575 results about "Sample handling" patented technology

A method for aligning a sample to an array is provided. An image of sample image of a sample can be received by a data processor. The sample image having a first resolution. An array image including an overlay of an array with the sample and an array fiducial can be received by the data processor. The array image having a second resolution lower than the first resolution of the sample image. The sample image can be regisered to the array image by aligning the sample image and the array image. An aligned image can be generated based on the registering. The aligned image can can include an overlay of the sample image with the array. The aligned image can be provided by the data processor. A method for detecing fiducials associated with an array is provided. Systems and non-transitory computer readable mediums performing the method are also provided.

A method of self-testing an imaging system of a sample handling apparatus is provided. Systems and non-transitory computer readable mediums performing the method are also provided.

The invention provides a food heavy metal pollution detection system based on plasma emission spectrum analysis, and aims to realize rapid and accurate detection of heavy metal elements in a food sample. The system comprises a sample processing module, an excitation module, a spectrum detection module, a signal processing module, a data analysis module and an output module. The sample processing module converts a food sample into an aerosol or steam state. The spectrum detection module is used for extracting spectrum characteristic information of heavy metal elements. And the signal processing module adopts an AI-driven spectrum denoising algorithm to remove background noise and interference signals. And the data analysis module calculates the concentration of each element based on the characteristic peak intensity and generates heavy metal pollution data. And the output module is used for visually displaying the detection result. According to the method, complex sample pretreatment steps are reduced, the detection efficiency and sensitivity are improved, and the method is suitable for food safety detection scenes and particularly has remarkable advantages in field rapid detection application of agricultural products, drinking water and processed food.

The invention relates to a soil detection system and a detection method. Soil detection equipment comprises a sampling module, a positioning module for generating original point sampling coordinates, a sample treatment module for chemical, electrochemical and biological treatment means, a detection module, a detection database, a detection control module, a generating and sending module and a sending and receiving module. The detection method comprises the steps of sampling and processing, binding coordinates, comparing abnormal data through preliminary detection, generating a pollution map, carrying out secondary detection on abnormal data, calculating a spatial uncertainty index, dynamically generating a near-origin secondary sampling coordinate, circularly sampling and detecting until the index reaches the standard or the density upper limit, and finally generating the pollution map and a prediction model. And the detection database is updated and optimized through machine learning.

The invention discloses an automatic sample adding and carrying centrifugal system which comprises a storage tank, a sample processing system, a turnover carrying shaft driving module, an in-tank carrying mechanism, a sample carrying mechanism and a control system, and the storage tank comprises a plurality of upper and lower interlayers used for storing sample turnover frames; the sample processing system is provided with a plurality of processing stations; the turnover carrying shaft driving module is integrally arranged on one side of the sample processing system in a horizontal straight line, and an automatic warehouse outlet is formed in one end, close to the storage warehouse, of the turnover carrying shaft driving module; the sample processing system further comprises a primary centrifugal machine and a secondary centrifugal machine which are arranged in the conveying direction of the turnover carrying shaft driving module. The in-warehouse carrying mechanism can carry the sample turnover frame back and forth between the storage warehouse and the automatic warehouse outlet; and the sample carrying mechanism can carry the sample back and forth between the waiting position of the turnover carrying shaft driving module and each processing station of the sample processing system. The device has the beneficial effects that the occupied space is reduced, and secondary centrifugation of the sample is realized.

