45 results about "Deoxygenated Hemoglobin" patented technology

The invention provides compositions containing hemoglobin, particularly PEGylated hemoglobin. The PEGylated hemoglobin molecule is capable of transferring oxygen or carbon monoxide bound thereto to a tissue with which it is in proximity. Exemplary PEGylated hemoglobin formulations of the invention are virally inactivated. Various compositions of the invention include deoxygenated hemoglobin, which may be conjugated with one or more water-soluble polymer. PEGylated hemoglobin includes those species in which the iron atom of the hemoglobin molecule is not bound to oxygen or any other species, and hemoglobin molecules in which a species other than oxygen, e.g., carbon monoxide, is bound to the iron atom. The compositions of the invention are formulated as hypo-, iso- or hypertonic solutions of the PEGylated hemoglobin. The compositions are of use to treat and/or ameliorate disease, injury and insult by providing for the oxygenation of tissues and/organs.

The mental state, such as mood or emotion, of an individual can be apprehended by a method using non-invasive biological light measurement technology. A biological light measurement device, which has an irradiation section, presents different tasks (at least a first task and a second task) to a subject, hemoglobin signals based on changes in the concentration of oxygenated hemoglobin and deoxygenated hemoglobin in the subject are calculated from the strength of light detected by a detection section, and a relative value using the hemoglobin signal at a predetermined measurement channel with respect to the first task, and the hemoglobin signal at a different predetermined measurement channel with respect to the second task is calculated.

The invention discloses a magnetic resonance imaging method which utilizes the fact that a tissue with different deoxygenated hemoglobin content has magnetic sensitive chatacteristics of different degrees, uses an asymmetric spin echo magnetic resonance imaging sequence, adopts a strategy of moving a 180-degree echo refocusing RF pulse position periodically, allows 180-degree echo refocusing pulses to distribute on both sides of a TE/2 time position in each period, and obtains a high-time-resolution multiple-echo image. Further, aiming at acquired multiple-echo signals, the magnetic resonance imaging method performs mobile estimation by taking length of a corresponding 180-degree echo refocusing pulse mobile period as a window width, adopts least square estimation, and obtains dynamic parameter images of R2, R2* and R2' simultaneously according to a signal attenuation index model. By adopting the magnetic resonance imaging method, the high-time-resolution dynamic R2, R2* and R2' parameter images can be obtained, and a dynamic curves in an arbitrary region of interest can be displayed.

A device and a method to measure the concentrations of oxygenated and deoxygenated hemoglobin in tissue around a tumor via near-infrared (NIR) spectroscopy with a photonic mixer device (PMD) is described.

The invention discloses a device for measuring oxygenated hemoglobin and deoxygenated hemoglobin and a near infrared brain imaging device. The device comprises an interface module, a near infrared receiving and transmitting module and a controller, wherein the near infrared transceiving module is provided with a plug-and-play interface and plugged in the interface module through the plug-and-playinterface, the near infrared receiving and transmitting module is driven by the controller to transmit preset-wavelength near infrared rays to measured cerebral cortex and receive light intensity signals generated when the near infrared rays are reflected by the measured cerebral cortex. The controller is connected with the interface module and used for receiving the light intensity signals outputby the near infrared receiving and transmitting module and measuring parameters of oxygenated hemoglobin and deoxygenated hemoglobin of the measured cerebral cortex according to the light intensity signals. Thus, according to the characteristic that hot plug is supported by the near infrared receiving and transmitting module, the aims of increasing and decreasing functions and channel number canbe realized, and the reusability of the device and the usage rate of parts can be increased.

The invention discloses an identification method of a movement velocity state based on cerebrum hemoglobin information. The method comprises the first step of making a testee autonomously execute riding movement under low-velocity, middle-velocity and high-velocity states; the second step of aiming at cortex hemoglobin concentration information recorded in the movement initial time, adopting a difference value of oxygen-containing hemoglobin and deoxygenated hemoglobin as an analysis parameter, and considering parameter characteristics of key channels via four frequency bands respectively based on a change rate mean value of the corresponding difference value; the third step of identifying three different kinds of velocity states. The change rate mean value of the difference value of the oxygen-containing hemoglobin and deoxygenated hemoglobin of the key channels under four frequency bands is directly utilized as a feature vector, and an extreme learning machine ELM algorithm is adopted to identify velocity grades.

