145 results about "Bone material" patented technology

A bone material dispensing system is provided. The bone material dispensing system comprises a funnel having a proximal portion, the proximal portion comprising a top end and a bottom end, the top end opposite the bottom end, the top end comprising a surface having a protrusion configured to receive a locking member of a bone material dispensing device and the bottom end comprising a connector configured to secure the funnel to the bone material dispensing device. A bone material dispensing system comprises a pusher and a holder is provided. A method of dispensing bone material with the bone material dispensing system is also provided.

The utility model provides a bone drill, including a protective shell, a drive shaft, an inner ring cutting blade and an outer ring cutting blade; the protective shell has a containing inner cavity and a clearance gap laterally connected to the containing inner cavity, and the clearance gap also extends to the end of the protective shell; the drive shaft passes through the head end of the protective shell to extend into the containing inner cavity, the inner ring cutting blade and the outer ring cutting blade are arranged in the containing inner cavity of the protective shell and assembled on the drive shaft, the drive shaft, the inner ring cutting blade and the outer ring cutting blade are distributed in sequence from the inside to the outside and are coaxially arranged, and the inner ring cutting blade and the outer ring cutting blade are partially exposed in the clearance gap. In this way, a bone block of a set shape can be directly cut out without additional processing, and bone material is saved; at the same time, the area that does not need to be cut is blocked by the protective shell, and the protective shell can well protect the soft tissue from being scratched.

The invention belongs to the technical field of cell small molecule compound reprogramming and bone tissue engineering material culture, and discloses a method for inducing fibroblasts to be reprogrammed into osteoblasts. According to the invention, small molecule compounds act on fibroblasts, each small molecule is endowed with characteristics of a set of characteristic gene expression mode, and the small molecules are divided into different modules according to the expression characteristic mode, so that the fibroblasts of the cells are converted into osteogenic differentiation, the osteogenic differentiation effect is enhanced and maintained, and the in-vivo development of the cells is simulated to a great extent; therefore, healthy osteoblasts can be prepared from the skin fibroblasts, cell stress pressure can be resisted, and the prepared cells are free of tumorigenicity, safe and healthy. The osteoblast disclosed by the invention can be applied to preparation of bone materials and medicines for treating bone defects, for example, the osteoblast and a traditional bone material are used for constructing an active bone tissue engineering material, so that the use of allogeneic bones commonly used in clinic at present is avoided, and the occurrence of adverse ethical events is reduced.

The invention belongs to the field of biomedical materials, and relates to a chitosan calcium sulphoaluminate-potassium magnesium phosphate composite bone material as well as a preparation method and application thereof. The calcium sulphoaluminate-potassium magnesium phosphate composite bone material is formed by curing a calcium sulphoaluminate-potassium magnesium phosphate composite bone material and a chitosan solution, the calcium sulphoaluminate-potassium magnesium phosphate composite bone material comprises the following components in percentage by mass: 5-40% of calcium sulphoaluminate, 0.01-3.0% of boric acid and the balance of dead burned magnesium oxide and monopotassium phosphate, and the molar ratio of magnesium in the dead burned magnesium oxide to phosphorus in the monopotassium phosphate is (1-4): 1. The material provided by the invention has remarkable mechanical property, biological activity, cytotoxicity, injectability, non-transmissivity, coagulation property, degradability, absorbability and the like. Meanwhile, the bone material contains unreacted and degradable monopotassium phosphate, magnesium oxide and other substances, and due to the reasonable degradability and absorbability design of the bone material, the material can be gradually degraded in vivo and can grow along with bone tissue, and the treatment effect is further improved.

The invention discloses a patient-specific finite element model-based vertebroplasty optimization method and a related device. The method comprises the following steps of: constructing a patient-specific three-dimensional spine model according to a vertebral bone structure and a vertebral soft tissue structure; discretizing the patient-specific three-dimensional spine model into tetrahedral finite element grids, endowing each finite element unit with bone material attributes according to pixel values of CT scanning images, and endowing intervertebral disc and ligament soft tissue structures with soft tissue material attributes; determining an optimal bone cement injection path and an optimal bone cement injection amount of the tetrahedral finite element mesh; and simulating the vertebroplasty in the tetrahedral finite element mesh, predicting the stress distribution of the vertebrae, the rigidity of the vertebrae and the stress change of the adjacent vertebrae after the operation, and presenting the simulation result of the simulated vertebroplasty in a three-dimensional visual form. According to the method, personalized optimization and prediction of preoperative simulation of the vertebroplasty are realized by constructing the patient-specific finite element model, and an efficient auxiliary reference operation scheme is provided for an operator.

