53 results about "Sample plane" patented technology

There is provided a microscopy device capable of (i) moving a liquid immersion objective lens to a location where liquid, such as an oil or water, can be applied to the liquid immersion objective lens, and (ii) moving the liquid immersion objective lens having liquid applied thereto to a sample holder, to be used to acquire images of a sample. The liquid application process can be automated so that the liquid on the objective lens is replenished as necessary. The device can automatically focus the lens to facilitate scanning, and can be configured to change objective lenses. Other embodiments, including using such a device in high content / high throughput scanning, are also described.

This application relates to the field of analytical chemistry detection technology, and in particular to a sample rack for a liquid chromatography-mass spectrometry (LC-MS) instrument used for TDM detection. The rack includes a support mechanism with a sample placement box at the top and a heat-insulating mechanism at the top. The invention utilizes components such as a pull-out plate, a spare support plate, and a table. The sliding engagement between the pull-out plate and the table allows for convenient horizontal sliding of the pull-out plate to retrieve and place samples placed in a first positioning slot. Simultaneously, the spare support plate is fixedly connected to a support side plate, enabling the categorized storage of samples after testing. These components work together to form an orderly sample management system, achieving the modular, partitioned design that efficiently distinguishes and quickly retrieves samples in different testing states, significantly improving the convenience and standardization of experimental operations.

Systems and methods for automated cap removal with an autosampler system are described. In an aspect, an autosampler system includes, but is not limited to, a sample rack; a sample vessel stabilizer configured to transition the sample rack between a load / unload state and a lock state; an uncapper supported by a first z-axis support; and a sample probe supported by a second z-axis support, wherein the uncapper is configured to remove a cap from a sample vessel held by the sample rack when the sample rack is in the lock state, and wherein the uncapper is configured to change the position of the removed cap to permit access to an interior of the sample vessel by the sample probe without removing the sample vessel from the sample rack.

Techniques for measuring single synaptic signals under varying experimental conditions include controlling a video recording microscope to capture, at multiple different times, a first imaged area in a sample holder as a video frame when the sample holder is disposed on a stage and holds a sample of neuronal tissue combined with at least one fluorophore that emits a corresponding electromagnetic wavelength in a synapse during synaptic activity. At least one synaptic region of interest is determined based on a group of pixels in the first imaged area that record electromagnetic emissions from the fluorophore at the different times. An ordered time series of emission intensity is recorded in each of the synaptic region of interest. Peak emission intensity values in the time series are corrected for transmitter label transients. The ordered time series with corrected peak emission intensity values are stored in a data structure with a standard format.

The invention relates to an X-ray imaging apparatus (1) comprising: an X-ray source (2) generating an X-ray beam (F); a two-dimensional X-ray detector (3) comprising pixels (3a); a sample holder (4) configured to support a sample (E); at least one modulator (5), the at least one modulator (5) being a film on which a helical transmission modulation pattern is formed.

The application discloses a kind of multilayer sample pretreatment device and processing method, multilayer sample pretreatment device includes frame body, first shelf layer, second shelf layer and transfer unit, first shelf layer includes sequentially arranged several first warehouse storage sites, second shelf layer includes sequentially arranged code scanning position and several second warehouse storage sites, transfer unit is between code scanning position and second warehouse storage site, between first shelf layer and second shelf layer, second shelf layer and subsequent detection process, conveying unit between transfer sample frame.Sample pretreatment method, transfer unit preferentially transfers sample frame and test tube thereon between second shelf layer and subsequent detection process, recovery conveying unit.The application has reasonable structure, can adapt to large quantities of sample processing, conveying efficiency is high and degree of automation is high, and it is conducive to popularization and application.

This invention discloses a porous sample holder for nano-ion probe analysis suitable for geological sample analysis. It includes a square sample holder body with multiple sample mounting holes, specifically three 1-inch circular holes, two 0.5-inch circular holes, and two 10-millimeter circular holes. The holes are spaced appropriately and equipped with limiting structures. The sample holder body is made of titanium alloy, possessing high strength, low weight, and excellent vacuum compatibility, meeting the needs of nano-ion probe analyzers for high-throughput, batch analysis of multiple samples. This sample holder has a reasonable structural design, is easy to load, and can effectively improve the efficiency of micro-area analysis of geological samples, showing promising application prospects.