The invention discloses a near-infrared brain imaging spectrum classifying method based on cognition task testing. A near-infrared brain imaging spectrum at least comprises a first curve corresponding to the oxyhemoglobin concentration and a second curve corresponding to the deoxygenated hemoglobin concentration. The classifying method comprises the following specific steps: 1, reading the near-infrared brain imaging spectrum obtained by a near-infrared brain imager, and extracting the waveform characteristics of the first curve and the second curve of the near-infrared brain imaging spectrum; and 2, comparing the waveform characteristics obtained in the step 1 with a preset value, and classifying the near-infrared brain imaging spectrum according to the comparison result. The near-infrared brain imaging spectrum classifying method based on the cognition task testing provided by the invention can be applied to the fundamental research in the field of psychology or applied to the clinic for automatically classifying the near-infrared brain imaging spectrum.

The invention relates to an improved polymerized hemoglobin preparation method. According to the invention, a hemoglobin aqueous solution with matrix-free human deoxyhemoglobin weight/volume content of 4-14% is adopted as a raw material. Under an inert gas environment and a stirring condition, an aldehyde-type bi-functional crosslinking agent is delivered into the raw material solution through a titanium rod; a polymerization reaction is carried out under a temperature of 0-10 DEG C, such that polymerized hemoglobin with an average molecular weight of 100-210kD and a preferable molecular weight of 110-170kD is obtained. A molar ratio of hemoglobin to the aldehyde-type bi-functional crosslinking agent is 4-8:1. With the method, the polymerized hemoglobin product with relatively low average molecular weight, relatively narrow molecular weight distribution, and effective conversion rate reaching 69% can be prepared, such that a problem of non-uniform molecular weight distribution in product of current polymerized hemoglobin preparation is effectively avoided. The operation is simple, and equipment cost is low.

The invention relates to a device for quantitatively detecting the spectral content distribution of oxygenated hemoglobin and deoxygenated hemoglobin. The device comprises a light source module, an imaging module, an adjusting bracket, an image data transmission link, a control command transmission link and a computer. As a technical means of high spectral imaging is adopted, the full cover detection is realized in a detected region, and a characteristic spectrum of the oxygenated hemoglobin and the deoxygenated hemoglobin is extracted through using a spectral decomposition technology, the calculation is carried out by utilizing a regional oxygen saturation computational formula, and the device and the method have the characteristics of acquiring comprehensive information and being high in precision without any reagent.

The invention relates to a method for preserving the stability of a hemoglobin blood substitute comprising maintaining the hemoglobin blood substitute in an atmosphere substantially free of oxygen. The invention also involves a method for producing a stable polymerized hemoglobin blood-substitute from blood. The method of this invention includes mixing blood with an anticoagulent to form a blood solution, washing the red blood cells in the blood solution and then separating the washed red blood cells from the white blood cells. This method also includes disrupting the red blood cells to release hemoglobin and form a hemoglobin solution, which is then treated by high performance liquid chromatography to form a hemoglobin eluate. The hemoglobin eluate is then deoxygenated, contacted with a first sulfhydryl compound to form an oxidation-stabilized deoxygenated hemoglobin solution, and mixed with a cross-linking agent to form a polymerization reaction mixture, which is then polymerized. The polymerized hemoglobin solution is then diafiltered with a physiologic solution and with a sulfhydryl compound, whereby the polymerized hemoglobin solution is made physiologically acceptable, and whereby the sulfhydryl compound scavenges oxygen, to form a stable polymerized hemoglobin blood-substitute, which is then packaged and stored in an atmosphere substantially free of oxygen.

