804 results about "Sample handling" patented technology

A method of self-testing an imaging system of a sample handling apparatus is provided. Systems and non-transitory computer readable mediums performing the method are also provided.

A method of capturing analytes from a sample is provided. A first substrate including a sample is mounted on a first member of a sample handling device and mounting a second substrate including an array of capture probes on a second member of the sample handling device. A first reagent medium is applied to the first and / or second substrate and moving the first member and / or the second member to fluidically couple the sample and the array of capture probes via the first reagent medium. The sample and the array of capture probes are fluidically decoupled by moving the first member and / or the second member and a second reagent medium is applied to the first and / or second substrate and moving the first member and / or the second member to fluidically couple the sample and the array of capture probes via the second reagent medium. Related systems and apparatuses are also provided.

A method for aligning a sample to an array is provided. An image of sample image of a sample can be received by a data processor. The sample image having a first resolution. An array image including an overlay of an array with the sample and an array fiducial can be received by the data processor. The array image having a second resolution lower than the first resolution of the sample image. The sample image can be registered to the array image by aligning the sample image and the array image. An aligned image can be generated based on the registering. The aligned image can include an overlay of the sample image with the array. The aligned image can be provided by the data processor. A method for detecting fiducials associated with an array is provided. Systems and non-transitory computer readable mediums performing the method are also provided.

A method for aligning a sample to an array is provided. An image of sample image of a sample can be received by a data processor. The sample image having a first resolution. An array image including an overlay of an array with the sample and an array fiducial can be received by the data processor. The array image having a second resolution lower than the first resolution of the sample image. The sample image can be regisered to the array image by aligning the sample image and the array image. An aligned image can be generated based on the registering. The aligned image can can include an overlay of the sample image with the array. The aligned image can be provided by the data processor. A method for detecing fiducials associated with an array is provided. Systems and non-transitory computer readable mediums performing the method are also provided.

A method of self-testing an imaging system of a sample handling apparatus is provided. Systems and non-transitory computer readable mediums performing the method are also provided.

The invention provides a food heavy metal pollution detection system based on plasma emission spectrum analysis, and aims to realize rapid and accurate detection of heavy metal elements in a food sample. The system comprises a sample processing module, an excitation module, a spectrum detection module, a signal processing module, a data analysis module and an output module. The sample processing module converts a food sample into an aerosol or steam state. The spectrum detection module is used for extracting spectrum characteristic information of heavy metal elements. And the signal processing module adopts an AI-driven spectrum denoising algorithm to remove background noise and interference signals. And the data analysis module calculates the concentration of each element based on the characteristic peak intensity and generates heavy metal pollution data. And the output module is used for visually displaying the detection result. According to the method, complex sample pretreatment steps are reduced, the detection efficiency and sensitivity are improved, and the method is suitable for food safety detection scenes and particularly has remarkable advantages in field rapid detection application of agricultural products, drinking water and processed food.

The invention relates to a soil detection system and a detection method. Soil detection equipment comprises a sampling module, a positioning module for generating original point sampling coordinates, a sample treatment module for chemical, electrochemical and biological treatment means, a detection module, a detection database, a detection control module, a generating and sending module and a sending and receiving module. The detection method comprises the steps of sampling and processing, binding coordinates, comparing abnormal data through preliminary detection, generating a pollution map, carrying out secondary detection on abnormal data, calculating a spatial uncertainty index, dynamically generating a near-origin secondary sampling coordinate, circularly sampling and detecting until the index reaches the standard or the density upper limit, and finally generating the pollution map and a prediction model. And the detection database is updated and optimized through machine learning.

The utility model provides a laser particle size analysis pretreatment device and battery slurry detection equipment, and belongs to the technical field of battery slurry stirring analysis. The laser particle size analysis pretreatment device comprises a stirring assembly and an ultrasonic assembly, wherein the stirring assembly comprises a first driving unit and a plurality of stirring rods connected with the first driving unit; the ultrasonic assembly comprises an ultrasonic transducer and a box body, the box body is provided with a containing cavity, a plurality of containers in one-to-one correspondence with the stirring rods are arranged in the containing cavity, the containers are used for containing slurry to be treated, and the ultrasonic transducer is used for applying ultrasonic vibration to the slurry in the containers; and the plurality of stirring rods are configured to synchronously rotate under the driving of the first driving unit so as to respectively stir the slurry in the corresponding containers. According to the structural design, multiple groups of samples can be automatically stirred and ultrasonically vibrated at the same time, the sample treatment efficiency can be improved, and the sample treatment consistency can also be improved.

