79 results about "Tri calcium phosphate" patented technology

The invention provides a moniliella malayi and a fungicide and application thereof, and relates to the field of microorganisms. The acer rubrum is specifically acer rubrum RA, and the preservation number of the acer rubrum RA is CGMCC (China General Microbiological Culture Collection Center) No.35889. The acer rubrum RA can be used for preparing the acer rubrum. The strain has the capability of decomposing inorganic phosphorus, is wide in phosphorus-dissolving range, can decompose tricalcium phosphate, iron phosphate and aluminum phosphate, and particularly still has very strong capability of decomposing inorganic phosphorus under a low-temperature condition; the strain has the capability of producing siderophore and IAA at low temperature; the strain has an inhibition effect on various pathogenic bacteria causing field crop diseases, and can inhibit diseases such as corn root rot, sorghum leaf spot or wheat root rot; the strain can be colonized in a soil environment of 5-40 DEG C, a microbial inoculum prepared from the strain can promote crop growth, the crop yield is remarkably improved, and high yield can be achieved even if the usage amount of phosphate fertilizer is reduced.

The present invention relates to a medical device manufactured using the additive manufacturing process (3D printing). It is a medical device used preferably as a bone graft composed of a porous structure based on bioceramics based on β-tricalcium phosphate (β-TCP) or hydroxyapatite, which may or not contain nanostructures in its composition, for example: carbon nanostructures (graphene, graphene oxide, reduced graphene oxide, carbon nanotubes, etc.) and, in preferred embodiments, stem cells and polymeric membrane. Also, the present invention relates to the use of this device as a bone graft and the process of preparing this device.

Implantable bone compositions are provided. The implantable compositions comprise hydratable bone putties. The hydratable bone putties comprise porous ceramic granules having an average diameter from about 50 μm to 800 μm and the composition has a texture value above about 1000. The porous ceramic granules comprise hydroxyapatite and beta-tricalcium phosphate. The implantable bone compositions further include collagen carriers. In some embodiments, the hydratable bone putty can be hydrated to form a non-settable flowable cohesive cement or gel. Methods of making and using the implantable compositions are also provided.

The invention discloses a functional osteochondral repair material which comprises a cartilage layer, a transition layer and a bone layer which are sequentially connected, the cartilage layer takes hyaluronic acid, I-type collagen and chitosan as base materials, the transition layer takes hydroxyapatite and a polylactic acid-glycolic acid copolymer as base materials, and the bone layer takes hyaluronic acid, I-type collagen and chitosan as base materials. The bone layer takes beta-tricalcium phosphate, hydroxyapatite and a polylactic acid-glycolic acid copolymer as base materials, the invention relates to the technical field of medical biological materials, by designing the organic-inorganic composite transition layer, the gradient connection cartilage layer and the bone layer, and the interfacial shear strength is greater than or equal to 0.5 MPa, the problem of interlayer stripping of a traditional layered material is effectively solved, and the medical material has the advantages of high mechanical strength, high mechanical strength and high mechanical strength. According to the selective laser sintering 3D printing material, the shearing stress and the compression stress during joint movement can be borne, mature medical material production equipment such as freeze drying, compression molding and sintering is adopted in the preparation process, large-scale batch production can be achieved, meanwhile, personalized preparation of selective laser sintering 3D printing is supported, and the requirements of different clinical scenes are met.

The invention provides a sustained-release pellet containing gamma-aminobutyric acid, the sustained-release pellet comprises a pellet core and a coating layer wrapping the pellet core, the pellet core contains a physiologically active substance, and the physiologically active substance is gamma-aminobutyric acid; the pellet core comprises the following components in parts by weight: 15-40 parts of gamma-aminobutyric acid, 30-55 parts of a filling agent, 1-30 parts of a lubricating agent and 0.5-5 parts of an anti-caking agent; the filling agent comprises at least one of microcrystalline cellulose, powdery cellulose, starch and derivatives thereof, hydroxypropyl cellulose, hydroxypropyl methylcellulose, low-substituted hydroxypropyl cellulose, sugar or sugar alcohol and fruit and vegetable powder; the lubricant comprises at least one of talcum powder, magnesium stearate, stearic acid, glycerol and leucine; the anti-caking agent comprises at least one of magnesium carbonate, tricalcium phosphate, calcium hydrophosphate and silicon dioxide.

