19 results about "Light dose" patented technology

The invention discloses a multi-mode nonlinear optical microscopic imaging device and system, and the device achieves the two-photon and three-photon excitation imaging of a sample through an integrated light source module, a dispersion compensation module, a scanning light path module, a fluorescence obtaining module, a synchronous control module and a signal processing module. Fluorescence intensity imaging and fluorescence lifetime imaging can be supported at the same time; wherein the scanning light path module is driven by the random mask to realize sparse scanning, so that scanning point locations are effectively reduced, and the exciting light dosage is reduced; the synchronous control module performs time window screening and processing on the fluorescence signal based on the pulse synchronous signal and the position code, so that the signal acquisition efficiency is improved; the signal processing module adopts an FPGA (Field Programmable Gate Array) to carry out real-time image reconstruction and life calculation, so that the imaging speed and quality are ensured; and the master control PC can also perform high-fidelity reconstruction on the sparse sampling image through a deep learning model, so that high-speed, low-light-dose and high-resolution nonlinear fluorescence intensity and life imaging is realized.

The present application belongs to the technical field of hair loss treatment, and particularly relates to a phototherapy and drug synergistic intervention system for androgenetic alopecia of human scalp. In the system, the drug is angelica extract with a concentration of 0.1-500 ug / mL; the phototherapy light source is a red light LED light source with a wavelength of 600-700 nm; the light irradiance is 2-100 mW / cm 2 ; the light dose is 2-20 J / cm 2 ; the irradiation mode is steady light or pulsed light; and the synergistic intervention mode is that the phototherapy and the drug application are performed synchronously or the phototherapy is performed within 0.5-2 hours after the drug application. Experiments show that the light-drug combined intervention significantly improves cell viability, ATP level, migration ability, IGF1 and VEGF secretion, reduces ROS and MDA levels, inhibits Caspase-3 activity, regulates BCL2 / BAX expression, activates Wnt, Hh and PI3K pathways, and inhibits BMP and TGF-beta pathways. The present application provides a treatment scheme with clear timing and standardization, and realizes safe, non-invasive and efficient hair loss treatment.

A phototherapy device is disclosed for irradiating tissues, such as those within a patient's body cavity, with light to induce various biological effects. These biological effects may include at least one of the following: inactivation and / or inhibition of the growth of one or more pathogens, upregulation of local immune responses, increase of endogenous nitric oxide reserves, release of nitric oxide from endogenous reserves, and induction of anti-inflammatory effects. The biological effects may also include upregulation and downregulation of inflammatory immune response molecules within the target tissue. The wavelength of light is selected based on the expected biological effects on one or more of the target tissue type and target pathogens. Whether using light of a single wavelength or light of multiple wavelengths, phototherapy can provide a variety of pathogenic biological effects. A device for phototherapy is disclosed that provides a light dose to induce biological effects on various target pathogens and tissues with enhanced efficacy and reduced cytotoxicity.

A method of volumetric additive manufacturing, comprising rotating a vial of photocurable resin; creating patterns of structured light images of an object to be manufactured so that the shape of the light dose distribution matches a desired shape of the object; correcting for diffusion within the vial; projecting the patterns of structured light images via a projector onto the rotating vial of photocurable resin thereby printing the object corrected for diffusion; and removing the printed object from the vial.

The invention provides a light dose control method and device and a physical therapy lamp, and relates to the technical field of physical therapy lamps, the physical therapy lamp comprises at least one light emitting array, light emitting monomers with different wavelengths and different numbers are configured in the array, and a touch screen is used for generating a control signal of a target light dose. After the system receives the control signal, a light dose calculation process is started, distribution information, wavelength types and irradiation distances of the light-emitting monomers and preset irradiance data corresponding to different wavelengths and distances are obtained, and the output percentage, the pulse mode, the power mode and the irradiation time of each wavelength channel are obtained. The system calculates the current light dose based on the irradiance data, the output percentage, the pulse coefficient, the irradiation time and the power coefficient, and adjusts the irradiation parameters of the light-emitting array according to the difference value between the calculation result and the target light dose, including the adjustment power, the pulse mode, the irradiation time or the number of switches of the light-emitting monomers, so that the output light dose meets the target requirement.

