148 results about "Tri calcium phosphate" patented technology

The invention discloses two phosphate solubilizing bacteria and application of microbial agents thereof, and belongs to the technical field of microorganisms. The preservation number of the bacillus cereus Sau.XJ-4 is CCTCC (China Center For Type Culture Collection) NO: M 20242890; the preservation number of the arthrobacter sp. Sau.XJ-5 is CCTCC (China Center for Type Culture Collection) NO: M 20242891. The bacillus cereus Sau.XJ-4 and the bacillus cereus Sau.XJ-5 have the characteristics of saline-alkali resistance, aluminum resistance and the like, insoluble inorganic mineral substances such as tricalcium phosphate can be effectively decomposed, insoluble nutrient elements such as nitrogen, potassium and phosphorus in soil are promoted to be converted into soluble nutrients, the content of available nutrients in the soil is increased, and the yield and the quality are improved; the fertilizer can also relieve aluminum stress of plants and promote growth and development of the plants, and has important significance for fully exerting soil ecological fertility and keeping balance of an agricultural ecological environment.

The invention discloses a preparation method of a three-dimensional porous white phosphorus calcium stone ceramic bracket with piezoelectric biological activity, and belongs to the field of brackets. The preparation method of the scaffold comprises the following steps: uniformly dipping a polymer foam template with a certain pore size and porosity in slurry composed of beta-tricalcium phosphate and a binder, carrying out high-temperature sintering to remove organic matters, carrying out a hydrothermal reaction on the inorganic scaffold in an aqueous solution containing magnesium ions, converting beta-tricalcium phosphate into white calcomanite, and carrying out drying to obtain the scaffold. And then carrying out high-temperature annealing treatment to obtain the white calcomanite porous ceramic bracket with piezoelectric biological activity. The prepared ceramic scaffold is controllable in composition and degradation rate, excellent in mechanical property, electroactive, free of cytotoxicity and remarkable in osteogenesis induction effect, and the porosity and aperture of the scaffold are suitable for cells to enter and grow. The preparation method of the white phosphorite three-dimensional piezoelectric ceramic bracket is simple and easy to implement, controllable in process and easy to amplify.

The invention provides a moniliella malayi and a fungicide and application thereof, and relates to the field of microorganisms. The acer rubrum is specifically acer rubrum RA, and the preservation number of the acer rubrum RA is CGMCC (China General Microbiological Culture Collection Center) No.35889. The acer rubrum RA can be used for preparing the acer rubrum. The strain has the capability of decomposing inorganic phosphorus, is wide in phosphorus-dissolving range, can decompose tricalcium phosphate, iron phosphate and aluminum phosphate, and particularly still has very strong capability of decomposing inorganic phosphorus under a low-temperature condition; the strain has the capability of producing siderophore and IAA at low temperature; the strain has an inhibition effect on various pathogenic bacteria causing field crop diseases, and can inhibit diseases such as corn root rot, sorghum leaf spot or wheat root rot; the strain can be colonized in a soil environment of 5-40 DEG C, a microbial inoculum prepared from the strain can promote crop growth, the crop yield is remarkably improved, and high yield can be achieved even if the usage amount of phosphate fertilizer is reduced.

The invention relates to bone paste for repairing bone wounds and a preparation method of the bone paste, and belongs to the technical field of biomedical material manufacturing. The bone paste is prepared from nanoscale calcium-phosphorus biphase ceramic, biomimetic mineralized collagen fiber, biodegradable polymer, modified hyaluronic acid, beta-cyclodextrin coated recombinant human bone morphogenetic protein-7, an angiogenesis accelerant and an immunoregulation additive according to a certain proportion. The nano-scale calcium-phosphorus dual-phase ceramic is hydroxyapatite and beta-tricalcium phosphate dual-phase ceramic; the biomimetic mineralized collagenous fiber is prepared by mixing type I collagen freeze-dried fiber with hydroxypropyl chitosan and performing mineralization; the modified hyaluronic acid is hyaluronic acid-sulfydryl and hyaluronic acid-hydrazide; the angiogenesis accelerant is a polylactic acid sustained release microsphere loaded with tanshinone and hydroxyl polyethylene glycol biotin; the immunoregulation additive is disodium glycyrrhizinate, lentinan and astragalus polysaccharide. The bone paste can effectively improve the bone induction capacity, promote vascularization generation and reduce the immunogenicity risk.

