degradability.

This invention relates to a portable arthroscopy, comprising a cable connecting the lens, a traction unit for driving the lens to swing, a steering unit behind the lens, and a scope tube. When the steering unit rotates around its axis of rotation, pulling one of the traction units connected to it backward causes the lens to swing toward the side where the traction unit is located. The arthroscopy lens can swing at various angles to introduce light into the joint cavity; the acquired images can be transmitted to a matching terminal device for display. The arthroscopy of this invention has a simple structure and can be used only once to avoid or reduce sterilization work; the small diameter of the scope tube results in smaller incisions and easier handling; the arthroscopy can also have a surgical tool intervention channel, and is equipped with various surgical tools, any one of which can be selected and installed at the intervention channel for joint examination or treatment.

The invention discloses a pharmaceutical composition for targeted removal of osteoarthritis articular cavity apoptotic cells and application, and belongs to the technical field of biological medicines. The pharmaceutical composition comprises a targeting ligand, an apoptotic cell scavenger and a drug carrier, the targeting ligand is selected from an anti-phosphatidylserine monoclonal antibody or Annexin V protein, and can be specifically combined with phosphatidylserine on the surface of an apoptotic cell; the apoptotic cell scavenger is selected from demethoxycurcumin, andrographolide and the like, and can promote apoptotic cell phagocytosis and inhibit inflammatory factor release; and the drug carrier is hyaluronic acid-polylactic acid copolymer nanoparticles, and has good articular cavity retention property and drug sustained release effect. The pharmaceutical composition disclosed by the invention can be used for accurately targeting apoptotic cells in osteoarthritis articular cavities, efficiently removing the apoptotic cells, inhibiting inflammatory response and delaying cartilage degeneration, is good in biological safety and provides a new effective means for treating osteoarthritis.