The application discloses an airway sterilization treatment device and method, and relates to the technical field of medical devices; the airway sterilization treatment device comprises an irradiation module, a dose monitoring unit and a control unit, the irradiation module is used for emitting blue light for sterilization to an airway target position; the dose monitoring unit is arranged on the irradiation module, and the dose monitoring unit is used for monitoring an actual light dose received by a mucous membrane surface of the airway target position; the control unit is electrically connected with the dose monitoring unit and the irradiation module, and the control unit is used for closed-loop control of blue light output of the irradiation module according to the actual light dose fed back by the dose monitoring unit, so as to make the actual light dose reach a preset target dose. According to the application, the actual light dose received by the mucous membrane surface is monitored during blue light irradiation, and the blue light output of the irradiation module is closed-loop controlled according to the actual light dose, so that the final delivered light dose is consistent with the target dose, and the treatment effect and safety are guaranteed.

The application discloses a near-infrared heptamethine cyanine dye and application thereof in the field of photothermal therapy. 2000 After being wrapped into nanoparticles, the photothermal stability of the heptamethine cyanine dye is greatly enhanced, no photobleaching occurs in four photothermal cycle experiments, the heptamethine cyanine dye has high efficient photothermal conversion capacity, and the photothermal conversion efficiency is as high as 82%. The photothermal reagent prepared from the heptamethine cyanine dye has significant cell killing capacity at low concentration and low light dose under light excitation, and has low dark toxicity. The near-infrared heptamethine cyanine dye provided by the application has simple structure, simple synthesis mode and excellent clinical application potential.

The application provides a lighting control method, a lighting system and a terminal for a weak window space, and the method comprises the following steps: based on a preset space use rule, dynamically dividing a weak window space into a plurality of functional areas; the functional areas comprise a normal activity area, a transition guide area and a sunlight coordination area; acquiring a time period in which effective natural light exposure can be performed in the future, and defining the time period as a coordination time window; in the coordination time window, activating a lighting unit of the transition guide area to generate a dynamic light path connecting the normal activity area and the sunlight coordination area; the dynamic light path is used to guide a user to move from the normal activity area to the sunlight coordination area to receive natural light, so as to receive natural light meeting a vitamin D synthesis light dose threshold. The application significantly improves the biological availability and utilization efficiency of natural light resources in a weak window environment, and provides a feasible technical path for a healthy building, an underground space and a high-density urban office scene.

A medical device can include a body and a photosensitizer integrated with the body. The medical device can passively resist colonization by bacteria under ambient light. The medical device can also actively resist colonization by bacteria by releasing reactive oxygen species (ROS) in response to a light dose applied over a duration between 1 second and 1 hour ranging from 0.5 J / cm 2 to 320 J / cm 2 . The body can be formed from a base resin. The photosensitizer can be compounded with the base resin. The photosensitizer can be absorbed into the base resin. The medical device can include a coating disposed on a surface of the body. The photosensitizer can be disposed within the coating. The medical device can include a catheter adapter and a catheter extending distally from the catheter adapter. The catheter can be co-extruded with the photosensitizer and another material.

A method and apparatus for light intervention to enhance hypoxia resistance, as well as related equipment, are disclosed. The method includes: acquiring first user information characterizing a user's photosensitivity and second user information characterizing the user's circadian rhythm state at their original geographical location; acquiring light dose conditions for light intervention based on the first user information; acquiring time conditions for light intervention based on the second user information; and obtaining light intervention conditions for performing the light intervention based on the light dose conditions and time conditions. Since photosensitivity affects the influence of light dose on circadian rhythms, and circadian rhythm state can improve the fit between time conditions and circadian rhythm state, combining the first and second user information is beneficial to improving the accuracy of light intervention conditions. Furthermore, regulating the human body's circadian rhythm through light intervention enhances the body's resistance to hypoxia, thus improving the economy, safety, and simplicity of enhancing hypoxia resistance.

