103 results about "Biomanufacturing" patented technology

Nutritive proteins are provided. In some embodiments the nutritive proteins comprise a protein digestibility corrected amino acid score (PDCAAS) that exceeds a benchmark protein. Also provided are nucleic acids encoding the proteins, recombinant microorganisms that make the proteins, methods of making the proteins using recombinant microorganisms, compositions that comprise the proteins, and methods of using the proteins, among other things.

This invention fills several voids in bioreactor technology that allows efficient connection of aspects of physical science (optics, electronics, physical chemistry, sensors) to aspects of microbial and cell culture physiology in a uniquely interactive manner. This is accomplished mathematically through decision making software that utilizes detected changes in the course of fermentation. Decisions are aimed at determining the optima for cellular growth, optimizing for production or degradation of metabolites or substrates, or determining the limits of growth under various combinations of conditions. The invention determines optima or limits in a manner more quickly and at less cost than traditional methods. The basis for the computer generated decisions may be first or second derivative changes observed such as inflection points, limits on allowable rates of change, or the like. The most common measured parameter controlling the decision making process is the optically observed growth of the cells (e.g. microbial, animal, or plant cell cultures) under study. Any other measurable parameter (e.g. pH, temperature, pigment production) may be used to control the process (i.e., the independent variable). This process and variations of this process on a laboratory scale are valuable for research and development, education, pilot plant models, and bio-manufacturing optimization, including scale up to production volumes.

The invention discloses a genetic engineering strain for producing (R, R)-2,3-butanediol, as well as a construction method and an application thereof, and belongs to the field of genetic engineering. The genetic engineering strain is a genetic engineering strain obtained by transforming escherichia coli (Escherichia coli)MG1655 by a budB gene, a budA gene and a ydiL gene through an expression vector pTrc99a. The strain disclosed by the invention is capable of highly producing a high-purity(R,R)-2,3-butanediol in a case of not adding inductive agents and has the advantages of good cell growth, quick consumption of the substrate, short fermentation period and low cost at the same time. The engineering strain also has important industrial application value for the bio-manufacturing of the (R, R)-2,3-butanediol.

Described herein are three dimensionally shaped biofabricated materials and method of making three dimensionally shaped biofabricated materials.

The present invention provides a production module for large-scale production of cells and / or cell-derived products such as antibodies or virus; a production suite comprising a plurality of functionally connected production modules of the invention; and a method for large-scale production of cells and / or cell-derived products using the production modules and / or production suites of the invention.

The invention discloses a patterned bacterial cellulose membrane, and a preparation method and application thereof, and belongs to the technical field of polymer materials and biological manufacturing. The preparation method comprises the steps of: fully mixing a prepolymer A of polydimethylsiloxane with a curing agent B, then adding an organic solvent, then adding water dropwise, stirring the mixture, allowing the mixture to stand to allow the mixture to be initially solidified, heating and solidifying the mixture, removing the organic solvent and water to obtain water-emulsified polydimethylsiloxane functional sponge, floating the patterned PDMS sponge model on the surface of a culture liquid capable of producing bacterial cellulose, and performing fermentation culture for 12-48 h to obtain the patterned bacterial cellulose membrane. The method for preparing the patterned bacterial cellulose membrane by utilizing the PDMS sponge has characteristics of a simple process, short fermentation time, high pattern fidelity, and capability of allowing the pattern height to be 10 [mu]m to 2 mm, and the membrane has good biocompatibility and is an ideal environmentally friendly biomedical material.