12921results about "External electrodes" patented technology

Devices and methods for the non-invasive stimulation of nerves, such as the vagus nerve, include a housing and an electrode coupled to the housing. The electrode is configured to be positioned adjacent to, or in contact with, an outer skin surface of a patient. A source of energy is coupled to the housing and operably coupled to the electrode. The source of energy emits an electrical impulse to the electrode such that the electrical impulse passes through the outer skin surface of the patient to a nerve at a target region in the patient sufficient to modulate the nerve. The electrical impulse comprises burst periods and constant periods, wherein each burst period includes 2 to 20 pulses and has a duration of less than 20,000 microseconds.

Systems, devices and methods are provided for stimulating one or more nerves within a user. A system comprises stimulator having an electrode configured for contacting the outer skin surface at a target location and an energy source coupled to the stimulator, The energy source is configured to generate at least one electrical impulse and to transmit the electrical impulse transcutaneously from the electrode through the outer skin surface of the user to a selected nerve in the user. In certain aspects, the systems and methods are particularly useful for non-medical purposes, such as reducing stress and anxiety, enhancing relaxation, improving sleep, energy, concentration and mood, increasing mental or physical performance, promoting mental health, recovery and wellness, generally improving the health and wellbeing of a user and / or for temporarily or permanently improving intelligence, learning capacity, memory retention, recall, mood, alertness and / or sleep efficiency in human beings.

An in vitro training method for training genioglossus muscle strength includes adhering an electrode patch of an in vitro training device to a bottom of a chin of a user during a non-sleep period. The electrode patch receives an electrical stimulation signal from an electrical stimulation module of the in vitro training device to stimulate the genioglossus muscle of the user through transdermal electrical stimulation. The electrode patch includes a body surface adhering face and an assembling face opposite to the body surface adhering face. The body surface adhering face is adhered to the bottom of the chin of the user to align with the genioglossus muscle. The electrical stimulation module is disposed on the assembling face and in electrical connection with the electrode patch. The electrical stimulation module sends an electrical stimulation signal to stimulate the genioglossus muscle through transdermal electrical stimulation.

This brain stimulation guide device for positioning a brain stimulation device that stimulates the patient's brain with an electric field or magnetic field, comprises: a face mask mounted on the patient's face; band straps for fixing the face mask to the patient's face; and a procedure device holder which is fixed to the face mask and to which a brain stimulation device having a built-in magnetic coil for generating a magnetic field is mounted, wherein the face mask covers at least portions of the patient's nose, temples, and cheekbones. The brain stimulation guide device can place a brain stimulation device, which is a procedure tool, in an accurate position and thus improve the effect of a procedure.

The patent application describes an adaptable neuromodulation device for transcranial electrical brain stimulation. The system can generate complex poly-modulated waveforms by combining multiple pulse parameters in a randomized manner across dimensions like amplitude, frequency, phase, timing, and polarity. It leverages both digital and analog modulation techniques for waveform versatility. The device features pathway optimization algorithms that tune stimulation using neural feedback data to target specific brain region shapes with greater precision. It also enables closed-loop operation for responsiveness to physiological changes. The application details the mathematical and computational foundations, spanning graph theory to generate digital twins. It highlights applications from cognitive enhancement to seizure control. Overall, the innovation promises versatility and precision in non-invasive neuromodulation through adaptable, optimized waveforms grounded in sophisticated modeling.

An in vitro training method includes scanning a user's oral cavity to create a first oral cavity model. An articulator body is selected according to the first oral cavity model, and plural first customized electrode sheets are formed and assembled onto the articulator body to obtain an in vitro training device. The user bites the in vitro training device during a non-sleep period and uses the plural first customized electrode sheets to proceed with electrical stimulation on a top surface and two sides of a tongue of the user, thereby training a muscular endurance of infrahyoid muscles of the user for a training period. The user's oral cavity is scanned again to create a second oral cavity model. The first oral cavity model is compared with the second oral cavity model to timely renew the customized electrode sheets when the image over rate is lower than 80%.

The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.

A tool has an outer assembly, which includes a deployment tube, extending around, and moveable with respect to an inner assembly of the tool; the inner assembly includes a single pull wire and a distal member configured to engage an end of an implantable medical device. The deployment tube includes an articulating segment located just proximal to an enlarged distal-most portion, which contains the device and the distal member. Relatively soft and stiff sections of a composite sidewall define the articulating segment and extend alongside one another, such that, when the pull wire is actuated, the composite sidewall causes bending of the segment in two directions. A handle assembly of the tool includes a control member for the pull wire, and may further include a flushing subassembly that has a connector port located at an end of the handle assembly that is opposite a proximal port of the handle.

