The invention provides a one-time splicing measurement device of a large-aperture optical element profile, relating to a measurement device of an optical element profile. The one-time splicing measurement device is provided with a Y-axis linear motor, Y-axis linear guide rails, a base, a movement controller, a stand column, a cross beam, a measurement sensor, a linear motion lead screw nut pair, a coupling, a measuring head movement driving motor, Z-axis linear guide rails, a Z-axis linear motor, a measuring head connecting base, a Z-axis workbench, an X-axis workbench, X-axis linear guide rails, an X-axis linear motor, a workpiece, a workpiece rotary table, a connecting base, a rotary motor, a Y-axis workbench and a computer. The one-time splicing measurement device can realize one-time splicing measurement; particularly specific to a large-aperture workpiece, measurement steps are reduced by adopting the measurement device; the one-time splicing measurement device is simple in measurement process, high in measurement efficiency, simple and compact in structure and convenient to operate.