Rapidly solidified calcium phosphate cement composite material and its preparation method

A fast-setting calcium phosphate and composite material technology, applied in the intersection of materials science and biomedicine, can solve the problems of low strength, slow setting speed of calcium phosphate bone cement, poor mechanical properties, etc., and achieve high mechanical properties and shorten setting time. , good effect of biological electromagnetic effect

Inactive Publication Date: 2008-02-20
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Calcium phosphate cement (CPC) is a new type of self-fixing bioactive bone cement, which has good biocompatibility, osteoconductivity, degradability, plasticity, and less heat generated by the reaction. It is an ideal bone replacement However, calcium phosphate bone cement has slow setting speed, low strength, and poor mechanical properties. The mechanical properties are only between cancellous bone and cortical bone, and its high brittleness and poor load-bearing ability greatly limit its application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] 1) Analytical pure calcium hydrogen phosphate dihydrate (DCPD) was dried at 120°C for 10 h, and analyzed with analytically pure CaCO 3 The powder was mixed through a 200-mesh sieve by dry ball milling at a molar ratio (mol) of 2:1, and the mixed powder was calcined in a high-temperature sintering furnace to 1250°C. At room temperature, white loose α-tricalcium phosphate bone cement (α-TCP) powder was obtained;

[0019] 2) In terms of weight percentage, 99.4% α-tricalcium phosphate bone cement and 0.6% carbon nanotubes are mechanically milled to obtain bone cement composite powder;

[0020] 3) 100mg of chitosan with a degree of deacetylation of 95% was dissolved in 4.5ml of 0.1mol L -1 In hydrochloric acid, fully stir for 2 hours to obtain a clear solution; dissolve 500mg of β-sodium glycerophosphate in 0.5ml of deionized water, add dropwise to the chitosan solution at a volume ratio of 1:9, and stir while dripping , after the solution is mixed, continue to stir for 20...

Embodiment 2

[0026] 1) Analytical pure calcium hydrogen phosphate dihydrate (DCPD) was dried at 120°C for 10 h, and analyzed with analytically pure CaCO 3 The powder is mixed by ball milling in a 2:1 (mol) method and calcined in a high-temperature sintering furnace to 1250°C. After holding for 2 hours, it is quickly taken out, and cooled down to room temperature at a rate of 120°C / min to obtain white loose α-phosphoric acid. Tricalcium bone cement (α-TCP) powder;

[0027] 2) In terms of weight percentage, 99.5% α-tricalcium phosphate bone cement and 0.5% carbon nanotubes are mechanically milled to obtain bone cement composite powder;

[0028] 3) 90mg of chitosan with a degree of deacetylation of 95% was dissolved in 4.5ml of 0.1mol L -1 In hydrochloric acid, fully stirred for 2 hours to obtain a clear solution; 400mg β-sodium glycerophosphate was dissolved in 0.5ml deionized water, and was added dropwise to the chitosan solution according to the volume ratio of 1:9, and stirred while drip...

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Abstract

The present invention discloses a quick-concreting composite material of calcium phosphate solid cement, comprising a solid phasing part and a liquid phasing part; the preparation method of the composite material is that: preparing Alpha-TCP solid cement powder with solid-state sintering; forcing the Alpha-TCP cement powder and the carbon nanotube via the ball mill, and then acquiring the solid cement composite powder; putting the different quantity of chitosan and Beta-sodium glycero-phosphate respectively into the dilute hydrochloric acid and deionized water, obtaining the mixing liquid of solid cement; putting the solid cement composite powder and the hydroxyapatite seed into the mixing liquid of solid cement; evenly mixing the solid cement slurry and then pouring into the mould to be exhausted and planned; acquiring quick-concreting composite material of calcium phosphate solid cement. The present invention provides a quick-concreting composite material of calcium phosphate solid cement which has great mechanical property, short concreting time, certain bioelectromagnetic effects and good biocompatibility, and the preparation method.

Description

1. Technical field [0001] The invention relates to a bone cement composite material and a preparation method thereof, in particular to a fast-setting calcium phosphate bone cement composite material and a preparation method thereof. It belongs to the intersection field of materials science and biomedicine. 2. Background technology [0002] Calcium phosphate cement (CPC) is a new type of self-fixing bioactive bone cement, which has good biocompatibility, osteoconductivity, degradability, plasticity, and less heat generated by the reaction. It is an ideal bone replacement However, calcium phosphate bone cement has slow setting speed, low strength, and poor mechanical properties. The mechanical properties are only between cancellous bone and cortical bone, and its high brittleness and poor load-bearing ability greatly limit its application. Due to the unique hollow tubular structure and properties of carbon nanotubes (CNTs) and their potential applications in nanoelectronic de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12
Inventor 孙康宁刘爱红孙晓宁朱广楠
Owner SHANDONG UNIV
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