58 results about "Sample handling" patented technology

This invention discloses a controlled-release solid film formulation for pesticides, its preparation method, and its applications. This invention upgrades pesticides from liquid / powder formulations to solid film formulations, utilizing the solid film to physically block pesticide drift, diffusion, and loss, reducing off-target effects at the source. Through the combined use of physical and chemical techniques, pesticides are uniformly distributed within the solid film, and the pesticide release cycle is synchronized with the solid film degradation, achieving precise controlled release. This solid film formulation is applied from the beginning of crop growth, synchronized with the plant growth cycle, providing early preventative effects through quantitative controlled release of pesticides. This solid film formulation also functions as a mulch film; its preparation process is simple and easy, it is completely degradable and requires no recycling, reducing costs. The identification method of this invention utilizes selective precipitation separation technology, achieving high pesticide extraction efficiency of 95%-98%, especially suitable for low water-soluble pesticides. The drug identification process is simple to operate: the entire process takes less than 4 hours, requires no complex purification steps, and is suitable for batch sample processing.

This utility model relates to the field of metallographic preparation technology, specifically to a metallographic sample fixture, including a base, a support platform for placing metallographic samples on the base, a housing between the support platform and the base, and a plurality of claws arranged in a circular array on the housing. The claws are rotatably connected to the housing, and the top of the claws has a protruding abutment portion. A push rod is slidably arranged on the housing, one end of the push rod abutting against the bottom of the claws. An adjustment component is provided inside the housing, the adjustment component including a turntable and a plurality of protrusions arranged in a circular array on the circumference of the turntable. The outer surface of the protrusions protrudes outward to form an arc-shaped surface, and the arc-shaped surface of the protrusions abuts against the other end of the push rod. The metallographic sample pre-fabrication fixture provided by this utility model has a simple structure and is easy to operate, which can solve the problems of difficult sample handling and uneven sample grinding during the metallographic sample polishing process.

The application discloses a flow cytometry sample processing system and belongs to the technical field of automatic processing of biological samples. The flow cytometry sample processing system comprises a machine table, a flow tube block placing structure, a transfer mechanical arm, a shaking module and a centrifuge. The flow tube block placing structure is arranged on the machine table, a flow tube block is arranged on the flow tube block placing structure, a flow tube is arranged on the flow tube block, the transfer mechanical arm provided with a clamping jaw can integrally transfer the flow tube block provided with a clamping hole to the shaking module and the centrifuge, and the whole process automation is truly realized, and the sample centrifugal processing efficiency is improved.

In one aspect, the application relates to a robotic sample handling system comprising a controller and a robot arm, the robot arm being controllable to be positioned within a horizontal XY plane parallel to a work area and along a vertical Z axis perpendicular to the work area. The work area comprises a module provided with a movable element (550) for interacting with a sample container (170). The module is equipped with a mechanism comprising: - a first linear element (210) and a second linear element (220), the first and second linear elements extending along the vertical direction Z and being mounted to the module in such a way that each linear element is movable in a downward and upward direction between a raised position and a lowered position; and - at least one rotor element (230) engaged with each of the first and second linear elements, such that when one of the first and second linear elements is in the raised position, exerting a downward force on this linear element results in: displacement of this linear element in the downward direction; rotation of the at least one rotor element; and, displacement of the other linear element in the upward direction. The movable element (550) is mounted in connection with the rotor element and is displaceable between a first position and a second position. The controller is configured to control the robot arm to displace the movable element by pushing against one of the first and second linear elements in the Z direction downward when this linear element is in the raised position.

A rapid formaldehyde content detection device for hair products, relating to the field of formaldehyde detection technology, is used to achieve rapid and accurate detection of formaldehyde in hair products while meeting the requirements of convenience. The rapid formaldehyde content detection device for hair products includes a housing, an optical detection system, a sample processing system, an electronic control system, a software system, and a transparent detection tube. The housing is rectangular, with three drawer-style compartments inside: the upper compartment is the optical detection system compartment, the middle compartment is the electronic control system compartment, and the lower compartment is the sample processing and storage compartment. Shock-absorbing rubber pads and metal supports are installed between the optical detection system compartment and the electronic control system compartment, and between the electronic control system compartment and the sample processing and storage compartment. The bottom of the housing has binding straps for securing it, and the side of the housing has an openable transparent observation window. The optical detection system includes a laser light source module, a spectral collection component, and a detector. The sample processing system includes a sample stage, auxiliary devices, and a transparent detection tube.

