17 results about "Deoxygenated Hemoglobin" patented technology

An electronic device comprises a housing configured to contact a user's skin, an optical transmitter array, an optical receiver, a memory element and a processing element. The optical transmitter array outputs a plurality of optical signals that pass through the user's skin, each of the plurality of optical signals having one of three wavelengths. The optical receiver receives the optical signals and generates corresponding photoplethysmogram (PPG) signals. The memory element stores absorption constants for deoxyhemoglobin blood content, oxyhemoglobin blood content and glycated hemoglobin blood content, each absorption constant associated with one of the first wavelength, the second wavelength or the third wavelength. The processing element determines a glycated hemoglobin blood level for the user based on a ratio of a determined glycated hemoglobin blood content to a sum of determined deoxyhemoglobin blood content, a determined oxyhemoglobin blood content and a determined glycated hemoglobin blood content.

To provide a blood sugar level measuring device and a blood sugar level measuring method capable of accurately calculating a blood sugar level.SOLUTION: The blood glucose level measurement device 1 includes a light output unit 3 that outputs measurement light L to a living body 6, a light detection unit 4 that detects the measurement light L transmitted through the living body 6, a time phase difference calculation unit 51 that calculates a time phase difference between an oxygenated hemoglobin waveform and a deoxygenated hemoglobin waveform based on a detection result of the light detection unit 4, a blood glucose level calculation unit 52 that calculates a blood glucose level of the living body 6 based on the calculated time phase difference, and a blood glucose level calibration unit 54 that calibrates the blood glucose level calculated by the blood glucose level calculation unit 52. The blood-sugar-level calibrating unit 54 performs calibration such that the blood sugar level calculated by the blood-sugar-level calculating unit 52 during sleep of the living body 6 or in a predetermined period after the living body 6 wakes up from sleep corresponds to a reference blood sugar level set in advance.SELECTED DRAWING: Figure 3

The application discloses a blood oxygen distribution imaging method and system based on double-band diffuse reflection space mapping, relates to the field of non-contact physiological parameter detection for biomedical optical application, and comprises the following steps: acquiring a double-band diffuse reflection original image sequence of a to-be-detected tissue region under two specific bands, obtaining normalized double-band images and a region of interest through preprocessing and region segmentation; estimating an effective optical path ratio between the two specific bands based on image gradient information in a local neighborhood of each pixel, and constructing a local optical path correction matrix; according to a double-band reflection attenuation ratio, a corresponding effective optical path ratio, and extinction coefficients of oxygenated hemoglobin and deoxygenated hemoglobin under the two specific bands, a double-band inversion model based on an improved Lambert-Beer law is used to calculate a preliminary blood oxygen saturation, and a two-dimensional blood oxygen saturation distribution map is generated through spatial regularization optimization. Therefore, the spatial representation capability, inversion stability and imaging accuracy of non-contact blood oxygen imaging can be improved.

An electro-optical device, an apparatus comprising the electro-optical device and a method of conducting functional near-infrared spectroscopy analysis using such an apparatus. The electro-optical device comprises: a light source arranged to irradiate a target spot of the head of a subject with light emission including a plurality of light components having distinct wavelengths, wherein light components with distinct wavelength are arranged to be partially absorbed by hemoglobin in blood passing though the target spot with distinct absorption ratios; and a light sensor arranged to detect light reflection from the target spot, wherein light reflection is adapted to be further processed for determination of relative concentrations of oxygenated hemoglobin and deoxygenated hemoglobin in the target spot based on a change of each of the light components with respective wavelength in the light reflection when compared to the light emission.

To provide a blood sugar level measuring device and a blood sugar level measuring method capable of measuring a blood sugar level with high measurement accuracy and improving the driving time of the blood sugar level measuring device.SOLUTION: The blood glucose level measurement device 1 includes the acquisition unit 62 that acquires the waveform calculation data for calculating the oxygenated hemoglobin waveform and the deoxygenated hemoglobin waveform by outputting light to the living body and detecting the light transmitted through the living body, the phase difference calculation unit 63 that calculates the time phase difference between the oxygenated hemoglobin waveform and the deoxygenated hemoglobin waveform, and the blood glucose level calculation unit 64 that calculates the blood glucose level of the living body based on the time phase difference. The acquiring unit 62 is configured to be able to execute first sampling for acquiring the waveform calculation data at a first sampling rate and second sampling for acquiring the waveform calculation data at a second sampling rate higher than the first sampling rate.SELECTED DRAWING: Figure 2

This blood glucose level measurement device comprises: an acquisition unit that outputs light to a living body and detects the light transmitted through the living body, thereby acquiring waveform calculation data for calculating an oxygenated hemoglobin waveform and a deoxygenated hemoglobin waveform; a phase difference calculation unit that calculates a temporal phase difference between the oxygenated hemoglobin waveform and the deoxygenated hemoglobin waveform; and a blood glucose level calculation unit that calculates the blood glucose level of the living body on the basis of the temporal phase difference. The acquisition unit is configured to be capable of executing first sampling for acquiring the waveform calculation data at a first sampling rate and second sampling for acquiring the waveform calculation data at a second sampling rate higher than the first sampling rate.

