243 results about "Bone grafting" patented technology

The invention relates to the technical field of medical instruments, and discloses an additive manufacturing bionic bone trabecula full-porous interbody fusion cage which is applied to spinal fusion surgery and is of a bionic bone trabecula full-porous structure made of medical metal through a laser melting or electron beam melting additive manufacturing technology. The interbody fusion cage comprises a front end face, a rear end face, a first side surface, a second side surface, an upper fusion face and a lower fusion face, the upper fusion face and the lower fusion face make direct contact with a vertebral body end plate of a spine, anti-skid teeth are arranged on the surfaces of the upper fusion face and the lower fusion face, and a bone grafting window penetrating through the upper fusion face and the lower fusion face is formed in the center of the interbody fusion cage. The interbody fusion cage has the structure and mechanical property similar to those of cancellous bone and trabecular bone of a human body, can improve the bone combination area and bone ingrowth space, has excellent initial and long-term stability, and can effectively reduce stress shielding so as to improve the bone fusion capability.

The invention discloses a spinal surgery postoperative patient rehabilitation intelligent management system and method, and relates to the technical field of spinal surgery postoperative rehabilitation management, and the system can carry out real-time analysis on implant displacement characteristics, and can carry out early warning on potential deviation of an implant in advance. The first analysis module can calculate the risk index Fx of the implant, so that timely correction or adjustment is promoted, the risk of implant deviation is reduced, and the occurrence rate of postoperative complications is reduced. And the second analysis module is specially used for extracting wear characteristics of the implant, constructing an implant wear index Ms, and helping a doctor to intervene in time by monitoring the wear condition of the implant in real time so as to avoid dysfunction or risk caused by wear of the implant. And the third analysis module calculates a comprehensive fusion index ZRh by extracting bone grafting area change characteristics, bone mineral density and rehabilitation bone healing information, so that a doctor can know bone mineral density change and rehabilitation conditions of a patient, a treatment scheme is adjusted, and a rehabilitation effect is improved.

The invention provides an interbody fusion prosthesis and an interbody fusion prosthesis component, the interbody fusion prosthesis comprises an interbody fusion main body, the interbody fusion main body is provided with a bone grafting cavity, and the bone grafting cavity penetrates through the surface of the interbody fusion main body to form a first opening in the interbody fusion main body; and the first end plate is movably arranged at the first opening, and the first end plate is provided with a first avoiding position for avoiding the first opening and a first shielding position for covering the first opening. According to the technical scheme, the problem that in the related technology, the bone filling material in the bone grafting cavity has the falling risk is effectively solved.

A kit of parts from which selection is made to form an intervertebral fusion device. The kit of parts comprises a plurality of different endplates and a core component. Each of the plurality of different endplates is configured to be received in an intervertebral space defined between first and second vertebrae. The core component is configured to engage with each of the plurality of endplates and a selected one of the plurality of endplates when the selected endplate and the core component are received in the intervertebral space. Each of the plurality of endplates defines a bone graft aperture which is open at top and bottom surfaces of the endplate and extends between the top and bottom surfaces, the thus defined bone graft apertures being of substantially the same dimensions as one another when the plurality of endplates are in plan view. The core component defines a bone graft material holding space having a holding space opening in one of a core component top surface and a core component bottom surface of the core component. The holding space opening is of substantially the same dimensions as each of the bone graft apertures when the core component is in plan view. The holding space opening is substantially coextensive with the bone graft aperture of the selected endplate in plan view and when the core component is engaged with and in registration with the selected endplate.

A bone graft composition comprising a calcium phosphate putty is provided. A method of repairing a bone defect in a patient by applying the bone graft composition is also provided.

The invention of the gradient porous structured sacral prosthesis and the manufacturing process aims to create an alternative replacement for bone loss in patients who require bone replacement. The gradient porous structured sacral prosthesis consists of an artificial bone fragment, a metal rod, and a set of screws for fixing the fragments. The manufacturing process consists of seven steps: Identifying the position and boundaries of the bone, First-step topology optimization, Second-step topology optimization, Defining the structural pattern and unit cell size, Designing the artificial bone implant, Mechanical performance testing of the implant, and Fabrication of the sacral implant. The devices and processes according to the present invention are clearly sequenced and characterized. Modification or change in the manufacturing sequence or use may reduce the capabilities of the present invention or make it unusable for the purposes of the present invention.

