The invention discloses a closed-loop feedback type opto-acoustic-electromagnetic integrated brain work rhythm adjusting device. The closed-loop feedback type opto-acoustic-electromagnetic integrated brain work rhythm adjusting device comprises an electroencephalogram signal detection module, an electroencephalogram signal preprocessing module, an adjusting controller and an opto-acoustic-electromagnetic integrated adjusting module, and the closed-loop feedback type opto-acoustic-electromagnetic integrated brain work rhythm adjusting device, a detection brain area and a response brain area jointly form a closed-loop feedback type structure. Signals collected by the electroencephalogram signal detection module from the detection brain area are preprocessed by the electroencephalogram signal preprocessing module and then transmitted into the adjusting controller to calculate the difference value between the signals and a reference value, an opto-acoustic-electromagnetic integrated nerve adjusting signal is generated, the opto-acoustic-electromagnetic integrated adjusting module is controlled to adjust the a response brain area of a target brain, therefore, the working rhythm of the target brain reaches a reference value. According to the device, working rhythm adjustment gain far beyond single stimulation can be provided, a plurality of working rhythms of the brain can be adjusted with different gains so as to deal with complex nerve dysfunction, and the closed-loop feedback structure is adopted, so that long-term use of a patient in various scenes is facilitated.