Cortical functional multi-mode imaging system

Abstract

The invention discloses a cortical functional multi-mode imaging system. The system comprises a wide-spectrum light source, a laser diode and a red light-emitting diode which are arranged above cortex dispersedly; a coaxial filter is respectively arranged in front of the wide-spectrum light source and the red light-emitting diode; backward scattered light come from the cortex is split into two paths by a dispersion prism; one path of the backward scattered light is connected with a first charge coupled device through a liquid crystal tunable filter; the other path of the backward scattered light is connected with a second charge coupled device through a filter; and the two charge coupled devices are respectively connected with two computers. The system solves the difficult problem of technology integration of fluorescence imaging and intrinsic signal optical imaging for a long time by introducing the liquid crystal tunable filter; and the intracellular pH value, cerebral blood volume,deoxygenated hemoglobin and cerebral blood flow changes can be obtained at the same time by combining laser speckle imaging so as to provide an effective means for researching brain functions and disease mechanisms more completely in detail.

Description

technical field

[0001] The patent of the invention belongs to the field of biomedical imaging, and specifically relates to a functional multi-mode imaging system of the cerebral cortex, which can simultaneously monitor the pH value change of the cerebral cortex, the change of cerebral blood volume, the change of deoxygenated hemoglobin concentration and the change of blood flow velocity. It is suitable for the functional study of the cerebral cortex in biomedicine. Background technique

[0002] Traditional pH detection mainly uses pH-sensitive electrodes, but this method can only detect a single point and is invasive. The change information of intracellular pH can be obtained by using pH-sensitive dyes for fluorescence imaging; endogenous signal optical imaging is a technique to detect the retroreflected light of the cortex, which mainly reflects the change of hemoglobin concentration; laser speckle imaging is used in It has been widely used to reflect changes in blood flo...

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