The application discloses a spinal anterior structural bone grafting internal fixation device, which comprises a fixing sheath and a steel nail group, the steel nail group is arranged in the fixing sheath, the steel nail group comprises a first fixing nail, a second fixing nail and a third fixing nail, the top of the first fixing nail is connected with a bent first connecting arm, and the top of the second fixing nail is connected with a bent second connecting arm; an adjusting part for adjusting the telescopic length of the first connecting arm and the second connecting arm is arranged on a convex ring of the inner wall of the fixing sheath in a clearance fit mode, and a locking part is arranged above the convex ring; the third fixing nail is arranged in a through hole of the fixing sheath, the top surface of the third fixing nail is provided with a pressing block, and the pressing block presses the locking part into the space between the convex ring and the adjusting part. The device has good stability after the overall structure is combined, and the bone grafting block is fixed firmly; in addition, the device is light and thin, has a small volume, and thus needs a small wound to be formed, has less bleeding, has less damage to the bone, and reduces trauma during and after the operation.

A cage type support for bone grafting capable of achieving heat balance comprises a support shell and a base, and a multipurpose cavity is formed in the base. The inner cavity of the bracket shell is communicated with the multi-purpose chamber through a heat convection pipe group; the multipurpose cavity is configured to be a heat dissipation end communicated with the inner cavity, and heat balance of the inner cavity and the multipurpose cavity is achieved through a heat convection pipe set communicated between the multipurpose cavity and the inner cavity; a stable supporting foundation is provided, the osseointegration process is promoted, heat balance of the whole stent is achieved, the internal temperature of the femoral head is properly increased, local blood circulation of the femoral head is accelerated, cell activity is enhanced, metabolism is accelerated, proliferation and differentiation of related cells such as bone cells are promoted, angiogenesis and bone repair are promoted, and gas exchange is facilitated. The implant can be used for promoting the discharge of hydrops and pneumatosis, continuously releasing intraosseous pressure and providing a storage space and path for therapeutic drugs and / or nutritional ingredients, and the implant realizes multi-system collaboration and promotes overall rehabilitation.

The invention relates to the field of oral medicine, and discloses an oral bone grafting navigation system based on multi-modal mixed reality interaction, which comprises a data processing module, a mixed reality display module and a navigation module, the data processing module is used for acquiring CBCT data and oral scanning data of the oral cavity of the patient, generating a composite three-dimensional model fusing bone tissue and dentition morphology according to the acquired data, and obtaining the three-dimensional morphology, the target placement position and the screw fixing position of the bone grafting bone sheet; the mixed reality display module comprises a head-mounted display device capable of displaying the virtual indication unit and the virtual operation area presentation unit; and the navigation module comprises a navigation marker and an optical positioning camera and is used for tracking the spatial positions of the surgical instrument, the bone sheet and the screw in real time. According to the system and the method, multi-modal image data are combined, and the mixed reality display module and the navigation module are combined, so that real-time visual guidance of the bone slice position and the screw implanting path is realized, and the bone grafting operation efficiency and safety are improved.

The invention discloses a 3D printing bone grafting window-free porous tantalum metal interbody fusion cage which comprises a fusion cage body, the fusion cage body is integrally formed by machining medical-grade tantalum metal, and a clamping hole is formed in the front side of the fusion cage body and used for being connected with an operation instrument; the two groups of porous net racks are respectively fixed on the upper surface and the lower surface of the fusion cage body, the outer side surface of each porous net rack is a contact interface, and each contact interface is of an arc-shaped structure; bayonets are symmetrically formed in the inner wall of the front side of the fusion cage body, the clamping hole is formed between the bayonets, and the bayonets are used for limiting operation instruments. The porous tantalum material with high biological activity and high porosity is adopted, reliable spinal fusion can be achieved on the premise that bone grafting is not needed, the problems of bone taking trauma and donor region complications related to bone grafting and immunoreaction caused by allogeneic bone grafting are effectively solved, and therefore the occurrence risk of postoperative complications is reduced, and the bone grafting success rate is increased. The postoperative recovery process of the patient is improved.

