47 results about "Laser Speckle Imaging" patented technology

An apparatus and method for measuring perfusion in a tissue. The method comprising the steps of recording images of the tissue under laser light, calculating a plurality of contrast images from the plurality of images of the tissue, determining a power spectrum of scattered light from the plurality of contrast images, and determining perfusion from the power spectrum. The apparatus comprises a digital video camera, a laser light source, and a processor arranged to operate the camera to produce a plurality of images with different exposure times, receive the plurality of images from the camera and process the images to determine a power spectrum and determine perfusion from the power spectrum.

An apparatus for wide-field functional imaging (WIFI) of tissue includes a spatially modulated reflectance/fluorescence imaging (SI) device capable of quantitative subsurface imaging across spatial scales, and a laser speckle imaging (LSI) device capable of quantitative subsurface imaging across spatial scales using integrated with the (SI) device. The SI device and LSI device are capable of independently providing quantitative measurement of tissue functional status.

Apparatus and method according to an exemplary embodiment of the present invention can be provided for analyzing tissue. For example, the apparatus can include at least one first arrangement configured to illuminate at least one anatomical structure with at least one of at least one electro-magnetic radiation. The apparatus can also include at least one second arrangement that may include at least two wave-guiding arrangements associated with one another that are configured to receive a further electro-magnetic radiation reflected from the tissue and transmit at least one speckle pattern associated with the further electro-magnetic radiation. The wave-guiding arrangements may be structured so as to reduce crosstalk therebetween.

Methods and apparatus for measuring perfusion using transmission laser speckle imaging are provided. The apparatus comprises a coherent light source and a detector configured to measure transmitted light associated with an unfocused image at one or more locations. The coherent light source and detector are positioned in a transmission geometry. The apparatus further comprises means for securing the coherent light source and the detector to the tissue sample in a fixed transmission geometry relative to the tissue sample. The apparatus may further comprise at least one processor to receive information from the detector and process detected variations in transmitted light intensity to determine a single metric of perfusion. The method may comprise the steps transilluminating a tissue sample with coherent light, recording spatial and/or temporal variations in the transmitted light signal, determining speckle contrast value(s), and computing a metric of perfusion.

The equipment for monitoring micro circulation body flow time-space response characteristic on mesentery includes an optical path and an imaging system. In the optial path, the laser bean from helium neon laser is coupled to fiber bundle to form homogeneous diffused beam; and the imaging system consists of stereo microscope with CCD camera, image collecting card with image collecting and controlling software. The CCD signal is output to the image collecting card connected to PC, the collection parameters are set via the image collecting and controlling software and local blood flow information are obtained with the image signal and via the signal analysis software. The equipment provides one new way to the research of influence of medicine and other stimulation to the micro circulation blood flow on mesentery.

The invention discloses an imaging system of an endoscope.According to the system, one end of a first switch is connected with red laser and the other end of the first switch is connected with a first controllable decorrelation device to serve as a first channel; one end of a second switch is connected with a green light source and the other end of the second switch is connected with a first controllable decorrelation device to serve as a second channel; one end of a third switch is connected with a blue light source and the other end of the third switch is connected with a third controllable decorrelation device to serve as a third channel; the first channel, the second channel and the third channel are connected with a mixer, and mixed signal light is output; the first controllable decorrelation device in the first channel is not enabled, output signal light is used for laser speckle imaging, a laser speckle angiography image is generated, output signal light of the second channel and the third channel is used for narrow-band light imaging, and a narrow-band light image is generated.The imaging system of the endoscope breaks through narrow-band light imaging depth, detects the angiemphraxis condition, and improves the capacity of recognizing blood vessel depth information.

The invention discloses a frequency domain laser speckle imaging based blood flow velocity measuring method. The frequency domain laser speckle imaging based blood flow velocity measuring method comprises the following steps of illuminating laser beams on a measured object, imaging the measured object through an imaging system, collecting an original speckle image of the measured object through an image sensor, transferring dynamic speckle intensity with single pixel points being in a time domain of the collected original speckle image into a frequency domain, calculating the power spectral density, performing polynomial fitting on the power spectral density to obtain a smooth curve, transferring the smooth curve into the time domain through Fourier transform, calculating an autocovariance function of the pixel points and performing normalization, establishing a blood velocity measuring model, obtaining a relationship between the covariance function and the blood velocity and finally performing fitting to obtain a blood velocity value. The frequency domain laser speckle imaging based blood flow velocity measuring method has the advantages of not only eliminating static noise, improving the blood velocity measuring accuracy, avoiding influences from imaging environmental factors such as intensity and illumination angles and improving the measuring stability.

The invention discloses multi-modality imaging equipment combining opto-acoustic imaging and laser speckle imaging. The multi-modality imaging equipment combining opto-acoustic imaging and laser speckle imaging comprises a 532nm pulse laser source, a 632.8nm He-Ne laser source, an opto-acoustic modulating light path, a laser speckle modulating light path, a reflector group, an opto-acoustic signalacquiring system, a laser speckle blood flow acquiring system and an upper computer. The multi-modality imaging equipment combining opto-acoustic imaging and laser speckle imaging disclosed by the invention can detect haemodynamics parameters including cellular structures in blood vessels, blood flow and the like continuously and simultaneously in a real-time same-view-field manner, and effectively and accurately transmit the acquired multi-modality parameters to the upper computer for processing; and besides, the composition of the multi-modality imaging equipment can be simplified, and high-distinguishability opto-acoustic imaging and laser speckle blood flow imaging are effectively combined, so that the measuring steps and the measuring time of different parameters are greatly reduced,and strong support is provided for clinical diagnosis and treatment of vascular diseases in future.