A method of loading consumables into a sample processing instrument. In the method, a tray storing sample processing consumables is aligned with a support cavity defined by a support of the sample processing instrument. A flange is contacted with a portion of the support, where the flange extends outward from a wall of a cover coupled to the tray. The cover is decoupled from the tray by pressing a panel of the cover, and the tray is seated in the support cavity.

The application discloses a controllable liquid level parallel automatic solid phase extraction instrument, and belongs to the field of analytical chemistry sample pretreatment. The extraction instrument comprises a liquid adding system, a solid phase extraction column array unit and a collecting tube device which are electrically connected with a control system. The solid phase extraction column array unit is arranged below the liquid adding system, and the collecting tube device is arranged below the solid phase extraction column array unit. The liquid adding system comprises a liquid adding pipe for adding reagents to the solid phase extraction column array unit. The extraction column has the function of automatically controlling or maintaining the liquid level, and the diameter and height of each component of the extraction column can be flexibly adjusted according to the requirement. The liquid level in the extraction column can be monitored, all the extraction columns can simultaneously and in parallel process samples, and the sample processing efficiency and reliability are improved.

The application discloses a kind of multilayer sample pretreatment device and processing method, multilayer sample pretreatment device includes frame body, first shelf layer, second shelf layer and transfer unit, first shelf layer includes sequentially arranged several first warehouse storage sites, second shelf layer includes sequentially arranged code scanning position and several second warehouse storage sites, transfer unit is between code scanning position and second warehouse storage site, between first shelf layer and second shelf layer, second shelf layer and subsequent detection process, conveying unit between transfer sample frame.Sample pretreatment method, transfer unit preferentially transfers sample frame and test tube thereon between second shelf layer and subsequent detection process, recovery conveying unit.The application has reasonable structure, can adapt to large quantities of sample processing, conveying efficiency is high and degree of automation is high, and it is conducive to popularization and application.

A method of processing a sample includes verifying that an identifier of a first carrier detected at a first position on a host conveyor assembly is associated with a first sample on which a first assay is scheduled to be performed with a first instrument. The method includes diverting the first carrier from the host conveyor assembly to a first intermediate conveyor assembly. The method includes transporting the first carrier to a first processing position within the first instrument. The method includes verifying that an identifier of the first carrier detected at the first processing position is associated with the first sample. The method includes transferring at least a portion of the first sample from a first processing receptacle coupled to the first carrier to a first assay receptacle. The method includes performing the first assay by subjecting the portion of the first sample to nucleic acid amplification reaction conditions.

An exemplary method and system is disclosed that facilitate the integration of multiplexed single-cell impedance cytometry in a high throughput format, which can be deployed upstream from microfluidic sample preparation and / or downstream to microfluidic cell separation. In exemplary method and system may employ impedance-based quantification of cell electrophysiology on the same microfluidic chip (i.e., “on-chip”) to provide distinguishing phenotypic information on the sample, without the need for additional sample handling, preparation or dilution steps as would be needed for other flow cytometry techniques.

The application discloses a magnetic linkage non-contact driving closed cartridge, relates to the technical field of closed sample processing and detection, and comprises a base and an upper cover. A pipette is arranged in the inner cavity of the upper cover. The central hole of the pipette is slidably sleeved on the cylindrical inner recess of the upper cover. The upper end surface of the pipette is provided with a support part around the central hole. The support part is provided with groove cavities. A magnetic part one is fixedly embedded in each groove cavity. A pipette tip is fixedly arranged on the outer ring of the pipette. The rotation and axial movement of the pipette are controlled by using magnetic force, thereby forming non-contact driving. The sealing property of the cartridge is effectively ensured. Meanwhile, the sealing ring and other mechanisms are avoided, the difficulty of sealing the internal space is greatly reduced, the leakage risk is reduced, the size of the driving mechanism is reduced, and the precision of pipette movement control is greatly improved.

Certain embodiments are based on the discovery of a method for monitoring formation and dissociation of E2-Ubl conjugates in protein ubiquitination reactions. The methods use the fluorescence signal produced by a FRET-active E2-Ubl conjugate, wherein E2 is covalently labeled with one fluorophore, Ubl is labeled with a second fluorophore, and the two fluorophores form a FRET-active pair. The methods can be used in different assays in which E2-Ubl conjugates are formed or dissociated, for example in assays for monitoring enzymatic activity of E1 ubiquitin activating enzymes or enzymatic activity of E3 ubiquitin ligases. The method allows monitoring formation or / dissociation of E2-Ubl conjugates in real time with high sensitivity using widely available scientific instruments for measuring fluorescence and does not require labor intensive and error prone sample processing and analysis procedures. The method enables measurements of E1 or E3 activity in the high-throughput format.

