Anti-infection biological ceramic artificial bone and application thereof

Abstract

The invention provides an anti-infection biological ceramic artificial bone and application thereof. The artificial bone is prepared by the following method that biological ceramics, bioglass sintering auxiliary agents and bonding agents are mixed; the obtained mixture is formed to obtain a composite blank body; the bioglass sintering auxiliary agents are selected from silicate glass and / or phosphate glass; antibacterial ions and bone vascularization promotion ions are mixed in the bioglass sintering auxiliary agents; the antibacterial ions are selected from one or several kinds of materials from silver, gallium, copper and zinc; the bone vascularization promotion ions are selected from one or several kinds of materials from magnesium, strontium, iron, boron, cobalt and lithium; the total amount of substances of oxides of the antibacterial ions and oxides of the bone vascularization promotion ions accounts for 0.1 to 60 percent of the amount of substance of the bioglass sintering auxiliary agents; the mol ratio of the antibacterial ions to the bone vascularization promotion ions is (0.05 to 20):1; the composite blank body is sintered to obtain the biological ceramic artificial bone. The anti-infection biological ceramic artificial bone has the advantages of high intensity and low cell toxicity; the antibacterial ion release speed is controllable; the release time is long.

Description

technical field [0001] The invention relates to the technical field of biomanufacturing or biomedical materials, in particular to an anti-infection bioceramic artificial bone and its application. Background technique [0002] During the clinical treatment of bone defects, the implantation of biomaterials is often accompanied by a greater risk of bacterial contamination, which is likely to form a source of chronic infection. Prevention and treatment of infection associated with bone implants is an urgent clinical problem that needs to be solved. The most widely used antibiotic delivery system material in clinic is polymethyl methacrylate (PMMA) bone cement, but PMMA bone cement does not degrade, has poor biological activity, easily causes loosening, and is difficult to restore the biological function of the bone defect area. In the treatment of bone defects, not only the anti-infection problem, but also the bone repair effect of bone repair materials should be considered. ...

AI Technical Summary

Problems solved by technology

Due to the slow degradation of bioceramics, the release rate of antibacterial ions is also slow

In addition, the sintering performance of bioceramic artificial bones is generally poor. In order to ensure that bioceramics have high enough strength, it is generally necessary to sinter at a relatively high temperature; this will lead to high crystallinity of bioceramics, and the degradation rate of materials And antibacterial ion release rate is further reduced

Therefore, it is necessary to incorporate high concentrations of antibacterial ions to achieve antibacterial and bactericidal effects in the initial stage of artificial bone implantation. However, long-term release of high concentrations of antibacterial ions will lead to obvious toxicity.