666 results about "Tri calcium phosphate" patented technology

An injectable and moldable putty comprising biodegradable calcium-based compounds including calcium sulfate, hydroxyapatite, and tricalcium phosphate is invented. The putty hardens into a solid body when mixed with water, saline, serum, or other neutral aqueous solutions. The hardening time of the putty can be tailored in order to meet the specific requirements of various dental or orthopedic applications. The pH of the putty is neutral during and after mixing. The invented putty may be used as bone graft, bone implant, or implantable drug delivery device.

Ceramic materials operable to repair a defect in bone of a human or animal subject comprising a porous ceramic scaffold having a bioresorbable coating, and a carrier comprising denatured demineralized bone. The ceramic may contain a material selected from the group consisting of hydroxyapatite, tricalcium phosphate, calcium phosphates, calcium carbonates, calcium sulfates, and combinations thereof. The compositions may also contain a bone material selected from the group consisting of: bone powder, bone chips, bone shavings, and combinations thereof. The bioresorbable coating may be, for example, demineralized bone matrix, gelatin, collagen, hyaluronic acid, chitosan, polyglycolic acid, polylactic acid, polypropylenefumarate, polyethylene glycol, or mixtures thereof.

Biologically active composites containing calcium phosphate, more specifically beta-tri-calcium phosphate, and methods of preparing the same are disclosed herein. Also disclosed are methods of restoring an osseous void and complimentary kits for the disclosed composites.

A composition of porous material and gel for preparing artificial bone is prepared from collagen and porous material chosen from alpha-tricalcium phosphate/hydroxy apatite, beta-tricalcium phosphate/hydroxy apatite-coral, calcium phosphate/hydroxy apatite, calcium carbonatel tricalcium phosphate, etc.

The present invention is one kind of new inorganic bone grafting material and belongs to the field of medical material. The inorganic bone grafting material consists of beta-tricalcium phosphate grain in 20-80 wt% and alpha-calcium sulfate semihydrate powder in 20-80 wt%, and the alpha-calcium sulfate semihydrate powder form layered structure in the surface and/or pores of beta-tricalcium phosphate grain. Both beta-tricalcium phosphate and alpha-calcium sulfate semihydrate have excellent biocompatibility and excellent in vivo degrading performance, and the composite artificial bone grain may be used in repairing bone defect of different shapes. The composite artificial bone grain has wide material source, convenient use, excellent performance, simple preparation process, low cost and other advantages.

Methods are provided for producing porous β-Tricalcium Phosphate (β-TCP). In the subject methods, β-TCP is combined with graphite to produce an intermediate greenware product. The intermediate greenware product is then sintered to produce porous β-TCP. The subject methods and compositions produced thereby find use in a variety of applications.

The present invention discloses a preparing method of the calcium phosphate cement/chitosan-gelatin composite scaffold, the process is as follows: mixing the alpha- tricalcium phosphate, monohydrate calcium biphosphate, hydroxyapatite and calcium carbonate according to the mass ration and rubbing, then obtaining the calcium carbonate cement solid powder; mixing the disodium hydrogen phosphate solution and the cement solid powder in the mass ratio and stirring to a mash, then filling into a mould, vacuum solidifying and mold releasing, after that, solidifying again and obtaining the calcium phosphate cement scaffold; subsequently, dissolving the chitosan and the gelatin into the acetic acid water solution, configuring the chitosan-gelatin solution and adding the glutaraldehyde water solution; putting the calcium phosphate cement scaffold into the chitosan-gelatin solution, in vacuum condition, filling chitosan-gelatin solution into the calcium phosphate cement scaffold, after that cooling and drying, obtaining the calcium phosphate cement/chitosan-gelatin composite scaffold. The prepared calcium phosphate cement/chitosan-gelatin composite scaffold has a perfect mechanical property and biological property.

The invention discloses a pre-mixing typed plaster calcium phosphate bone cement in the biological medical bone tissue material technology, which is characterized by the following: the solid powder and liquid powder with quality rate at 2.5-3.7: 1 are sealed container, the solid powder is beta-tricalcium phosphate and hydrated acid calcium phosphate with molar rate at 1:1, the liquid material is medical glycerin or polietilenglicol with molecular quantity at 400-800.