The invention discloses a set instrument for acetabulum tenon-and-mortise structural bone grafting and application, relates to the field of orthopedic surgical instruments, adopts a cylindrical ring file, a wedge-shaped angle file, a hollow trephine and a wedge-shaped osteotomy guide plate as the set instrument for acetabulum tenon-and-mortise structural bone grafting, and introduces a tenon-and-mortise structure mechanical embedding principle of Chinese traditional woodworking science into the field of acetabulum reconstruction. According to the acetabular cup prosthesis, a mortise and tenon structural bone grafting of an autologous femoral head is adopted, a Mortia and Tenon Bone Grafting technology (Mortia and Tenon Bone Grafting, MTBG) is innovatively put forward, an acetabular bone groove and a bone grafting block which are matched are prepared in a standardized mode, acetabular defects are embedded and filled through the accurately matched bone block, and the coverage rate and initial stability of the acetabular cup prosthesis are remarkably increased, and the bone fusion prospect of the acetabular cup prosthesis is remarkably improved; the hip joint function of the patient is obviously improved, pain is relieved, the walking ability is improved, and the life quality is improved; the invention provides a reliable and efficient new structural bone grafting technology, and the safety and long-term effect of DDH acetabulum reconstruction can be improved.

The invention discloses a spine titanium alloy bone grafting bed and a spine bone grafting operation method. The spine titanium alloy bone grafting bed comprises a body and side wing parts arranged on the two sides of the body. The main body and the side wing parts are integrally formed, the main body is provided with a plurality of through holes which are arranged in a display mode, and a polygonal hole is defined by every four through holes; and the end parts of the side wing parts can be arranged on a nail rod in the spine nail rod system in a bending manner. According to the spine titanium alloy bone grafting bed, the side wing parts of the spine titanium alloy bone grafting bed are bent and arranged on the nail rods, so that the use of screws is reduced, the operation difficulty is reduced, and the postoperative recovery of a patient is promoted.

The invention belongs to the technical field of medical instruments, and particularly relates to a multidirectional distraction osteogenesis correction system, in the multidirectional distraction osteogenesis correction system, the distance between a first fixing sleeve and a second fixing sleeve in supporting assemblies can be adjusted through a second traction assembly, and the distance between the two sets of supporting assemblies can be adjusted through a first traction assembly; the bilateral tooth-bone metastasis plate can be adjusted in the two-dimensional moving direction and the moving amount, the bilateral tooth-bone metastasis plate is allowed to move asymmetrically, transverse and sagittal differential distraction osteogenesis is achieved, and the bilateral tooth-bone metastasis plate is particularly suitable for cleft lip and palate patients with maxillary sagittal and transverse development insufficiency. According to the multidirectional distraction osteogenesis correction system, bilateral asymmetric distraction osteogenesis can be achieved, unilateral / bilateral alveolar process fractures of the front section of the maxillary dental arch are narrowed, the success rate of an alveolar process fracture bone grafting operation is increased, the alveolar bone mass of the middle section of the maxillary dental arch is increased, dentition congestion is relieved, space is provided for repair treatment, and the difficulty of subsequent treatment such as orthognathic surgery is reduced.

The utility model relates to a bone grafting instrument. The bone grafting instrument comprises a handle, an extension tube, a sealing cover and a storage bin for placing broken bones, the front end of the handle protrudes from back to front to form a protruding part, the extension pipe is communicated with the protruding part, and the sealing cover is in threaded connection with the end, away from the extension pipe, of the handle. According to the bone grafting instrument, through the mechanical structure of the pushing rod and the pushing plate, broken bones can be rapidly and effectively pushed to the position between adjacent vertebrae from the storage bin, the operation efficiency is greatly improved, the operation time and discomfort of a patient are reduced, the top plate and the closing assembly are used in cooperation, the broken bones can be accurately controlled to be released in the pushing process, and the bone grafting effect is improved. Compared with the prior art, excessive scattering or blocking of broken bones is avoided, the accuracy and the success rate of an operation are guaranteed, in addition, the storage bin is closed through the closing assembly, the broken bones are effectively prevented from leaking in the pushing process, the clean and sterile state of an operation area is kept, and the infection risk is reduced.

