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47 results about "Laser Speckle Imaging" patented technology
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A noninvasive, non-scanning optical imaging technique that provides full-field visualization of blood flow to the tissue being imaged, which provides information about tissue perfusion and the efficiency of disease treatment.
Laser Speckle Imaging Systems and Methods
ActiveUS20110013002A1Eliminate vibrational motionEliminate relative motionImage analysisDiagnostics using lightDigital videoLaser light
An apparatus and method for measuring perfusion in a tissue. The method comprising the steps of recording images of the tissue under laser light, calculating a plurality of contrast images from the plurality of images of the tissue, determining a power spectrum of scattered light from the plurality of contrast images, and determining perfusion from the power spectrum. The apparatus comprises a digital video camera, a laser light source, and a processor arranged to operate the camera to produce a plurality of images with different exposure times, receive the plurality of images from the camera and process the images to determine a power spectrum and determine perfusion from the power spectrum.
Owner:CALLAGHAN INNOVATION
APPARATUS AND METHOD FOR WIDEFIELD FUNCTIONAL IMAGING (WiFI) USING INTEGRATED STRUCTURED ILLUMINATION AND LASER SPECKLE IMAGING
ActiveUS20090118622A1Minimal artifactHigh degree of fidelity and spatial localizationMaterial analysis by optical meansCatheterWide fieldFunctional imaging
An apparatus for wide-field functional imaging (WIFI) of tissue includes a spatially modulated reflectance / fluorescence imaging (SI) device capable of quantitative subsurface imaging across spatial scales, and a laser speckle imaging (LSI) device capable of quantitative subsurface imaging across spatial scales using integrated with the (SI) device. The SI device and LSI device are capable of independently providing quantitative measurement of tissue functional status.
Owner:MODULATED IMAGING
System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque
Apparatus and method according to an exemplary embodiment of the present invention can be provided for analyzing tissue. For example, the apparatus can include at least one first arrangement configured to illuminate at least one anatomical structure with at least one of at least one electro-magnetic radiation. The apparatus can also include at least one second arrangement that may include at least two wave-guiding arrangements associated with one another that are configured to receive a further electro-magnetic radiation reflected from the tissue and transmit at least one speckle pattern associated with the further electro-magnetic radiation. The wave-guiding arrangements may be structured so as to reduce crosstalk therebetween.
Owner:THE GENERAL HOSPITAL CORP
Perfusion assessment using transmission laser speckle imaging
Methods and apparatus for measuring perfusion using transmission laser speckle imaging are provided. The apparatus comprises a coherent light source and a detector configured to measure transmitted light associated with an unfocused image at one or more locations. The coherent light source and detector are positioned in a transmission geometry. The apparatus further comprises means for securing the coherent light source and the detector to the tissue sample in a fixed transmission geometry relative to the tissue sample. The apparatus may further comprise at least one processor to receive information from the detector and process detected variations in transmitted light intensity to determine a single metric of perfusion. The method may comprise the steps transilluminating a tissue sample with coherent light, recording spatial and / or temporal variations in the transmitted light signal, determining speckle contrast value(s), and computing a metric of perfusion.
Owner:TYCO HEALTHCARE GRP LP
Apparatus and method for widefield functional imaging (WiFI) using integrated structured illumination and laser speckle imaging
ActiveUS8509879B2High degree of fidelity and spatial localizationSufficient spatiotemporal resolutionMaterial analysis by optical meansCatheterWide fieldFluorescence
Owner:MODULATED IMAGING
Method for monitoring micro circulation blood flow time-space response characteristic on mesentery by using laser speckle imaging instrument
InactiveCN1391869AMonitor blood flow velocitySimple structureMaterial analysis by optical meansCatheterCcd cameraStereo microscope
The equipment for monitoring micro circulation body flow time-space response characteristic on mesentery includes an optical path and an imaging system. In the optial path, the laser bean from helium neon laser is coupled to fiber bundle to form homogeneous diffused beam; and the imaging system consists of stereo microscope with CCD camera, image collecting card with image collecting and controlling software. The CCD signal is output to the image collecting card connected to PC, the collection parameters are set via the image collecting and controlling software and local blood flow information are obtained with the image signal and via the signal analysis software. The equipment provides one new way to the research of influence of medicine and other stimulation to the micro circulation blood flow on mesentery.