The invention discloses a cation-doped biphase calcium phosphate material and a preparation method and application thereof.The preparation method comprises the steps that a chemical precipitation method is adopted, the reaction process is precisely regulated and controlled, firstly, a reaction is carried out in an acidic microenvironment with the pH being 2-6, then aging is carried out under the alkaline condition with the pH being 9-12, and a two-step pH precise control strategy that acidity is carried out first and then alkalinity is carried out is adopted, so that the cation-doped biphase calcium phosphate material is obtained. According to the strategy, thermodynamic interference of cation doping on the HA / beta-TCP phase proportion can be effectively counteracted, and stable control over product phase composition is achieved. The preparation method has the core advantages that the proportion of hydroxyapatite (HA) to beta-tricalcium phosphate (beta-TCP) in the prepared biphase calcium phosphate material is highly stable, and the proportion does not obviously fluctuate in a specific range of the cation doping amount due to the change of the doping amount or cation types; the problem that the phase proportion is uncontrollable due to doping in the prior art is solved.

The invention relates to a method in the technical field of inorganic materials, in particular to a method for preparing metal element doped hydroxyapatite through a high-temperature solid-phase method, a product prepared through the method and application of the product. Through two steps of high-temperature solid-phase reaction, metal-doped beta-tricalcium phosphate (beta-TCP) is synthesized in advance to serve as a reaction precursor, the metal-doped beta-tricalcium phosphate and calcium carbonate are subjected to solid-phase reaction at high temperature to generate metal-doped hydroxyapatite, the distribution uniformity of doped elements in a final hydroxyapatite product is guaranteed, and by controlling the temperature and time, the metal-doped hydroxyapatite is prepared. Generation of impure phases can be effectively inhibited, and doped hydroxyapatite with single phase composition is obtained. The method is simple in process, free of solvent and high in yield, metal ions with different functions can be flexibly introduced, directional regulation and control of functionality such as biological activity, mechanical property and antibacterial property of a final hydroxyapatite material are achieved, and a new way with great industrialization prospects is provided for large-scale and low-cost preparation of high-performance doped hydroxyapatite.

The invention relates to a bone-like layered calcium silicate / tricalcium phosphate heterogeneous biological ceramic as well as a preparation method and application thereof. The preparation method of the bone-imitating layered calcium silicate / tricalcium phosphate heterogeneous biological ceramic comprises the following steps: (1) mixing calcium silicate powder, an additive and a solvent to obtain calcium silicate tape casting slurry; mixing the tricalcium phosphate powder, an additive and a solvent to obtain tricalcium phosphate tape casting slurry; (2) respectively carrying out tape casting on the calcium silicate tape casting slurry and the tricalcium phosphate tape casting slurry to obtain a calcium silicate green tape and a tricalcium phosphate green tape; (3) alternately laminating the calcium silicate green tape and the tricalcium phosphate green tape, and performing pressurization treatment to obtain a composite ceramic body; and (4) degumming and sintering the composite ceramic green body to obtain the bone-like layered calcium silicate / tricalcium phosphate heterogeneous biological ceramic.

The invention belongs to the technical field of cosmetics, and particularly relates to an anti-darkness powder make-up composition and a preparation method thereof. According to the anti-darkness powder make-up composition provided by the invention, the oil control capacity of the anti-darkness powder make-up composition is enhanced by carrying out alkali treatment modification on the polymethylsilsesquioxane, and the anti-darkness powder make-up composition is matched with nonionic silicon surfactants such as tricalcium phosphate, bismuth oxychloride, trimethoxysilyl polydimethylsiloxane / trimethylsiloxy ammonia-terminated polydimethylsiloxane and the like; the anti-darkness powder makeup fixing composition has the effects of instantly brightening the skin color and resisting darkness for a long time, so that the technical problem that the makeup is easy to become dark after makeup fixing in the prior art is solved.