The invention relates to a preparation method of a plastic bone grafting material and the plastic bone grafting material.The preparation method comprises the following steps that a, phenyl phosphate lithium salt is dissolved in a phosphoric acid buffer salt solution to obtain a mixed solution, and Ge MA is dissolved in the mixed solution to obtain a Ge MA gel solution; b, bone meal and the Ge MA gel solution are subjected to a cross-linking effect, so that the bone meal and the Ge MA gel solution are fully mixed, then light source irradiation is conducted, the bone meal hydrogel bone grafting material is obtained, and the particle size of the bone meal is 0.25-0.5 mm. According to the preparation method of the plastic bone grafting material, provided by the invention, the bone meal and the Ge MA gel solution are subjected to cross-linking and then subjected to light source irradiation, so that the bone meal and the hydrogel are uniformly mixed, the compatibility of an organic phase and a bone meal particle interface is good, and the prepared plastic bone grafting material is relatively high in plasticity and good in osteoinductivity; and the cell adhesion rate is high.

The invention provides a distractable fusion cage for a post-grafted bone, and belongs to the technical field of medical instruments. The invention provides a post-grafted bone distraction fusion cage which comprises a lower fusion piece and an upper fusion piece, the upper fusion piece covers the lower fusion piece, the lower fusion piece comprises a front inner plate, a rear inner plate and a lower fusion plate, and the front inner plate and the rear inner plate are vertically arranged on the front side and the rear side of the upper end face of the lower fusion plate. The upper fusion piece comprises a front side outer plate, a rear side outer plate and an upper fusion plate, the front side outer plate and the rear side outer plate are vertically arranged on the front side and the rear side of the lower end face of the upper fusion plate, the front side inner plate is located on the inner side of the front side outer plate, a front limiting piece is arranged between the front side inner plate and the front side outer plate, and the rear side inner plate is located on the inner side of the rear side outer plate. According to the distractable fusion cage for bone post-grafting, the upper fusion piece and the lower fusion piece can be distracted, the distracting distance between the upper fusion piece and the lower fusion piece is locked through the front limiting piece, bone grafting is conducted after distracting, the bone grafting amount is increased, and bone fusion is facilitated.

The utility model provides a mushroom-shaped femoral head support, relates to the technical field of medical instruments, and solves the technical problems that the existing femoral head support is connected through welding, the memory function of metal is easily influenced by the welding connection, the welding part is easy to fall off, the product is separated, and the appearance and the operation effect of an implanter are seriously influenced. The bone grafting device comprises a supporting piece used for supporting the femoral head in the necrotic area and a supporting pipe used for forming a bone grafting channel, the supporting piece and the supporting pipe are integrally formed into a pipe shape, and the supporting piece comprises a plurality of sets of arched beams used for opening the femoral head in the necrotic area and arc-shaped heads used for being connected with the arched beams. Due to the adoption of the integral structure, the material and the space are saved, the required bony channel is smaller, and the trauma to the femoral neck is reduced; the success rate of an operation is improved, complications are reduced, and the life quality of a patient is improved.

The utility model discloses an intervertebral bone grafting device. The intervertebral bone grafting device comprises a cylinder body, a plugging piece and a piston, wherein the cylinder body is used for containing aggregate, the cylinder body is provided with a bone inlet and a bone outlet, the bone inlet and the bone outlet are arranged in a spaced mode in the axial direction of the cylinder body, and the bone outlet is formed in the circumferential side wall of the cylinder body; the blocking piece is used for blocking the bone outlet, the bone outlet comprises an opening state and a blocking state, and the blocking piece can move so that the bone outlet can be switched between the opening state and the blocking state; the piston can axially and movably penetrate through the barrel, one end of the piston is matched with the inner side wall of the barrel, and the piston is used for pushing aggregate. According to the intervertebral bone grafting device, the controllability of aggregate is better, and the accuracy and safety of the bone grafting process can be improved.

A post-bone-grafting expandable cage includes a main body, a blade assembly fitted to the main body, and a pushing assembly fitted to the blade assembly, wherein an end cover is interference-fitted on one end face of the main body. The main body comprising a screw section, a side section integrally connected to two ends of the screw section respectively, and an opening section integrally connected to the side section. The pushing assembly includes a first U-shaped base and a threaded rod fixedly connected to the first U-shaped base. The threaded section of the threaded rod extends out of an end face of the first U-shaped base, a square cylindrical section of the threaded rod penetrates the first U-shaped base. The threaded section of the threaded rod is threadedly matched with the threaded through-hole, and the first U-shaped base is provided in a fitting manner with the blade assembly.

