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74 results about "Myoglobin" patented technology
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Myoglobin (symbol Mb or MB) is an iron- and oxygen-binding protein found in the muscle tissue of vertebrates in general and in almost all mammals. It is distantly related to hemoglobin which is the iron- and oxygen-binding protein in blood, specifically in the red blood cells. In humans, myoglobin is only found in the bloodstream after muscle injury. It is an abnormal finding, and can be diagnostically relevant when found in blood.
Clinical rehabilitation data management and evaluation system for rhabdomyolysis patient
The invention provides a clinical rehabilitation data management and evaluation system for a rhabdomyolysis patient, and relates to a medical information management system. The system comprises an index acquisition module, a rate detection module, a curvature analysis module, a node identification module and a trend construction module. According to the method, the rate difference sequence of creatine kinase and myohemoglobin and the curvature sequence of urine sodium and serum creatinine are compositely calculated, the limitation of traditional single-parameter static analysis is broken through, the dynamic capture of a multi-index collaborative trend is realized, and a joint evolution label system is constructed by combining the consistency judgment of creatine kinase and blood potassium concentration change directions; according to the method, multi-system interaction risk nodes are accurately positioned, statistics is performed on direction consistency proportional distribution of myoglobin and serum creatinine in an association time period, discrete parameter association is converted into a dynamic visual model, and the problems of data discreteness misjudgment and collaborative evolution mode splitting in the traditional technology are solved. And a multi-dimensional dynamic evaluation framework of the rhabdomyolysis rehabilitation process is provided for clinic.
Owner:THE FIRST MEDICAL CENT CHINESE PLA GENERAL HOSPITAL
Time-dependent evaluation of test strips for differentiating hemoglobin and myoglobin in urine
The invention relates to methods, devices, and software for distinguishing hemoglobin (Hb) from myoglobin (Mb) in urine samples using peroxidase-reactive test strips. A time-resolved video of the color change on the test pad is recorded, and hue values are extracted and analyzed over time. Diagnostic differentiation between Hb and Mb is achieved by evaluating the hue-time curve, in particular via endpoint hue values and the ratio of integrated hue values in distinct time intervals. The invention further comprises a standardized optical setup for recording, a software-based evaluation algorithm, and a refillable cartridge for in-situ urine analysis devices containing appropriate test fields. The invention enables combined testing with additional urine parameters and is suitable for medical and non-clinical applications such as sport and home diagnostics.
Owner:MEDIPEE GMBH
A cardiovascular marker quality control and a preparation method thereof
The application belongs to the technical field of biological detection, and discloses a cardiovascular marker control article and a preparation method thereof. The cardiovascular marker control article comprises a serum matrix, antigens, a preservative and a stabilizer. The antigens include cardiac troponin I antigens, creatine kinase isoenzyme antigens, myoglobin antigens, amino-terminal brain natriuretic peptide precursor antigens, brain natriuretic peptide antigens, D-dimer antigens, heart-type fatty acid-binding protein antigens, myeloperoxidase antigens and lipoprotein phospholipase A2 antigens. The stabilizer includes at least one of D-trehalose, sucrose, glycine, inositol and polyethylene glycol. The cardiovascular marker control article can cover various cardiovascular disease markers, including heart failure, pulmonary embolism, vasculitis and atherosclerosis, myocardial injury, myocardial infarction and the like. The control article can be used as a third-party control article for indoor and inter-laboratory quality control of a cardiovascular disease screening and auxiliary diagnosis measurement system.