The invention relates to a micro-fluidic chip for sequencing a single virus genome and a sequencing method. The micro-fluidic chip comprises a first functional area, a delay pipeline, a fusion pipeline, a second functional area and a fusion electrode, the first functional area is used for generating first liquid drops of virus-in-oil and lysate; two ends of the delay pipeline are respectively connected with the first functional area and the fusion pipeline; the second functional area is used for generating second liquid drops of the oil bag amplification reaction liquid, and the second functional area is connected with the fusion pipeline to enable the second liquid drops to enter the fusion pipeline; a fusion point is arranged on the downstream of the joint of the fusion pipeline and the second functional area, and the fusion electrode can act on the fusion point to fuse the first liquid drop and the second liquid drop. According to the micro-fluidic chip disclosed by the invention, single-virus whole genome amplification can be completely completed on a single chip, so that the operation steps are simplified, the complexity of sample treatment is reduced, pollution and sample loss are effectively avoided, and the efficiency, the stability and the reliability are improved.

The invention discloses an automatic sample adding and carrying centrifugal system which comprises a storage tank, a sample processing system, a turnover carrying shaft driving module, an in-tank carrying mechanism, a sample carrying mechanism and a control system, and the storage tank comprises a plurality of upper and lower interlayers used for storing sample turnover frames; the sample processing system is provided with a plurality of processing stations; the turnover carrying shaft driving module is integrally arranged on one side of the sample processing system in a horizontal straight line, and an automatic warehouse outlet is formed in one end, close to the storage warehouse, of the turnover carrying shaft driving module; the sample processing system further comprises a primary centrifugal machine and a secondary centrifugal machine which are arranged in the conveying direction of the turnover carrying shaft driving module. The in-warehouse carrying mechanism can carry the sample turnover frame back and forth between the storage warehouse and the automatic warehouse outlet; and the sample carrying mechanism can carry the sample back and forth between the waiting position of the turnover carrying shaft driving module and each processing station of the sample processing system. The device has the beneficial effects that the occupied space is reduced, and secondary centrifugation of the sample is realized.

An integrated sample processing system including an analyzer and a mass spectrometer is disclosed. The integrated sample processing system can perform multiple different types of detection, thereby providing improved flexibility and better accuracy in processing samples. The detection systems in the sample processing system may include an optical detection system and a mass spectrometer.

The present invention discloses a method and a system for monitoring condition of a sample handling system connected to a gas analyzer. The sample handling system comprises a sample line for supplying a gas sample to the gas analyzer, and sample handling devices. The system for monitoring condition, receives measurements from temperature and pressure sensors connected to the sample line and obtains operating characteristics of the sample handling devices based on the measurements and model of the sample handling system; and determines the condition of the sample handling system based on comparison of the operating characteristics of the sample handling device against a plurality of reference values associated with the sample handling device.

The invention discloses a pesticide residue quantitative analysis system based on Raman spectrum, and relates to the technical field of analytical chemistry and detection.The pesticide residue quantitative analysis system comprises an acquisition module, a processing module, an analysis module and a regulation and control module, the acquisition module is used for acquiring samples and Raman scattering signals, converting the Raman scattering signals into original spectrum data and transmitting the original spectrum data to the processing module; calibrating the original spectrum data, acquiring calibrated spectrum data, transmitting the calibrated spectrum data to an analysis module, comparing the calibrated spectrum data with a pesticide standard spectrum library, outputting a quantitative analysis result of pesticide residues, transmitting the quantitative analysis result to a regulation and control module, storing the pesticide standard spectrum library and the calibrated spectrum data, and correcting sample detection deviation by using the calibrated spectrum data. And through the regulation and control unit, full-process automatic operation from sample processing to result output is realized, the detection reliability is improved through spectrum compensation and characteristic peak comparison, efficient automation is realized through task scheduling and time sequence synchronization, and hardware fault tolerance, authority management and multi-scene adaptation capabilities are realized.