This blood glucose level measurement device comprises: a blood glucose level estimation unit that outputs light to a living body, detects light transmitted through the living body, calculates, on the basis of the result of the detection, a temporal phase difference between an oxygenated hemoglobin waveform relating to the oxygenated hemoglobin concentration of the blood in the living body and a deoxygenated hemoglobin waveform relating to the deoxygenated hemoglobin concentration of the blood in the living body, and calculates the blood glucose level of the living body on the basis of the calculated temporal phase difference; and a body movement detection unit that detects a parameter relating to body movement of the living body. In cases where the parameter detected by the body movement detection unit or the variation in the parameter is equal to or below a threshold value, the blood glucose level estimation unit stores the calculated blood glucose level in a storage unit.

The application discloses a kind of gingival tissue hemodynamics spectral index construction systems based on near infrared spectroscopy, it is characterized in that, including visible near infrared spectrometer and data processing unit;Wherein, the visible near infrared spectrometer is used to collect the spectral data of each target site around the tooth to be detected;The data processing unit is used to normalize the spectral curve in each spectral data collected to consistent measurement background, determine the spectral absorption characteristics of gingival tissue oxyhemoglobin and deoxyhemoglobin is extracted;Then based on the spectral absorption characteristics obtained, gingival tissue hemodynamics index is calculated.The gingival tissue hemodynamics spectral index obtained based on the application can assist in quickly, accurately, non-invasively and cost-effectively completing periodontal tissue inflammation detection, and provides accurate and effective assistance for the clinical diagnosis of periodontitis.

This patent describes an advanced method for the accurate optical quantification of antioxidant carotenoids in biological tissues. The method addresses interference from melanin and hemoglobin through comprehensive correction techniques. It involves creating a tangent line for melanin correction using absorbance values at 650 nm and 700 nm, measuring the corrected optical density (OD) of carotenoids at 488 nm, measuring the corrected OD of blood at 577 nm, converting the Blood OD from 577 nm to 488 nm using oxyhemoglobin and deoxyhemoglobin extinction coefficients, and subtracting the Blood OD from the Carotenoid OD to obtain the final Carotenoid OD. This innovative approach provides reliable, non-invasive, and precise measurements of carotenoid levels in tissues, facilitating improved health assessments and personalized nutrition strategies.

The present invention is an in vivo non-invasive method and apparatus for the measurement of the arterial blood oxygen saturation status of a patient, the method is a generalized improvement on conventional pulse oximetry to correct for its skin pigmentation bias and significant errors in oxygen saturation assessment in the presence of methemoglobin. The method requires an additional red light sensor with an infrared long pass filter to conventional pulse oximetry, and utilizes red and infrared light and sensors to non-invasively measure the peripheral pulse optical plethysmograph waveforms (PPG) at three light wavelengths, red, long pass red and infrared, positioned over a finger, or ear or other extremity, and from the pulse oximetric ratio of ratios transforms the PPG measurements by a processing device that determines the subject's arterial blood oxygen saturation directly, without the need for an empirical correction as is required in conventional pulse oximetry. The method determines the red transmitted light waveform and thus quantifies the wavelength shift from the incident red light due to the subject's skin pigmentation, and from in vivo hemoglobin extinction coefficients, determines the relative concentrations of oxygenated and deoxygenated hemoglobin and methemoglobin in the subject's arterial blood.

An input interface is configured to receive a signal corresponding to a quantity of light that has passed through a living tissue of a subject. A pressurization controller is configured to control a pressurizing operation performed with a pressurization device attached to a body of the subject, thereby changing at least one of a thickness of the living tissue, an amount of blood contained in the living tissue, an amount of cellular interstitial fluid contained in the living tissue, an amount of blood flowing into the living tissue, and an amount of blood flowing out from the living tissue. A processor is configured to acquire, from a temporal change of the signal due to the pressurizing operation, a feature quantity that is used for estimating at least one of a physiological state of the living tissue and a disease state of the subject. An output interface is configured to output a signal corresponding to the feature quantity. The light includes first infrared light for which for which a difference between the absorbance of oxygenated hemoglobin in blood and absorbance of deoxygenated hemoglobin is less than a prescribed value; and second infrared light for which absorbance of water is more than absorbance of hemoglobin.