Owner:HUAZHONG UNIV OF SCI & TECH
Three-direction displacement measurement method based on laser speckle imaging technology
ActiveCN103837084ADisadvantages that it takes a lot of manpower to changeEasy to installUsing optical meansLaser transmitterImaging lens
The invention relates to a three-direction displacement measurement method based on a laser speckle imaging technology. The three-direction displacement measurement method based on the laser speckle imaging technology can achieve synchronous three-direction displacement measurement. According to the technical scheme, the method includes the following steps that firstly, two laser transmitter sets are installed on a reference point, and a laser speckle imaging system is installed on a position I; secondly, light beams are transmitted to an imaging target surface by the laser transmitters and are focused to form a speckle image by an imaging lens, the speckle image is received by an imaging photoelectric device, and the coordinate values of the center points of two speckles relative to the imaging system are found out by a signal processing unit through an image processing algorithm and serve as original values; thirdly, the laser speckle imaging system is moved to a position II, light beams are transmitted to the imaging target surface by the laser transmitters, and the coordinate values of the center points of two speckles relative to the imaging system are found out and serve as test values; fourthly, the test values are compared with the original values, and the horizontal displacement and the vertical displacement are worked out; fifthly, the three-direction displacement of the position II where test points are located relative to the position I is worked out.
Owner:ZHEJIANG HUADONG SURVEYING MAPPING & GEOINFORMATION
Imaging system of endoscope
The invention discloses an imaging system of an endoscope.According to the system, one end of a first switch is connected with red laser and the other end of the first switch is connected with a first controllable decorrelation device to serve as a first channel; one end of a second switch is connected with a green light source and the other end of the second switch is connected with a first controllable decorrelation device to serve as a second channel; one end of a third switch is connected with a blue light source and the other end of the third switch is connected with a third controllable decorrelation device to serve as a third channel; the first channel, the second channel and the third channel are connected with a mixer, and mixed signal light is output; the first controllable decorrelation device in the first channel is not enabled, output signal light is used for laser speckle imaging, a laser speckle angiography image is generated, output signal light of the second channel and the third channel is used for narrow-band light imaging, and a narrow-band light image is generated.The imaging system of the endoscope breaks through narrow-band light imaging depth, detects the angiemphraxis condition, and improves the capacity of recognizing blood vessel depth information.
Owner:SONOSCAPE MEDICAL CORP
Frequency domain laser speckle imaging based blood flow velocity measuring method
ActiveCN104173038AImprove measurement accuracyEliminate static noiseDiagnostic recording/measuringSensorsDynamic speckleSpeckle imaging
The invention discloses a frequency domain laser speckle imaging based blood flow velocity measuring method. The frequency domain laser speckle imaging based blood flow velocity measuring method comprises the following steps of illuminating laser beams on a measured object, imaging the measured object through an imaging system, collecting an original speckle image of the measured object through an image sensor, transferring dynamic speckle intensity with single pixel points being in a time domain of the collected original speckle image into a frequency domain, calculating the power spectral density, performing polynomial fitting on the power spectral density to obtain a smooth curve, transferring the smooth curve into the time domain through Fourier transform, calculating an autocovariance function of the pixel points and performing normalization, establishing a blood velocity measuring model, obtaining a relationship between the covariance function and the blood velocity and finally performing fitting to obtain a blood velocity value. The frequency domain laser speckle imaging based blood flow velocity measuring method has the advantages of not only eliminating static noise, improving the blood velocity measuring accuracy, avoiding influences from imaging environmental factors such as intensity and illumination angles and improving the measuring stability.
Owner:亿慈(上海)智能科技有限公司
System and method for rapid examination of vasculature and particulate flow using laser speckle contrast imaging
Examination of the structure and function of blood vessels is an important means of monitoring the health of a subject. Such examination can be important for disease diagnoses, monitoring specific physiologies over the short- or long-term, and scientific research. This disclosure describes technology and various embodiments of a system and method for imaging blood vessels and the intra-vessel blood flow, using at least laser speckle contrast imaging, with high speed so as to provide a rapid estimate of vessel-related or blood flow-related parameters.
