The invention discloses a multi-factor comprehensive simulation accelerated testing device for a climatic environment. The multi-factor comprehensive simulation accelerated testing device comprises a testing box in which a sample frame is arranged, a light source system, an intelligent spraying system, a temperature and humidity regulating system, a circulation air system and a control system. With the adoption of the device, an environmental effect with five environmental factors, such as illumination, corrosive medium, temperature, humidity and air speed can be simultaneously simulated or strengthened; actions, such as radiation power variation, atomizing (or spraying), heating (or cooling), air speed and the like of the light source can be controlled by using an PLC (programmable logic controller) or a singe-chip so as to simulate and strengthen a plurality of typical climate environments; drying and watering circulation on the surface of a sample in the test box can be controlled well through adopting intelligent atomizing (or spraying) control; and accelerated ratio and relevance are improved. The testing device can be used for developing two kinds of different light aging test and damp heat test so as to achieve the effect that one box has multi purposes.