The present disclosure relates to a fluidics system with vacuum sampling. The fluidics system comprises a flow cell, a sampling subsystem, a sheath subsystem, a waste subsystem and a compressed air subsystem. The sampling subsystem is coupled with an inlet of the flow cell and provides sample fluid to the flow cell. The sheath subsystem is coupled with the inlet of the flow cell and provides sheath fluid to the flow cell. The waste subsystem is coupled with an outlet of the flow cell, and the sheath fluid and the sample fluid are discharged from the waste subsystem after passing through the outlet of the flow cell. The compressed air subsystem is coupled with the sheath subsystem and provides compressed air to the sheath subsystem. Further provided are a sample processor and a method for controlling a sample flow rate in the sample processor according to the present disclosure. The fluidics system, the sample processor and the method for controlling the sample flow rate in the sample processor according to the present disclosure can achieve significantly improved control accuracy.

This application discloses a method for determining the fermentation degree of Bozhou chrysanthemum glutinous rice wine based on volatile components, relating to the field of alcoholic beverage fermentation detection technology. The method includes: S1. Sample preparation: 2 mL of Bozhou chrysanthemum glutinous rice wine sample is placed in a 20 mL headspace vial, 10 µL of 100 ppm 2-octanol internal standard solution is added, and the vial is sealed and incubated at 60°C for 15 min. Three parallel samples are set up for each sample; S2. Headspace sampling; S3. GC-IMS combined detection; S4. Data processing and qualitative analysis; S5. Multidimensional analysis of volatile components; S6. Screening of characteristic volatile components; S7. Determination of fermentation degree. This method for determining the fermentation degree of Bozhou chrysanthemum glutinous rice wine based on volatile components applies GC-IMS technology to the determination of the fermentation degree of Bozhou chrysanthemum glutinous rice wine. The detection process is carried out at room temperature, which can truly reflect the actual flavor components in the sample. Furthermore, it eliminates the need for sample enrichment and concentration; liquid samples can be directly detected via headspace sampling, saving time and effort and achieving high detection efficiency.

Diagnostic detection chip device designs that reduce cost of fabrication and assembly are described herein. Such chip device designs include features that facilitate use of the chip within a chip carrier device with integrated fluid flow control features and compatibility with conventional sample cartridges and sample processing systems. Associated methods of manufacture and assembly of the chip devices are also provided herein.

The application discloses a kind of Sabina pollen aerosol chemical component detection and feature database construction method, comprising the following steps: (1) sample processing: collecting Sabina flower, after drying and crushing, extraction is obtained to be measured solution;(2) using the method of ultra-high performance liquid chromatography-quadrupole / or electrostatic field orbitrap high-resolution mass spectrometry, small molecule chemical components in Sabina pollen are systematically separated and identified;(3) data processing: including database establishment, data acquisition and processing, relevant literature search, representative compound selection and cleavage rule derivation.The present application not only lays a theoretical foundation for the rapid screening of Sabina pollen allergenic small molecule markers, the analysis of allergenic mechanisms, and the prevention and control of spring pollen allergy, but also provides a referenceable technical method for the identification of chemical components and mass spectrometry behavior research of similar pollen plants.

The application provides an electron beam lithography machine sample taking and delivering system, which is an electron beam lithography machine sample taking and delivering system based on a cavity isolation technology, a pre-receiving cavity (equipped with a two-stage vacuum system of a molecular pump and a mechanical pump) with independent vacuum pumping capacity is arranged to dynamically isolate the main sample cavity, and a door valve is used for realizing local vacuum maintenance during sample transmission. The technical effect is that: through the pre-receiving cavity pre-vacuum and the sample cavity vacuum isolation mechanism, the sample changing operation only needs to perform local vacuum pumping on the pre-receiving cavity for a short time, and compared with the traditional whole cavity vacuum pumping process, the speed is significantly improved; the molecular pump group operation time is shortened, the single sample changing energy consumption is reduced; the modular vacuum system design reduces the equipment area and the vacuum pipeline complexity, and through the closed loop control of the air release valve and the vacuum gauge, the system reliability and the maintenance convenience are significantly improved.