A slide imaging device (110) for digital morphology in hematology is disclosed, comprising at least one z-axis stage (112) configured to place a microscope slide (114) at a sample plane, wherein a biological sample may be placed on the microscope slide (114), wherein the z-axis stage (112) is configured to set a relative distance along the optical axis (118) of the slide imaging device (110) between the microscope slide (114) and the imaging system (116) of the slide imaging device (110). The slide imaging apparatus (110) further includes at least one sample beam path and at least one autofocus beam path, the at least one autofocus beam path including at least one pattern illumination source (132), the at least one pattern illumination source including at least one light emitter (134) and at least one grating (136), wherein the grating (136) is tilted relative to the optical axis (118) of the slide imaging apparatus (110), wherein the autofocus beam path includes at least one second transmission system (140) and at least one autofocus camera (138), wherein the second transmission system (140) is configured to allow a pattern generated by the pattern illumination source (132) to be projected onto the sample plane and to allow a pattern reflected from the sample plane to be propagated to the autofocus camera (138), wherein the autofocus camera (138) is configured to generate at least one digital autofocus image of the pattern reflected from the sample plane. The slide imaging apparatus (110) further includes at least one processing unit (148) configured to analyze the digitally autofocused image, wherein the analysis includes spatial analysis of contrast and determination of the image location with maximum contrast. The slide imaging apparatus (110) further includes at least one control unit (150) configured to control the z-axis stage (112) taking into account the determined image location to position the microscope slide (114) along the optical axis (118) of the slide imaging apparatus (110).

This utility model provides a low-pressure test chamber, comprising: a low-pressure test chamber body; a guide rod fixedly connected to the left side inside the low-pressure test chamber body; a sample rack installed in the center of the guide rod; a guide hole through the center of the left side of the sample rack, fitting the guide rod; the guide rod installed in the guide hole; a mounting groove on the right side of the sample rack; an internal height adjustment device installed in the mounting groove; a rotating rod installed on the right side of the sample rack; the top end of the rotating rod rotatably connected to the top of the inner wall of the low-pressure test chamber body; and an external height adjustment device installed at the bottom end of the rotating rod. This low-pressure test chamber, by incorporating the internal and external height adjustment devices, can quickly adjust the height of the sample rack and allows for external adjustment of the sample rack height.

The application relates to a teaching laser speckle interferometry experimental device for measuring material micro-morphology, belonging to the technical field of real-time diagnosis of material morphology of a tokamak wall. The device comprises a laser, a beam expander, a collimating mirror, a sample holder, two groups of beam splitters, a piezoelectric phase-shifting mirror, an imaging lens, a CCD camera and an optical platform. The device has a simple structure, the sensitivity can be dynamically expanded and selected according to actual detection conditions, and speckle interference fringes are obtained by subtracting the intensity field distribution functions before and after the surface displacement or deformation of the measured object. Compared with traditional morphology detection methods, physical contact with the measured object is reduced, thereby avoiding secondary deformation of the measured object and causing system errors.

This invention discloses a fully automated sample pretreatment system for liquid addition, extraction, and filtration, belonging to the field of chemical analysis pretreatment technology. Addressing the problems of low efficiency, health risks, and information confusion associated with manual operation in existing technologies, this invention provides a solution, comprising: a first multi-dimensional robotic arm working in conjunction with a first scanning device to automatically scan, open, and add liquid to sample tubes; a second multi-dimensional robotic arm to move the sample rack, after liquid addition, into an ultrasonic water bath for extraction and then remove it; a three-axis moving mechanism integrating a third gripper and a syringe clamping module to complete secondary scanning, opening, aspiration, filter installation, pressure filtration, and the coding, opening, and closing of glass vials; and a controller coordinating the collaborative work of all components. This invention is mainly used for sample pretreatment in chemical analysis laboratories, achieving full automation of the liquid addition, extraction, and filtration process, improving processing efficiency and sample information traceability.