The invention discloses a mechanically controllable composite membrane material, which comprises a three-dimensional porous scaffold composed of bacterial cellulose, and bioactive ceramic nanoparticles are uniformly dispersed in and on the surface of the three-dimensional porous scaffold; the bioactive ceramic nanoparticles are one or more of tricalcium phosphate, bioactive glass, calcium silicate and hydroxyapatite. According to the invention, the bioactive ceramic nanoparticles are uniformly loaded inside and on the surface of the three-dimensional porous scaffold formed by bacterial cellulose, and the composite membrane material can be endowed with a unique biological function by adjusting the types of the bioactive ceramic nanoparticles. The composite membrane material prepared by an in-situ, ectopic or chemical deposition method and the like can realize synergy and balance of mechanical properties and biological functions, and the structural design of the composite membrane material provides necessary mechanical support and also gives consideration to flexible fit with fragile nervous tissues, so that the composite membrane material has a wide application prospect in the field of neurosurgery.

The invention provides a PVC stabilizer, zinc p-tert-butyl benzoate and a preparation method and application thereof, and relates to the technical field of polymer materials. The PVC stabilizer disclosed by the invention is prepared from the following components in parts by weight: 8 to 16 parts of zinc p-tert-butylbenzoate, 1 to 3 parts of zinc 2-ethylhexanoate, 1.3 to 3 parts of barium stearate, 0.6 to 1.8 parts of tricalcium phosphate, 2.8 to 4.4 parts of dipentaerythritol and 0.2 to 1 part of tromethamine. The preparation method of the zinc p-tert-butylbenzoate comprises the following steps: mixing and dissolving p-tert-butylbenzoic acid and a solvent; and then mixing with a zinc compound and a catalyst, heating to 90-105 DEG C, and reacting to obtain high-yield zinc p-tert-butyl benzoate. Zinc p-tert-butylbenzoate cooperates with zinc 2-ethylhexanoate, barium stearate, tricalcium phosphate, dipentaerythritol and tromethamine, so that the stability of a PVC product is improved, and the transparency and mechanical properties of the PVC product are improved.

The present invention relates to a bone graft composition in which a lappaconitine derivative is surface-adsorbed on a scaffold comprising tricalcium phosphate (TCP) and hydroxyapatite (HA). In the composition of the present invention, the osteogenesis-promoting properties of the lappaconitine derivative are combined with the osteoconductivity of the TCP / HA scaffold, thereby improving problems such as high-concentration adverse effects, unstable adsorption patterns, and localized excessive formation, which occur in existing protein-based osteogenic factors.

To provide a bone regeneration material having both antibacterial properties and high aesthetic properties, and to provide a method for producing the bone regeneration material.SOLUTION: A bone regeneration material in a cotton form comprising a biodegradable fiber, wherein the biodegradable fiber contains calcium phosphate, silver ion-solid solution calcium phosphate, and a biodegradable polymer, and a content ratio of the silver ion-solid solution calcium phosphate to a total amount of the calcium phosphate and the silver ion-solid solution calcium phosphate is 60 mass% or more. The silver ion solid solution calcium phosphate is preferably silver ion solid solution β - tricalcium phosphate.SELECTED DRAWING: None

This utility model discloses a skull base defect repair device with adjustable function, including a card body. The front side of the card body is convex, and the rear side is concave. A clamping part is provided at the center of the front side of the convex side. The clamping part is arranged in an "I" shape. With the card body and clamping part provided, compared with other rigid reconstruction materials, this invention uses β-tricalcium phosphate material that can absorb human bone. It is made by mechanical processing or 3D printing technology. It has good biodegradability, biocompatibility, and non-toxicity. It can be used as an ideal bone substitute material for rigid reconstruction. In addition, this application also has the advantages of being ultra-thin, having stable clamping and good sealing effect, which can greatly reduce the occurrence of complications such as rejection reaction, postoperative cerebrospinal fluid leakage, postoperative brain tissue protrusion, and intracranial infection.

