9 results about "Calcium phosphate cement" patented technology

The invention relates to a method in the technical field of biomedical materials, in particular to a preparation method of high-strength calcium silicon-phosphate bone cement as well as a product and application of the high-strength calcium silicon-phosphate bone cement. A silicon element is introduced on the basis of calcium phosphate bone cement, the preparation method of the calcium silicon-phosphate bone cement is provided, calcium silicon-phosphate is prepared through a high-temperature calcination method and compounded with alpha-TCP, then the calcium silicon-phosphate compounded hydroxyapatite bone cement is prepared through a hydration reaction, the crystalline phase structure and solubility of the material are optimized, and the calcium silicon-phosphate bone cement is prepared. The degradation rate and the new bone growth rate are more synchronous, and finally, the material is completely replaced by new bone tissues; compared with traditional calcium phosphate cement, mechanical properties such as compressive strength of the silicon-calcium phosphate bone cement are improved, and clinical requirements of non-bearing or low-bearing parts can be better met. The preparation method is simple and convenient, adopts simple raw materials, is suitable for mass production, and has a wide clinical application prospect.

This method for producing a microorganism carrier comprises: a slurry preparation step for preparing a slurry containing a cement component that contains calcium phosphate and a microorganism-containing solution that contains active microorganisms, which are active, and water; and a curing step for curing the slurry. The active microorganisms may be one or more selected from fungi, bacteria, and archaea. The amount of the active microorganisms contained in the microorganism-containing solution may be 1.0 × 105 cells / mL to 1.0 × 109 cells / mL.

The application provides a preparation method of an anti-infection bone repair promoting preparation for sequentially regulating a macrophage immune microenvironment, which comprises the following steps: uniformly mixing 1-10% flavone modified hydroxyapatite, 2-10% sodium alginate hydrogel, 0.1-1% hydrogen sulfide sustained release carrier and 79-96.9% tricalcium phosphate in proportion by weight percentage, adding a calcium chloride aqueous solution, uniformly stirring, and freeze-drying. The flavone tricalcium phosphate, the calcium phosphate cement of the light crosslinking alginate hydrogel containing the hydrogen sulfide sustained release carrier, exhibits the function of regulating the macrophage immune microenvironment, and the preparation itself can better realize the function of sequentially inducing the macrophages in a bone damage microenvironment to be induced to M1 type polarization and then to M2 type polarization.

The present invention provides a method for treating chlorine-containing organic waste, which relates to the fields of chemical industry and environmental protection technology. The present invention uses an efficient and environmentally friendly plasma reactor to treat chlorine-containing organic waste. The characteristics of plasma high temperature, high energy density and rapid reaction are utilized to enable a small reactor to have a large processing capacity. By controlling the temperature of the reaction, the chlorine-containing organic waste can be fully cracked and converted into high-value-added products, obtaining solid products mainly composed of carbon and phosphorus and gaseous products mainly composed of acetylene and hydrogen chloride; the solid products are sent to the downstream cement plant to prepare calcium phosphate cement; the gaseous products are sent to the downstream polyvinyl chloride production section to prepare vinyl chloride monomer, or after purification and separation by conventional separation means such as absorption and adsorption, they are used for other process purposes, thus realizing the resource utilization of hazardous waste. In addition, the entire process is a closed cycle, does not require incineration, does not generate other waste, and does not generate dioxins, and can achieve zero emissions of pollutants.

The present innovation relates to biomaterials, particularly, to the synthesis method of octacalcium phosphate. The method can be applied in the commercial manufacturing of biomaterials for bone tissue regeneration or dental restoration, such as bioinks for 3D printing, calcium phosphate cements, bioceramics, composites and drug delivery systems. The current invention developed a rapid, instant, controllable as well as reproducible procedure for the continuous synthesis of octacalcium phosphate.

This invention relates to the field of bone repair technology, specifically to drug-loaded microsphere-modified porous calcium phosphate bone cement, its preparation method, and repair material. The solid phase of the porous calcium phosphate bone cement consists of a porous calcium phosphate bone cement matrix and drug-loaded microspheres dispersed therein. The porous calcium phosphate bone cement matrix has a three-dimensional interconnected pore structure, and the drug-loaded microspheres have a core-shell structure, with the outer shell being a biodegradable material and the core being a osteoinducing factor. This porous calcium phosphate bone cement utilizes porous CPC to provide space for bone integration, and the drug-loaded microspheres achieve long-term controlled release of the osteoinducing factor, achieving efficient bone defect repair through an integrated "bone conduction-bone induction-bone integration" process.

The application relates to the technical field of bone tissue engineering materials, in particular to a modified polylactic acid fiber, a gradient-degradable calcium phosphate bone cement and a preparation method. The modified polylactic acid fiber comprises the following components in parts by weight: 85-100 parts of polylactic acid, 5-15 parts of a nucleating agent, 2-5 parts of a plasticizer and 0.2-0.5 parts of a surfactant. The crystallinity and degradation rate of the polylactic acid are changed by adjusting the combination ratio of the modified material of the polylactic acid, so that the modified polylactic acid fiber with different degradation properties is obtained. The modified polylactic acid fiber with different degradation properties is combined to prepare the calcium phosphate bone cement with multi-stage gradient degradation which can be accurately controlled, a plurality of gradient degradation processes are formed in the bone repair stage, and the bone tissue growth speed can be perfectly adapted through control, so that the calcium phosphate bone cement is suitable for the field of bone repair and is especially suitable for bone defects caused by orthopedic diseases related to the elderly.

The application discloses a bone repair composite material with gelatin microspheres capable of releasing drugs and a preparation method thereof, and comprises the following steps: preparing a microfluid channel by 3D printing and performing surface modification on the microfluid channel by adopting tetramethyldisiloxane; adding gelatin into a phosphate buffer solution, dissolving, then adding antibiotics, stirring uniformly, and obtaining an aqueous phase; uniformly mixing mineral oil and a dispersing agent to obtain an oil phase; simultaneously feeding the aqueous phase and the oil phase into the modified microfluid channel to obtain drug-loaded gelatin microspheres; adding a crosslinking agent into the drug-loaded gelatin microspheres, freeze-drying, obtaining a drug-encapsulated gelatin drug packaging micro-particle carrier, and then mixing the drug-encapsulated gelatin drug packaging micro-particle carrier with calcium phosphate cement, and solidifying.

The invention discloses bone cement loaded with a bisphosphate modified nano iron oxide diagnosis and treatment integrated probe as well as a preparation method and application of the bone cement. The bone cement is composed of a calcium phosphate bone cement matrix and diagnosis and treatment integrated probes uniformly dispersed in the calcium phosphate bone cement matrix. The probe takes superparamagnetic ferroferric oxide nanoparticles as a core, a bone targeting function is realized by connecting diphosphate molecules through surface coordination, and the outer layer is coated with a liposome membrane to enhance biocompatibility and prolong cycle time and is used as a drug carrier. The bone cement disclosed by the invention has excellent mechanical properties, biological activity and multi-mode diagnosis and treatment functions; on one hand, the bone cement can be used as a bone defect filling material to provide mechanical support and promote bone regeneration; and on the other hand, the nano iron oxide in the probe can be used as a magnetic resonance imaging contrast agent, the diphosphate modification endows the probe with natural targeting ability to bone tissues and a curative effect of inhibiting osteoclasts, the liposome encapsulation realizes long-acting slow release and controllable release of the drug, and the systemic toxicity is reduced.