Sample holder, and systems and methods for imaging and illuminating samples in a sample holder A sample holder (310, 310', 310'', 710) comprises: one or more recesses (312) for receiving a respective sample (350) for imaging, each recess comprising: sidewall portions (316) extending from a first end of the recess to a second end of the respective recess, and a base portion (314) located at one of said first end or said second end. The respective sidewall portions of each recess are inclined towards the respective sidewall portions of the other recesses of the plurality of recesses. A method comprises: providing a sample holder (310) comprising at least one recess (312) for receiving the sample (350); and imaging the sample using a camera (302); wherein each recess comprises: sidewall portions (316) extending from a first end to a second end of the recess, and a base portion (314) located at one of said first end or said second end of the recess, wherein respective central axes of each recess are aligned with lines of sight from the camera. The sidewall portions of each recess may be aligned with lines of sight from the camera. The recesses may be illuminated from the first end with convergent light. The convergent light may converge towards a point located at an effective aperture of the camera.

The utility model discloses a kind of pretreatment devices for wafer high-temperature degassing, comprising: vacuum chamber, upper cover mechanism is provided on it, the vacuum chamber has water-cooled interlayer;Barrel-shaped heating system, be located in vacuum chamber and be connected with upper cover mechanism;And sample holder is suspendedly installed in vacuum chamber by displacement platform, the sample holder can be lifted in vertical direction by displacement platform, and drive sample holder rotation, the sample holder can be completely entered into barrel-shaped heating system upwards.The utility model simple structure, by adopting barrel-shaped heating system, and cooperate the rotary motion of sample stage, make sample heat more evenly, to significantly improve degassing effect.In addition, vacuum chamber is equipped with water-cooled interlayer, not only can resist higher degassing temperature, also help to compress cavity volume, improve the vacuum degree of pretreatment cavity, to realize the effective balance of multiple performance indicators.

A carrier for a sample holder includes a frame defining a holding space to receive the sample holder. The frame is configured to enclose the sample holder at least partially on a plurality of sides. The frame is configured to enable visual inspection of at least a sample area of the sample holder. The frame includes at least one handling structure configured to be engaged by a handling device.

A sample rack recovery method after an accidental interruption of operation of a sample rack manipulation device (10), a sample rack manipulation device (10) capable of performing the method, an automatic detection system (1) comprising the device (10), and a computer-readable medium in which a program for executing the method is stored. The device (10) comprises a conveying device (103) adapted to move in a transport area (TB) to convey a sample rack (30) between a loading / unloading area (TA), sampling areas (TD, TE) and a buffer area (TC). The method comprises: a conveying device detection step of detecting the state of a conveying device (103); a sample rack detection step of detecting the position of a sample rack (30) in a sample rack manipulation device (10); and a sample rack recovery step of conveying the sample rack (30) to a loading / unloading area (TA) by the conveying device (103) according to the detection results of the conveying device (103) and the sample rack (30).

Systems and methods for operating a cabinet irradiator. The methods comprise: receiving a sample holder in a receptacle of an XYZ stage platform of the cabinet irradiator (sample(s) is(are) disposed on the sample holder); controlling the XYZ stage platform to move the sample holder under a camera such that an optical axis is centered over a sample area of the sample holder; displaying a top-down image of the at least one sample in a first graphical user interface along with at least one virtual box having an adjustable size and being movable relative to the top-down image; receiving a user input specifying at least one area of the at least one sample that is to be irradiated via movement and or resizing of the at least one virtual box; receiving a user input selecting or defining an irradiation treatment plan; and irradiating the sample(s) in accordance with irradiation treatment plan.

The utility model discloses a bacteria endotoxin gel method detection device based on automatic control, including work table, the upper end of work table is provided with sample holder, the right -hand member of sample holder is provided with dilution frame correspondingly, dilution frame is provided with three groups, the right -hand member of dilution frame is provided with oscillation frame correspondingly, the rear end of oscillation frame is installed tip head area correspondingly, this patent device easy operation, man -machine interface is friendly, has reduced manpower cost, has improved work efficiency, the device degree of automation is high, has reduced the risk factor that human interference possibly brings maximum limit, and whole device can realize automatic gel result determination simultaneously, result calculation can, and can real -time monitoring whole test process, realizes the traceability of metadata simultaneously, can carry out endotoxin gel method detection to a large number of samples simultaneously, adapts to the demand of large -scale detection.