This invention provides a calcium phosphate-polycaprolactone composite scaffold, its preparation method, and its applications. The raw materials for preparing the calcium phosphate-polycaprolactone composite include polycaprolactone, β-tricalcium phosphate, and hydroxyapatite. The resulting composite scaffold possesses functions of promoting immunity and regulating bone regeneration. The preparation method of this invention involves first forming a hydroxyapatite / polycaprolactone composite film, which is then broken down and recombined with β-tricalcium phosphate to form a composite solution. The resulting 3D-printed composite scaffold not only possesses good mechanical strength and biocompatibility but also induces stem cell proliferation and osteogenic differentiation, and induces macrophage regeneration and polarization. It can be used to regulate immune cell responses, induce a bone immune microenvironment conducive to bone formation, thereby enhancing bone regeneration, and can be used for the repair and regeneration of tissue defects.

The invention provides a piezoelectric composite material compositely integrated by high-performance piezoelectric conductive hydrogel and a biphase bone scaffold. The piezoelectric composite material is formed by compositing piezoelectric hydrogel, conductive hydrogel and a tricalcium phosphate / hydroxyapatite biphase scaffold, the piezoelectric hydrogel is formed by wrapping glycine nanofibers with a modified polymer; the conductive hydrogel is formed by complexing a polymer solution containing lithium acetate, borate ions and a hydroxyl compound. The pressure-responsive self-generating composite material which is high in conductivity, high in voltage, high in support and biodegradable is formed by integrating the pressure-conductive hydrogel and the biphase bone scaffold, construction of a composite hydrogel system which is high in voltage, high in conductivity, high in support strength and biodegradable is achieved, and the application requirement of a high-performance bone repair material system is met.

The invention relates to the field of oral alveolar bone repair materials, provides a magnesium metal / PLGA-TCP composite porous microsphere bone repair material and a preparation method thereof, and aims to solve the problems that in the prior art, magnesium ion release is uncontrollable, corrosion is accelerated due to the fact that PLGA is degraded to produce acid, and a microsphere hole structure is single. According to the technical scheme, the preparation method comprises the following steps: dispersing metal magnesium microspheres and beta-tricalcium phosphate in dichloromethane, then adding PLGA and ethyl cellulose, stirring and dissolving to form an oil phase solution, taking a polyvinyl alcohol solution as an outer water phase, dissolving gelatin in part of the polyvinyl alcohol solution as an inner water phase, dropwise adding the inner water phase into the oil phase, and carrying out dual-power ultrasonic emulsification to form a primary emulsion; magnesium metal / PLGA-TCP composite microspheres are prepared through a microfluidic device, the microspheres are solidified and then subjected to water bath to remove gelatin, and then freeze drying is conducted to obtain the multistage through hole microspheres which are used for preparing an oral cavity alveolar bone repair material.

The invention discloses an osteochondral integrated sponge scaffold as well as a preparation method and application thereof, and belongs to the field of osteochondral repair materials. The preparation method comprises the following steps: (1) mixing a collagen dispersion liquid and a polyvinyl alcohol solution, then adding a phosphate buffer solution and beta-tricalcium phosphate, and then obtaining lower-layer hydrogel through a pouring method; (2) mixing the collagen dispersion liquid with a polyvinyl alcohol solution, then adding a phosphate buffer solution, and then obtaining upper-layer hydrogel through a pouring method; and (3) pouring the upper-layer hydrogel on the lower-layer hydrogel, constructing a sponge scaffold through a multi-time freeze-thawing method and a freeze-drying method, and finally soaking the sponge scaffold in thrombin to obtain the osteochondral integrated sponge scaffold. The scaffold can adsorb platelet-rich plasma, has certain adhesion capacity, can realize in-situ fixation and biological integration at a defect part, can well recover physical and biological dysfunctions of bone joints and osteochondral bones, and provides a potential application idea for clinical treatment of osteochondral defects.