Owner:VASOPTIC MEDICAL
Multi-modality imaging equipment combining opto-acoustic imaging and laser speckle imaging
InactiveCN110179446AEfficient integrationSimple compositionCatheterSensorsDiagnostic Radiology ModalityImaging equipment
The invention discloses multi-modality imaging equipment combining opto-acoustic imaging and laser speckle imaging. The multi-modality imaging equipment combining opto-acoustic imaging and laser speckle imaging comprises a 532nm pulse laser source, a 632.8nm He-Ne laser source, an opto-acoustic modulating light path, a laser speckle modulating light path, a reflector group, an opto-acoustic signalacquiring system, a laser speckle blood flow acquiring system and an upper computer. The multi-modality imaging equipment combining opto-acoustic imaging and laser speckle imaging disclosed by the invention can detect haemodynamics parameters including cellular structures in blood vessels, blood flow and the like continuously and simultaneously in a real-time same-view-field manner, and effectively and accurately transmit the acquired multi-modality parameters to the upper computer for processing; and besides, the composition of the multi-modality imaging equipment can be simplified, and high-distinguishability opto-acoustic imaging and laser speckle blood flow imaging are effectively combined, so that the measuring steps and the measuring time of different parameters are greatly reduced,and strong support is provided for clinical diagnosis and treatment of vascular diseases in future.
Owner:NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
Method and apparatus for the assessment of pulpal vitality using laser speckle imaging
InactiveUS20120301839A1Minimally invasiveNot time-consumeTeeth fillingDental toolsDentistrySpeckle imaging
The invention includes a noninvasive method for characterizing dental pulpal vitality of a tooth including the steps of irradiating the tooth with at least partially coherent light, and speckle imaging to provide quantitative feedback to an end user of pulpal blood flow in the tooth, and the tangible records made by such a method. The invention also includes an apparatus for noninvasively characterizing dental pulpal vitality of a tooth comprising a source of at least partially coherent light for irradiating the tooth characterized by a speckle pattern, optics for directing the at least partially coherent light onto the tooth, including a corresponding pulpal cavity within the tooth, a detector for detecting transmission of the at least partially coherent light through the tooth, and a processor coupled to the detector speckle imaging to provide a quantitative feedback of pulpal blood flow in the tooth.
Owner:RGT UNIV OF CALIFORNIA
System and method for providing noninvasive diagnosis of compartment syndrome using exemplary laser speckle imaging procedure
InactiveUS20080234586A1Simple interfaceHigh and low riskDiagnostics using lightMaterial analysis by optical meansMedicineElectromagnetic radiation
Exemplary systems and methods can be provided for providing information associated with tissue. For example, it is possible to illuminate the tissue with at least one electromagnetic radiation which is a coherent light and / or a partially coherent light. The electromagnetic radiation reflected from the tissue can be received and speckle patterns may be formed associated with the electromagnetic radiation. In addition, changes can be analyzed in the speckle patterns at time intervals sufficient to measure motion of or within a fascial compartment of the tissue. For example, it is also possible that the electromagnetic radiation is an interfered radiation from a sample and a reference. Further, the speckle patterns can be measured at different depths within the sample by moving the reference.
Owner:THE GENERAL HOSPITAL CORP
Multi-modal imaging device combining photoacoustic and fiber-optic laser speckle
ActiveCN110251099ARealize real-time synchronization detectionSmall sizeCatheterSensorsFiberData acquisition
The invention discloses a multi-modal imaging device combining photoacoustic and fiber-optic laser speckle, which comprises a light source module, a motor control module and a data acquisition module. The multi-modal imaging device has reasonable structure and simple structure, and realizes real-time synchronous simultaneous field detection of blood vessel structure, blood flow and blood oxygen, the combination of a high-resolution photoacoustic imaging technology and an endoscopic laser speckle imaging technology greatly reduces the measurement steps and time of different parameters, and provides a strong support for the clinical diagnosis and treatment of tumor and vascular diseases in the future.