The invention relates to the technical field of biological materials for 3D printing, in particular to a polyether-ether-ketone composite material with an enhanced 3D printing function and a preparation method of the polyether-ether-ketone composite material. The invention discloses a polyether-ether-ketone composite material with an enhanced 3D printing function. The material is prepared from the following raw materials in parts by mass: 75-85 parts of polyether-ether-ketone, 5-10 parts of a modified bioactive material, 1-3 parts of carbon nanotubes, 0.5-2 parts of an organic nucleating agent, 0.1-1 part of a biological regulator and 0.1-1 part of an antibacterial agent, the modified bioactive material is modified hydroxyapatite and / or modified tricalcium phosphate. According to the basic formula, the synergistic effect of multifunctional components is achieved, the defects of an existing PEEK material in the aspects of biological activity and crystallization performance are overcome through the components such as polyether-ether-ketone, the modified bioactive material and the carbon nanotubes which are meticulously proportioned, and excellent mechanical performance and biocompatibility are provided.

The present invention relates to a bone trauma repair bone paste and a preparation method thereof, belonging to the technical field of biomedical material manufacturing. The bone paste of the present invention is prepared by mixing nano calcium phosphate biphasic ceramics, biomimetic mineralized collagen fibers, biodegradable polymers, modified hyaluronic acid, β-cyclodextrin-coated recombinant human bone morphogenetic protein-7, angiogenesis promoters and immunomodulatory additives in a certain proportion; the nano calcium phosphate biphasic ceramics are hydroxyapatite and β-tricalcium phosphate biphasic ceramics; the biomimetic mineralized collagen fibers are prepared by mineralizing freeze-dried fibers of type I collagen admixed with hydroxypropyl chitosan; the modified hyaluronic acid is hyaluronic acid-thiol and hyaluronic acid-hydrazide; the angiogenesis promoter is a polylactic acid sustained-release microsphere loaded with tanshinone and hydroxy polyethylene glycol biotin; the immunomodulatory additive is disodium glycyrrhizinate, lentinan and astragalus polysaccharide. The bone paste can effectively improve the bone induction ability, promote angiogenesis and reduce the risk of immunogenicity.

The invention belongs to the technical field of biomedical materials, and particularly relates to a long-acting antibacterial biomass orthopedic material and a preparation method thereof. The nutrient solution is prepared from the following raw materials: calcium nitrate tetrahydrate, ammonium dihydrogen phosphate, gallium nitrate, zinc nitrate hexahydrate, antibiotics, 2-methylimidazole, sulphobetaine methacrylate and a photoinitiator. A three-layer synergistic structure is constructed through a Ga-doped beta-tricalcium phosphate core / a pH-responsive ZIF-8 and antibiotic shell / a photocuring sulfobetaine (pSBMA) brush layer, and the process adopts three conventional continuous steps of water-phase coprecipitation, room-temperature self-assembly and room-temperature photocuring, so that a high-energy physical deposition or complex surface activation process is avoided; the interlayer compatibility and repeatability are ensured; the finally obtained biomass material realizes triple functions of adhesion barrier resistance, drug burst release and long-term ion antibiosis in a microscopic level, and maintains biocompatibility in a macroscopic level.

