Accurate light control system and light control method

Abstract

The invention provides an accurate light control system and a light control method. The system comprises: a laser speckle illumination subsystem, which provides laser speckle illumination light; a spatial light stimulation subsystem, which provides spatial stimulation light; an imaging acquisition subsystem, which is used for receiving the laser speckle illumination light and the space stimulationlight, coupling the laser speckle illumination light and the space stimulation light and providing an imaging view field for laser speckle imaging; and an image processing subsystem, which comprisesa feedback adjustment module that outputs an adjustment signal to the spatial light stimulation subsystem according to the imaging result of laser speckles and enables the spatial light stimulation subsystem to output adjusted spatial stimulation light, and a view field matching module that is used for carrying out space matching on an adjusted space stimulation light field and an imaging view field before next imaging. According to invention, an image is collected in real time through the image processing subsystem; feedback is carried out to adjust space stimulation light; new light stimulation is formed by the adjusted space stimulation light; a new biological image is obtained according to the new light stimulation; and finally, the closed-loop light control system capable of realizingreal-time control of the space stimulation light is obtained.

Description

technical field [0001] The invention relates to the field of optical imaging, in particular to a precise light control system and a light control method. Background technique [0002] Optical control is a method to control the activity, state and characteristics of the material through the interaction between the light field and the material. Especially for biological tissues, light is one of the important means to regulate their physiological function status. For example, the embolization of blood vessels can be formed by using photochemical effects. The cerebral ischemia method based on the photochemical principle can use the irradiation beam to select the area and location of the infarction, and has the advantages of simple operation and good repeatability. However, in the current photochemical ischemia, it is difficult to achieve flexible and precise regulation of the irradiation beam due to the lack of methods to dynamically modulate the temporal-spatial distribution ...

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Problems solved by technology

[0003] In particular, the traditional photochemical cerebral ischemia process lacks real-time evaluation of the vascular blockage caused by photochemical effects, so it is impossible to adjust the dose of irradiated light in real time, which often leads to early opening of the blood-brain barrier, and may cause serious microvascular damage, that is, the source of blood vessels. cerebral edema

Lack of real-time blood flow imaging feedback methods can also cause direct infarction and ischemia of brain tissue in the perivascular cortical area due to excessive light dose when a single small vessel is embolized

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