There is provided a surface-protective composition, wherein the difference between a water contact angle X1 measured by the following method 1 and a water contact angle X2 measured by the following method 2 (X1-X2) is 10° or more. (Method 1) A film 1 composed of the surface-protective composition is formed on a substrate. Then, in accordance with JIS R3257:1999, purified water is dropped onto the film 1, and the water contact angle of the film 1 is measured immediately after the dropping and is defined as a water contact angle X1. (Method 2) A film 1 is obtained in the same manner as (Method 1). Light is applied to the obtained film 1 using a high‑pressure mercury lamp under the conditions of an illuminance of 20 mW / cm2, an irradiation time of 150 seconds, and an integrated light dose of 3000 mJ / cm2, thereby obtaining a film 2. Then, in accordance with JIS R 3257:1999, the water contact angle of the film 2 is measured 60 seconds after dropping purified water onto the film 2, and is defined as a water contact angle X2.

The invention discloses a PDT treatment temperature sensing optical fiber probe based on a molten ball-FP cavity and a preparation method thereof, relates to the technical field of medical optical treatment, and aims to solve the problems that an existing PDT optical fiber probe is uneven in light dose delivery, lack of'temperature-power 'cooperative monitoring in the treatment process, poor in power detection adaptability and high in deep transmission loss. According to the technical scheme, a molten ball part is arranged on a coreless optical fiber; a coating layer at one end of the coreless optical fiber is removed, a cladding is subjected to fused tapering to form a tapering part, UV glue is arranged on the tapering part, and an FP cavity structure is formed between the tapering part and the UV glue; an integrated design of a coreless optical fiber matrix, a molten ball treatment section (a molten ball part), a tapering structure, FP cavity temperature sensing and in-vitro tetrahedron CCD photosensitive element power detection is adopted, light energy is enhanced through molten ball light condensation, lateral light emitting distribution is optimized through tapering, real-time temperature sensing is achieved through an FP cavity, and the temperature sensing precision is improved. Therefore, precise light dose delivery and multi-parameter cooperative monitoring of PDT treatment are realized.

The application belongs to the technical field of neuromorphic computing and artificial intelligence hardware, and discloses a high-linearity organic all-optical synapse thin film, a preparation method thereof, a synapse device and an optical dose sensing system. The thin film is formed by doping triphenylphosphine (TPP) as a host and N,N-dimethyl-1,1-binnaphthyl diamine (BINN) as a guest in a polymethyl methacrylate (PMMA) matrix, and then performing heat treatment to form a glassy blend thin film. Under the excitation of an ultraviolet light pulse, the light emission intensity of the thin film has a high-linearity growth relationship with the cumulative dose of the input light pulse, thereby forming a high-linearity organic all-optical synapse device. The application further provides an optical dose sensing system integrated with the device, which can linearly map the incident light dose to the light emission response of the device, and after photoelectric conversion and signal processing, realizes quantitative sensing and display of the optical dose. The application has excellent linearity, low energy consumption, simple preparation and high system integration.

The invention relates to the technical field of LED illumination control, in particular to an LED dimming control method and system based on illumination closed-loop feedback, and provides the following scheme: a group of orthogonal multi-frequency micro-amplitude modulation sequences are superposed on a baseline drive of a target light receiving dose trajectory, and the amplitude-phase response characteristics of an illumination channel are excited, so that the illumination closed-loop feedback is realized. And a time sequence signal output by the illumination sensor is collected. And carrying out multi-scale Hankel embedding and singular spectrum analysis on the time sequence signal, extracting main subspaces under different windows and solving a common intersection direction on a Grassmann manifold so as to obtain a real narrow-band response. Inputting the response into a parameterized radiation transmission prior model, solving hidden variables such as transmittance, scattering intensity and film forming state of an optical window, calculating an equivalent light receiving dose estimated value, and dynamically correcting baseline drive of the LED array according to the equivalent light receiving dose estimated value to realize stable closed-loop control of the real light receiving dose.

