Anti-infection biological ceramic artificial bone and application thereof

A bioceramics and artificial bone technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of slow degradation of bioceramics, slow degradation rate and release rate of antibacterial ions, and high crystallinity of bioceramics

Active Publication Date: 2017-09-22
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the slow degradation of bioceramics, the release rate of antibacterial ions is also slow
In addition, the sintering performance of bioceramic artificial bones is generally poor. In order to ensure that bioceramics have high enough strength, it is generally necessary to sinter at a relatively high temperature; this will lead to high crystallinity of bioceramics, and...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] with P 2 o 5 、Na 2 CO 3 , CaCO 3 , SrCO 3 , AgNO 3 as the raw material, and the glass oxide corresponding to each substance is P 2 o 5 、Na 2 O, CaO, SrO, Ag 2 O, mix the raw materials evenly, put them into the furnace, heat to 1300°C, keep warm for 2 hours to obtain a clear glass solution, then pour the glass solution into water to quench, collect glass particles, dry at 150°C, and grind, that is Obtain Ag and Sr bioglass sintering aid (composition is 45P 2 o 5 -20Na 2 O-15CaO-12SrO-8Ag 2 O);

[0048] β-tricalcium phosphate, bioglass sintering aid and polyvinyl alcohol powder were ball milled to obtain a homogeneous mixture, which was then dried at 80°C. The mass ratio of β-tricalcium phosphate to bioglass sintering aid is 80:20. Based on the total mass of β-tricalcium phosphate, bioglass sintering aid and polyvinyl alcohol as 100%, the mass percentage of polyvinyl alcohol is 2%.

[0049] Put the dried mixture into the mould, carry out compression moldin...

Embodiment 2

[0052] SiO 2 , CaCO 3 ,P 2 o 5 , Ga 2 o 3 , AgNO 3 , SrCO 3 As the raw material, the glass oxide corresponding to each substance is SiO 2 , CaO, P 2 o 5 , Ga 2 o 3 、Ag 2 O and SrO, mix the raw materials evenly, put them in the furnace, heat to 1400°C, keep warm for 2 hours to obtain a clear glass solution, then pour the glass solution into water to quench, collect the glass particles, dry and grind to obtain Containing Ag, Ga and Sr bioglass sintering aids (the composition is 49SiO 2 -36CaO-2P 2 o 5 -5Ga 2 o 3 -2Ag 2 O-6SrO);

[0053] The calcium silicate, the bioglass sintering aid and the methyl cellulose are ball-milled to obtain a uniform mixture, and then mixed with water to obtain a mixture slurry. The mass ratio of calcium silicate and bioglass sintering aid is 85:15. Based on 100% of the total mass of calcium silicate, bioglass sintering aid and methyl cellulose, the mass percentage of methyl cellulose is 15%. Based on the total mass of calcium sil...

Embodiment 3

[0057] with P 2 o 5 、Na 2 CO 3 , CaCO 3 , ZnO, CuO, AgNO 3 is the raw material, and the glass oxide corresponding to each substance is P 2 o 5 、Na 2 O, CaO, ZnO, CuO, Ag 2 O, mix the raw materials evenly, put them into the furnace, heat them to 1200°C, and keep them warm for 2 hours to obtain a clear glass solution, then pour the glass solution into water to quench, collect the glass particles, dry, and grind to obtain Ag-containing , Cu and Zn bioglass sintering aids (composition is 50P 2 o 5 -25Na 2 O-15CaO-6ZnO-4CuO-5AgO);

[0058] Adding hydroxyapatite, β-tricalcium phosphate and biological glass sintering aid into polyvinyl butyral solution, and obtaining uniform mixture slurry after ball milling. The mass ratio of hydroxyapatite, β-tricalcium phosphate calcium carbonate and bioglass sintering aid is 35:55:10. The concentration of polyvinyl butyral was 7%. Based on 100% of the total mass of hydroxyapatite, β-tricalcium phosphate calcium carbonate, bioglass sin...

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Abstract

The invention provides an anti-infection biological ceramic artificial bone and application thereof. The artificial bone is prepared by the following method that biological ceramics, bioglass sintering auxiliary agents and bonding agents are mixed; the obtained mixture is formed to obtain a composite blank body; the bioglass sintering auxiliary agents are selected from silicate glass and/or phosphate glass; antibacterial ions and bone vascularization promotion ions are mixed in the bioglass sintering auxiliary agents; the antibacterial ions are selected from one or several kinds of materials from silver, gallium, copper and zinc; the bone vascularization promotion ions are selected from one or several kinds of materials from magnesium, strontium, iron, boron, cobalt and lithium; the total amount of substances of oxides of the antibacterial ions and oxides of the bone vascularization promotion ions accounts for 0.1 to 60 percent of the amount of substance of the bioglass sintering auxiliary agents; the mol ratio of the antibacterial ions to the bone vascularization promotion ions is (0.05 to 20):1; the composite blank body is sintered to obtain the biological ceramic artificial bone. The anti-infection biological ceramic artificial bone has the advantages of high intensity and low cell toxicity; the antibacterial ion release speed is controllable; the release time is long.

Description

technical field [0001] The invention relates to the technical field of biomanufacturing or biomedical materials, in particular to an anti-infection bioceramic artificial bone and its application. Background technique [0002] During the clinical treatment of bone defects, the implantation of biomaterials is often accompanied by a greater risk of bacterial contamination, which is likely to form a source of chronic infection. Prevention and treatment of infection associated with bone implants is an urgent clinical problem that needs to be solved. The most widely used antibiotic delivery system material in clinic is polymethyl methacrylate (PMMA) bone cement, but PMMA bone cement does not degrade, has poor biological activity, easily causes loosening, and is difficult to restore the biological function of the bone defect area. In the treatment of bone defects, not only the anti-infection problem, but also the bone repair effect of bone repair materials should be considered. ...

Claims

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Application Information

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IPC IPC(8): A61L27/10A61L27/12A61L27/54A61L27/56A61L27/50
CPCA61L27/10A61L27/12A61L27/50A61L27/54A61L27/56A61L2300/10A61L2300/102A61L2300/104A61L2300/404A61L2300/412A61L2300/602A61L2430/02
Inventor 何福坡田野伍尚华
Owner GUANGDONG UNIV OF TECH
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