The invention provides an artificial intelligence-based preoperative evaluation system for maxillary posterior tooth region implantation, which comprises the following steps of: constructing an oral cavity CBCT (cone beam computed tomography) image library, and further constructing a maxillary sinus basic model, an oral cavity maxillary posterior tooth region implantation decision design model and an oral cavity maxillary posterior tooth region windowing bone grafting decision design model; constructing a maxillary sinus downstream task model according to the maxillary sinus basic model; inputting the to-be-detected oral cavity CBCT image data into the maxillary sinus downstream task model, and calling the oral cavity maxillary posterior tooth region implantation decision design model to generate a first decision or calling the oral cavity maxillary posterior tooth region windowing bone grafting decision design model to generate a second decision according to the output qualitative and quantitative characteristics, so as to carry out preoperative evaluation. According to the method, the different characteristics in the oral cavity CBCT image are intelligently identified in a whole process, and the optimal oral cavity maxillary posterior tooth area implantation decision is generated to carry out oral cavity maxillary posterior tooth area implantation preoperative evaluation, so that the reliability of the oral cavity maxillary posterior tooth area implantation preoperative evaluation is improved.

The invention belongs to the technical field of medical instruments, and particularly relates to a transpedicular vertebral body bone grafting device which comprises a mounting assembly. Comprising a mounting frame, jackets arranged on the two sides of the bottom of the mounting frame, threaded sleeves arranged on one sides of the jackets, threaded rods arranged in inner cavities of the threaded sleeves, hand wheels arranged at one ends of the threaded rods, fixed clamping plates arranged at the other ends of the threaded rods and sliding grooves formed in the top of the mounting frame. An adjusting assembly, comprising a sliding seat which is arranged in an inner cavity of a sliding groove and slides left and right along the sliding groove, a fixing pin arranged on one side of the sliding seat, a connecting rod arranged on one side of the sliding seat, hinge frames arranged on one side of the connecting rod, a hinge shaft arranged between the hinge frames, a self-locking motor arranged on one side of the hinge frames, and a turnover seat arranged on the surface of the hinge shaft, wherein the output end of the self-locking motor is connected with the hinge shaft. The bone grafting device is reasonable in structure, convenient to adjust, assemble and disassemble in the using process, high in flexibility, high in safety and beneficial to improving the success rate of an operation, and meanwhile the position and the angle of the bone grafting device are convenient to adjust.

The present application belongs to the technical field of biomedical materials, and relates to a bone repair material, a preparation method therefor, and use thereof. The preparation method comprises the following steps: mixing a sodium hyaluronate gel and bone graft particles to prepare a mixture; and performing heat treatment on the mixture under a second heat treatment condition, removing the solvent, and preparing a bone repair material, wherein the second heat treatment condition comprises: (1) the temperature of the heat treatment is about 100 °C-130 °C, and the heat treatment time is about 10 min-30 min; and (2) the pH value of the mixture is about 3-5. The amount of sodium hyaluronate per 100 g of the sodium hyaluronate gel is about 2 g-6 g. The sliding performance of the bone repair material is effectively reduced, and the repair effect is excellent.

The utility model relates to the technical field of medical instruments, in particular to an atlantoaxial bone grafting device. The atlantoaxial bone grafting device comprises a bone grafting funnel and a bone grafting device, wherein the bone grafting funnel comprises a hollow pipe part and a funnel part arranged at the top end of the hollow pipe part; the funnel pushing piece comprises a first pushing rod and a pushing part arranged at the top end of the first pushing rod; wherein the first pushing rod can be arranged in the hollow pipe part, and when the pushing part is limited above the opening in the top end of the hollow pipe part, the bottom end of the first pushing rod extends out of the opening in the bottom end of the hollow pipe part; the bottom end of the first pushing rod is a flat and blunt end. According to the technical scheme, the surgical instrument for bone grafting of the atlantoaxial lateral mass joint is provided, bone grafting is accurately and effectively completed through one-time operation of the bone grafting funnel, the surgical operation difficulty is remarkably reduced, the bleeding risk is reduced, the surgical time is shortened, and the postoperative fusion rate is increased.

1. The name of the design product: Bone wax filler. 2. The use of the design product: Used for operations such as conveying, filling, and stirring bone defect and bone cavity fillers in the bone system during bone grafting surgery. 3. The design key points of the design product: lie in the shape. 4. The picture or photo that best shows the design key points: the combined state diagram 1. 5. Other situations that need to be explained - Component description: Component 1 is the tube body, and Component 2 is the injection part.