The invention discloses a pesticide residue quantitative analysis system based on Raman spectrum, and relates to the technical field of analytical chemistry and detection.The pesticide residue quantitative analysis system comprises an acquisition module, a processing module, an analysis module and a regulation and control module, the acquisition module is used for acquiring samples and Raman scattering signals, converting the Raman scattering signals into original spectrum data and transmitting the original spectrum data to the processing module; calibrating the original spectrum data, acquiring calibrated spectrum data, transmitting the calibrated spectrum data to an analysis module, comparing the calibrated spectrum data with a pesticide standard spectrum library, outputting a quantitative analysis result of pesticide residues, transmitting the quantitative analysis result to a regulation and control module, storing the pesticide standard spectrum library and the calibrated spectrum data, and correcting sample detection deviation by using the calibrated spectrum data. And through the regulation and control unit, full-process automatic operation from sample processing to result output is realized, the detection reliability is improved through spectrum compensation and characteristic peak comparison, efficient automation is realized through task scheduling and time sequence synchronization, and hardware fault tolerance, authority management and multi-scene adaptation capabilities are realized.

The invention discloses a digital acoustic fluidic chip, a preparation method and a multi-dimensional sample processing method, the digital acoustic fluidic chip comprises an upper polar plate and a lower polar plate, and the upper polar plate comprises a glass layer, a coating layer and an upper hydrophobic layer which are arranged in sequence; the lower polar plate comprises a lower hydrophobic layer, a dielectric layer, an electrode layer and a substrate which are arranged in sequence; the electrode layer comprises an EWOD pin electrode, a driving electrode, a sound wave pin electrode and an interdigital transducer; the interdigital transducer comprises a sound field and electric field multiplexing module, a sound standing wave field and thermal field module, a focusing sound field and thermal field module and a sound vortex enrichment module; each driving electrode is connected with one EWOD pin electrode, the two sides of the sound field and electric field multiplexing module, the two sides of the sound standing wave field and thermal field module, the two sides of the focusing sound field and thermal field module and the two sides of the sound vortex enrichment module are all connected with the two sound wave pin electrodes, and one side of the sound field and electric field multiplexing module is further connected with one EWOD pin electrode. The method has the advantages of multi-dimensional sample treatment and high-flexibility treatment.

The invention belongs to the technical field of medical treatment, and particularly relates to a hemoglobin chyle joint detection device and a detection method.The hemoglobin chyle joint detection device comprises a shell, an analysis mechanism is arranged in the shell, and a colorimetric tube is inserted into the upper surface of the shell; the analysis mechanism comprises a light source module, a sample processing module, an optical detection module and a data processing module; the optical detection module synchronously acquires absorbance signals under two wavelengths through double detectors; the data processing module calculates hemoglobin concentration and chyle degree based on the dual wavelength absorbance values. The method is different from traditional single-index detection, two-parameter synchronous analysis of hemoglobin and chyle is achieved for the first time, and the preliminary screening efficiency before blood donation is remarkably improved. By adopting a dual-wavelength correction algorithm, the influence of residual absorption interference of hemoglobin at 580-700nm on chyle index determination is eliminated, and the influence of absorption interference of chyle at 480-570nm on hemoglobin determination is eliminated. The method is suitable for rapid screening on a blood sampling site to realize informatization management of detection data.

Provided herein are kits, systems and methods for analyzing analytes from a biological sample. The system includes an upper housing configured to receive a sample substrate and a thermal element configured to control a temperature of the sample substrate. The system includes a lower housing and an alignment mechanism coupling the upper housing to the lower housing. The alignment mechanism is configured to move the upper housing, the lower housing, or both into an arrangement having an open configuration, a closed configuration, or an intermediate configuration therebetween. The thermal element is configured to cool the sample substrate.

The invention provides a full-automatic pretreatment system and method for a soil sample, and belongs to the field of soil sample treatment.The system comprises a weighing device, a digestion device, a transfer device and a constant volume device with a workbench, the constant volume device comprises a first mechanical arm used for grabbing and cap screwing, a second mechanical arm used for pipetting, an annular conveying unit provided with a plurality of pipe supports, a pipe clamping unit and a liquid level calibration unit, and the pipe supports are provided with containing grooves matched with digestion pipes and colorimetric pipes respectively. The first manipulator is set to grab and screw caps of the digestion tube and the colorimetric tube from a first position of the annular conveying unit, and the second manipulator is set to transfer liquid from a second position of the annular conveying unit. The full-process automatic operation from weighing to final volume fixing and subpackaging of the soil samples is achieved, the working efficiency of the system is remarkably improved, and especially the treatment efficiency of a large batch of soil samples is improved.