The invention provides an optical imaging method based on a layer structure. In the method, specific space distribution and optical properties of all substance layers are considered fully, optical information (absorption coefficients and scattering coefficient of all layers) of all the corresponding layers can be separated. By applying the optical information to a biological system, the physiological parameter information (deoxygenated hemoglobin content, oxygen-poor hemoglobin content, melanin content and epidermal depth). For example, the model is combined with the SFDI technology and applied to a forearm reactive congestion experiment and skin mole detection, and a good result is obtained.

The present invention is a method for preparing a hemoglobin based oxygen carrier to deliver oxygen to tissue. The method comprises mixing a deoxygenated hemoglobin with a maleimide-activated polyakylene oxide (PAO) to obtain an oxygen carrying product. This product is characterized as having 2 to about 8 PAO moieties covalently bound to a deoxygenated hemoglobin and a p50 less than native stroma-free hemoglobin from the same animal source when measured under the same conditions.

The invention discloses a photoacoustic ultrasonic bimodal imaging system and method for transplanted kidney. The system comprises a pulse laser which is used for the transplanted kidney to generate an photoacoustic signal; the ultrasonic transducer is used for receiving the photoacoustic signal and converting the photoacoustic signal into an electric signal; the ultrasonic transceiving module isused for transmitting and receiving electric signals; a photoacoustic signal processing unit; a data collection unit; and the computer is used for controlling the pulse laser and the ultrasonic transceiving module, performing image reconstruction on the digitized photoacoustic signal to obtain a photoacoustic image, and performing color coding on the photoacoustic image to realize development of functional information such as transplanted kidney microvascular distribution, intravascular blood oxygen content, oxygenated/deoxygenated hemoglobin content and the like. Structural imaging of the transplanted kidney can be achieved, functional information such as castruty distribution, intravascular blood oxygen content and oxygenated/deoxygenated hemoglobin content of the transplanted kidney canbe provided, and namely simultaneous real-time imaging of the structure and the function of the transplanted kidney is achieved.

The invention discloses a non-invasive exercise fatigue intervention and evaluation method. The method comprises the following steps: step 1, a laser acupuncture and moxibustion combined percutaneous acupoint electrical stimulation composite intervention method is adopted, and laser and current synchronous stimulation is realized by using a composite intervention probe; and step 2, an an exercise fatigue and intervention effect assessment method is adopted by means of firstly, establishing an upper limb fatigue model for exercise fatigue assessment, then establishing an exercise fatigue fusion assessment model by using indexes such as a visual simulation score table, oxygenation/deoxygenated hemoglobin concentration, surface electromyogram signals, maximum equal-length contraction tension and the like, and then adopting the fusion evaluation model for verifying the intervention effect of laser acupuncture and moxibustion combined percutaneous acupoint electrical stimulation composite intervention on exercise fatigue through a control experiment. The invention provides a new clinical thought for preventing and treating exercise fatigue, and has important significance in improving the athletic performance of athletes, reducing the risk of exercise injury and diseases and encouraging people to exercise so as to promote physical and psychological health.

The invention belongs to the field of cerebral blood oxygen detection, and provides a cerebral blood oxygen detection system. The cerebral blood oxygen detection system comprises an acquisition module and a data processing module, wherein the acquisition module comprises N groups of light sources and M groups of detectors, the N groups of the light sources and the M groups of the detectors are arranged on the same side of a to-be-detected sample, and the N groups of the light sources emit at least three kinds of near-infrared light with different wavelengths into the to-be-detected sample; at least two groups of the detectors in the M groups of the detectors respectively receive near-infrared light signals which are not absorbed by the to-be-detected sample; and the data processing module is used for processing the near-infrared light signals according to the corrected Lambert-Beer law to obtain cerebral blood oxygen information of the to-be-detected sample. The system solves the technical problems that in the prior art, when the cerebral blood oxygen information is detected, the light sources and the detectors are arranged on two sides of the to-be-detected sample respectively, an optical density signal needs to penetrate through the tissue of the to-be-detected sample, the optical path is long, interference of other chromophores except oxygen-containing hemoglobin and deoxidized hemoglobin in the calculation process is large, and the calculation result error is larger.