The utility model provides an intraoperative autogenous bone granule crushing device, and belongs to the technical field of medical treatment. Comprising a bone crushing outer cylinder; the bone crushing inner cylinder is positioned in the bone crushing outer cylinder; a crushing structure is mounted on the bone crushing inner cylinder; the driving part is positioned on the bone crushing inner cylinder and is used for driving the bone crushing inner cylinder to rotate; the bone crushing ring is positioned on the inner wall of the bone crushing outer cylinder and is in threaded connection with the inner wall of the bone crushing outer cylinder; and the transmission rod is mounted on the driving part and rotates along with the driving part. According to the bone crusher, the crushing structure on the bone crushing inner cylinder is matched with the crushing structure on the inner wall of the bone crushing ring, the bone crushing ring can move up and down in the bone crushing outer cylinder through the two-way thread structure, bone crushing materials are crushed from multiple dimensions, and compared with the prior art, the bone crusher can more effectively enable the sizes of crushed bone particles to be more uniform, so that the bone crushing efficiency is improved. The strict requirements on the size and the uniformity of the small-particle crushed bone in the operation are met, and the stable performance of the crushed bone material in the subsequent operation is facilitated.

The utility model discloses screening equipment for selecting simulated bone materials and cancellous structures, which is characterized in that a torque measuring instrument is fixed below a fixing frame, and a test block fixing mechanism for fixing and positioning a to-be-tested bone planting test block is fixedly arranged on a measuring workbench of the torque measuring instrument; the screwdriver can rotate in the circumferential direction and can be installed on the fixing frame in the mode that the screwdriver can ascend and descend by a set distance in the axial direction, the lower end of the screwdriver is provided with a pattern matched with the head of a to-be-locked simulation planting nail on a bone planting test block, and the rotation driving device installed on the fixing frame can drive the screwdriver to rotate. The balance weight mechanism which can be installed on the fixing frame in a lifting mode provides axial downward pressure for the screwdriver, the torque measuring instrument can detect the torque applied to the bone planting test block by the screw, the controller controls the rotation driving device to operate, and the bone planting test block is simple in structure, convenient to operate and high in practicability. According to the utility model, the material for simulating the alveolar bone in the dental implant practical training model can be selected more objectively, and errors caused by subjective hand feeling selection are avoided.

The invention relates to a preparation method of a plastic bone grafting material and the plastic bone grafting material.The preparation method comprises the following steps that a, phenyl phosphate lithium salt is dissolved in a phosphoric acid buffer salt solution to obtain a mixed solution, and Ge MA is dissolved in the mixed solution to obtain a Ge MA gel solution; b, bone meal and the Ge MA gel solution are subjected to a cross-linking effect, so that the bone meal and the Ge MA gel solution are fully mixed, then light source irradiation is conducted, the bone meal hydrogel bone grafting material is obtained, and the particle size of the bone meal is 0.25-0.5 mm. According to the preparation method of the plastic bone grafting material, provided by the invention, the bone meal and the Ge MA gel solution are subjected to cross-linking and then subjected to light source irradiation, so that the bone meal and the hydrogel are uniformly mixed, the compatibility of an organic phase and a bone meal particle interface is good, and the prepared plastic bone grafting material is relatively high in plasticity and good in osteoinductivity; and the cell adhesion rate is high.

