5 results about "Calcium phosphate cement" patented technology

The invention relates to a method in the technical field of biomedical materials, in particular to a preparation method of high-strength calcium silicon-phosphate bone cement as well as a product and application of the high-strength calcium silicon-phosphate bone cement. A silicon element is introduced on the basis of calcium phosphate bone cement, the preparation method of the calcium silicon-phosphate bone cement is provided, calcium silicon-phosphate is prepared through a high-temperature calcination method and compounded with alpha-TCP, then the calcium silicon-phosphate compounded hydroxyapatite bone cement is prepared through a hydration reaction, the crystalline phase structure and solubility of the material are optimized, and the calcium silicon-phosphate bone cement is prepared. The degradation rate and the new bone growth rate are more synchronous, and finally, the material is completely replaced by new bone tissues; compared with traditional calcium phosphate cement, mechanical properties such as compressive strength of the silicon-calcium phosphate bone cement are improved, and clinical requirements of non-bearing or low-bearing parts can be better met. The preparation method is simple and convenient, adopts simple raw materials, is suitable for mass production, and has a wide clinical application prospect.

This method for producing a microorganism carrier comprises: a slurry preparation step for preparing a slurry containing a cement component that contains calcium phosphate and a microorganism-containing solution that contains active microorganisms, which are active, and water; and a curing step for curing the slurry. The active microorganisms may be one or more selected from fungi, bacteria, and archaea. The amount of the active microorganisms contained in the microorganism-containing solution may be 1.0 × 105 cells / mL to 1.0 × 109 cells / mL.

This invention relates to the field of bone repair technology, specifically to drug-loaded microsphere-modified porous calcium phosphate bone cement, its preparation method, and repair material. The solid phase of the porous calcium phosphate bone cement consists of a porous calcium phosphate bone cement matrix and drug-loaded microspheres dispersed therein. The porous calcium phosphate bone cement matrix has a three-dimensional interconnected pore structure, and the drug-loaded microspheres have a core-shell structure, with the outer shell being a biodegradable material and the core being a osteoinducing factor. This porous calcium phosphate bone cement utilizes porous CPC to provide space for bone integration, and the drug-loaded microspheres achieve long-term controlled release of the osteoinducing factor, achieving efficient bone defect repair through an integrated "bone conduction-bone induction-bone integration" process.

The application discloses a bone repair composite material with gelatin microspheres capable of releasing drugs and a preparation method thereof, and comprises the following steps: preparing a microfluid channel by 3D printing and performing surface modification on the microfluid channel by adopting tetramethyldisiloxane; adding gelatin into a phosphate buffer solution, dissolving, then adding antibiotics, stirring uniformly, and obtaining an aqueous phase; uniformly mixing mineral oil and a dispersing agent to obtain an oil phase; simultaneously feeding the aqueous phase and the oil phase into the modified microfluid channel to obtain drug-loaded gelatin microspheres; adding a crosslinking agent into the drug-loaded gelatin microspheres, freeze-drying, obtaining a drug-encapsulated gelatin drug packaging micro-particle carrier, and then mixing the drug-encapsulated gelatin drug packaging micro-particle carrier with calcium phosphate cement, and solidifying.

The invention discloses bone cement loaded with a bisphosphate modified nano iron oxide diagnosis and treatment integrated probe as well as a preparation method and application of the bone cement. The bone cement is composed of a calcium phosphate bone cement matrix and diagnosis and treatment integrated probes uniformly dispersed in the calcium phosphate bone cement matrix. The probe takes superparamagnetic ferroferric oxide nanoparticles as a core, a bone targeting function is realized by connecting diphosphate molecules through surface coordination, and the outer layer is coated with a liposome membrane to enhance biocompatibility and prolong cycle time and is used as a drug carrier. The bone cement disclosed by the invention has excellent mechanical properties, biological activity and multi-mode diagnosis and treatment functions; on one hand, the bone cement can be used as a bone defect filling material to provide mechanical support and promote bone regeneration; and on the other hand, the nano iron oxide in the probe can be used as a magnetic resonance imaging contrast agent, the diphosphate modification endows the probe with natural targeting ability to bone tissues and a curative effect of inhibiting osteoclasts, the liposome encapsulation realizes long-acting slow release and controllable release of the drug, and the systemic toxicity is reduced.