Owner:GUANGZHOU TEBSUN BIO TECH DEV
Storage cabinet for myoglobin determination kits
Owner:HENAN BLUEWOR MEDICAL EQUIP CO LTD
A method for detecting the concentration of dissolved co in a fermentation broth
The application discloses a method for detecting the concentration of dissolved CO in fermentation liquor. The method comprises the following steps: (1) preparing CO saturated aqueous solution, oxygen-free aqueous solution, sodium hydrosulfite solution as a reference solution and deoxygenated myoglobin solution; (2) preparing an absorbance-CO saturation standard curve; (3) sampling and detection: taking a sample from the fermentation liquor as a sample to be detected by a sampling device, injecting the sample to be detected into a cuvette, adding 2.5 mL of deoxygenated myoglobin solution in the cuvette in advance and sealing the cuvette, adjusting zero with the reference solution, detecting the absorbance of the cuvette containing the sample to be detected at a wavelength of 415-425 nm by a spectrophotometer, substituting the obtained absorbance into the absorbance-CO saturation standard curve obtained in step (2) to obtain the corresponding CO saturation, and then converting the CO saturation into the concentration of dissolved CO according to the known CO solubility. The detection method has the characteristics of taking and measuring immediately, rapidness and simplicity.
Owner:GUANGZHOU INST OF ENERGY CONVERSION CHINESE ACAD OF SCI
Medium-temperature beef fresh-keeping production method
PendingCN121176507AMeat/fish preservation by freezing/coolingMeat/fish preservation using chemicalsCold chainProcess engineering
The invention discloses a medium-temperature beef fresh-keeping production method, and belongs to the technical field of medium-temperature beef production. The method comprises the following steps: segmenting and classifying slaughtering parts; hanging the cut meat for air cooling, and performing gradient cooling at the same time to complete first treatment; controlling the oxygen concentration, and performing cold plasma treatment to complete second treatment; and then carrying out quick-cooling drying, packaging and cold chain management in sequence. The juice loss is inhibited through air cooling control in combination with gradient cooling; hypoxia and cold plasmas cooperate to block myohemoglobin oxidation and maintain the value of redness a; all the steps have a synergistic effect to solve the four industrial pains of water return, decoloration, poor tenderness and short shelf life of the medium-temperature beef.
Owner:SHANDONG AGRICULTURAL UNIVERSITY
Protein powder compositions and methods for preparing the same
PendingUS20260174869A1Transportation and packagingMetal-working apparatusPROTEIN S HEERLENAluminium oxides
Embodiments of the present disclosure generally relate to protein powder compositions and methods for preparing the same. In one or more embodiments, methods include coating a plurality of protein powder particles containing myoglobin with an aluminum oxide coating to form a plurality of coated particles during an atomic layer coating (ALC) process. The protein powder compositions have improved properties over the corresponding uncoated protein powder. The protein powder compositions have greater flowability, density, and a greater level of recoverability over the corresponding uncoated protein powder.
Owner:APPLIED MATERIALS INC
A composition for enhancing the antioxidant activity of vitamin c and its derivatives
The application discloses a composition for improving the antioxidant activity of vitamin C and derivatives thereof. By testing vitamin C solutions and vitamin C derivative solutions added with different concentrations of mussel myoglobin without a dopa group, it is found that when the mass ratio of vitamin C or vitamin C derivatives and mussel myoglobin without a dopa group is 1:0.001-1, the stability of vitamin C or vitamin C derivatives can be improved, and a new approach for effectively enhancing the antioxidant activity of vitamin C and derivatives thereof in cosmetics is provided.
Owner:XIAN DENUOHISI MEDICAL TECH CO LTD
A mussel myoglobin-based bone repair material and a preparation method thereof
Owner:XIAN DENUOHISI MEDICAL TECH CO LTD
Plasma protein marker for identifying or assisting in identifying parathyroid cancer and parathyroid adenoma and application thereof
The invention discloses a plasma protein marker for identifying or assisting in identifying parathyroid cancer and parathyroid adenoma and application of the plasma protein marker. The method comprises the following steps: firstly, collecting plasma specimens of a parathyroid carcinoma patient and a parathyroid adenoma patient before an operation, and screening through an unmarked quantitative proteomics technology to obtain 24 differential expression proteins; on the basis of the other part of plasma specimens of the parathyroid carcinoma patient and the parathyroid adenoma patient collected before the operation, the 24 differential expression proteins are verified through a parallel reaction monitoring technology; finally, three plasma protein markers (myoglobin, coronin-1A and a polyimmunoglobulin receptor) which can be used for identifying the parathyroid carcinoma and the parathyroid adenoma are obtained. Experiments prove that the plasma protein marker or the combination thereof can be used for auxiliary differential diagnosis of parathyroid carcinoma and parathyroid adenoma, and has important significance for improving the accuracy of preoperative diagnosis of parathyroid carcinoma.