This invention provides a sample pretreatment kit and its application for the simultaneous detection of Aβ40, Aβ42, and lencanezumab, belonging to the field of biodetection technology. The kit includes: mixed magnetic beads, internal standard solution, trypsin digestion solution, enzyme digestion enhancer, and ammonia; the mixed magnetic beads are composed of protein A magnetic beads and streptavidin magnetic beads; the internal standard solution is composed of… 15 N-labeled Aβ40, 15 This kit consists of N-labeled Aβ42 and lencanezumab internal standard peptides. The pretreatment kit eliminates the need for anti-IgG1 antibodies, requiring only Protein A for detection, thus shortening sample processing time, greatly simplifying the sample handling process, and increasing throughput. The kit can simultaneously detect Aβ40, Aβ42, and lencanezumab, providing more reliable data support for clinical diagnosis and treatment efficacy evaluation, and significantly promoting the development of companion detection technologies for Alzheimer's disease biomarkers and therapeutic drugs.

The utility model provides a kind of microfluidic chip, including the mixing layer, dilution layer, filter layer and focusing layer that are sequentially stacked, each functional layer internal flow passage sequence communication, to build a compact structure, complete automation cell sample processing system of function.Firstly, mixed flow channel is used to mix cell liquid and diluent, then through mixing and diluting cavity, cell liquid is efficiently and uniformly gradient diluted;Subsequently, sample flow is filtered to accurately remove impurities and cell mass, improve the purity of sample.Finally, the liquid focusing section in focusing layer can arrange the processed cells by hydrodynamics, so that it is arranged in order to pass, to create ideal conditions for subsequent cell counting device accurate optical detection and counting.By sequentially stacking the four functional layers of mixing, dilution, filtration and focusing, the overall volume of the microfluidic device is significantly reduced, and the automation and optimization of the whole sample processing process are realized.

The present invention relates to a cartridge (101) for sample pre-treatment. The cartridge (101) includes a sample chamber (103) that is defined at a top portion (101a) of the cartridge (101) and configured to receive the sample and a pre-treatment reagent through an opening that is and are lysed to for a pre-treated sample. The cartridge (101) also includes a plurality of reaction wells (105) that are defined at a bottom portion (101b) of the cartridge (101). Further, at least one valve (104) is fluidly connected to the sample chamber (103) and the plurality of reaction wells (105). The at least one valve (104) is configured to control a flow of the pre-treated sample from the sample chamber (103) to the plurality of reaction wells (105). The cartridge (101) further includes a cap (102) that is externally connectable to the opening defined on the sample chamber (103).

This application relates to proteomics extraction technology, specifically to a proteomics pretreatment device and an automated reaction system including the same. More specifically, it relates to a stacked proteomics pretreatment device adapted to an automated platform and an automated reaction system including the same. This application provides a proteomics pretreatment device, comprising: a carrier, and, located inside the carrier, a fastening layer, an ion exchange layer, a support layer, an extraction layer, and a leak-proof layer stacked from top to bottom; wherein the support layer comprises glass beads with an average particle size of 100-200 μm. Using the proteomics pretreatment device of this invention can reduce air bubbles while improving the uniformity of experimental data. The proteomics pretreatment device provided by this invention can achieve automated operation based on automated devices, improving sample processing throughput while also improving the accuracy of quantitative analysis.

A sample processor including a body including an inner surface that defines a chamber including an opening in a side of the body and including a volume to accommodate a least one microscope slide therein; a door comprising a first position to cover the opening of the body and a second position to expose a portion of the chamber through the opening; a slide bed disposed in the chamber; one of an internal humidity generator disposed in the chamber and an external humidity generator coupled to the chamber. A system including at least one sample processor at least one reagent outside the body of the at least one sample processor and a method including subjecting a sample on a microscope slide in a sealed chamber to a pressure greater than ambient and a humidity greater than 60 percent; and processing the sample.

Provided herein are methods and compositions for processing a target nucleic acid sequence. The methods and compositions provided herein comprise a detergent, a solubilizer, and a cyclodextrin configured to stabilize enzymes and nucleic acids. The processed target nucleic acid sequence can be further contacted with a reaction mixture used in nucleic acid amplification (e.g., isothermal amplification). The processed target nucleic acid sample can be contacted with a stabilization buffer configured to stabilize one or more enzymes in nucleic acid amplification. The processed target nucleic acid sample can be further contacted with an amplification buffer configured to increase the rate of amplification during nucleic acid amplification (e.g., isothermal amplification).