One embodiment of the invention is directed to a sample processing system for analyzing a biological sample from a patient. The sample processing system comprises: a plurality of analyzers comprising at least one mass spectrometer, wherein each analyzer in the plurality of analyzers is configured to acquire at least one measurement value corresponding to at least one characteristic of the biological sample; at least one data storage component which stores (i) a list of parameters for the plurality of analyzers, and (ii) at least two condition sets, which contain data associated with completing one or more test orders. The condition sets contain data which differ by at least one variable; and a control system operatively coupled to the plurality of analyzers, and the at least one data storage component. The control system is configured to (i) determine which condition set of the at least two condition sets to use based on the determined condition set, (ii) determine which analyzer or analyzers of the plurality of analyzers to use to process each test order based on the determined condition set and one or more parameters from the list of parameters, and (iii) cause the determined analyzer or analyzers to acquire one or more measurement values for the biological sample.

The invention provides a micro-fluidic chip which comprises a uniform mixing layer, a chip dissolving cavity-dilution layer, a filtering layer and a focusing layer, cell sap and diluent can be preliminarily mixed by the uniform mixing layer and then fully diluted in the dilution layer, and the problem of non-uniformity possibly caused by single-time large-amplitude dilution is avoided. Then, the filter layer can effectively remove impurities and clotted cells. And finally, the focusing layer realizes cell focusing. The four functional layers of uniform mixing, diluting, filtering and focusing are sequentially stacked and integrated, so that the overall size of the microfluidic equipment is remarkably reduced, and high automation and optimization of the whole sample treatment process are realized.

Provided is a characteristic element combination anomaly derivative method of determining occurrence of a deep concealed plate-shaped ore body of a hydrothermal deposit. The method determines the spatial occurrence of the deep concealed ore body of the hydrothermal deposit through four working procedures, including: fine measurement of a metallogenic structure and systematic collection of samples, sample processing and multi-element quantitative analysis, mathematical model construction of characteristic element combination anomaly, and determination of the occurrence (the strike, the dip direction, the dip angle and the pitch direction) of the deep concealed ore body. The method solves the problem of judging the occurrence of the deep concealed ore body by interpreting geochemical anomalies of a primary halo and a secondary halo.

The invention discloses a large yellow croaker origin traceability discrimination method based on an element and FTIR fusion fingerprint spectrum. The method comprises the following steps: S1, sample treatment; s2, data acquisition: S2.1, mineral element data acquisition, and S2.2, FTIR spectrum acquisition; and S3, data analysis. Precise classification of production areas can be realized through principal component analysis (PCA), clustering analysis (CA) and linear discriminant analysis (LDA), the overall discriminant accuracy of back substitution inspection of the discriminant model reaches 100%, and the overall discriminant accuracy of cross inspection reaches 97.3%. The element and infrared spectrum fusion fingerprint technology is applied to the source tracing of the large yellow croaker producing area, and the application prospect is wide.

The utility model provides a high-flux non-contact ultrasonic crusher driven by fluid to rotate, which is provided with an annular groove, and liquid discharged from the interior of the annular groove relatively acts with a bracket baffle at the bottom of a disc-shaped bracket, so that the disc-shaped bracket is driven by the fluid to rotate relative to the annular groove, and ultrasonic treatment is carried out in the annular groove. According to the invention, batch samples are rotated in the annular ultrasonic field, so that the batch samples can be ultrasonically crushed under the same condition, the treatment condition is homogenized, the sample treatment capacity requirement is met, the consistency of sample crushing results is improved, and the treatment efficiency is greatly improved.