The invention discloses a skeleton material suitable for additive manufacturing and a preparation method thereof.The method comprises the following steps that S1, CNTs are added into ethyl alcohol, stirring and ultrasonic dispersion are conducted, and CNTs ethyl alcohol dispersion liquid is obtained; s2, PEEK powder is added into the CNTs ethanol dispersion liquid, stirring and ultrasonic dispersion are carried out, and a CNTs-PEEK-ethanol blending liquid is obtained; s3, stirring the CNTs-PEEK-ethanol blended solution until the weight of the CNTs-PEEK-ethanol blended solution is not reduced any more, so as to obtain CNTs-PEEK powder; s4, after the CNTs-PEEK powder is dried, the CNTs-PEEK powder is extruded, and a CNTs-PEEK wire is obtained; s5, after the CNTs-PEEK wire is dried again, the CNTs-PEEK wire is subjected to high-temperature melting extrusion printing, and the personalized skeleton scaffold is obtained; the invention provides a bone material which is suitable for additive manufacturing, good in mechanical property and not prone to brittle fracture and a preparation method of the bone material.

The invention provides a bionic bone material as well as a preparation method and application thereof. The bionic bone material comprises a photocuring polymer monomer, protein molecules, modified polysaccharide molecules and piezoelectric nanoparticles, the protein molecules and the modified polysaccharide molecules can be crosslinked. Therefore, the bionic bone material disclosed by the invention combines a rigid-soft dual-network structure and the piezoelectric nanoparticles, can simulate mechanical properties, a porous structure and electrophysiological activity of natural bones, and has the characteristics of rapid curing, low thermal damage, high biocompatibility and the like.

The application provides a bone crushing device, which comprises a shell, a first bone crushing structure and a second bone crushing structure, the shell is internally provided with a bone crushing channel, the bone crushing channel has an inlet end and an outlet end, the first bone crushing structure is arranged on the side wall of the bone crushing channel, the first bone crushing structure has a plurality of first hinge teeth, and each first hinge tooth is arranged towards the inner side of the bone crushing channel; the second bone crushing structure is rotatably connected to the side wall of the bone crushing channel, the second bone crushing structure has a plurality of second hinge teeth, and the second hinge teeth and the first hinge teeth are alternately arranged; when the second bone crushing structure rotates, the second hinge teeth can form a shearing action with the first hinge teeth. The bone crushing device of the application drives the second hinge teeth to form shearing with the first hinge teeth through the rotation of the second bone crushing structure, so as to refine the bone material to be crushed, thereby obtaining bone graft particles meeting the requirements of reimplantation. Compared with the traditional bone rongeur, the bone crushing device of the application is simpler to operate, more convenient to use, faster to obtain bone graft particles and higher in efficiency.

The invention relates to a preparation method of an immunity-enhancing eel bone peptide composition, and belongs to the technical field of biological extraction. Comprising the following steps: a) pretreatment: sequentially performing low-temperature freeze-drying on eel aggregate, crushing the eel aggregate to 200 meshes or below, degreasing the eel aggregate with ethanol, and performing acid-process deliming to obtain pretreated aggregate; b) three-stage composite enzymatic hydrolysis: performing three-stage composite enzymatic hydrolysis on the pretreated aggregate to obtain enzymatic hydrolysate; c) enzyme deactivation and centrifugation: performing enzyme deactivation on the enzymatic hydrolysate, performing centrifugal separation, and removing insoluble substances to obtain clear liquid; d) ultrafiltration separation: performing ultrafiltration separation on the clear liquid to remove macromolecular impurities so as to obtain a collagen peptide concentrated solution; and e) debitterizing, deodorizing and drying: debitterizing and deodorizing the collagen peptide concentrated solution, and drying to obtain eel bone collagen peptide powder. The fishy smell and bitter taste are effectively removed, and the biological activity, purity and palatability of the product are remarkably improved.

The invention relates to the field of medical instruments, and provides a conicity-locked osseointegration prosthesis. The osseointegration prosthesis comprises an implantation prosthesis, a percutaneous device and an abutment screw, a plurality of fixing ridges are arranged on the periphery of the implantation prosthesis, intraosseous fixation is achieved in a press-fit mode, a taper locking structure is combined to prevent the implantation prosthesis from sinking, and it is ensured that the position of the implantation prosthesis is fixed after implantation; a flushing hole communicated with the internal flushing cavity is further formed in the periphery of the implant prosthesis, and the implant prosthesis can be used for injecting medicine into the medullary cavity, implanting bone materials and the like or used for follow-up flushing treatment for intramedullary infection possibly occurring in the later period. The percutaneous device and the implanted prosthesis are connected through the anti-rotation structure and the taper locking structure, the percutaneous section has the surface state formed through surface treatment, stimulation to surrounding soft tissue is reduced, the anti-infection capacity is improved, and the percutaneous sealing effect is improved. By optimizing the implantation structure and the percutaneous interface design, the intraoperative operation difficulty is reduced, the intraoperative time is shortened, meanwhile, the percutaneous stoma is reduced, and the infection risk is reduced.

