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44 results about "Light dose" patented technology

Lighting dose real-time controlling apparatus in photolithography system

The invention discloses a lighting dose real-time controlling apparatus. The apparatus comprises orderly arranged components along an optical axis, which are: a light source, a lighting system, a mask bench, an object lens, and a workpiece bench. A first light energy detector and a second energy spot sensor are respectively arranged in the lighting system and on the workpiece bench. The apparatus is characterized in that: a third light energy detector is arranged in the light path between the first light energy detector and a second light energy spot sensor. The third light energy detector is used for measuring the lighting dose in real time during exposure. With the apparatus provided by the invention, light intensity between the first light energy detector and a second light energy spot sensor can be measured in real time during exposure, such that a yield is not influenced. The third light energy detector is arranged between the first light energy detector and a second light energy spot sensor, such that an influence of varied optics transmissivities between a first and a third light energy detectors is avoided. Therefore, a complicated transmissivity prediction model is not required. An accurate energy measured on a silicon surface can be obtained through simple reforming. Dose controlling can be carried out upon exposure fields according to the measuring results, such that dose accuracy can be improved.
Owner:SHANGHAI MICRO ELECTRONICS EQUIP (GRP) CO LTD

Guided photodynamic therapy

A Photodynamic Therapy (PDT) system with an elongated interventional device (IDV) with a bundle of optical fibers (F1, F2, F3) forming respective light exit ports which can be individually accessed. The bundle has an optical shape sensing fiber (OSS), e.g. including Fiber Bragg Gratings, arranged for sensing position and orientation (P_O) of the light exit ports. A processor executes a control algorithm which generate a light dose signal (LDS) to allow generation of light outputs (LD1, LD2, LD3) to the plurality of optical fibers (F1, F2, F3) accordingly. The control algorithm generates the light dose signal (LDS) in response to the determined position and orientation of the light exit ports (P_O), and three-dimensional body anatomy image information obtained by a first image modality (I1), e.g. X-ray, MRI, CT, ultrasound, or PET-CT. This combination allows precise application of a light dose distribution for PDT treatment of a tumor with a minimal destruction of connective tissue. In embodiments, the control algorithm takes image information regarding distribution of a photo sensitizer in the body tissue (I2) as input. The control algorithm may further take into account image information regarding a concentration of oxygen in the body tissue (I3). Both of such inputs allow a more precise PDT light application.
Owner:KONINKLIJKE PHILIPS ELECTRONICS NV

Pure oxygen- photodynamic composite skin therapeutic instrument

The invention discloses a pure oxygen- photodynamic composite skin therapeutic instrument which comprises a main body, an irradiator and a spiral arm connected between the main body and the irradiator, wherein a light source circuit board is arranged on the irradiator, and a light-emitting element is fixedly arranged on the light source circuit board; and an oxygen spray nozzle unit is further arranged on the irradiator, an oxygen making device is arranged on the main body, and the oxygen spray nozzle unit is connected to the oxygen making device through a pipeline. The tissue oxygen concentration can be increased and the photodynamic therapeutic effect can be significantly improved by adopting a design of the oxygen making device and the oxygen spray nozzle unit; by adopting the design of a light wavelength feedback module and a light dose feedback module, the pure oxygen-photodynamic composite skin therapeutic instrument can ensure that an irradiated region can obtain the same light dose so that the photodynamic therapeutic effect can be improved; and as the light-emitting element is a composite light-emitting diode with three wavelengths, the single wavelength or the two wavelengths or the three wavelengths can be selected for performing combined therapy according to actual needs.
Owner:广州美锐健康产业股份有限公司

Optical power therapentic equipment with fluorescence diagnostic function and operation method

A photodynamic therapy device with the function of the fluorescence diagnosis comprises a host and an operating head which is connected with the host. The interior of the host comprises a core control module which controls the operating head. The interior of the operating head aggregates LED array treatment light source, LED array fluorescence excitation light source and an image acquisition module. The host is set into the treatment mode or the diagnosis mode through controlling the open and close of the LED array fluorescence excitation light source and the LED array treatment light source. The host analyzes a fluorescence image which is collected by the image collecting module and issues a cue signal or a control command after the comparison of the analytic data and the presetting data. The photodynamic therapy device has the diagnosis module and the treatment module which can realize the site confirmation of the light scope before the treatment and the individual design of the light dose, the real-time detection of the response in the treatment and the automatic adjustment, the follow-up assessment of the lethal effect and early detection of the residual tumor after the treatment. The photodynamic therapy device also provides an operation method of the photodynamic device with the function of the fluorescent diagnosis.
Owner:深圳市微创医学科技有限公司

Homogeneous creatine kinase chemiluminiscence detection reagent and preparation method thereof