Described herein are methods, kits and systems for sample enrichment, multi-step library preparation, sample normalization, detection of sample biomolecules and combinations thereof. Enrichment and multi-step library preparation is described in the context of microfluidic workflows. Sample barcoding methods and kits are described for increasing sample throughput while reducing background in negative samples. Integrated microfluidic devices comprising sample processing unit cells coupled to an array of reaction sites are provided for integrated workflows.

The utility model provides an automatic sample injection system, which comprises a tray for accommodating a sample bottle; the conveying device comprises an upper conveying frame and has a first conveying direction for horizontally conveying the trays; the lower conveying frame is located below the upper conveying frame and has a second conveying direction for horizontally conveying the trays, and the first conveying direction is opposite to the second conveying direction; the lifting device comprises a lifting seat which is positioned on the same side of the upper conveying frame and the lower conveying frame; and the bearing frame is matched with the lifting seat and can vertically move in the extending direction of the lifting seat so as to be in butt joint with the conveying ends of the upper conveying frame and the lower conveying frame correspondingly, and transfer of the trays among the upper conveying frame, the lower conveying frame and the bearing frame is achieved. The sample detection and preparation efficiency is improved, the sample detection and preparation precision is improved, the method can adapt to the batch sample treatment process, and the batch sample detection and analysis requirement is greatly met.

The invention relates to the technical field of water quality detection, and particularly discloses a water quality detection device and method based on water environment pollution control, and the device comprises a water quality sampling assembly which is used for collecting layered water quality samples at different depths of a to-be-detected water area; the sample treatment assembly is communicated with the water quality sampling assembly and is used for mixing the layered water quality samples; the water quality data detection assembly comprises a first water quality data collector and a second water quality data collector; the data processing assembly is electrically connected with the water quality data detection assembly and used for processing and outputting the layered water quality index data and the mixed water quality index data, and the data processing assembly comprises a data preprocessing unit and a multi-dimensional data fusion unit which are in signal connection with each other so as to output standardized water quality data, the multi-dimensional data fusion unit is used for carrying out fusion processing on the standardized water quality data; therefore, the detection precision of the water quality detection device is improved.

The present invention relates to the preparation and application of a micro-cell in-situ microreactor. By subjecting the inner wall of a capillary to silanization treatment and modifying epoxy groups on its surface through free radical polymerization reaction, an open-tubular capillary column is prepared. Then, polyethyleneimine and iodoacetic acid-N-succinimidyl ester are successively modified by covalent bonding to prepare a solid-phase alkylated capillary microreactor. The advantages of the present invention are that proteomic sample processing is carried out in-situ, which is conducive to reducing sample loss caused by multiple transfers during traditional sample processing. Therefore, this solid-phase alkylated open-tubular column is suitable for proteomic pretreatment of trace samples. In addition, this method is tolerant to various surfactants and strong lysis reagents and has good sample compatibility.

Interoperable systems for performing sample preparation and analysis in a closed environment include a fluidic cartridge, including chambers for sample and reagents and sample processing, reaction chambers, chamber-connecting channels, and fluid control valves, actuators for closing and selectively opening one or more valves of the cartridge, a syringe pump and syringe driver for effecting fluid movement between chambers of the cartridge, thermal modules for heating or cooling reaction chambers disposed between the thermal modules, a thermal module actuator for moving the thermal modules into and out of thermal contact with the reaction chambers, a contact detector for detecting the presence of a fluidic cartridge between the thermal modules, optical fibers for transmitting optical signals through openings in at least one of the thermal modules, and optical devices for transmitting optical signals through the fibers to the reaction chambers and / or receiving optical signals transmitted by the optical fibers from the reaction chambers.

The invention relates to the technical field of geological exploration, and particularly discloses a geological exploration data extraction method, which comprises the steps of multi-source data acquisition, preprocessing, feature data extraction, data fusion and verification and data output. Geological radar data, gravity data, magnetic method data and soil samples are collected; the pretreatment comprises filtering, correction and sample treatment; feature extraction comprises fault wrinkle identification, abnormal body distribution inversion and element content analysis; building an association model by fusing data, and reworking when field verification is carried out and the accuracy is lower than 85%; and finally outputting the data passing the verification. According to the method, multi-source data are integrated, technologies such as self-adaptive median filtering are adopted, through fusion verification, the comprehensiveness, accuracy, reliability and efficiency of data extraction are improved, and the method adapts to a complex geological environment.