Owner:NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
Endoscope type laser speckle blood flow imaging probe
ActiveCN109009060AAchieve adherence measurementAchieving Simultaneous DetectionSensorsBlood flow measurementLaser Speckle ImagingSmall lens
The invention discloses an endoscope type laser speckle blood flow imaging probe which comprises the components of an ocular lens, a focusing part, a flexible pipe part, a head end part, a joint adapter, a cold light source interface, a flexible pipe, an image transmitting optical fiber, light transmitting optical fibers, a quartz optical fiber protecting layer, a quartz optical fiber, a quartz optical fiber epitaxial part and a small lens. According to the endoscope type laser speckle blood flow imaging probe, a laser speckle blood flow imaging system is combined with an endoscope, thereby realizing blood flow detection of intracavitary organs such as an alimentary canal. The number of the light transmitting optical fibers is increased in the probe. Four light transmitting optical fiberssurround the image transmitting fiber, thereby increasing a light receiving area of a tissue, realizing more uniform and sufficient light and effectively preventing light spots. According to the endoscope type laser speckle blood flow imaging probe, laser speckle imaging is combined with spectrum detection; a fiber laser device is used for supplying a laser source and a broadband light source; theendoscope type laser speckle blood flow imaging probe realizes simultaneous detection of the blood flow and the blood oxygen of the intracavitary organs; and in designing of the probe, the position of the image transmitting optical fiber is properly adjusted, thereby overcoming defects in detection by an existing endoscope, and realizing wall-adhering measurement of the blood flow.
Owner:NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
Laser speckle imaging systems and methods
ActiveUS9226661B2Eliminate relative motionImage analysisDiagnostics using lightDigital videoRadiology
An apparatus and method for measuring perfusion in a tissue. The method comprising the steps of recording images of the tissue under laser light, calculating a plurality of contrast images from the plurality of images of the tissue, determining a power spectrum of scattered light from the plurality of contrast images, and determining perfusion from the power spectrum. The apparatus comprises a digital video camera, a laser light source, and a processor arranged to operate the camera to produce a plurality of images with different exposure times, receive the plurality of images from the camera and process the images to determine a power spectrum and determine perfusion from the power spectrum.
Owner:CALLAGHAN INNOVATION
Multi-spectral laser imaging (MSLI) methods and systems for blood flow and perfusion imaging and quantification
Some embodiments of the present inventive concept provide a system that uses two wavelengths of differential transmittance through a sample to apply laser speckle or laser Doppler imaging. A first of the two wavelengths is within the visible range that has zero or very shallow penetration. This wavelength captures the anatomical structure of tissue / organ surface and serves as a position marker of the sample but not the subsurface movement of blood flow and perfusion. A second wavelength is in the near Infra-Red (NIR) range, which has much deeper penetration. This wavelength reveals the underlying blood flow physiology and correlates both to the motion of the sample and also the movement of blood flow and perfusion. Thus, true motion of blood flow and perfusion can be derived from the NIR imaging measurement without being affected by the motion artifact of the target.
Owner:EAST CAROLINA UNIVERISTY
Position compensation device and method in annular rolled piece machining process
ActiveCN106040750AReal-time online monitoringReal-time correctionRoll mill control devicesMetal rolling arrangementsSize measurementLaser scanning
The invention provides a position compensation device in the annular rolled piece machining process. The position compensation device uses laser to detect the size of an annular rolled piece in an on-line mode and comprises a laser scanning unit, a laser speckle imaging unit and a control unit. The laser scanning unit collects data of the annular rolled piece in the rolling process, the laser speckle imaging unit and the laser scanning unit are synchronous, and a speckle image is formed on the surface of the annular rolled piece; and the control unit controls the laser scanning unit and the laser speckle imaging unit, and the position compensation quantity of the annular rolled piece is calculated based on the data collected by the laser scanning unit and the speckle image formed by the laser speckle imaging unit. The invention further provides a position compensation method in the annular rolled piece machining process. According to the position compensation device and method in the annular rolled piece machining process, the size of the annular rolled piece which is subjected to grinding and expansion can be measured, the difference value of the radius change of the annular rolled piece can be compensated, and accordingly cross section restoration of the annular rolled piece can be achieved.