Systems, devices, and methods for neurostimulation using a combination of implantable and external devices to treat pain are disclosed.

A high-density mapping catheter comprising a catheter shaft comprising a proximal end and a distal end, the catheter shaft defining a catheter shaft longitudinal axis extending between the proximal end and the distal end, a flexible tip portion (10) fixed adjacent to the distal end of the catheter shaft, the flexible tip portion comprising a flexible framework comprising nonconductive material forming a plurality of electrode-carrying arms (188, 190, 192, 194), wherein each of the plurality of electrode-carrying arms (188, 190, 192, 194) converges with at least one other of the plurality of electrode-carrying arms at a distal end of the flexible tip portion (10), and a plurality of microelectrodes (196) mounted on the flexible framework and forming a flexible, planar array of microelectrodes (196) adapted to conform to tissue, wherein the plurality of microelectrodes (196) are mapping electrodes, wherein the flexible framework is configured to facilitate relative movement among at least some of the plurality of microelectrodes (196) relative to other of the plurality of microelectrodes (196), and wherein the nonconductive material insulates each of the plurality of microelectrodes (196) from other of the plurality of microelectrodes (196).

A catheter comprising an elongated catheter body, and an electrode assembly distal of the catheter body, the assembly comprising a plurality of spines, wherein each spine has a distal end that is connected to the distal end of at least one other spine, wherein each spine has an electrode-carrying portion, the electrode-carrying portions of all spines of the assembly being in a single common plane, and wherein all spines of the assembly have a uniform exposed total length.

Flexible high-density mapping catheter tips and flexible ablation catheter tips with onboard high-density mapping electrodes are disclosed. These tips can be used for diagnosing and treating cardiac arrhythmias. The flexible, distal tips are adapted to conform to tissue and comprise a plurality of microelectrodes mounted to permit relative movement among at least some of the microelectrodes. The flexible tip portions may comprise a flexible framework forming a flexible array of microelectrodes (for example, a planar or cylindrical array) adapted to conform to tissue and constructed at least in part from nonconductive material in some embodiments. The flexible array of microelectrodes may be formed from a plurality of rows of longitudinally-aligned microelectrodes. The flexible array may further comprise, for example, a plurality of electrode-carrying arms or electrode-carrier bands. Multiple flexible frameworks may be present on a single device. A delivery adapter having an internal compression cone is also disclosed.

Flexible high-density mapping catheter tips and flexible ablation catheter tips with onboard high-density mapping electrodes are disclosed. These tips can be used for diagnosing and treating cardiac arrhythmias. The flexible, distal tips are adapted to conform to tissue and comprise a plurality of microelectrodes mounted to permit relative movement among at least some of the microelectrodes. The flexible tip portions may comprise a flexible framework forming a flexible array of microelectrodes (for example, a planar or cylindrical array) adapted to conform to tissue and constructed at least in part from nonconductive material in some embodiments. The flexible array of microelectrodes may be formed from a plurality of rows of longitudinally-aligned microelectrodes. The flexible array may further comprise, for example, a plurality of electrode-carrying arms or electrode-carrier bands. Multiple flexible frameworks may be present on a single device. A delivery adapter having an internal compression cone is also disclosed.

A system for analyzing measurements performed on a biological subject, the system including one or more processing devices configured to acquire subject data at least in part captured by a measurement system including at least one substrate including a plurality of microstructures configured to breach a functional barrier of the subject and a sensor operatively connected to at least one microstructure, the at least one sensor being configured to measure response signals from the at least one microstructure, and analyze the subject data using at least one model to determine an indicator at least partially indicative of a physiological state of the subject.

Various aspects of this disclosure relate to a prosthetic cover comprising an array of sensors, which transmit signals to an array of electrodes in a liner that fits over a residual limb of an amputee. Different interactions with the prosthetic cover cause different activation of the electrodes to transmit electrical current through different areas of the residual limb and modulate neurons differently within the residual limb. Various aspects of this disclosure also relate to a prosthetic liner with a substrate that includes electrodes for transcutaneous electrical nerve stimulation and / or electronic muscle stimulation for a residual limb.