The present application relates to the technical field of coal sampling machinery, and particularly relates to a novel automobile sampling machine, which comprises a sampling execution device, a sample processing device and a control device. The sampling execution device is provided with a screw drill type sampling head, a driving mechanism, a lifting mechanism and a cleaning mechanism; the sample processing device comprises a sample collector and a sample preparation unit. The control device is connected with each device through an industrial communication bus and is configured to perform a sampling point random determination operation to generate coordinate information, control the sampling head to move to a target position, then drive the outer cylinder sawtooth structure to rotate and cut and break the lump coal in a breaking mode, and then switch to a sampling mode to drive the internal drill rod to drill and sample; the sampling amount is monitored through a sensor to generate a stop signal, the sampling head is controlled to be lifted to the sample collector to release the coal sample, and finally the cleaning mechanism is started to clean the residues. The present application realizes the automatic sampling of coal of all particle sizes and effectively solves the sample distortion problem caused by the fact that lump coal cannot be sampled.

The present invention discloses a pressure-balanced continuous discharge device for waste liquid in sample pretreatment, belonging to the technical field of water quality sample treatment. A pressure-balanced continuous discharge device for waste liquid in sample pretreatment includes: a filtrate collection bottle; a liquid inlet pipe and a first vacuum pipe are connected to the bottle mouth of the filtrate collection bottle; a waste liquid converter; the waste liquid converter is respectively connected to the top and bottom of the filtrate collection bottle; the waste liquid converter is also respectively connected to a first waste liquid bottle and a second waste liquid bottle. Through the conversion of the waste liquid converter, the waste liquid alternately enters the first waste liquid bottle and the second waste liquid bottle to achieve continuous discharge. The waste liquid converter of the present invention can change the filtrate flow path, and under the action of an external vacuum device, alternately introduce the filtrate into the first waste liquid bottle and the second waste liquid bottle to achieve continuous discharge of the filtrate. The whole operation is simple, avoiding repeated emptying and vacuum pumping operations, thereby improving the sample quality and greatly improving the operation and work efficiency.

This invention discloses a controlled-release solid film formulation for pesticides, its preparation method, and its applications. This invention upgrades pesticides from liquid / powder formulations to solid film formulations, utilizing the solid film to physically block pesticide drift, diffusion, and loss, reducing off-target effects at the source. Through the combined use of physical and chemical techniques, pesticides are uniformly distributed within the solid film, and the pesticide release cycle is synchronized with the solid film degradation, achieving precise controlled release. This solid film formulation is applied from the beginning of crop growth, synchronized with the plant growth cycle, providing early preventative effects through quantitative controlled release of pesticides. This solid film formulation also functions as a mulch film; its preparation process is simple and easy, it is completely degradable and requires no recycling, reducing costs. The identification method of this invention utilizes selective precipitation separation technology, achieving high pesticide extraction efficiency of 95%-98%, especially suitable for low water-soluble pesticides. The drug identification process is simple to operate: the entire process takes less than 4 hours, requires no complex purification steps, and is suitable for batch sample processing.

Systems and corresponding methods transfer liquid sample from a first container having a cap with a sample collection swab coupled thereto to a second container having a cap without such sample collection swap coupled thereto. Other systems and corresponding methods remove a cap having no sample collection swab coupled thereto from a first container and remove a cap having a sample collection swab coupled thereto from a second container containing a liquid sample. The cap with the sample collection swab coupled thereto is then secured to the first container and the cap having no sample collection swap coupled thereto is then secured to the second container.