Owner:PEKING UNION MEDICAL COLLEGE HOSPITAL
Corynebacterium glutamicum for synthesizing high-activity heme protein and application of corynebacterium glutamicum
The invention provides corynebacterium glutamicum for synthesizing high-activity heme protein and application, and belongs to the technical field of genetic engineering. By enhancing globin gene transcription and optimizing heme prothetic group supply, the synthetic ability of hemoglobin and myoglobin is improved. The corynebacterium glutamicum constructed by the invention can enable the titers of soybean hemoglobin, clover hemoglobin, bovine myoglobin and porcine myoglobin to reach 1.10 g / L, 1.12 g / L, 0.56 g / L and 1.14 g / L respectively during shake flask fermentation, and enables the heme binding rates of produced S-Hb, C-Hb, B-Mb and P-Mb to be improved by 3.64 times, 2.38 times, 1.60 times and 1.49 times respectively, which can be similar to those of naturally extracted standard substances H-Mb and B-Hb.
Owner:JIANGNAN UNIV
A system for managing and evaluating clinical rehabilitation data for a patient with rhabdomyolysis
The application provides a clinical rehabilitation data management and evaluation system for rhabdomyolysis patients, and relates to a medical information management system.The system comprises an index acquisition module, a rate detection module, a curvature analysis module, a node identification module and a trend construction module.In the application, the rate difference sequence of creatine kinase and myoglobin and the curvature sequence of urine sodium and blood creatinine are combined to break through the limitations of traditional single-parameter static analysis, realize dynamic capture of multi-index collaborative trend, construct a joint evolution label system by combining the consistency discrimination of creatine kinase and blood potassium concentration change direction, accurately locate the multi-system interaction risk nodes, and statistically distribute the direction consistency proportion of myoglobin and blood creatinine in the correlation period, so as to convert the discrete parameter correlation into a dynamic visual model.The method solves the problems of data dispersion misjudgment and collaborative evolution mode fragmentation in the traditional technology, and provides a multi-dimensional dynamic evaluation framework for the rhabdomyolysis rehabilitation process in clinical practice.
Owner:THE FIRST MEDICAL CENT CHINESE PLA GENERAL HOSPITAL
A broad-spectrum universal nano-coated probiotic based on mussel myoglobin and its preparation method and application
The application discloses a kind of broad-spectrum general-purpose nano-coating probiotics based on Mytilus edulis mucin and a preparation method and application thereof.The method accelerates the deposition of Mytilus edulis mucin on the surface of probiotics by means of non-covalent bond, hydrogen bond, cation-pi and other supramolecular interaction modes between Mytilus edulis mucin and bacteria, and realizes the independent coating of probiotics by complexing and coordinating the catechol group in Mytilus edulis mucin with cations and driving it to self-assemble into nanoscale aggregates.The Mytilus edulis mucin nano-coating provided by the application is not only suitable for encapsulating aerobic bacteria, but also has a protective effect on anaerobic bacteria, and can realize the synchronous release of probiotics.More importantly, the addition of cations enhances the adhesion ability of probiotics while improving the density of the coating network structure, resulting in nano-coating probiotics with high stability and biocompatibility.The nano-coating probiotics provided by the application have simple and efficient preparation process, are suitable for large-scale production, and are expected to become an ideal carrier for probiotic delivery.