This invention belongs to the field of brain function testing technology, specifically disclosing a method and system for assessing care efficacy based on near-infrared super-scanning. This method uses a near-infrared brain functional imaging (fNIRS) system to simultaneously acquire light intensity data from the prefrontal, parietal, and occipital cortices of subjects performing cooperative cognitive tasks with caregivers, converting this data into oxygenated and deoxygenated hemoglobin concentrations for individual-level analysis. Brain region matching is completed, and interbrain synchronous activity is detected through transfer entropy analysis and combined power spectrum analysis to obtain the magnitude and directionality of interbrain synchronicity. Based on the magnitude and directionality of interbrain synchronicity, the level of care efficacy between patients with cognitive impairment and their caregivers is assessed. This technical solution utilizes super-scanning technology to analyze and obtain the level of care efficacy between patients with cognitive impairment and their caregivers, thereby facilitating focused observation and care for patients with cognitive impairment.

Methods and systems for measuring hemoglobin concentration (cHb). A retinal tissue having blood vessels is illuminated by light including two isosbestic wavelengths (λ1,λ2). The isosbestic wavelengths(λ1,λ2) correspond to isosbestic points where oxy- and deoxyhemoglobin (HbIO2,Hb) have the same molar extinction coefficient. Measurements are collected of a plurality of backscattered reflection intensities (I(χb,λ1), I(xt,λ1), I(χb,λ2), I(xx,X2)). Preferably, the measurements are spectrally resolved at least for the two isosbestic wavelengths (λ1,λ2) and position-resolved for at least a blood vessel location (xb) coinciding with a selected blood vessel and a tissue location (xt) coinciding with the retinal tissue without blood vessel. The hemoglobin concentration (cHb) can be calculated based on a combination of the measurements at the two isosbestic wavelengths (λt,λ2).

This blood glucose level measurement device comprises: a light output unit; a light detection unit that detects light output by the light output unit and transmitted through a living body; a temporal phase difference calculation unit that calculates the temporal phase difference between an oxygenated hemoglobin waveform and a deoxygenated hemoglobin waveform on the basis of the detection result from the light detection unit; a blood glucose level calculation unit that calculates the blood glucose level of the living body on the basis of the temporal phase difference calculated by the temporal phase difference calculation unit; and a blood glucose level calibration unit that calibrates the blood glucose level calculated by the blood glucose level calculation unit. The blood glucose level calibration unit carries out the calibration such that the blood glucose level calculated by the blood glucose level calculation unit during sleep of the living body or during a prescribed period or time after waking up from the sleep corresponds to a preset reference blood glucose level.

The data processing device (170) is configured to acquire at least one digital input image (130) representing a reflected light image of a biological object (106) and comprising a plurality of input pixels (230, 232). A blood concentration value is determined at an input pixel (230, 232) of the plurality of input pixels (230, 232), the blood concentration value representing a blood volume at a location of the subject (106) imaged in the input pixel (230, 232). Further, a blood oxygenation value is determined at the input pixel (230, 232), the blood oxygenation value representing an amount of deoxygenated hemoglobin and / or an amount of oxygenated hemoglobin at the location of the subject (106). Output pixels (230, 234) of the digital output color image (160) are generated by assigning a color (222) to each output pixel (230, 234), the color (222) depending on the blood oxygenation value and the blood concentration value.

The application relates to the medical imaging field, in particular to an oxygen saturation quantitative imaging device and method for an endoscope, the device comprising a light source part; a shooting part configured to collect reflected light of a target area under light source illumination and output a collected color image and exposure control parameters corresponding to the color image; an image processing part comprising: a spectrum reconstruction module for performing image gain reduction processing on the color image and reconstructing a single waveband image signal of a set wavelength; a light intensity estimation module for calculating light intensity data of the light source respectively; a quantitative calculation module for calculating a light absorption coefficient based on the light intensity data, and solving oxygenated hemoglobin concentration, deoxygenated hemoglobin concentration and oxygen saturation value based on the light absorption coefficient, and generating an oxygen saturation distribution image. The oxygen saturation image generated by the application has rich anatomical structure information and accurate physiological parameter information, and can intuitively display a tissue hypoxic area.

A light emitting device emits: first light including a first wavelength at which an absorbance of oxygenated hemoglobin is larger than an absorbance of deoxygenated hemoglobin; and second light including a second wavelength at which the absorbance of deoxygenated hemoglobin is larger than the absorbance of oxygenated hemoglobin. A light detecting device outputs first and second signals respectively corresponding to intensities of the first and second light that have passed through a living tissue. A processing device acquires: a first difference value between light attenuations of the first and second light based on the signals while compression of the living tissue is performed; and a second difference value between the light attenuations based on the signals after the compression is cancelled. A processing device acquires an index corresponding to an oxygen saturation of blood contained in the living tissue based on a difference between the first and second difference values.