A neuromodulation system, device, and method are disclosed. In an embodiment, a neuromodulation system includes a processor, a signal generator, a first electrode, and a second electrode. The processor in cooperation with the signal generator, the first electrode, and the second electrode are configured to deliver a transcutaneous stimulation to a mammal. The transcutaneous stimulation is configured by the processor for inducing voluntary movement in the mammal. The first electrode is positioned transcutaneously on a spinal cord and / or spinal cord dorsal roots of the mammal. Additionally, the second electrode is placed transcutaneously on or over at least one of the spinal cord and / or the spinal cord dorsal roots, a muscle, a nerve, or on or near a target end organ or bodily structure of the mammal. The second electrode is in communication with the first electrode through a hardwire or wireless connection.

It is disclosed new conducting and stretchable hydrogels and “one-pot” process to making them from natural and eco-friendly components, including gelatin, chitosan, and glycerol. Various conducting materials, such as poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS), thermally reduced graphene (TRG), or MXene are introduced in the hydrogels to enhance their conductivity. The resulting conducting hydrogels exhibit remarkable robustness, do not require crosslinking agent, and possess a unique thermo-reversible property, simplifying the fabrication process and ensuring enhanced long-term stability. Moreover, their fabrication is sustainable, employing environmental-friendly materials and processes, while retaining their skin-friendly characteristics. It is also disclosed hydrogel electrodes that were tested for ECG signal acquisition and outperformed the commercial electrodes. The hydrogel-based electrodes deliver high-quality ECG signals, boasting a superior signal-to-noise ratio (SNR) and remarkable resilience against interference and motion artifacts, compared to their commercial AgCl counterparts.

The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. Included is a method of treating tissue with electrical energy, the method comprising: delivering electrical energy to tissue using one or more electroporation devices comprising one or more electrodes; and cooling the tissue, surrounding tissue, one or more of the electrodes, or one or more of the electroporation devices to minimize heating. In embodiments, the invention can be used to treat solid tumors, such as brain tumors, and in some embodiments, exemplary methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.

The invention discloses a cranial nerve double-path stimulation intelligent regulation and control method and system for Parkinson's disease, and relates to the technical field of medical treatment and neural engineering, and the method comprises the steps: obtaining an electroneurographic signal of a target patient based on a stimulation electrode, and determining neural activity features according to the electroneurographic signal; the stimulating electrodes comprise a first stimulating electrode and a second stimulating electrode; determining a nerve evaluation value according to the nerve activity characteristics, and generating a co-stimulation parameter based on the nerve evaluation value; initial stimulation parameters of the stimulation electrode are adjusted based on the co-stimulation parameters, the target patient is stimulated through the stimulation electrode, and cranial nerve two-way stimulation intelligent regulation and control for the Parkinson's disease are completed. According to the invention, by introducing the abnormal oscillation mode and evaluating the synchronism characteristics of the neural network in real time, the neural activities of the deep brain and the vagus nerve area are comprehensively quantified, and the accuracy of nerve regulation and control is improved; by generating collaborative stimulation parameters and comprehensively considering the mutual influence of the two stimulation pathways, intelligent collaborative regulation and control are realized.

Method and systems are described for identifying electrodes for stimulation of a patient using a stimulation system. The stimulation system includes at least one stimulation lead implanted in a patient and having electrodes disposed thereon. The method includes obtaining a plurality of bioelectrical signals, wherein each of the bioelectrical signals is obtained using a different one, or a different combination, of the electrodes; analyzing a dataset including the bioelectrical signals to identify at least one fundamental component of the dataset, each of the at least one fundamental component identifying a contribution of one or more of the electrodes to the fundamental component; and using at least one of the at least one fundamental component to identify one or more of the electrodes for stimulation according to the contribution of each of the one or more of the electrodes to the at least one of the at least one fundamental component.

The invention discloses a vagus nerve stimulation parameter closed-loop adjustment method and system based on electroencephalogram characteristics. The method comprises the steps that real-time electroencephalogram signals of a patient are obtained, and time domain information and frequency domain information of the electroencephalogram signals of all frequency bands in the real-time electroencephalogram signals are extracted; on the basis of the time domain information and the frequency domain information of the electroencephalogram signals of all the frequency bands, electroencephalogram signal index features are calculated, and the electroencephalogram signal index features comprise an electroencephalogram signal power spectrum, a brain dynamic symmetry feature, a brain function connection feature and a rhythm feature; determining the state type of the patient according to the electroencephalogram signal index characteristics; determining parameter configuration information of vagus nerve stimulation according to the state type of the patient; and adjusting parameters of the vagus nerve electrical stimulation equipment according to the parameter configuration information of vagus nerve stimulation. According to the invention, timely and accurate electrical stimulation can be applied to a patient, the treatment accuracy is improved, the stimulation efficiency and the treatment effect are enhanced, side effects are reduced, and more accurate and individualized treatment management is realized.