The application provides an artificial bone material and a preparation method thereof, wherein the material quality of the artificial bone material includes, with the total dry matter of the artificial bone material being 100%, 70%-90% of coral hydroxyapatite particles, 5%-30% of recombinant human collagen, and 0-7% of excipients. The artificial bone material provided by the application has high porosity and a longitudinal gradient structure, can simulate the characteristics of natural bone tissue, and has excellent biocompatibility, biodegradability, hydrophilicity, osteogenic performance and shape memory function.

A method for treating an artificial bone implant with blood, according to the method bone material is placed in a container configured to be filled with blood, wherein the container comprises an opening and a cover configured to cover the opening of the container and a fixed separator that separates a bottom part and an upper part. The separator is provided with holes so that when the container is filled with whole blood, the blood in the bottom part is in full contact with the blood in the upper part, and wherein the bone material is in the upper part, on top of the separator.

The invention discloses a traditional Chinese medicine ingredient modified bone graft material and a preparation method thereof, and relates to the technical field of bone graft materials. The feed additive is prepared from the following raw materials: calcined bone meal and a traditional Chinese medicine extract, the traditional Chinese medicine extract comprises a radix salviae miltiorrhizae extract and / or a radix scutellariae extract. The preparation method comprises the following steps: preparing calcined bone meal, preparing simulated body fluid and preparing the modified bone graft material. The product material can be applied to a dental bone grafting material. The traditional Chinese medicine extract is loaded on the bone material, and the bone material is modified, so that the bone graft material with good biocompatibility, osteogenesis promoting capability and better osteogenesis induction potential can be obtained.

An augment device includes a hollow sleeve surrounding a channel extending through the hollow sleeve from a top to a bottom of the hollow sleeve, the hollow sleeve comprising a wall having an inner face and an outer face. The hollow sleeve includes at least one bending joint, the bending joint being configured for compressing the channel. Thereby the hollow sleeve may be compressed under an external force, leading to a decreased circumference and width of the hollow sleeve. This leads to a gap between the perimeter of the augment device and surrounding bone material, breaking any connections. By virtue of this, a much facilitated removal of the augment device can be achieved. Further, an extraction tool includes grippers for engaging and compressing the augment device, and further instruments, particularly a jig, for achieving an effective removal.

A bone implant (10) for encapsulating bone material (12) is provided. The bone implant includes a cover (18), which may be a biodegradable mesh. The cover is configured to be wound to a certain diameter to at least partially encapsulate the bone material within the cover. In some embodiments, the cover includes a body portion (80) and a closure portion (82) adjacent to the body portion. The closure portion is configured to hold the cover in its wound configuration to a predetermined diameter to at least partially encapsulate the bone material. A kit and method of using the bone implant are also provided.

A bone material dispensing device is provided. The bone material dispensing device includes a housing having a proximal end, a distal end, and a longitudinal axis. The proximal end has a first opening, and the distal end has a second opening. The first opening and the second opening are configured to slidably accommodate at least a portion of a plunger. A locking member is provided, which is pivotally connected to an upper surface of the housing and extends adjacent to the upper surface of the housing. The locking member includes a locking surface extending adjacent to the distal end of the housing, and the locking surface is configured to engage a portion of a tubular member, a funnel, or a combination thereof. The locking member is movable in a locked position to lock the portion of the tubular member, the funnel, or the combination thereof with the housing. A bone material dispensing system and a method for implanting bone material using the bone material dispensing system are also provided.