The present invention relates to a medical device manufactured using the additive manufacturing process (3D printing). It is a medical device used preferably as a bone graft composed of a porous structure based on bioceramics based on β-tricalcium phosphate (β-TCP) or hydroxyapatite, which may or not contain nanostructures in its composition, for example: carbon nanostructures (graphene, graphene oxide, reduced graphene oxide, carbon nanotubes, etc.) and, in preferred embodiments, stem cells and polymeric membrane. Also, the present invention relates to the use of this device as a bone graft and the process of preparing this device.

The invention relates to the technical field of yoghourt preparation, in particular to normal-temperature cheese yoghourt capable of promoting calcium absorption and a preparation method of the normal-temperature cheese yoghourt. The normal-temperature cheese yoghurt mainly comprises the following raw materials in parts by weight: 60-70 parts of concentrated milk, 10-15 parts of distilled water, 5-10 parts of single cream, 2-10 parts of cream cheese, 2-10 parts of xylitol, 1-6 parts of starch, 0.1-0.5 part of tricalcium phosphate, 0-0.05 part of mogroside, 0.001-0.005 part of a leavening agent, 0.001-0.006 part of vitamin A and 0.001-0.006 part of vitamin D. The cheese yoghurt is reasonable in component matching, simple and stable in preparation process, free of preservatives and colloids, low in production cost and suitable for industrial production. The prepared product is uniform and stable, tastes fine and smooth, can be stably stored for a long time at normal temperature (at least 6 months at normal temperature), maximally retains the rich flavor and high nutrition density of cheese and the refreshing taste and digestibility of yoghourt, and meets the requirements of consumers on healthy, safe, delicious and convenient high-quality dairy products.

Implantable bone compositions are provided. The implantable compositions comprise hydratable bone putties. The hydratable bone putties comprise porous ceramic granules having an average diameter from about 50 μm to 800 μm and the composition has a texture value above about 1000. The porous ceramic granules comprise hydroxyapatite and beta-tricalcium phosphate. The implantable bone compositions further include collagen carriers. In some embodiments, the hydratable bone putty can be hydrated to form a non-settable flowable cohesive cement or gel. Methods of making and using the implantable compositions are also provided.

The invention provides a mineralized gel type physalis alkekengi leavening agent and application thereof in preparation of physalis alkekengi tofu. The method comprises the following steps: firstly, forming an EGCG-Ca < 2 + > complex from epigallocatechin gallate and tricalcium phosphate in soybean clear water, inducing TCP nanosheets to be self-assembled, and interpenetrating with a soybean protein network to construct a mineralized gel skeleton; the mineralized gel type sour slurry leavening agent is prepared by firstly preparing a skeleton, then immobilizing lactic acid bacteria in micropores of the skeleton and finally performing electrostatic grafting on soybean peptide, so that the gel strength, the water binding capacity, the flavor and the like of sour slurry bean curds are improved, and the nutrition and the quality of the bean curds are further improved.

The invention belongs to the field of ceramic preparation, and particularly relates to bone china with high thermal shock resistance and a preparation method thereof. In order to solve the problem of insufficient thermal shock resistance of bone china in the prior art, the invention provides the bone china with high thermal shock resistance and the preparation method thereof, and the bone china adopts a three-layer gradient structure design and comprises a matrix layer, a middle transition layer and a surface compact layer. The matrix layer contains hydroxyapatite, bone ash, modified palygorskite, a fluxing agent and kaolin, the middle transition layer adopts anorthite and beta-tricalcium phosphate, and the surface compact layer is composed of ZrO2 and SiO2. The structure is optimized through segmented sintering and laser treatment, thermal stress concentration is remarkably reduced, and meanwhile excellent mechanical strength is guaranteed.

