According to a first aspect, the invention relates to a multimodal
optical sectioning microscope (200, 400, 600) for full-field imaging of a volumic and scattering sample comprising:—a full-field OCT
system for providing an image of a first section in depth of the sample comprising an illumination sub-
system (201, 401, 601) and a full-field imaging interferometer with a detection sub
system (208, 408, 608) and an optical conjugation device for optically conjugating the sample and said detection sub system, wherein said optical conjugation device comprises a
microscope objective (203, 403, 603),—a supplementary full-field
optical sectioning imaging system for providing a fluorescent image of a second section in depth of said sample comprising a
structured illumination microscope with an illumination sub system (623), means (421, 422) for generating at the focal plane of said
microscope objective of said full-field imaging interferometer a variable spatial pattern illumination and a detection sub system (624), optically conjugated with said focal plane of the
microscope objective.