Devices and methods to mitigate the erroneous signal imparted by physical and / or chemical process incident upon analyte-selective electrochemical sensors that are non-analyte-related in origin are disclosed herein. A sensing system featuring at least one of an analyte-selective sensor and at least one of an analyte-invariant sensor.

Systems, devices, and methods for electrically stimulating peripheral nerve(s) to treat various disorders are disclosed, as well as signal processing systems and methods for enhancing diagnostic and therapeutic protocols relating to the same. Personalized therapy based on algorithms and aggregated data are also provided.

A medical apparatus for a patient comprises an external system and an implantable system. The external system is configured to transmit one or more transmission signals, each transmission signal comprising at least power or data. The implantable system is configured to receive the one or more transmission signals from the external system, and to deliver stimulation energy to the patient. Methods of delivering stimulation energy are also provided.

Embodiments of the present invention provide an eye mask for providing a therapy to eyes of a user. The eye mask comprises an inner layer, an outer layer and a circuit board. The inner layer has a first depression cavity and a second depression cavity such that the periphery of the first depression cavity and the second depression cavity form a convex edge. The circuit board comprises a plurality of LEDs for providing photo therapy and a micro-current element in arranged on the inner layer for providing micro-current therapy around the eyes of the user. A protective layer is provided over the LEDs to prevent direct exposure of eyes with the light emitted by the plurality of LEDs.

The invention discloses a closed-loop transcranial alternating current stimulation system based on phase-amplitude coupling stimulation, and the system comprises an alternating current stimulation current source which is used for generating a current signal with a fixed frequency; the stimulation and collection integrated electrode is connected with the alternating current stimulation current source and used for being worn on the head, conducting electric stimulation on a target scalp area and collecting electric signals of the target scalp area; the electroencephalogram acquisition front end is connected with the stimulation and acquisition integrated electrode and is used for acquiring electroencephalogram data according to the acquired electric signals; and the DSP processor is connected with the electroencephalogram acquisition front end and is used for executing a control algorithm according to the electroencephalogram data and adjusting parameters of the alternating current stimulation current source so as to control the stimulation and acquisition integrated electrode to perform closed-loop regulation and control on the brain. Based on the real-time electroencephalogram feedback technology, a set of closed-loop transcranial alternating current stimulation technology is constructed, phase-coupling regulation and control of the cortex are achieved, and the application range of the transcranial alternating current stimulation technology in the aspect of cognitive ability regulation and control is widened.

The present invention provides systems and methods for treatment planning and / or administering electrical pulses that elicit desired cell death mechanisms. Embodiments of the invention include selection of pulse parameters to tailor cell death type.

A neuromodulation system is provided herein. The system can include a cuff electrode, an electronics package, which can be part of a neuromodulation device; an external controller; a sensor; and a computing device. The neuromodulation device can include an antenna including an upper and a lower coil electrically connected to each other in parallel. The computing device can execute a closed-loop algorithm based on physiological sensed data relating to sleep.

A headset for use in delivering electrical stimulation to the skin surface of the head or in sensing one or more parameters of the head of a user.

The invention provides an electrode plate, a tumor electric field treatment system and a temperature detection and signal control method, the electrode plate comprises a flexible circuit board and a plurality of electrode units arranged on the flexible circuit board at intervals, and the plurality of electrode units are divided into a plurality of row groups and a plurality of column groups on a circuit. The electrode unit includes a dielectric element and a temperature sensor having a signal terminal and a ground terminal, and the dielectric element is short-circuited with the signal terminal of the temperature sensor. A plurality of conductive traces are embedded in the flexible circuit board, the plurality of conductive traces comprise a plurality of grounding wires and a plurality of dual-purpose signal wires, the grounding wires are arranged in one-to-one correspondence with the column groups, and the grounding wires are in short circuit with the grounding ends of the temperature sensors corresponding to the electrode units of the corresponding column groups and then are grounded. The dual-purpose signal lines are arranged in one-to-one correspondence with the row groups, and the dual-purpose signal lines are connected in series with the electrode units of the corresponding row groups.