Provided are a preparation process for a modified hydroxyapatite and the use thereof. The preparation process comprises the following steps: S1. removing impurities from coral by using a sodium hypochlorite solution, followed by crushing to obtain coral particles; S2. subjecting the coral particles and a phosphate solution to a hydrothermal reaction at a pH value of 9-11 to obtain coralline hydroxyapatite; S3. mixing and reacting the coralline hydroxyapatite and an ion source to obtain an ion source-doped coralline hydroxyapatite; and S4. heating the ion source-doped coralline hydroxyapatite, and sintering and cooling same to obtain an ion source-doped coralline β-tricalcium phosphate, wherein the ion source comprises a strontium source. The modified hydroxyapatite prepared by the preparation process has a better degradation performance and mechanical adaptability, which improves the biological activity and osteoinductivity of coral artificial bones, and facilitates bone tissue ingrowth.

A thermoplastic composition includes specific amounts of a poly (phenylene ether), an impact modifier (including a hydrogenated block copolymer of an alkenyl arene and a conjugated diene), an organophosphate flame retardant, a flame retardant synergist (including phosphazene), and optionally, tricalcium phosphate. The thermoplastic composition can be used to make various articles, particularly suitable for thin wall applications.

The invention discloses a functional osteochondral repair material which comprises a cartilage layer, a transition layer and a bone layer which are sequentially connected, the cartilage layer takes hyaluronic acid, I-type collagen and chitosan as base materials, the transition layer takes hydroxyapatite and a polylactic acid-glycolic acid copolymer as base materials, and the bone layer takes hyaluronic acid, I-type collagen and chitosan as base materials. The bone layer takes beta-tricalcium phosphate, hydroxyapatite and a polylactic acid-glycolic acid copolymer as base materials, the invention relates to the technical field of medical biological materials, by designing the organic-inorganic composite transition layer, the gradient connection cartilage layer and the bone layer, and the interfacial shear strength is greater than or equal to 0.5 MPa, the problem of interlayer stripping of a traditional layered material is effectively solved, and the medical material has the advantages of high mechanical strength, high mechanical strength and high mechanical strength. According to the selective laser sintering 3D printing material, the shearing stress and the compression stress during joint movement can be borne, mature medical material production equipment such as freeze drying, compression molding and sintering is adopted in the preparation process, large-scale batch production can be achieved, meanwhile, personalized preparation of selective laser sintering 3D printing is supported, and the requirements of different clinical scenes are met.

The invention provides a sustained-release pellet containing gamma-aminobutyric acid, the sustained-release pellet comprises a pellet core and a coating layer wrapping the pellet core, the pellet core contains a physiologically active substance, and the physiologically active substance is gamma-aminobutyric acid; the pellet core comprises the following components in parts by weight: 15-40 parts of gamma-aminobutyric acid, 30-55 parts of a filling agent, 1-30 parts of a lubricating agent and 0.5-5 parts of an anti-caking agent; the filling agent comprises at least one of microcrystalline cellulose, powdery cellulose, starch and derivatives thereof, hydroxypropyl cellulose, hydroxypropyl methylcellulose, low-substituted hydroxypropyl cellulose, sugar or sugar alcohol and fruit and vegetable powder; the lubricant comprises at least one of talcum powder, magnesium stearate, stearic acid, glycerol and leucine; the anti-caking agent comprises at least one of magnesium carbonate, tricalcium phosphate, calcium hydrophosphate and silicon dioxide.

The present invention provides a vitamin premix and a preparation process thereof, and belongs to the technical field of food additives, the preparation process is as follows: fat-soluble vitamin mixed particles, mixed water-soluble vitamins and mixed minerals are added into a mixer for mixing, then vitamin C, magnesium taurate, amino acids and tricalcium phosphate are added for continuous mixing, and sieving is performed to obtain the vitamin premix. Wherein the fat-soluble vitamin mixed particles comprise the following raw materials: vitamin A, vitamin E acetate, vitamin D3, vitamin K2, Arabic gum, modified protein and beta-cyclodextrin; the mixed water-soluble vitamins comprise the following raw materials: vitamin B1, vitamin B2, vitamin B5, vitamin B12, folic acid and nicotinamide; the mixed mineral substance comprises the following raw materials: ferrous glycinate, calcium citrate, magnesium citrate and zinc glycinate. The vitamin premix prepared by the invention can be used as a nutritional supplement in various foods, is convenient to use, and has good stability and mixing uniformity.