Implant drill (1), in particular dental implant drill, comprising a mounting area (10) and a machining area (30), wherein the implant drill (1) extends in a longitudinal direction (L), wherein the distal end regions in the longitudinal direction (L) of the implant drill (1) are formed in particular by the mounting area (10) and the machining area (30), wherein the processing area (30) has at least two processing structures (32), wherein the processing area (30) is designed in such a way as to be characterized by the processing structures (32), that it can remove bone material during a positive rotation around the longitudinal direction (L) and that it can compact bone material during a negative rotation around the longitudinal direction (L), wherein the machining area (30) is limited in the longitudinal direction (L) by a stop flange (60), wherein the processing area (30) has different processing sections (B1, B2, B3, B4) along the longitudinal direction (L), wherein the implant drill (1) has at least three processing sections (B1, B2, B3, B4), wherein the machining sections (B1, B2, B3, B4) form different outer contour slope angles (α1, α3) with the longitudinal direction (L) or are cylindrical around the longitudinal direction (L), wherein the implant drill (1), in particular the machining area (30), has a transition machining section (B3), wherein the transition machining section (B3) forms an outer contour slope angle (α3) with the longitudinal direction (L), and wherein the outer contour slope angle (α3) of the transition machining section (B3) is in a range of 7° to 15°.

Provided is a method for manufacturing a ring-shaped bone grafting substitute. The method for manufacturing a ring-shaped bone grafting substitute includes a biodegradable polymer providing step of providing a biodegradable polymer, a molding material providing step of providing a molding material in which the biodegradable polymer and a bone material are mixed; a molding material injection step of injecting the molding material into a ring-shaped mold such that a hole is formed in the center thereof; and ring-shaped bone grafting substitute molding step of freeze-drying the molding material having been injected into the ring-shaped mold at a temperature lower than a predetermined reference temperature, thereby molding the resultant into a ring-shaped bone grafting substitute.

The invention provides a calcium sulfate hemihydrate composite material with an antibacterial property, a preparation method of the calcium sulfate hemihydrate composite material and application of the calcium sulfate hemihydrate composite material in antibacterial bone repair. The preparation method comprises the following steps: firstly, selecting a polymer with good biocompatibility to be crosslinked with phthalocyanine, and then coating the surface of calcium sulfate hemihydrate with a phthalocyanine-polymer in a coordination manner through an in-situ synthesis method, so as to synthesize the calcium sulfate hemihydrate osteogenic material with uniform micron-sized granularity. According to the phthalocyanine-polymer-calcium sulfate hemihydrate composite material disclosed by the invention, the problems of drug resistance and toxic and side effects of antibiotics are solved through photodynamic and photo-thermal combined antibacterial properties; the defects that calcium sulfate hemihydrate is easy to absorb moisture and cannot ensure the bone repair performance are avoided through polymer coating; through the tissue scaffold effect of the polymer, adhesion and proliferation of new bone cells are facilitated, and the bone repair survival rate is greatly increased; moreover, through an in-situ synthesis method, the granularity of the calcium sulfate hemihydrate is effectively controlled, and the plasticity of the bone cement is ensured.

The invention provides a dual-network antibacterial bone repair material and a preparation method and application thereof, and relates to the technical field of biological materials, the dual-network antibacterial bone repair material comprises mineralized collagen and an antibacterial material; the mineralized collagen comprises a collagen layer and hydroxyapatite deposited and mineralized on the collagen layer; the antibacterial material and the collagen layer are mutually crosslinked. The material simulates a bone material of a minimum structural unit of a natural bone, can achieve a better osteogenic induction effect, and has better mechanical properties by taking collagen macromolecules as a scaffold; the mineralized collagen and the antibacterial material are cross-linked to form a double-network interpenetrating structure, the antibacterial material is connected with collagen macromolecules, the antibacterial function is achieved, the collagen macromolecules are indirectly connected through cross-linking of the antibacterial material, and the mechanical property of the material is further improved. The dual-network antibacterial bone repair material can simultaneously have osteogenic induction, antibacterial and early-stage good mechanical properties.