Owner:YANSHAN UNIV
Endoscope imaging and laser speckle imaging integrated imaging system
ActiveCN106264453AAccurate Pathological Imaging DataEndoscopesSensorsLight-emitting diodePenetration depth
The invention provides an endoscope imaging and laser speckle imaging integrated imaging system. The endoscope imaging and laser speckle imaging integrated imaging system comprises an endoscope imaging subsystem, a laser speckle imaging subsystem and image integration processing equipment, in the endoscope imaging subsystem, a CCD (charge coupled device) detector and an LED (light emitting diode) light source are both arranged on a first end of an endoscope hose pipe, and are electrically connected with a first image processing device; in the laser speckle imaging subsystem, a laser assembly is arranged on the first end of the endoscope hose pipe, a second image processing device is arranged on the downstream of a light path of the laser assembly, and the first image processing device and the second image processing device are electrically connected with the image integration processing equipment. The endoscope imaging and laser speckle imaging integrated imaging system has the advantages that by adopting the technical scheme, the problems of limitation of laser speckle imaging by the optical imaging illuminating structure and failure to in-vitro scanning and imaging due to small photon penetration depth in the prior art are solved.
Owner:SHENZHEN INST OF ADVANCED TECH
Perfusion assessment using transmission laser speckle imaging
Owner:TYCO HEALTHCARE GRP LP
Cortical functional multi-mode imaging system
ActiveCN101926644BSimultaneously monitor changesSimultaneous monitoring of pHDiagnostic recording/measuringSensorsLight-emitting diodeMaterials science
The invention discloses a cortical functional multi-mode imaging system. The system comprises a wide-spectrum light source, a laser diode and a red light-emitting diode which are arranged above cortex dispersedly; a coaxial filter is respectively arranged in front of the wide-spectrum light source and the red light-emitting diode; backward scattered light come from the cortex is split into two paths by a dispersion prism; one path of the backward scattered light is connected with a first charge coupled device through a liquid crystal tunable filter; the other path of the backward scattered light is connected with a second charge coupled device through a filter; and the two charge coupled devices are respectively connected with two computers. The system solves the difficult problem of technology integration of fluorescence imaging and intrinsic signal optical imaging for a long time by introducing the liquid crystal tunable filter; and the intracellular pH value, cerebral blood volume,deoxygenated hemoglobin and cerebral blood flow changes can be obtained at the same time by combining laser speckle imaging so as to provide an effective means for researching brain functions and disease mechanisms more completely in detail.
Owner:HUAZHONG UNIV OF SCI & TECH
System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque
Apparatus and method according to an exemplary embodiment of the present invention can be provided for analyzing tissue. For example, the apparatus can include at least one first arrangement configured to illuminate at least one anatomical structure with at least one of at least one electro-magnetic radiation. The apparatus can also include at least one second arrangement that may include at least two wave-guiding arrangements associated with one another that are configured to receive a further electro-magnetic radiation reflected from the tissue and transmit at least one speckle pattern associated with the further electro-magnetic radiation. The wave-guiding arrangements may be structured so as to reduce crosstalk therebetween.
Owner:THE GENERAL HOSPITAL CORP
Accurate light control system and light control method
ActiveCN111012325AEnhanced couplingGuaranteed spatial distributionSensorsBlood flow measurementImaging processingOphthalmology
The invention provides an accurate light control system and a light control method. The system comprises: a laser speckle illumination subsystem, which provides laser speckle illumination light; a spatial light stimulation subsystem, which provides spatial stimulation light; an imaging acquisition subsystem, which is used for receiving the laser speckle illumination light and the space stimulationlight, coupling the laser speckle illumination light and the space stimulation light and providing an imaging view field for laser speckle imaging; and an image processing subsystem, which comprisesa feedback adjustment module that outputs an adjustment signal to the spatial light stimulation subsystem according to the imaging result of laser speckles and enables the spatial light stimulation subsystem to output adjusted spatial stimulation light, and a view field matching module that is used for carrying out space matching on an adjusted space stimulation light field and an imaging view field before next imaging. According to invention, an image is collected in real time through the image processing subsystem; feedback is carried out to adjust space stimulation light; new light stimulation is formed by the adjusted space stimulation light; a new biological image is obtained according to the new light stimulation; and finally, the closed-loop light control system capable of realizingreal-time control of the space stimulation light is obtained.
