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Medicine controlled functional cement with calcium phosphate being as framework and its preparation method

A calcium phosphate bone cement, drug controlled release technology, applied in medical science, prosthesis, surgery, etc., can solve the problems of easy to cause osteolysis, long-term foreign body existence, material brittleness, etc., to promote rapid healing, accelerated degradation, Excellent performance

Inactive Publication Date: 2003-10-08
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For a long time, the repair of bone defects has mainly used autologous bone grafting combined with allogeneic bone grafting, but both methods have their own disadvantages: the number of sources of autologous bone is limited, and there are at least 10% surgical complications in bone harvesting operations , it takes a long time to crawl and replace after implantation; allogeneic bone has different degrees of immune rejection and potential risk of disease transmission
However, with the further deepening of basic research and the further expansion of clinical applications, it was found that the PMMA drug-loading system has many shortcomings: poor tissue compatibility, strong heat release during the curing process can easily cause burns and necrosis of surrounding tissues, monomers are toxic to the human body, materials Non-degradation, long-term presence of foreign bodies in the body (or one by one during treatment, the patient is very painful), incomplete drug release, etc., make the treatment results difficult to satisfy, and the application is limited. However, the design of this functional material is worth learning
However, it is found that the material is brittle, has poor elastic strength, is difficult to absorb in the body, and easily causes osteolysis.

Method used

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  • Medicine controlled functional cement with calcium phosphate being as framework and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Weigh 50 mg of ethyl cellulose, dissolve it in acetone under water bath conditions, after it is completely dissolved, add 100 mg of tobramycin, stir evenly, pour 2 g of liquid paraffin containing 8 ml of Span 80, and circulate water at 60 ° C Constant temperature, stirring, suction filtration, washing, and drying to prepare tobramycin microcapsules.

[0034] Weigh 0.1g of pore-forming agent (200~350μm), calcium hydrogen phosphate, tetracalcium phosphate, and 3g of CPC powder with a particle size less than 20μm, and add the prepared tobramycin microcapsules at the same time. Disperse evenly in the bowl, add 1.2g of normal saline, use a dental knife to mix and evenly form a mud mass, place it in a 37°C, 100% humidity environment for 48 hours, and then soak it in a simulated buffer solution, and take samples at appropriate time intervals. The concentration of tobramycin was determined by ultraviolet spectrophotometry, which indicated that the degree of drug-loaded porous c...

Embodiment 2

[0036] Weigh 50 mg of ethyl cellulose, dissolve it in acetone under water bath conditions, after it is completely dissolved, add 100 mg of naproxen sodium, stir evenly, pour 2 g of liquid paraffin containing 8 ml of Span 80, and circulate water at 60 ° C Constant temperature, stirring, suction filtration, washing, and drying to prepare naproxen sodium microcapsules. Weigh 0.1g of pore-forming agent (200~350μm), calcium hydrogen phosphate, tetracalcium phosphate, and 3g of CPC powder whose particle size is less than 20μm, and add the prepared naproxen sodium microcapsules at the same time. Disperse evenly in the bowl, add 1.2g of normal saline, use a dental knife to mix and evenly form a mud mass, place it in a 37°C, 100% humidity environment for 48 hours, and then soak it in a simulated buffer solution, and take samples at appropriate time intervals. The concentration of naproxen sodium was determined by ultraviolet spectrophotometry, which showed that the degree of drug-loade...

Embodiment 3

[0038] Weigh 50 mg of ethyl cellulose, dissolve it in acetone under the condition of water bath, after it is completely dissolved, add 100 mg of rifampicin, stir evenly, pour 2 g of liquid paraffin containing 8 ml of Span 80, and circulate water at 60°C to keep the temperature constant , stirring, suction filtration, washing, and drying to obtain rifampicin microcapsules. Weigh 0.1g of pore-forming agent (200~350μm), calcium hydrogen phosphate, tetracalcium phosphate, and 3g of CPC powder with a particle size of less than 20μm, and add the prepared rifampicin microcapsules at the same time. Disperse evenly in medium, add 1.2g of normal saline, use a dental knife to mix and evenly form a mud mass, place it in a 37°C, 100% humidity environment for 48 hours, and then soak it in a simulated buffer solution, take samples at appropriate time intervals, and use ultraviolet light The concentration of rifampicin was determined by spectrophotometry, which indicated that the release of d...

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Abstract

A calcium phosphate cement with the function of controlling medicine release for repairing dysostosis, treating osteomyelitis and preventing infection and recurrence of osteoma is prepared from porous calcium phosphate cement and medicine capsules containing antibacterial medicine, antineoplastic medicine, anti-flammatory antalgic medicine, antituberculosis, etc. Its advantages are slow medicinesreleasing, and high curative effect.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a controlled-release drug-loaded calcium phosphate bone cement for hard tissue repair and drug treatment and an application thereof. Background technique [0002] Bone defect caused by trauma, tumor and other reasons is a difficult problem in clinical treatment. For a long time, the repair of bone defects has mainly used autologous bone grafting combined with allogeneic bone grafting, but both methods have their own disadvantages: autologous bone is limited by the number of sources, and there are at least 10% surgical complications in bone harvesting operations , It takes a long time to crawl and replace after implantation; allogeneic bone has different degrees of immune rejection and potential risk of disease transmission. The artificial synthetic substitute material can avoid the defects of biological source repair materials, and is an ideal repair material for bone defects. ...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/50A61L31/16
Inventor 刘昌胜黄粤陈芳萍
Owner EAST CHINA UNIV OF SCI & TECH
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