An absorbable internal fixing material for bone fracture is prepared from polylactic acid (50-90 wt.%), tricalcium phosphate (1-40 wt.%) and hydroxylapatitie (1-40 wt.%) through mixing then and then hot die pressing at 80-1230 deg.C and under 0.11-25 MPa or hot extruding at 80-230 deg.c. The granulality of hydroxylapatite and tricalcium phosphate is less than 100 microns. Its advantages are high strength, high strength, high X-ray visualization and high biocompatibility.

The present invention relates to surgical material. The material includes biologically absorbable polymer 10-90 wt%, un-sintered calcium phosphate salt 5-80 wt%, and bone growth factor less than 10 wt%. The biologically absorbable polymer includes polyester, chitosan, chondroitin sulfate, collagen, alginate, etc.; and the calcium phosphate salt is un-sintered hydroxyapatite or tricalcium phosphate of granularity less than 100 microns. The hard tissue repairing material is prepared through mixing biologically absorbably polymer, un-sintered calcium phosphate salt and bone growth factor dispersed in solvent, molding, freeze drying to eliminate solvent and obtain the composition. The composition has the function of promoting bond healing and excellent biocompatibility.

The present invention relates to surgical material. The material includes biological absorbable polymer 10-90 wt%, un-sintered calcium phosphate salt 9-80 wt% and active matter less than 50 wt%. The biologically absorbable polymer includes polyester, chitosan, chondroitin sulfate, collagen, alginate, etc.; and the calcium phosphate salt is un-sintered hydroxyapatite or tricalcium phosphate of granularity less than 100 microns. The hard tissue repairing material is prepared through mixing biologically absorbable polymer, un-sintered calcium phosphate salt, etc. dispersed in solvent, freeze drying to eliminate solvent and obtain porous material and mixing with active matter. The composition has the function of promoting bone healing and excellent biocompatibility.

The invention relates to a 3D-printed multi-structure bone composite scaffold. The 3D-printed multi-structure bone composite scaffold comprises a multi-layer structure, wherein different layers are made of composite materials in different proportions through 3D printing, and the 3D-printed multi-structure bone composite scaffold has different 3D printing fiber spacings and porosity factors. The specific structure comprises a bionic bone structure, the outer layer is low in porosity and small in aperture to simulate a compact bone structure, the inner layer is high in porosity and large in aperture to simulate a cancellous bone structure, and the scaffold similar to a real bone structure is integrally formed; in an osseointegration structure, the outer layer is high in porosity and large inaperture so as to promote integration with surrounding bones, the inner layer is low in porosity and small in aperture so as to support the overall structure while promoting osseointegration, and thewhole structure is suitable for repairing bone defects. The material of the scaffold is preferably a composite material of tricalcium phosphate (TCP) and polycaprolactone (PCL), and the scaffold hasgood biocompatibility and printability. The bone repair effect is promoted by adding metal ions and performing surface modification treatment.

The invention discloses a Penicillium, a preparation method and applications thereof, Penicillium fungus PSM11-5 is separated from a vanadium ore sample; insoluble tricalcium phosphate, sodium metavanadate, cobalt hydroxide and basic nickel carbonate are taken as indicating compounds; and a fungal strain is screened by testing the capability of decomposing the tricalcium phosphate, the sodium metavanadate, the cobalt hydroxide and the basic nickel carbonate. The Penicillium PSM11-5 is Penicillium sp.PSM11-5 CCTCCM208207. The strain is utilized for carrying out biological leaching of phosphorus and biological metallurgy, metals of phosphorus, vanadium, nickel, cobalt and the like are leached from lean ores, discarded ores, submarginal ores, difficult-to-mine ores, difficult dressing ores and refractory ores, thereby fully utilizing the mineral resources, reducing the metallurgical costs and protecting the ecological environment. The PSM11-5 is utilized for leaching the phosphorus from low-grade phosphate rock powder, a biological fertilizer is prepared to be applied to the soil, thereby leading the soil to contain higher content of soluble phosphorus which can be utilized by crops; the strain further leaches insoluble phosphorus which is deposited in the soil before, thereby reducing phosphorus fertilizer and reducing gas pollution caused by the phosphorus fertilizer and water pollution caused by the phosphorus fertilizer.