The invention belongs to the technical field of biomedical materials, and discloses a natural tooth composite material bone grafting scaffold for alveolar bone repair and a design and preparation method thereof. The method comprises the following steps: collecting orthodontic teeth, impacted teeth, multiple teeth, loose teeth and other natural teeth extracted in oral medical treatment, and performing technical treatment to obtain raw material powder; ball-milling and mixing the bioactive glass powder, the carbon-based material powder and the natural dental powder to obtain mixed powder; the mixed powder is used as a raw material, and the bone grafting scaffold is obtained through computer aided design and digital light processing technology 3D printing; and modifying the surface of the 3D printing bracket by using the polydopamine-carbon-based material composite coating to obtain the natural tooth composite material bone grafting bracket. The natural tooth composite material bone grafting scaffold obtained by the invention has good mechanical property, controllable degradation property and antibacterial property, and has good biocompatibility and osteogenesis efficiency.

The invention provides a construction method of a personalized bone grafting guiding device for femoral neck fracture, which belongs to the technical field of digital medicine, and comprises the following steps: 1, three-dimensional reconstruction, 2, virtual reduction, 3, determination of bone grafting points, 4, determination of a bone attachment surface, using a 3-matic uniform offset tool to uniformly offset the extracted bone attachment surface to the outer side (i.e., the direction opposite to the bone surface) by 1-2 mm, and finally obtaining the personalized bone grafting guiding device for femoral neck fracture. 5, determining a bone grafting path, and 6, generating a kirschner wire sleeve based on the diameter of the kirschner wire so as to generate the bone grafting guider. Effective bony support is provided for the femur by attaching the attaching part to the rear side of the greater trochanter side of the femur of the patient, and the sleeve is guided through the generated kirschner wire. By using the bone grafting guiding device, a Kirschner wire can be accurately guided to a bone defect area, namely a bone grafting target area, in a femoral neck fracture closed reduction operation.

The presented invention discloses a stand-alone unilateral biportal endoscopy device (200) for intervertebral fusion, the device (200) comprising: an arthrodesis cage body (208) having a bone grafting cavity (317) for placing bone grafts; a first locking screw (204), attached to an upper surface of the arthrodesis cage body (208), comprising a first anteriorly pointed drilling tip (403); and a second locking screw (210), attached to a lower surface of the arthrodesis cage body (208), comprising a second anteriorly pointed drilling tip (407); wherein the first locking screw (204) and the second locking screw (210) are inclined at an angle to arthrodesis cage body (208), for contacting a plurality of vertebral bodies (101, 102); the device is posteriorly inserted between the vertebral bodies (101, 102) and is closer to centre of rotation and movement axis (CORA) of the vertebral bodies (101, 102)

The present invention provides a cervical vertebrae prosthesis, which includes: a solid layer, the solid layer including an anterior plate and a posterior plate that are interconnected, the anterior plate and the posterior plate together forming a receiving cavity, the anterior plate being an arc-shaped structure, the axis of the anterior plate extending in the vertical direction; a porous layer, the porous layer filling the receiving cavity; wherein the cervical vertebrae prosthesis has a first bone grafting hole that extends in the vertical direction and passes through the upper and lower end surfaces of the porous layer, and the cervical vertebrae prosthesis also has a second bone grafting hole that passes through the anterior plate and extends into the porous layer. The technical solution provided by this application can solve the problem in the related art that the cervical vertebrae prosthesis cannot increase the amount of bone grafting while meeting the structural strength.

The invention discloses a traditional Chinese medicine ingredient modified bone graft material and a preparation method thereof, and relates to the technical field of bone graft materials. The feed additive is prepared from the following raw materials: calcined bone meal and a traditional Chinese medicine extract, the traditional Chinese medicine extract comprises a radix salviae miltiorrhizae extract and / or a radix scutellariae extract. The preparation method comprises the following steps: preparing calcined bone meal, preparing simulated body fluid and preparing the modified bone graft material. The product material can be applied to a dental bone grafting material. The traditional Chinese medicine extract is loaded on the bone material, and the bone material is modified, so that the bone graft material with good biocompatibility, osteogenesis promoting capability and better osteogenesis induction potential can be obtained.