The invention discloses a cation-doped biphase calcium phosphate material and a preparation method and application thereof.The preparation method comprises the steps that a chemical precipitation method is adopted, the reaction process is precisely regulated and controlled, firstly, a reaction is carried out in an acidic microenvironment with the pH being 2-6, then aging is carried out under the alkaline condition with the pH being 9-12, and a two-step pH precise control strategy that acidity is carried out first and then alkalinity is carried out is adopted, so that the cation-doped biphase calcium phosphate material is obtained. According to the strategy, thermodynamic interference of cation doping on the HA / beta-TCP phase proportion can be effectively counteracted, and stable control over product phase composition is achieved. The preparation method has the core advantages that the proportion of hydroxyapatite (HA) to beta-tricalcium phosphate (beta-TCP) in the prepared biphase calcium phosphate material is highly stable, and the proportion does not obviously fluctuate in a specific range of the cation doping amount due to the change of the doping amount or cation types; the problem that the phase proportion is uncontrollable due to doping in the prior art is solved.

The invention discloses beta-tricalcium phosphate-based photocuring formed ceramic slurry and a preparation method thereof, and the beta-tricalcium phosphate-based photocuring formed ceramic slurry comprises the following components in parts by volume: 66-75 parts of modified ceramic powder, 25-30 parts of a resin premixed solution, and a dispersant accounting for 10-20% of the mass fraction of the modified ceramic powder, the modified ceramic powder is a KH560 or KH570 modified ceramic powder body; the mass ratio of the beta-tricalcium phosphate to the hydroxyapatite to the 3Y-TZP is (4-10): (2-6): 1, and the average particle size of the beta-tricalcium phosphate is 6-12 [mu] m and / or 1-4 m; the average particle size of the HA particles is 1-4 m and / or 300-500 nm; the average particle size of the 3Y-TZP particles is 300 to 500 nm and / or 80 to 120 nm. The high solid content, the high dispersion stability and the good rheological property are guaranteed, meanwhile, degreasing sintering densification is considered, the mechanical stability of a green body is effectively improved, the density and the mechanical property of a sintered body are optimized, meanwhile, the good biocompatibility and the biological activity of beta-TCP are reserved, and therefore the requirements of high-standard medical application such as bone repair and bone replacement are met.

The invention relates to a method in the technical field of inorganic materials, in particular to a method for preparing metal element doped hydroxyapatite through a high-temperature solid-phase method, a product prepared through the method and application of the product. Through two steps of high-temperature solid-phase reaction, metal-doped beta-tricalcium phosphate (beta-TCP) is synthesized in advance to serve as a reaction precursor, the metal-doped beta-tricalcium phosphate and calcium carbonate are subjected to solid-phase reaction at high temperature to generate metal-doped hydroxyapatite, the distribution uniformity of doped elements in a final hydroxyapatite product is guaranteed, and by controlling the temperature and time, the metal-doped hydroxyapatite is prepared. Generation of impure phases can be effectively inhibited, and doped hydroxyapatite with single phase composition is obtained. The method is simple in process, free of solvent and high in yield, metal ions with different functions can be flexibly introduced, directional regulation and control of functionality such as biological activity, mechanical property and antibacterial property of a final hydroxyapatite material are achieved, and a new way with great industrialization prospects is provided for large-scale and low-cost preparation of high-performance doped hydroxyapatite.