The invention provides a monoclonal antibody capable of specifically recognizing a specific metabolic fragment of human amyloid protein and application of the monoclonal antibody, and belongs to the technical field of genetic engineering. The invention provides a hybridoma cell strain AB5H, and the preservation number of the hybridoma cell strain AB5H is CCTCC (China Center For Type Culture Collection) NO: C201255. The hybridoma cell strain AB5H disclosed by the invention can secrete a monoclonal antibody which has relatively high activity and can specifically recognize human beta amyloid protein A beta 40; the monoclonal antibody is high in titer, can be used as a capture antibody, and is used for preparing a human Abeta40 protein quantitative detection kit and quantitatively detecting the content of Abeta40 in cerebrospinal fluid and blood, so that the detection result deviation caused by the fact that the content of Abeta40 in peripheral blood is easily influenced by metabolism, sample treatment conditions and methods and individual differences is overcome, and the detection accuracy is improved. The variation degree of a detection result is reduced, so that a judgment boundary value of a blood A beta detection result is conveniently obtained, and AD early diagnosis is realized.

A liquid sample processing method includes opening a closed container by removing a closure of the container from an opening of the container to access a liquid sample collector including a liquid sample collection member and an elongated handle. Before removing the closure, the container may be secured with a holder. After separating the liquid sample collection member, a plunger with a liquid pathway extending through it is pushed downward to compress the liquid sample collection member such that at least some of the liquid sample flows through the liquid pathway.

The utility model discloses high-throughput cell sample integrated treatment equipment, which comprises an equipment cabin, a treatment flow control device and an equipment function module, the treatment flow control device is in signal connection with the equipment function module, the treatment flow control device is arranged outside the equipment cabin, and the equipment function module is in signal connection with the equipment cabin. The equipment function module is fixedly mounted in the equipment cabin; the equipment function module comprises a centrifugal mechanism, a perforated plate transfer mechanism, a multi-channel pipetting mechanism, a constant-temperature culture module, a sample treatment platform, a glass slide suction mechanical arm, a supporting mechanism, a glass slide bin and a dispersion chamber. According to the application, cycle synchronization, suspension, separation, fixation and dispersion of cells are automatically completed, functional modules in culture, harvesting and slide preparation links in a sample treatment process are highly integrated, a perforated plate is used for replacing a traditional centrifugal tube for sample treatment, batch harvesting of samples and slide preparation treatment are realized, and the production efficiency is improved. The sample treatment flux and the sample treatment efficiency are improved, and meanwhile, the sample treatment consistency is also improved.

The invention discloses a digital acoustic fluidic chip, a preparation method and a multi-dimensional sample processing method, the digital acoustic fluidic chip comprises an upper polar plate and a lower polar plate, and the upper polar plate comprises a glass layer, a coating layer and an upper hydrophobic layer which are arranged in sequence; the lower polar plate comprises a lower hydrophobic layer, a dielectric layer, an electrode layer and a substrate which are arranged in sequence; the electrode layer comprises an EWOD pin electrode, a driving electrode, a sound wave pin electrode and an interdigital transducer; the interdigital transducer comprises a sound field and electric field multiplexing module, a sound standing wave field and thermal field module, a focusing sound field and thermal field module and a sound vortex enrichment module; each driving electrode is connected with one EWOD pin electrode, the two sides of the sound field and electric field multiplexing module, the two sides of the sound standing wave field and thermal field module, the two sides of the focusing sound field and thermal field module and the two sides of the sound vortex enrichment module are all connected with the two sound wave pin electrodes, and one side of the sound field and electric field multiplexing module is further connected with one EWOD pin electrode. The method has the advantages of multi-dimensional sample treatment and high-flexibility treatment.

The invention belongs to the technical field of medical treatment, and particularly relates to a hemoglobin chyle joint detection device and a detection method.The hemoglobin chyle joint detection device comprises a shell, an analysis mechanism is arranged in the shell, and a colorimetric tube is inserted into the upper surface of the shell; the analysis mechanism comprises a light source module, a sample processing module, an optical detection module and a data processing module; the optical detection module synchronously acquires absorbance signals under two wavelengths through double detectors; the data processing module calculates hemoglobin concentration and chyle degree based on the dual wavelength absorbance values. The method is different from traditional single-index detection, two-parameter synchronous analysis of hemoglobin and chyle is achieved for the first time, and the preliminary screening efficiency before blood donation is remarkably improved. By adopting a dual-wavelength correction algorithm, the influence of residual absorption interference of hemoglobin at 580-700nm on chyle index determination is eliminated, and the influence of absorption interference of chyle at 480-570nm on hemoglobin determination is eliminated. The method is suitable for rapid screening on a blood sampling site to realize informatization management of detection data.