An optical element surface treating device for a lithography system performs an atomic layer treatment process and includes: a sample holder holding the optical element; a treatment head (120) with a first outlet (121) supplying a first precursor fluid (PF1) to a treatment region (102A) on the surface of the optical element, a cleaning assembly (123) removing excess first precursor fluid from the treatment region, and a second outlet (122) supplying a second precursor fluid (PF2) into the treatment region, wherein the first precursor fluid and the second precursor fluid provide an atomic layer deposition or etching process in the treatment region, and the first or the second precursor fluid is a liquid: and a movement unit (130) moving the treatment head relative to the sample holder with the optical element. The first outlet, the cleaning assembly, and the second outlet are guided one by one over the treatment region.

The utility model discloses a kind of sample holder for vacuum parallel concentrator, including bottom plate set up from top to bottom, support plate, support plate is provided with placing hole, the bottom of bottom plate is provided with low-temperature anti-steam dry module, and bottom plate is provided with the connecting hole that is communicated with low-temperature anti-steam dry module;Opening and closing mechanism is arranged at connecting hole;Support plate is provided with driving mechanism.In initial stage of reaction, the tail pipe of concentration cup does not extend into low-temperature anti-steam dry module, so as to be able to accept the sufficient heating of water bath;With the progress of reaction, the tail pipe of concentration cup can be driven by driving mechanism to pass through connecting hole downward and extend into low-temperature anti-steam dry module.At this time, the concentrated solution in tail pipe can be low-temperature protected by low-temperature anti-steam dry module.Compared with prior art, the vertical position of concentration cup is adjusted by driving mechanism in the utility model, so that the solution of concentration cup can be fully heated in initial stage of reaction, and the efficiency of concentration operation is improved.

There are provided a sample holder that allows in-situ observation of a sample such as a gas or liquid under light irradiation and an electron microscope. An environment cell is formed in combination of two silicon chips, each including a membrane and a frame supporting the membrane, the frame being provided on the opening. The environment cell is accommodated in a main body of the sample holder, and fixed by a lid. The openings of the lid, the two silicon chips, and the main body are placed so as to overlap with each other along the optical axis of an electron beam of an electron microscope. A light emitting element is placed at a position where any one of the openings of the two silicon chips is allowed to be irradiated with light.

A double-confinement heated sample holder and a method for analyzing a sample using said sample holder. The invention relates to a sample holder (1) for analysis by X-ray scattering and / or X-ray spectroscopy, comprising: - an internal cell (3) including a cavity, configured to hermetically contain a sample to be analyzed, and windows opposite each other on either side of the cavity, each window being closed by a pane of glass transparent at least to X-rays; - a housing including at least one compartment, referred to as the first compartment (7), configured to hermetically contain the internal cell, and windows opposite each other on either side of the first compartment, each window being closed by a sheet transparent at least to X-rays; - at least one heating element (5) inserted in the housing so as to heat the cavity of the internal cell. Figure for the abstract: Fig. 3

The utility model belongs to in situ test research, specifically relates to a high temperature and high pressure in situ testing device, including the casing of tubular, the casing's cylinder chamber constitutes the closed cavity, is provided with the sample holder for placing sample in the closed cavity, the casing is from one side to opposite another side is provided with the passage that passes through the casing, sample holder and is used for the ray to pass through, the sample is placed in the through -hole that the passage formed on the sample holder, is provided with the light window on the port of the passage on the casing cylinder wall, the outside of casing is provided with the air -inlet and outlet interface that communicates the sealed cavity, is provided with the heat -insulating cylinder in the closed cavity, the heat -insulating cylinder and the cylinder wall of casing seal and fit, the passage passes through the heat -insulating cylinder, heating device is located in the sample holder's frame body in the heat -insulating cylinder chamber, the frame body of sample holder and the heat -insulating cylinder chamber wall between the heat -insulating cylinder chamber are arranged and form the air gap interval, the air gap interval and the heat -insulating cylinder mutually cooperate, can better inhibit the high temperature on the sample holder to the outer shell transmission.

