This invention discloses a method for fabricating a
photonic crystal hydrogel film sensor with a self-reporting
elastic modulus function and its application. The method involves fabricating a
hydrogel film with a periodic
photonic crystal structure and constructing a bio-interface on its surface that can dynamically regulate
cell adhesion, detachment, spreading, migration, proliferation, and differentiation. An
optical imaging system is used to acquire images of the structural
color changes of the
photonic crystal hydrogel film.
Image processing extracts color parameters, which are then converted into changes in reflected
wavelength and the film deformation field. The
elastic modulus of the film is calculated by inverting the deformation field generated by microspheres of known
mass placed on the film surface, combined with an elasticity model. By combining the
cell-interface interaction deformation field, the
cell-interface interaction force and its
spatial distribution can be obtained. A photonic
crystal hydrogel film sensor with a self-reporting
hardness function is constructed. This method achieves integrated biomechanical research combining dynamic regulation and real-time monitoring, offering advantages such as non-destructive operation, real-time imaging, and acquisition of mechanical
spatial distribution.