Owner:HUST SUZHOU INST FOR BRAINMATICS
An endoscopic imaging system
Owner:SONOSCAPE MEDICAL CORP
Handheld blood-flow imaging device
Owner:RGT UNIV OF CALIFORNIA
Blood flow dynamic detection method and system based on laser speckle imaging and medium
InactiveCN113367675AImprove visualizationImprove signal-to-noise ratioDiagnostics using lightSensorsLaser Speckle ImagingImage quality
The invention discloses a blood flow dynamic detection method and system based on laser speckle imaging and a medium. The blood flow dynamic detection method based on laser speckle imaging comprises the following steps: irradiating a biological tissue to be detected with a light beam, and scattering to obtain a laser speckle image; selecting continuous image frames from the laser speckle image to calculate a covariance matrix; performing characteristic decomposition on the covariance matrix to obtain feature values and corresponding feature vectors; selecting the feature vectors with relatively large feature values to reconstruct static tissue information; filtering the static tissue information of the laser speckle image to extract blood information; and reducing noise interference to enhance visualization of the blood flow information. According to the method, the influence caused by static tissue scattering can be inhibited, the distinguishing capability on slow blood flow is improved, the signal-to-noise ratio of a reconstructed image is increased, the quality of the reconstructed image is greatly improved, the reconstruction speed of a blood flow image is greatly increased, and real-time detection and analysis on microcirculation blood flow are facilitated.
Owner:TIANJIN UNIV
Motion stabilized laser speckle imaging
PendingUS20200257185A1Accurate blood flow mapMedical imagingOptical sensorsBlood flow visualizationRadiology
Provided herein are devices and systems related to optics and medical diagnoses and treatments. In one embodiment, a system for visualization comprising a stabilizer incorporated into an optical device for blood flow visualization, and the optical device is a LSI handheld system. In another embodiment, the device is a handheld LSI device incorporated with a stabilizer, and used for diagnosing a disease or condition in a subject by providing blood flow visualization.
Owner:RGT UNIV OF CALIFORNIA
Viscoelasticity Detection System and Method Based on Low Frame Rate Laser Speckle Contrast Imaging
ActiveCN108577806BImprove convenienceReduce complexityDiagnostics using lightCatheterLight beamSpeckle contrast
The invention discloses a viscoelasticity detecting system and method based on low frame rate laser speckle contrast imaging. The detecting method comprises the following steps that the surface of thedetected sample is subjected to orthogonal oscillatory excitation, and a surface wave is formed; a laser beam shining on the surface of the detected sample is emitted; a multi-frame laser speckle image is collected in a lower frame rate and exposure time; propagation velocity of an aliasing wave is obtained after calculating and processing; a propagation velocity of the surface wave is calculatedthrough the velocity relation between propagation velocity of an aliasing wave and the propagation velocity of the surface wave; and elasticity and viscidity of the detected sample are obtained. Thedetecting system comprises an excitation subsystem and a laser speckle imaging subsystem. Through detecting the surface wave under the orthogonal oscillatory excitation, and using the collected propagation velocity of the aliasing wave at the lower frame rate to calculate the propagation velocity of the surface wave, viscoelastic modulus of the detected sample is quantitatively solved, and complexity and the cost of the detecting is lowered; and reflection type laser speckle imaging is adopted and facilitating convenience of the actual detecting.
Owner:EZHOU INST OF IND TECH HUAZHONG UNIV OF SCI & TECH +1
An image-based device and method for measuring railway snow depth
Owner:无锡长元新能源电动车科技发展有限公司
Blood flow measurement system using adherent laser speckle contrastive analysis
The invention relates to a blood flow measurement system using adherent laser speckle contrastive analysis. Disclosed herein are devices, systems, and methods for improved laser speckle imaging of a sample, such as vascularized tissue. The laser speckle imaging is used for determining the movement rate of the light scattering particles in the sample. The system includes a structure adjoining the light source and the photosensitive detector. The structure may be positioned adjacent the sample (e.g., coupled to the sample) and configured to face the light source and the detector relative to the sample such that surfaces including specular and diffuse reflections are not prevented from reflecting into the detection field of the detector. The separation distance along the structure between the light source and the detector may further enable selective depth penetration into the sample and biased sampling of multiple scattered photons. The system includes a processor operably coupled; the processor is programmed to derive a contrast metric from the detector and correlate the contrast metric with a rate of movement of the light scattering particles.
Owner:柯惠股份公司
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