The application relates to the field of centrifuges, and discloses a centrifuge facilitating sample tube limiting, which comprises a centrifuge box, a centrifugal table is rotationally arranged in the centrifuge box, a plurality of sample racks for placing sample tubes are fixed in the circumferential direction on the centrifugal table, a limiting plate for limiting the sample tubes is arranged on the top of the centrifugal table, and an adjusting assembly for adjusting the limiting state of the limiting plate is arranged; the limiting plate for limiting the sample tubes is arranged on the top of the centrifugal table, the limiting plate can effectively constrain the sample tubes in the centrifugal process, can effectively prevent the sample tubes from tilting or deviating due to inertia, and can avoid the situation that the tube body and the tube rack structure are stuck, so that the operator can directly take out the sample tubes without disassembling the internal rack of the centrifuge, the work efficiency is improved, the operation time and the labor cost are saved, the risk that the blood samples are polluted in the taking-out process is effectively reduced, and the safety and reliability of the experiment are ensured.

The application discloses a wafer surface activation bonding device and a bonding method, and relates to the technical field of wafer processing. The device comprises a clamp, a movable support rod and a bombardment particle emission device. The clamp comprises oppositely arranged first and second sample holders, and the first and second sample holders are each provided with a hard nonmetal back plate. Two wafers to be bonded are fixed on the hard nonmetal back plate, and the surface area of the two wafers to be bonded that is in contact with each other is a bonding area, which is surrounded by the surface of the hard nonmetal back plate. The movable support rod is arranged at least on the outer side of any one of the first and second sample holders, so that relative extrusion between the first and second sample holders is realized, and the bonding area of the surfaces of the two wafers to be bonded is fully contacted under the action of pressure. The bombardment particle beam spot emitted by the bombardment particle emission device uniformly covers the bonding area of the two wafers to be bonded. The application can effectively avoid the introduction of metal contamination at the bonding interface, and has the advantages of simple process, good compatibility and the like.

Systems and methods for improved sample gripping solutions are provided. In particular, this disclosure relates to sample holder sliding guides and methods for using the same. An exemplary apparatus for handling a sample may comprise a sample holder configured to engage with a sample, one or more gripping devices configured to grip the sample after insertion, and a guide. The sample holder may comprise one or more holding components configured to receive the sample in a flat position, and one or more fixing components configured to fix and maintain the sample in a flat position after insertion into the sample holder. The guide may comprise one or more guide components configured to allow the guide to be connected to components in the apparatus, to engage the sample holder with the sample, and to allow the sample holder to move together with the sample into one or more gripping devices.

Provided is a sample rack storage device, liquid chromatograph, liquid handler, and sample rack that have a small user workload without increasing the device structure and cost. The sample rack storage device includes: a first column of sample rack placement portions and a second column of sample rack placement portions that are arranged substantially in parallel along a first direction; and a sensor that is movable along a path that is substantially parallel to the first direction in the vicinity of a boundary between the first column of sample rack placement portions and the second column of sample rack placement portions. The sensor is capable of reading a bar code displayed on each of a plurality of first sample racks arranged in the first column of sample rack placement portions and a bar code displayed on each of a plurality of second sample racks arranged in the second column of sample rack placement portions, the position of the first bar code in each of the first sample racks and the position of the first bar code in each of the second sample racks being arranged so as not to overlap in the first direction.

An automatic analyzer includes a transportation line that executes carrying-in / out of a sample rack in which a sample is mounted from / to an analyzation unit, a cold storage that cools a plurality of the sample racks in which the sample having been measured in the analyzation unit is mounted, a transportation control unit that executes operation control for carrying-in of the sample rack from the transportation line to the cold storage and operation control for carrying-out of the sample rack from the cold storage to the transportation line, a front chamber that is disposed between the cold storage and the transportation line, the inner space of the front chamber being shielded from the outside, and a temperature / humidity control unit that controls temperature of the inside of the front chamber to temperature / humidity between those of the outside of the cold storage and those of the inside of the cold storage.