Exemplary systems and methods can be provided for providing information associated with tissue. For example, it is possible to illuminate the tissue with at least one electromagnetic radiation which is a coherent light and/or a partially coherent light. The electromagnetic radiation reflected from the tissue can be received and speckle patterns may be formed associated with the electromagnetic radiation. In addition, changes can be analyzed in the speckle patterns at time intervals sufficient to measure motion of or within a fascial compartment of the tissue. For example, it is also possible that the electromagnetic radiation is an interfered radiation from a sample and a reference. Further, the speckle patterns can be measured at different depths within the sample by moving the reference.

The invention discloses a multi-modal imaging device combining photoacoustic and fiber-optic laser speckle, which comprises a light source module, a motor control module and a data acquisition module. The multi-modal imaging device has reasonable structure and simple structure, and realizes real-time synchronous simultaneous field detection of blood vessel structure, blood flow and blood oxygen, the combination of a high-resolution photoacoustic imaging technology and an endoscopic laser speckle imaging technology greatly reduces the measurement steps and time of different parameters, and provides a strong support for the clinical diagnosis and treatment of tumor and vascular diseases in the future.

The invention discloses an endoscope type laser speckle blood flow imaging probe which comprises the components of an ocular lens, a focusing part, a flexible pipe part, a head end part, a joint adapter, a cold light source interface, a flexible pipe, an image transmitting optical fiber, light transmitting optical fibers, a quartz optical fiber protecting layer, a quartz optical fiber, a quartz optical fiber epitaxial part and a small lens. According to the endoscope type laser speckle blood flow imaging probe, a laser speckle blood flow imaging system is combined with an endoscope, thereby realizing blood flow detection of intracavitary organs such as an alimentary canal. The number of the light transmitting optical fibers is increased in the probe. Four light transmitting optical fiberssurround the image transmitting fiber, thereby increasing a light receiving area of a tissue, realizing more uniform and sufficient light and effectively preventing light spots. According to the endoscope type laser speckle blood flow imaging probe, laser speckle imaging is combined with spectrum detection; a fiber laser device is used for supplying a laser source and a broadband light source; theendoscope type laser speckle blood flow imaging probe realizes simultaneous detection of the blood flow and the blood oxygen of the intracavitary organs; and in designing of the probe, the position of the image transmitting optical fiber is properly adjusted, thereby overcoming defects in detection by an existing endoscope, and realizing wall-adhering measurement of the blood flow.

Some embodiments of the present inventive concept provide a system that uses two wavelengths of differential transmittance through a sample to apply laser speckle or laser Doppler imaging. A first of the two wavelengths is within the visible range that has zero or very shallow penetration. This wavelength captures the anatomical structure of tissue/organ surface and serves as a position marker of the sample but not the subsurface movement of blood flow and perfusion. A second wavelength is in the near Infra-Red (NIR) range, which has much deeper penetration. This wavelength reveals the underlying blood flow physiology and correlates both to the motion of the sample and also the movement of blood flow and perfusion. Thus, true motion of blood flow and perfusion can be derived from the NIR imaging measurement without being affected by the motion artifact of the target.

The invention provides a position compensation device in the annular rolled piece machining process. The position compensation device uses laser to detect the size of an annular rolled piece in an on-line mode and comprises a laser scanning unit, a laser speckle imaging unit and a control unit. The laser scanning unit collects data of the annular rolled piece in the rolling process, the laser speckle imaging unit and the laser scanning unit are synchronous, and a speckle image is formed on the surface of the annular rolled piece; and the control unit controls the laser scanning unit and the laser speckle imaging unit, and the position compensation quantity of the annular rolled piece is calculated based on the data collected by the laser scanning unit and the speckle image formed by the laser speckle imaging unit. The invention further provides a position compensation method in the annular rolled piece machining process. According to the position compensation device and method in the annular rolled piece machining process, the size of the annular rolled piece which is subjected to grinding and expansion can be measured, the difference value of the radius change of the annular rolled piece can be compensated, and accordingly cross section restoration of the annular rolled piece can be achieved.

The present invention relates to devices and methods of use thereof for real time blood flow measurements of skin. In one embodiment, the device is a compact laser speckle imaging, or LSI, system that is integrated with a dermatoscope. In another embodiment, the device allows the user to diagnose a disease or condition in an individual, or as part of an overall treatment regimen.

The invention discloses a blood flow dynamic detection method and system based on laser speckle imaging and a medium. The blood flow dynamic detection method based on laser speckle imaging comprises the following steps: irradiating a biological tissue to be detected with a light beam, and scattering to obtain a laser speckle image; selecting continuous image frames from the laser speckle image to calculate a covariance matrix; performing characteristic decomposition on the covariance matrix to obtain feature values and corresponding feature vectors; selecting the feature vectors with relatively large feature values to reconstruct static tissue information; filtering the static tissue information of the laser speckle image to extract blood information; and reducing noise interference to enhance visualization of the blood flow information. According to the method, the influence caused by static tissue scattering can be inhibited, the distinguishing capability on slow blood flow is improved, the signal-to-noise ratio of a reconstructed image is increased, the quality of the reconstructed image is greatly improved, the reconstruction speed of a blood flow image is greatly increased, and real-time detection and analysis on microcirculation blood flow are facilitated.

Provided herein are devices and systems related to optics and medical diagnoses and treatments. In one embodiment, a system for visualization comprising a stabilizer incorporated into an optical device for blood flow visualization, and the optical device is a LSI handheld system. In another embodiment, the device is a handheld LSI device incorporated with a stabilizer, and used for diagnosing a disease or condition in a subject by providing blood flow visualization.