Disclosed are nanofluidic analytical devices. The devices employ a sample processing region that includes a plurality of fluidically connected sample handling elements that, in combination, affect a physical change on a sample introduced into the sample processing region. This physical change can include, for example, purification of an analyte of interest present in the sample, concentration of an analyte of interest present in the sample, chemical modification (e.g., cleavage and / or chemical derivatization) of an analyte of interest present in the sample, or a combination thereof. The analytical devices further include a nanochannel comprising a plurality of in-plane nanopores in series fluidically coupled to the sample processing region. The in-plane nanopores can be used to detect and / or analyze analyte(s) present in the sample following processing by the sample processing region. These analytical devices can advantageously provide for the label-free detection of single molecules.

This utility model relates to the field of metallographic preparation technology, specifically to a metallographic sample fixture, including a base, a support platform for placing metallographic samples on the base, a housing between the support platform and the base, and a plurality of claws arranged in a circular array on the housing. The claws are rotatably connected to the housing, and the top of the claws has a protruding abutment portion. A push rod is slidably arranged on the housing, one end of the push rod abutting against the bottom of the claws. An adjustment component is provided inside the housing, the adjustment component including a turntable and a plurality of protrusions arranged in a circular array on the circumference of the turntable. The outer surface of the protrusions protrudes outward to form an arc-shaped surface, and the arc-shaped surface of the protrusions abuts against the other end of the push rod. The metallographic sample pre-fabrication fixture provided by this utility model has a simple structure and is easy to operate, which can solve the problems of difficult sample handling and uneven sample grinding during the metallographic sample polishing process.

An automated apparatus can provide pre-analytical processing of samples, racking and forwarding to an adjacent analyzer for analysis. The apparatus may have a controller that implements an auto-learn process to teach robotic handlers the locations within the workspace(s) of the apparatus. A robotic sample handler may include a sensor configured to generate a detection signal when in a near vicinity of a fiducial beacon in the workspace of the apparatus for biological sample preparation, preprocessing and / or diagnostic assay performed by one or more analyzers of the automated apparatus. The controller may control the robotic sample handler to conduct a search pattern so that a location of the fiducial beacon may be detected and thereafter calculated to obtain a more accurate location of the beacon. The calculated positions may then serve as a basis for the controlled movement of samples by the robot to and from locations of the workspace.

The application discloses a flow cytometry sample processing system and belongs to the technical field of automatic processing of biological samples. The flow cytometry sample processing system comprises a machine table, a flow tube block placing structure, a transfer mechanical arm, a shaking module and a centrifuge. The flow tube block placing structure is arranged on the machine table, a flow tube block is arranged on the flow tube block placing structure, a flow tube is arranged on the flow tube block, the transfer mechanical arm provided with a clamping jaw can integrally transfer the flow tube block provided with a clamping hole to the shaking module and the centrifuge, and the whole process automation is truly realized, and the sample centrifugal processing efficiency is improved.

The utility model discloses a food additive detection device which comprises a shell, the shell is of a hollow cylinder structure, a feeding hopper is arranged on the upper surface of the shell in a penetrating mode, a box body is fixedly connected to one side of the shell, a chromatographic column is arranged in the box body, an analyzer is fixedly arranged in the box body, and a detection module is arranged in the analyzer. An analyzer is fixedly mounted on the upper surface of the box body, the analyzer is connected with the chromatographic column, a control panel is fixedly mounted on the upper surface of the box body, the control panel is connected with the analyzer, a sample treatment structure is arranged in the shell, and the sample treatment structure is provided with a multi-stage treatment mode to treat food into sample liquid to be detected. According to the food additive detection device, the crushing cylinder, the stirring cylinder and the filtering cylinder are sequentially arranged in the shell, a food sample to be detected is pretreated, the food detection efficiency is improved, and treatment structures in the crushing cylinder, the stirring cylinder and the filtering cylinder are connected to the output end of the same motor through the rotating cylinder, so that the energy consumption of the device is reduced.