The invention provides tantalum-doped beta-tricalcium phosphate nanoparticles and a preparation method and application thereof, and belongs to the technical field of biological materials.The preparation method comprises the following steps that tantalum salt is dispersed in a complexing agent solution, the pH is adjusted to be 8-10, and a tantalum complexing solution is obtained; the preparation method comprises the following steps: respectively dispersing calcium salt and phosphate in water to obtain a Ca < 2 + > solution and a PO4 < 3-> solution; dropwise adding the tantalum complexing solution into the Ca < 2 + > solution, and stirring and mixing to obtain a first mixed solution; dropwise adding a PO4 < 3-> solution into the first mixed solution, stirring and mixing to obtain a second mixed solution, carrying out a hydrothermal reaction, separating out a reaction product after the reaction is completed, and carrying out freeze drying and high-temperature calcination to obtain the tantalum-doped beta-tricalcium phosphate nanoparticles. The tantalum-doped beta-tricalcium phosphate nano-particles prepared by the method are good in mechanical property, high in corrosion resistance and excellent in biological performance, and can be widely applied to the biomedical fields of bone tissue engineering, drug loading and the like and the field of functional ceramics.

Delayed-release micropellet particles containing γ-aminobutyric acid, characterized in that it comprises a pellet core and a coating layer surrounding the pellet core, wherein the pellet core contains a physiologically active substance, the physiologically active substance being gamma-aminobutyric acid; the pellet core comprises, calculated in parts by weight, the following components: 15 to 40 parts of gamma-aminobutyric acid, 30 to 55 parts of a filler, 1 to 30 parts of a lubricant, 0.5 to 5 parts of an anti-caking agent; wherein the filler comprises at least one of microcrystalline cellulose, powdered cellulose, starch and its derivatives, hydroxypropyl cellulose, hydroxypropyl methylcellulose, low-substituted hydroxypropyl cellulose, sugar or sugar alcohols and solid fruit and vegetable drinks; wherein the lubricant comprises at least one of talc, magnesium stearate, stearic acid, glycerol and leucine; wherein the anti-caking agent comprises at least one of magnesium carbonate, tricalcium phosphate, dicalcium phosphate and silicon dioxide.

The invention discloses a synthesis device and process of porous tricalcium phosphate / tetracalcium phosphate in the technical field of bone repair materials. The synthesis device comprises a synthesis sintering furnace, a placement mechanism and a separation device, the sintering table is used for placing a sintering material, the synthesis sintering furnace is used for synthesizing tricalcium phosphate, tetracalcium phosphate and a porous material, the placing mechanism is used for placing a sintering raw material, and the separating device is used for enabling the sintering table to be separated from the extending part one by one so as to enable material blocks to fall on the cooling plate. The detachable sintering table is arranged on the placing mechanism, and a high-temperature-resistant metal cooling plate is arranged in the sintering table; after sintering is completed, a sintering table is detached to enable material blocks to fall on a cooling plate, a cooling medium is introduced for cooling, the enough cooling rate is directly achieved in a furnace body, the problem that the cooling rate does not reach the standard due to one-by-one discharging is avoided, the disproportionation reaction of tetracalcium phosphate can be effectively reduced, the purity of tetracalcium phosphate is improved, and the service life of the tetracalcium phosphate is prolonged. Finally, the quality of the porous material is improved.