The invention discloses an affair handling process verification method and device based on a large model, equipment and a storage medium, and relates to the technical field of artificial intelligence, and the affair handling process verification method based on the large model comprises the steps: inputting a target government affair handling guide into a target large model, and obtaining affair handling process information corresponding to the target government affair handling guide; performing accuracy verification on a plurality of step information in the affair handling process information through a target verifier to obtain respective verification results of the step information, the target verifier inputting data by taking the sample affair handling process information as a model, and verifying the accuracy of the sample affair handling process information to obtain verification results of the step information; training by taking a real handling result of handling government affair items based on the sample handling process information as a model training label; and determining the accuracy rate of the affair handling process information based on each verification result, and outputting the affair handling process information to guide the handling of government affair items when the accuracy rate is greater than a preset threshold value. The success rate of handling government affairs based on the affair handling process can be improved.

Provided herein are kits, systems and methods for analyzing analytes from a biological sample. The system includes an upper housing configured to receive a sample substrate and a thermal element configured to control a temperature of the sample substrate. The system includes a lower housing and an alignment mechanism coupling the upper housing to the lower housing. The alignment mechanism is configured to move the upper housing, the lower housing, or both into an arrangement having an open configuration, a closed configuration, or an intermediate configuration therebetween. The thermal element is configured to cool the sample substrate.

The invention relates to a method for testing and judging the performance of a laser local soft region, which comprises the following steps of: S1, sampling, namely sampling from a thermoforming part to obtain a laser local soft region sample to be tested; s2, a sample treatment step: cutting the laser local soft region sample to obtain a to-be-measured surface; step S3, a hardness test step: carrying out hardness test on the to-be-tested surface; and S4, a data analysis step: drawing a hardness distribution curve, and judging whether the soft area performance of the to-be-detected surface meets a specified standard or not. The method is simple and high in reliability, the hardness of the laser local soft region sample to be tested is tested through the steps, and data obtained through the hardness test are analyzed, so that whether the performance of the laser soft region meets the standard or not is judged, and then whether the laser softening process is normal or not is judged; and reference and guidance effects can be achieved in the subsequent adjustment process of the laser softening parameters.

The invention provides a full-automatic pretreatment system and method for a soil sample, and belongs to the field of soil sample treatment.The system comprises a weighing device, a digestion device, a transfer device and a constant volume device with a workbench, the constant volume device comprises a first mechanical arm used for grabbing and cap screwing, a second mechanical arm used for pipetting, an annular conveying unit provided with a plurality of pipe supports, a pipe clamping unit and a liquid level calibration unit, and the pipe supports are provided with containing grooves matched with digestion pipes and colorimetric pipes respectively. The first manipulator is set to grab and screw caps of the digestion tube and the colorimetric tube from a first position of the annular conveying unit, and the second manipulator is set to transfer liquid from a second position of the annular conveying unit. The full-process automatic operation from weighing to final volume fixing and subpackaging of the soil samples is achieved, the working efficiency of the system is remarkably improved, and especially the treatment efficiency of a large batch of soil samples is improved.

This disclosure provides methods and compositions for sample processing, particularly for sequencing applications. Included within this disclosure are bead compositions, such as diverse libraries of beads attached to large numbers of oligonucleotides containing barcodes. Often, the beads provides herein are degradable. For example, they may contain disulfide bonds that are susceptible to reducing agents. The methods provided herein include methods of making libraries of barcoded beads as well as methods of combining the beads with a sample, such as by using a microfluidic device.

The present invention relates to the technical field of in vitro diagnosis, and discloses a sample treatment detection device and a sample treatment device.The sample treatment device comprises: a sample treatment module, which is provided with a sample adding channel and a plurality of solution bins, at least one solution bin is internally provided with magnetic beads for adsorbing nucleic acid or protein, the bottom of the solution bin is communicated with a closed pipette, and the pipette is provided with a sealing gasket; the liquid driving device is arranged in the sample processing module, and a syringe needle at the bottom of the liquid driving device can be inserted into the sealing gasket; at least one of the liquid driving device and the solution bin moves relatively under the driving of the power mechanism, so that the syringe needle of the liquid driving module is inserted into the pipette channels corresponding to different solution bins. The sample treatment device is high in pipetting efficiency, capable of improving the detection efficiency, compact in structure, small in size and wide in application range.