The invention discloses a voriconazole dispersible tablet and a preparation method thereof, relates to the technical field of pharmacy, and solves the technical problem of low bioavailability caused by low dissolution rate and slow disintegration speed of the conventional voriconazole dispersible tablet. The voriconazole dispersible tablet comprises 30-50 parts of voriconazole, 10-20 parts of a disintegrating agent, 15-25 parts of a sweetening agent, 3-8 parts of an adhesive, 1-2 parts of a lubricant and 8-16 parts of a pore forming agent, the pore-forming agent comprises beta-tricalcium phosphate and a polyethylene glycol-chitosan grafted copolymer, the pore-forming agent is prepared by performing ultrasonic treatment and freeze-drying on beta-tricalcium phosphate and a polyethylene glycol-chitosan grafted copolymer aqueous solution, and in the pore-forming agent, the polyethylene glycol-chitosan grafted copolymer is adsorbed in pores of beta-tricalcium phosphate; the voriconazole dispersible tablet provided by the invention can accelerate disintegration and dissolution of drugs, improves the dissolution rate and bioavailability of the drugs, and is high in drug stability and low in impurity content.

The invention relates to a bone-like layered calcium silicate / tricalcium phosphate heterogeneous biological ceramic as well as a preparation method and application thereof. The preparation method of the bone-imitating layered calcium silicate / tricalcium phosphate heterogeneous biological ceramic comprises the following steps: (1) mixing calcium silicate powder, an additive and a solvent to obtain calcium silicate tape casting slurry; mixing the tricalcium phosphate powder, an additive and a solvent to obtain tricalcium phosphate tape casting slurry; (2) respectively carrying out tape casting on the calcium silicate tape casting slurry and the tricalcium phosphate tape casting slurry to obtain a calcium silicate green tape and a tricalcium phosphate green tape; (3) alternately laminating the calcium silicate green tape and the tricalcium phosphate green tape, and performing pressurization treatment to obtain a composite ceramic body; and (4) degumming and sintering the composite ceramic green body to obtain the bone-like layered calcium silicate / tricalcium phosphate heterogeneous biological ceramic.

The invention belongs to the technical field of cosmetics, and particularly relates to an anti-darkness powder make-up composition and a preparation method thereof. According to the anti-darkness powder make-up composition provided by the invention, the oil control capacity of the anti-darkness powder make-up composition is enhanced by carrying out alkali treatment modification on the polymethylsilsesquioxane, and the anti-darkness powder make-up composition is matched with nonionic silicon surfactants such as tricalcium phosphate, bismuth oxychloride, trimethoxysilyl polydimethylsiloxane / trimethylsiloxy ammonia-terminated polydimethylsiloxane and the like; the anti-darkness powder makeup fixing composition has the effects of instantly brightening the skin color and resisting darkness for a long time, so that the technical problem that the makeup is easy to become dark after makeup fixing in the prior art is solved.

To provide an apatite-zirconium oxide composite having high mechanical strength and low elastic modulus, a restorative material, a medical device, and a method for producing a calcium phosphate-carbon atom-zirconium oxide composite.SOLUTION: A calcium phosphate-carbon atom-zirconium oxide composite comprises tricalcium phosphate, apatite represented by formula (1): Cas(PO4)t(X)u, and carbon atoms, and further comprises zirconium oxide, wherein in formula (1), X represents at least one selected from the group consisting of OH and CO3, s represents a number of 8 to 10, t represents a number of 4 to 6, and u represents a number of 1 to 2.SELECTED DRAWING: Figure 1

The invention discloses a mechanically controllable composite membrane material, which comprises a three-dimensional porous scaffold composed of bacterial cellulose, and bioactive ceramic nanoparticles are uniformly dispersed in and on the surface of the three-dimensional porous scaffold; the bioactive ceramic nanoparticles are one or more of tricalcium phosphate, bioactive glass, calcium silicate and hydroxyapatite. According to the invention, the bioactive ceramic nanoparticles are uniformly loaded inside and on the surface of the three-dimensional porous scaffold formed by bacterial cellulose, and the composite membrane material can be endowed with a unique biological function by adjusting the types of the bioactive ceramic nanoparticles. The composite membrane material prepared by an in-situ, ectopic or chemical deposition method and the like can realize synergy and balance of mechanical properties and biological functions, and the structural design of the composite membrane material provides necessary mechanical support and also gives consideration to flexible fit with fragile nervous tissues, so that the composite membrane material has a wide application prospect in the field of neurosurgery.