This invention relates to a biochemical sample processing and analysis device, comprising a housing and a display module, a sample processing module, a detection and analysis module, and a control system disposed within the housing. The sample processing module includes a sample box, a stock solution tank, a dilution tank, and a pipetting platform located on the upper part of the housing. A temperature control module is disposed below the sample box. The pipetting platform includes a three-dimensional motion mechanism, a pipette, and a pipetting pump. The detection and analysis module includes one or more of a photoelectric detection component, an ion detection component, and an enzyme membrane detection component. The control system is communicatively connected to the sample processing module, the detection and analysis module, and the display module.

This invention relates to the field of soil science and environmental testing equipment technology, and particularly to a soil profile collection machine, comprising: a collection machine body, a frame fixedly connected to one side of the collection machine body, a vertically arranged chain drive mechanism mounted on the frame, and a soil profiler detachably connected to the chain drive mechanism via a cover plate. This invention achieves automated and standardized profile collection by driving the detachable soil profiler vertically into the soil via the chain drive mechanism. The soil profiler adopts a trapezoidal wedge-shaped entry design, along with built-in springs and liners, effectively reducing the adsorption force and static friction between the sample side and the inner wall of the outer shell, avoiding potential sample structure damage due to excessive friction. Furthermore, the detachable connection design of the cover plate, hook, and hook on the chain drive mechanism allows for rapid separation and connection of the soil profiler and the drive mechanism, improving the convenience of sample handling.

This invention discloses an automatically positioning centrifuge, comprising: a centrifuge chamber containing a centrifugal motor, the output end of which is fixedly connected to a centrifugal spindle; a drive motor and a control motor with a shaft-locking function also located inside the centrifuge chamber; and a centrifugal rotor, positioned at the top of the centrifugal spindle for holding centrifuge tubes. This invention can automatically limit the position of the centrifugal spindle when the centrifuge lid is opened, providing emergency braking for the rotating rotor to handle unexpected situations. It can also maintain the spindle's position during rotor replacement, reducing the difficulty of the replacement process. Furthermore, after the centrifuge lid is opened, the invention allows a control component to move to a position aligned with the centrifugal rotor spindle, and through the cooperation of the control motor and a calibration component, the rotor can be precisely moved to a position convenient for manual or robotic sample handling, thereby reducing the difficulty of manual sample handling and providing a foundation for automated centrifuge operation.

The application provides a workstation control method, device, equipment, medium and product, and relates to the technical field of sample processing. The method comprises the following steps: receiving user input data, wherein the user input data comprises a first identifier of a to-be-processed sample, a second identifier of a to-be-controlled workstation, and an operation task required by the to-be-controlled workstation for the to-be-processed sample; inputting the user input data into a digital twin three-dimensional model to obtain simulation data output by the digital twin three-dimensional model; determining that there is no abnormal simulation data in the simulation data, generating a control instruction corresponding to the user input data, and sending the control instruction to the to-be-controlled workstation corresponding to the second identifier. The application improves the accuracy and reliability of workstation operation, reduces the risk of errors or failures in actual operation, and realizes efficient control and optimization of the sample processing process.

The utility model provides a kind of desulfurization slurry detection device, including detection module and with the detection module connection automation control module, the detection module includes pipeline and is sequentially arranged on the pipeline sampling assembly, filtering component and index detection component, the automation control module includes programmable logic controller and with the programmable logic controller connection data analysis software and touch screen display.The utility model can improve detection precision, sample processing capacity and degree of automation, reduce maintenance cost and complexity.

Systems and methods for improved sample gripping solutions are provided. In particular, this disclosure relates to sample holder sliding guides and methods for using the same. An exemplary apparatus for handling a sample may comprise a sample holder configured to engage with a sample, one or more gripping devices configured to grip the sample after insertion, and a guide. The sample holder may comprise one or more holding components configured to receive the sample in a flat position, and one or more fixing components configured to fix and maintain the sample in a flat position after insertion into the sample holder. The guide may comprise one or more guide components configured to allow the guide to be connected to components in the apparatus, to engage the sample holder with the sample, and to allow the sample holder to move together with the sample into one or more gripping devices.