The invention provides an antimicrobial phosphate glass composition including, in weight percent based on oxide: greater than 45 to 90 of P2O5, 0 to 60 of B2O3, 0 to 40 of SiO2, 0 to 20 weight percent of Al2O3, 0 to 30 of SO3, 0 to 0.1 of Li2O, 0 to 0.1 of Na2O, 0 to 0.1 of K2O, 0 to 40 of CaO, 0 to 40 of MgO, 0 to 15 of SrO, 0 to 40 of BaO, 0 to 40 of ZnO, 0 to 5 of Ag2O, 0 to 15 of CuO, 0 to 10 of Cr2O3, 0 to 10 of I—, 0 to 10 of TeO2, 0 to 10 of GeO2, 0 to 10 of TiO2, 0 to 10 of ZrO2, 0 to 10 of La2O3, 0 to 5 of Nb2O3, 0 to 5 of CeO2, 0 to 5 of Fe2O3, 0 to 5 of WO3, 0 to 5 of Bi2O3, and 0 to 5 of MoO3.