Multi-modality imaging equipment combining opto-acoustic imaging and laser speckle imaging

Abstract

The invention discloses multi-modality imaging equipment combining opto-acoustic imaging and laser speckle imaging. The multi-modality imaging equipment combining opto-acoustic imaging and laser speckle imaging comprises a 532nm pulse laser source, a 632.8nm He-Ne laser source, an opto-acoustic modulating light path, a laser speckle modulating light path, a reflector group, an opto-acoustic signalacquiring system, a laser speckle blood flow acquiring system and an upper computer. The multi-modality imaging equipment combining opto-acoustic imaging and laser speckle imaging disclosed by the invention can detect haemodynamics parameters including cellular structures in blood vessels, blood flow and the like continuously and simultaneously in a real-time same-view-field manner, and effectively and accurately transmit the acquired multi-modality parameters to the upper computer for processing; and besides, the composition of the multi-modality imaging equipment can be simplified, and high-distinguishability opto-acoustic imaging and laser speckle blood flow imaging are effectively combined, so that the measuring steps and the measuring time of different parameters are greatly reduced,and strong support is provided for clinical diagnosis and treatment of vascular diseases in future.

Description

technical field [0001] The invention relates to the technical field of multimodal noninvasive imaging, in particular to a multimodal imaging device combining photoacoustic and laser speckle. Background technique [0002] Photoacoustic imaging technology is a new type of non-invasive imaging technology that has developed rapidly in recent years. Based on the principle of photoacoustic effect, this technology is a non-invasive high-resolution imaging method that obtains two-dimensional tomography or three-dimensional stereoscopic tissue. The photoacoustic effect refers to the phenomenon that after an object is subjected to light with periodically changing intensity, it will expand with heat and contract with cold due to the periodic temperature change inside the object, thereby generating ultrasonic waves. Photoacoustic imaging technology combines the characteristics of optical imaging and acoustic imaging technology, and has the characteristics of high resolution, high contra...

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Problems solved by technology

[0005] At present, although photoacoustic imaging and laser speckle imaging have been realized, due to the limitation of operating equipment, there is no way to measure the structural parameters of tissues and cells in blood vessels, and to distinguish arteriovenous blood vessels and measure hemodynamic parameters. multimodal non-invasive imaging device

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