One embodiment of the invention is directed to a sample processing system for analyzing a biological sample from a patient. The sample processing system comprises: a plurality of analyzers comprising at least one mass spectrometer, wherein each analyzer in the plurality of analyzers is configured to acquire at least one measurement value corresponding to at least one characteristic of the biological sample; at least one data storage component which stores (i) a list of parameters for the plurality of analyzers, and (ii) at least two condition sets, which contain data associated with completing one or more test orders. The condition sets contain data which differ by at least one variable; and a control system operatively coupled to the plurality of analyzers, and the at least one data storage component. The control system is configured to (i) determine which condition set of the at least two condition sets to use based on the determined condition set, (ii) determine which analyzer or analyzers of the plurality of analyzers to use to process each test order based on the determined condition set and one or more parameters from the list of parameters, and (iii) cause the determined analyzer or analyzers to acquire one or more measurement values for the biological sample.

The present invention relates to the technical field of fully automatic detection of circulating tumor cells; specifically, it is a fully automatic circulating tumor cell enrichment device, comprising: a chip storage unit, a first reagent storage unit, a second reagent storage unit, a sensing device, a shaking device and a transfer device; the first reagent storage unit comprises a plurality of cleaning liquid storage boxes and at least one waste liquid storage box; the second reagent storage unit comprises a plurality of test reagent storage racks arranged in sequence; the shaking device is used to fully shake the liquid injected into the chip storage unit and accelerate the reaction; the chip storage unit comprises a structure for storing a positive separation circulating tumor cell chip; the device realizes the fully automatic capture and staining function of circulating tumor cells in blood samples, has the advantages of easy use and standardized process, can provide standardized sample processing means for various tumors, such as prostate tumors and colon cancer tumors, and has important significance for basic research and clinical application of tumors.

The invention provides a micro-fluidic chip which comprises a uniform mixing layer, a chip dissolving cavity-dilution layer, a filtering layer and a focusing layer, cell sap and diluent can be preliminarily mixed by the uniform mixing layer and then fully diluted in the dilution layer, and the problem of non-uniformity possibly caused by single-time large-amplitude dilution is avoided. Then, the filter layer can effectively remove impurities and clotted cells. And finally, the focusing layer realizes cell focusing. The four functional layers of uniform mixing, diluting, filtering and focusing are sequentially stacked and integrated, so that the overall size of the microfluidic equipment is remarkably reduced, and high automation and optimization of the whole sample treatment process are realized.

Provided is a characteristic element combination anomaly derivative method of determining occurrence of a deep concealed plate-shaped ore body of a hydrothermal deposit. The method determines the spatial occurrence of the deep concealed ore body of the hydrothermal deposit through four working procedures, including: fine measurement of a metallogenic structure and systematic collection of samples, sample processing and multi-element quantitative analysis, mathematical model construction of characteristic element combination anomaly, and determination of the occurrence (the strike, the dip direction, the dip angle and the pitch direction) of the deep concealed ore body. The method solves the problem of judging the occurrence of the deep concealed ore body by interpreting geochemical anomalies of a primary halo and a secondary halo.

The invention discloses a large yellow croaker origin traceability discrimination method based on an element and FTIR fusion fingerprint spectrum. The method comprises the following steps: S1, sample treatment; s2, data acquisition: S2.1, mineral element data acquisition, and S2.2, FTIR spectrum acquisition; and S3, data analysis. Precise classification of production areas can be realized through principal component analysis (PCA), clustering analysis (CA) and linear discriminant analysis (LDA), the overall discriminant accuracy of back substitution inspection of the discriminant model reaches 100%, and the overall discriminant accuracy of cross inspection reaches 97.3%. The element and infrared spectrum fusion fingerprint technology is applied to the source tracing of the large yellow croaker producing area, and the application prospect is wide.

The invention relates to a poplar variety and paper pulp rapid nondestructive identification method, a determination method, a system, equipment and a medium, and the method comprises the following steps: screening log segments through a sensor, processing the log segments into a sample, collecting near infrared spectrum data, carrying out chemical component testing, then purifying a spectrum by adopting adaptive filtering and inverse wavelet transform, and determining the poplar variety and paper pulp material. And screening features according to a wavelength selection strategy, constructing and training models, and fusing classification results output by a multi-model serial combination or parallel combination. On the system, sample processing, testing, data purification, model training and classification function modules are integrated, full-process automatic and intelligent management is achieved, the method is cooperatively executed on equipment through a database and a memory, and efficient operation of the method is ensured; executable instructions are stored on a medium, and wide deployment and application are facilitated. The method can automatically and accurately output classification results of the poplar wood and the paper pulp wood, the identification efficiency is remarkably improved, and personal errors are reduced.