The invention provides a PVC stabilizer, zinc p-tert-butyl benzoate and a preparation method and application thereof, and relates to the technical field of polymer materials. The PVC stabilizer disclosed by the invention is prepared from the following components in parts by weight: 8 to 16 parts of zinc p-tert-butylbenzoate, 1 to 3 parts of zinc 2-ethylhexanoate, 1.3 to 3 parts of barium stearate, 0.6 to 1.8 parts of tricalcium phosphate, 2.8 to 4.4 parts of dipentaerythritol and 0.2 to 1 part of tromethamine. The preparation method of the zinc p-tert-butylbenzoate comprises the following steps: mixing and dissolving p-tert-butylbenzoic acid and a solvent; and then mixing with a zinc compound and a catalyst, heating to 90-105 DEG C, and reacting to obtain high-yield zinc p-tert-butyl benzoate. Zinc p-tert-butylbenzoate cooperates with zinc 2-ethylhexanoate, barium stearate, tricalcium phosphate, dipentaerythritol and tromethamine, so that the stability of a PVC product is improved, and the transparency and mechanical properties of the PVC product are improved.

To provide a method for producing resin particles that enables stable production of flattened resin particles.SOLUTION: A method for producing resin particles comprises: a polymerization initiation step in which suspension polymerization of a monomer is initiated in an aqueous suspension containing water, the monomer, a specific amount of tricalcium phosphate having a specific average particle diameter, and an anionic surfactant; and a heat treatment step in which the aqueous suspension is treated at a temperature higher than that at the polymerization initiation point, at a specific timing, wherein the L / D of the resin particles is 0.85 or less.SELECTED DRAWING: None

The invention belongs to the technical field of soft capsules, and particularly discloses an opaque chewing soft capsule skin and a preparation method and application thereof.The opaque chewing soft capsule skin is prepared from, by mass, 10-45 parts of gel, 2-25 parts of opacifying agent, 15-45 parts of plasticizer, 1-15 parts of water holding agent, 0.1-2 parts of food additive and 20-40 parts of water; the opacifying agent comprises natural starch and a filling agent, and the filling agent comprises at least one of zinc oxide, calcium carbonate and tricalcium phosphate. The opaque chewing soft capsule skin can effectively solve the problems that the soft capsule skin is easy to react, the soft capsule material is easy to yellow and fade and the like, and meets the requirements of whiteness and shading property of the skin at the same time.

The present invention relates to a bone graft composition in which a lappaconitine derivative is surface-adsorbed on a scaffold comprising tricalcium phosphate (TCP) and hydroxyapatite (HA). In the composition of the present invention, the osteogenesis-promoting properties of the lappaconitine derivative are combined with the osteoconductivity of the TCP / HA scaffold, thereby improving problems such as high-concentration adverse effects, unstable adsorption patterns, and localized excessive formation, which occur in existing protein-based osteogenic factors.

To provide a bone regeneration material having both antibacterial properties and high aesthetic properties, and to provide a method for producing the bone regeneration material.SOLUTION: A bone regeneration material in a cotton form comprising a biodegradable fiber, wherein the biodegradable fiber contains calcium phosphate, silver ion-solid solution calcium phosphate, and a biodegradable polymer, and a content ratio of the silver ion-solid solution calcium phosphate to a total amount of the calcium phosphate and the silver ion-solid solution calcium phosphate is 60 mass% or more. The silver ion solid solution calcium phosphate is preferably silver ion solid solution β - tricalcium phosphate.SELECTED DRAWING: None