A system for harvesting bone material from a bone may include a rotary cutter defining a rotary cutter longitudinal axis extending between a rotary cutter proximal end and a rotary cutter distal end. The rotary cutter may have a drive shaft configured to receive input torque, and an osteochondral cutter configured to cut the tissue and receive the tissue material in response to rotation of the osteochondral cutter under pressure against the tissue. The system may further include a bone port defining a bone port longitudinal axis extending between a bone port proximal end and a bone port distal end. The bone port may have a bone port cannulation sized to closely fit over the osteochondral cutter. At least one of the bone port proximal end and the bone port distal end may be securable to the tissue. A stratiform tissue graft may be delivered through the bone port.

The present disclosure relates to a robotic system for removing bone material from an anatomical structure of a patient, comprising: a base (4), an end effector (2), the end effector being configured to hold a surgical tool (1), an actuation unit (3), the actuation unit being configured to translate the end effector relative to the base at least along one feed axis (A), a control unit, the control unit being connected to the actuation unit (3) and being configured to close the tool (1) and to command the actuation unit (3) to translate the end effector (2) along the feed axis (A) when the tool is closed, the control unit comprising a feedback unit, the feedback unit being configured to measure the force applied by the surgical tool (1) to the anatomical structure during the translation of the end effector (2) and, based on the measured force, to detect contact of the tool with the bone material of the anatomical structure.

This invention discloses a xenogeneic bone repair scaffold and its preparation method. The preparation method of the xenogeneic bone repair scaffold includes: a pretreatment step: obtaining bone blocks cut from animal bones, decellularizing, washing, and calcining to remove organic components to obtain a basic framework; a perfusion molding step: providing a mixed slurry of collagen, bioactive tricalcium phosphate, and a cross-linking agent, perfusing it into the basic framework under negative pressure vacuum, and freeze-drying to obtain a pre-formed composite xenogeneic bone; and a secondary cross-linking step: immersing the composite xenogeneic bone in a cross-linking agent for secondary cross-linking, and freeze-drying to obtain the xenogeneic bone repair scaffold. This xenogeneic bone repair scaffold completely removes immunogenic substances from the xenogeneic bone material while maintaining excellent water absorption and wetting properties to promote the regeneration of new bone and blood vessels.

The present disclosure provides a fiducial screw system. The system comprises a fiducial screw having a screw shaft configured to be inserted into a bone material and a screw head having or forming a fastening interface configured to cooperate with a fastening tool for inserting the fiducial screw into the bone material. The system further comprises an elongated tube forming a guiding channel, wherein the elongated tube has a proximal longitudinal end and a distal longitudinal end, and wherein the distal longitudinal end is shaped to be attachable or attached to the fiducial screw, e.g., to its head, and the proximal longitudinal end forms a guiding opening leading into the guiding channel.

An apparatus for mixing bone material with a liquid is provided. The apparatus includes a chamber having a proximal end and a distal end and bone material disposed within the chamber, the bone material comprising DBM particles of milled and lyophilized demineralized bone fibers; and a plunger having at least a portion slidably disposed within the proximal end of the chamber and configured to dispense the bone material mixed with the liquid from the distal end of the chamber when the plunger is in an extended position.

The invention discloses a high-connectivity porosity SiO2 / HA composite ceramic artificial bone material and a preparation method thereof, and belongs to the technical field of ceramic material preparation. The method adopts a synergistic process of template pretreatment, precise compounding and gradient calcination, and comprises the following steps: preparing SiO2 (at) PAA micelle particles, carrying out synergistic modification on the SiO2 (at) PAA micelle particles by SDS and Tween 80, mixing the SiO2 (at) PAA micelle particles with HA powder, regulating and controlling the stirring speed to prepare composite slurry, and carrying out gradient calcination to obtain the product. Regulating and controlling by ammonia water to enable SiO2 to form a broken cavity structure, and constructing a high-connectivity pore network; the double surfactants avoid particle aggregation, and low-speed stirring ensures the pore-forming effect. The material has high connectivity porosity and excellent mechanical properties, HA and an open pore SiO2 interface are tightly combined, bone tissue ingrowth and substance transmission can be promoted, the problems that a traditional HA material is large in brittleness, poor in pore connectivity, SiO2 agglomeration and the like are solved, the process is simple and controllable, and the material is suitable for large-scale production and scenes such as load-bearing bone repair.