The invention discloses a homogeneous creatine kinase chemiluminiscence detection reagent and a preparation method thereof. The method comprises steps of adopting gold nanoparticles, adding a water-soluble photosensitizer into the gold nanoparticles and acquiring a nanogold-photosensitizer compound, coupling the nanogold-photosensitizer compound with a creatine kinase monoclonal antibody, and generating electrostatic adsorption between the two under the isoelectric point environment condition of the creatine kinase monoclonal antibody through the charge property of the nanogold particles, so that the creatine kinase monoclonal antibody is coupled to the surfaces of the nanogold particles. The homogeneous creatine kinase chemiluminiscence detection reagent is obtained according to the preparation method disclosed by the invention, the utilization rate of the photosensitizer is increased, the production process is simplified, the production cost is reduced, a sandwich method detection principle is adopted to detect a detected object in use, the effective light dose of irradiation is increased, more photosensitizers are activated, a stronger photosensitive effect is generated, the difference between the excitation light wavelength and the emission wavelength is increased, and the detection identification degree is improved.
Owner:ZHEJIANG ZOYUN BIOTECH

Therapy method based on photodynamic therapy system, and photodynamic therapy system

The invention discloses a therapy method based on a photodynamic therapy system, and the photodynamic therapy system. The method comprises the following steps of: obtaining a fluorescence image generated when a photosensitizer on a tissue to be treated is irradiated; calculating the fluorescence image according to a fluorescence image processing algorithm, and determining the overexposure area andthe underexposed area of the fluorescence image; analyzing the overexposure area and the underexposed area of the fluorescence image according to a pre-set convolutional neural network model, and determining excitation light doses required by various points of the fluorescence image; and performing therapy by generating the therapy light intensity according to the excitation light doses requiredby various points of the fluorescence image. By implementation of the therapy method based on the photodynamic therapy system, and the photodynamic therapy system in the invention, the fluorescence image, the overexposure area and the underexposed area of which are marked, can be input into the pre-set convolutional neural network model; the excitation light parameters required by various points of the best fluorescence image can be determined and obtained according to output of the pre-set convolutional neural network model; therefore, optimal imaging is obtained by the minimum exposure time;and fluorescent bleach due to the excessive exposure time of the photosensitizer is reduced.
Owner:深圳市光科健康科技有限公司

Homogeneous method heart-type fatty acid binding protein chemiluminiscence detection reagent and preparation method thereof

The invention discloses a homogeneous method heart-type fatty acid binding protein chemiluminiscence detection reagent and a preparation method thereof. The method comprises steps of adopting gold nanoparticles, adding a water-soluble photosensitizer into the gold nanoparticles, acquiring a nanogold-photosensitizer compound, coupling the nanogold-photosensitizer compound with a heart-type fatty acid binding protein monoclonal antibody, generating electrostatic adsorption between the two under the isoelectric point environment condition of the heart-type fatty acid binding protein monoclonal antibody through the charge property of the gold nanoparticles, so that the heart-type fatty acid binding protein monoclonal antibody is coupled to the surfaces of the gold nanoparticles. The homogeneous method heart-type fatty acid binding protein chemiluminiscence detection reagent is obtained according to the preparation method disclosed by the invention; the utilization rate of the photosensitizer is increased, the production process is simplified, the production cost is reduced, a sandwich method detection principle is adopted to detect a detected object in use, the effective light dose ofirradiation is increased, more photosensitizers are activated, a stronger photosensitive effect is generated, the difference between the excitation light wavelength and the emission wavelength is increased, and the detection identification degree is improved.
Owner:ZHEJIANG ZOYUN BIOTECH

Homogeneous method troponin chemiluminescence detection reagent and preparation method thereof

The invention discloses a homogeneous method troponin chemiluminiscence detection reagent and a preparation method thereof. The method comprises steps of adopting gold nanoparticles, adding a water-soluble photosensitizer into the gold nanoparticles, acquiring a nanogold-photosensitizer compound, coupling the nanogold-photosensitizer compound with a troponin I monoclonal antibody, generating electrostatic adsorption between the two under the isoelectric point environment condition of the troponin I monoclonal antibody through the charge property of the gold nanoparticles, so that the troponinI monoclonal antibody is coupled to the surfaces of the gold nanoparticles. The troponin chemiluminiscence detection reagent obtained by the preparation method disclosed by the invention is a homogeneous method troponin chemiluminiscence detection reagent; the utilization rate of the photosensitizer is increased, the production process is simplified, the production cost is reduced, a sandwich method detection principle is adopted to detect a detected object in use, the effective light dose of irradiation is increased, more photosensitizers are activated, a stronger photosensitive effect is generated, the difference between the excitation light wavelength and the emission wavelength is increased, and the detection identification degree is improved.
Owner:ZHEJIANG ZOYUN BIOTECH
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