This invention provides a method for preparing an antimicrobial peptide composite material, comprising: S1 preparing a β-TCP / HyA porous substrate; S2 synthesizing mesoporous polydopamine (MPDA); S3 dispersing the β-TCP / HyA porous scaffold and the mesoporous polydopamine in deionized water for a second crosslinking reaction to form a β-TCP / HyA / MPDA composite suspension; and then adding the antimicrobial peptide KR to the β-TCP / HyA / MPDA composite suspension to induce a binding reaction, thereby obtaining the antimicrobial peptide composite material. This invention crosslinks β-tricalcium phosphate (β-TCP), hyaluronic acid (HyA), and mesoporous polydopamine (MPDA) to construct a multifunctional composite substrate that combines physical support, biocompatibility, and high-efficiency loading. The mesoporous structure of MPDA provides numerous anchoring sites for the antimicrobial peptide KR. Through MPDA adhesion and covalent fixation strategies for the antimicrobial peptide, high-density and high-activity loading of KR molecules is achieved, effectively solving the problems of easy detachment and "fixation leading to inactivation".

The present application relates to a kind of water product phagostimulant composition and its preparation method, belong to feed technology field, the composition includes the following raw materials: grain powder, inorganic powder, river snail meat powder, vegetable oil, gluten, egg yolk oil, yeast nucleotide;The grain powder includes puffed glutinous rice powder, puffed pea powder and barley malt powder, the inorganic powder includes tricalcium phosphate and titanium dioxide, and the vegetable oil includes perilla seed oil.This application selects puffed glutinous rice powder, puffed pea powder, tricalcium phosphate and titanium dioxide as visual phagostimulant component effectively accelerates the speed of fish positioning feed;At the same time, river snail meat powder, egg yolk oil, perilla seed oil and barley malt powder can promote water production animals sustained feeding from the different dimensions of stimulating olfaction, increasing palatability, stimulating taste and promoting intestinal absorption;In addition, the egg yolk oil selected in this application also has adhesion, and the addition of gluten in this application can reduce the dispersion rate of the composition in water, so that the composition has water production special performance.

The application provides a vitamin premix and a preparation process thereof, and belongs to the technical field of food additives, and the preparation process is as follows: adding mixed microparticles of fat-soluble vitamins, mixed water-soluble vitamins and mixed minerals into a mixer and mixing, then adding vitamin C, magnesium taurate, amino acids and tricalcium phosphate and continuing to mix, and sieving to obtain the vitamin premix. The raw materials of the mixed microparticles of fat-soluble vitamins include vitamin A, vitamin E acetate, vitamin D3, vitamin K2, acacia, modified protein and beta-cyclodextrin; the raw materials of the mixed water-soluble vitamins include vitamin B1, vitamin B2, vitamin B5, vitamin B12, folic acid and nicotinamide; and the raw materials of the mixed minerals include ferrous glycinate, calcium citrate, magnesium citrate and zinc glycinate. The vitamin premix prepared by the application can be used in various foods as a nutritional supplement, is convenient to use, and has good stability and mixing uniformity.

The invention discloses a bone-periosteum bionic stent for vascularized bone regeneration and a preparation method of the bone-periosteum bionic stent, and belongs to the technical field of bone repair. The stent comprises a bone bionic stent and a bionic periosteum, the bone bionic scaffold is of a hierarchical pore structure and is formed by compounding polycaprolactone, silk fibroin and beta-tricalcium phosphate through fused deposition 3D printing, and the surface of the bone bionic scaffold is subjected to alkali treatment so as to improve hydrophilicity and osteogenic activity; the bionic periosteum is printed on the surface of the bone bionic scaffold through a near-field direct writing technology and is composed of polycaprolactone, mineralized collagen and magnesium ions, and the mineralized collagen is distributed in the bionic periosteum in a gradient mode. Through integrated bionic design, structures and functions of natural bones and periosteum are simulated; the bone bionic support plays a role in mechanical support and bone formation promotion; the bionic periosteum rapidly releases magnesium ions in the early stage of degradation, and early vascularization is promoted; along with degradation, continuously released collagen induces mineralization of a collagen matrix in the later period; the stent has good cell compatibility and capability of promoting osteogenic differentiation and blood vessel formation.