This invention relates to the field of intelligent lighting control technology, and discloses an outdoor lighting fixture control method based on the Internet of Things (IoT). The method includes: acquiring multi-source sensing data to obtain a multi-source sensing data set; performing noise suppression and time-scale standardization on the multi-source sensing data set to obtain standardized ecological acoustic features; performing multi-factor fusion analysis on the standardized ecological acoustic features to obtain an ecological activity state; performing dose constraint mapping on the ecological activity state to obtain ecological light dose constraint information; and constructing a dose from the ecological light dose constraint information to obtain ecological light dose information. This invention employs a technical solution that integrates ecological acoustics and micro-meteorological information to construct an ecological activity state, achieving the technical effect of characterizing and quantifying highly sensitive ecological states such as migratory bird activity and insect aggregation, and realizing comprehensive constraint control of blue light composition, light spillover, and irradiation duration.

The application relates to the technical field of LED light control, in particular to an LED dimming control method and system based on light closed-loop feedback. The application proposes the following scheme: a group of orthogonal multi-frequency micro-modulation sequences are superimposed on the baseline driving of a target light dose trajectory, the amplitude-phase response characteristics of the light channel are excited, and the timing signals output by the light sensor are collected. The timing signals are subjected to multi-scale Hankel embedding and singular spectrum analysis, the main subspace under different windows is extracted, and the common intersection direction is obtained on the Grassmann manifold to obtain a real narrowband response. The response is input into a parameterized radiation transmission prior model, hidden variables such as optical window transmittance, scattering intensity and film forming state are solved, an equivalent light dose estimate value is calculated, and the baseline driving of the LED array is dynamically corrected according to the value, so that stable closed-loop control of the real light dose is realized.

The application provides a line scanning spectral optical coherence tomography system and device, wherein the imaging system comprises a light source generating device, a light splitting device, a reference arm, a sample arm, a signal detecting device and a signal generator; the sample arm is provided with a MEMS galvanometer and a one-dimensional scanning galvanometer, and the sample arm light path is turned on or turned off by controlling the angle deflection of the MEMS galvanometer; only in the light path turning-on period during the exposure of the area array camera, the total light energy received by the sample tissue in the area array camera shooting period is equal to the effective light energy, the light utilization rate is significantly improved, the light power time sequence is synchronously controlled, the signal-to-noise ratio is enhanced under the premise of maintaining the safe light dose of the sample tissue, and high-quality imaging is realized.

The invention discloses an intelligent scanning fast super-resolution microscopic imaging method and device combined with the luminescence characteristic of an up-conversion nanoprobe, and the method comprises the following steps: S1, exciting the up-conversion nanoprobe to emit a first fluorescence signal and a second fluorescence signal based on double-laser-beam regulation and control; s2, forming an effective excitation region smaller than a diffraction limit on the surface of the sample by utilizing light emission loss through double-beam coaxial coupling, and realizing super-resolution imaging in combination with point scanning; s3, detecting whether a probe mark exists in the scanning path or not in real time; and S4, regulating and controlling a scanning path according to a detection result, skipping an unmarked region, and only performing high-resolution scanning on a region marked by the probe to realize efficient and rapid super-resolution imaging. The super-resolution microscopic imaging method and the super-resolution microscopic imaging device have the advantages that the super-resolution microscopic imaging method and the super-resolution microscopic imaging device respectively realize super-resolution imaging and large-area intelligent judgment and marking of probe distribution by utilizing luminescence loss and luminescence enhancement, realize rapid intelligent scanning, remarkably shorten the imaging time of a sample and reduce the influence of light dose.

Methods and related devices for impinging light on tissue, for example within a body of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and / or inhibiting growth of one or more pathogens, upregulating a local immune response, stimulating enzymatic generation of nitric oxide to increase endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores of nitric oxide, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices and methods for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and targeted tissues with increased efficacy and reduced cytotoxicity.