The present invention discloses a quick-concreting composite material of calcium phosphate solid cement, comprising a solid phasing part and a liquid phasing part; the preparation method of the composite material is that: preparing Alpha-TCP solid cement powder with solid-state sintering; forcing the Alpha-TCP cement powder and the carbon nanotube via the ball mill, and then acquiring the solid cement composite powder; putting the different quantity of chitosan and Beta-sodium glycero-phosphate respectively into the dilute hydrochloric acid and deionized water, obtaining the mixing liquid of solid cement; putting the solid cement composite powder and the hydroxyapatite seed into the mixing liquid of solid cement; evenly mixing the solid cement slurry and then pouring into the mould to be exhausted and planned; acquiring quick-concreting composite material of calcium phosphate solid cement. The present invention provides a quick-concreting composite material of calcium phosphate solid cement which has great mechanical property, short concreting time, certain bioelectromagnetic effects and good biocompatibility, and the preparation method.

The invention relates to a 3D (three-dimensional) printing mesoporous bioactivity glass modified biological ceramic support, and a preparation method and application thereof. The biological ceramic support comprises a beta-tricalcium phosphate bioactivity support prepared by using a three-dimensional printing technology and mesoporous bioactivity glass coating the surface of the support uniformly. The biological ceramic support has good mechanical property, mineralization capability and osteogenic and hematopoietic activities, is expected to serve as an effective bone repairing material, and is a potential multifunctional hard tissue bioactivity implanting material.

This invention relates to a process to facilitate osteochondral bone remodeling in a subject by inducing regeneration of this bone to a healthy, vascularized state capable of supporting the underlying hyaline cartilage of articular joints and spinal discs, both biomechanically and metabolically and to deliver a bioactive agent. This process involves the steps of: administering an effective amount of an injectable in situ curing biomaterial composite to a site. The biomaterial composite product is prepared by a process involving the steps: admixing an alginate solution with a nonporous aggregate of β-tricalcium phosphate, in a sufficient amount to initiate polymerization of the alginate solution, to form a hydrogel having from between 10 to 20 percent by volume of β-tricalcium phosphate.

The invention discloses a beta-tricalcium phosphate/alginic acid composite microsphere and a preparation method and an application of the beta-tricalcium phosphate/alginic acid composite microsphere. The method comprises the following steps: dropwise adding a mixed solution of beta-tricalcium phosphate and sodium alginate into a calcium chloride solution of which the pH value is 4.5 to 5.0 by virtue of an electrostatic liquid dropping device, and continuing to calcify for a period of time after dropwise adding; pouring out the calcium chloride solution after reaction, then washing a calcified crosslinked microsphere with deionized water, and airing, so as to obtain the beta-tricalcium phosphate/alginic acid composite microsphere. The method is carried out at normal temperature without heating or reference to poisonous and harmful liquid and other volatile solids and gases. The beta-tricalcium phosphate/alginic acid composite microsphere prepared by using the preparation method has the advantage of wide particle size adjusting range and can be widely applied to tissue repair and drug carriers, and a plurality of micropores are formed in the surface of the beta-tricalcium phosphate/alginic acid composite microsphere, so as to be easy for cells to adhere, for tissue fluid to permeate and for loading of drugs, growth factors and cells, and therefore, the beta-tricalcium phosphate/alginic acid composite microsphere can be widely applied to tissue repair and drug carriers.

The present invention is carbonic acid type high activity partially crystallized calcium phosphate and its preparation. The material has the nonstoichiometric crystallization state between the crystal and amorphous substance and contains carbonate radical, Mg, Sr and Zn essential for human body bone tissue. It is prepared with water soluble phosphate and calcium salt as material and through adding carbonate, Sr salt and/or Mg salt and/or Zn salt, reaction in water solution, separating, drying and calcining reaction product to obtain carbonic acid type high activity partially crystallized calcium phosphate powder. The powder has high bioactivity, reaction activity and biodegradability, and may be used widely in replacing and repairing hard tissue.