Disclosed in the present invention are a novel artificial bone based on promoting neurovascular regeneration and a preparation method. The novel artificial bone comprises an artificial bone. The artificial bone is composed of β-tricalcium phosphate, polylactic acid-glycolic acid, a nano magnesium-based powder, and a piezoelectric polymer. The mass ratio of β-tricalcium phosphate to polylactic acid-glycolic acid in the artificial bone is 1:0-1:10. The nano magnesium-based powder and the piezoelectric polymer are mixed to form a piezoelectric composite solution, and the mass ratio of the nano magnesium-based powder to the piezoelectric polymer in the piezoelectric composite solution is 1:1-1:20, such that the surface of the artificial bone is modified by means of the piezoelectric composite solution, thereby forming a piezoelectric coating on the surface of the artificial bone; in this way, when the artificial bone is implanted into a bone defect site and is subject to stress, a charge and potential difference are generated. The present invention not only enhances the strength of the artificial bone, but also promotes the degradation of the artificial bone, stimulates local neurovascular regeneration, promotes the formation of new bone, and achieves the purpose of repairing osteonecrosis and bone defects.

This invention discloses a method for preparing viscous bone cement, comprising the following steps: S1: mixing a silk fibroin solution with a natural polymer solution to obtain a mixed solution; S2: processing the mixed solution obtained in step S1 to obtain powder A; S3: selecting a calcium-containing inorganic compound as a basic calcium salt, combining it with calcium supplement raw materials to adjust the calcium-to-phosphorus ratio to 1.67, and mixing the basic calcium salt with the calcium supplement raw materials to obtain calcium salt powder B; S4: mixing powder A obtained in step S2 with calcium salt powder B obtained in step S3 according to the mixing ratio to obtain solid powder C; this invention uses tricalcium phosphate and calcium dihydrogen phosphate as the curing substrate, introducing biodegradable silk fibroin and gelatin into the curing system, and the gelatin and silk fibroin carrying positive and negative charges respectively, and their electrostatic interaction giving them viscosity, providing a viscous substrate.

The invention relates to the technical field of food processing, discloses a preparation method of red date and cyperus esculentus composite meal replacement powder, and aims to solve the technical problems that the existing composite meal replacement powder is unreasonable in nutrition collocation, low in raw material utilization rate and easy to cake. The method is characterized by comprising the following steps: respectively preparing pretreated red date powder, pretreated cyperus esculentus powder and cured medicinal and edible powder, and then mixing all the products with modified silicon dioxide, sodium carboxymethyl cellulose, tricalcium phosphate and microcrystalline cellulose; wherein the pretreated red date powder is prepared by crushing dried date slices, performing enzymolysis, adding a composite wall material, performing freeze-drying and crushing, the pretreated cyperus esculentus powder is prepared by performing microwave puffing on cyperus esculentus meal, spraying a tea polyphenol solution, performing drying, performing graded crushing, and the cured medicinal and edible powder is prepared by mixing Chinese yam powder and lotus seed powder, performing steam explosion, performing drying and performing crushing. The method is mainly used for preparing the red date and cyperus esculentus composite meal replacement powder with balanced nutrition and good stability.

The application discloses an injectable anti-disintegration paste material and a preparation method and application thereof, and belongs to the field of biomedical materials. The paste material comprises a powder component and a liquid component. The powder component comprises tricalcium silicate powder, beta-tricalcium phosphate powder and anhydrous calcium dihydrogen phosphate. The liquid component is a hydroxypropyl methylcellulose aqueous solution with a mass percentage concentration of 1-3%. The mass ratio of the powder component to the liquid component of the paste material is 1.5-2.5:1. The prepared injectable anti-disintegration paste material has excellent anti-disintegration performance and injection performance, can be self-cured quickly, is convenient to operate and easy to fill, can prevent the paste from being eroded by a water-containing environment, can induce the generation of bone-like hydroxyapatite, and can be used in the field of dental repair such as pulp capping, root tip shaping and root canal treatment.

The invention relates to an autologous cancer vaccine and its preparation method. The autologous vaccine according to the present invention is based on hydroxyapatite and / or tricalcium phosphate particles onto which tumor proteins are adsorbed, these tumor proteins being enriched in HSP110.