Owner:OCEAN UNIV OF CHINA
Pregnancy disease risk prediction method and device based on biochemical indexes and program product
The invention relates to the field of intelligent medical treatment, in particular to a pregnancy disease risk prediction method and device based on biochemical indexes and a program product. Comprising the following steps: S1, acquiring serum biochemical index data of a pregnant woman; s2, comparing the serum biochemical indexes with a preset threshold value; the serum biochemical indexes include aspartate aminotransferase, total protein, albumin, lactic dehydrogenase, alkaline phosphatase, total bile acid, creatine kinase, blood sugar, urea nitrogen, uric acid, creatinine, glomerular filtration rate, potassium, chlorine, total calcium, serum magnesium, inorganic phosphorus, total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and homocysteine. When one or more of the myoglobin, the hypersensitive troponin I, the prealbumin, the cystatin C and the creatine kinase isoenzyme MB are abnormal, judging that the pregnancy eclampsia exists. The method is simple, convenient and rapid to operate and low in cost, can be clinically popularized to predict the health state of the pregnant woman on a large scale, and has good clinical value.
Owner:BEIJING OBSTETRICS & GYNECOLOGY HOSPITAL CAPITAL MEDICAL UNIV
Packaging kit (medical mussel myoglobin care solution)
1. The name of the design product: packaging kit (medical mussel mucin care solution). 2. The use of the design product: for product packaging. 3. The design points of the design product: in the pattern. 4. The picture or photo that best indicates the design points: main view of kit 2. 5. Other circumstances that need to be explained: The design product is a kit product, so it is used and sold as a set. Kit 1 is an inner packaging bottle, kit 2 is an outer packaging box, and kit 1 is packed into kit 2 for sale and use.
Owner:SHANDONG JINGYI TECHNOLOGY DEVELOPMENT CO LTD
System, method
PendingJP2026087377APhysical therapies and activitiesGymnastic exercisingPhysical medicine and rehabilitationSimulation
We propose a new method to support the physical condition management of athletes. [Solution] The system for supporting the physical condition management of athletes comprises a measuring device for measuring myoglobin contained in the athlete's blood, and a server that records the athlete's exercise load and the athlete's myoglobin measurement value. The server provides the athlete's exercise load and the athlete's measurement value in response to a request from a terminal.
Owner:SYSMEX CORP
Protein powder composition and method for preparing the same
Embodiments of this disclosure generally relate to protein powder compositions and methods for preparing them. In one or more embodiments, the method includes coating a plurality of protein powder particles containing myoglobin with an aluminum oxide coating to form a plurality of coated particles during an atomic layer coating (ALC) process. The protein powder composition has improved properties compared to the corresponding uncoated protein powder. The protein powder composition has greater flowability, density, and a higher level of recoverability compared to the corresponding uncoated protein powder.
Owner:APPLIED MATERIALS INC
Preparation process of myoglobin for chemical luminescence immunoassay quality control product
The application discloses a kind of myoglobin preparation process for chemiluminescence immunoassay quality control product, it is related to myoglobin preparation technical field, comprising the following steps: raw material pretreatment: after removing impurities of fresh pig heart muscle tissue, it is placed in automatic cleaning cutting equipment and is cut and cleaned, myoglobin extraction: muscle tissue after pretreatment is placed in grinding mechanism, and extraction fluid is added to grind, centrifugal separation: after extraction, mixed liquid is placed in high-speed centrifugal separation equipment and is centrifuged, to obtain supernatant, purification treatment: supernatant is purified by multistage filtration separation equipment, stabilization treatment: after purification, myoglobin solution is added with stabilizer, placed in gradient temperature control stirring system and stirred and mixed, low-temperature preservation, solve the problem that muscle tissue is cut into meat foam by manual shearing mode, grinding is not enough, so that separation effect is poor, leading to the problem that myoglobin purity is not high and activity is easily affected.
Owner:南通井兰生物技术有限公司
Preparation method and application of a carbon dioxide-responsive imprinted modified electrode for detecting myoglobin
The present invention belongs to the field of electrochemical technology and discloses a method for preparing a carbon dioxide-responsive imprinted modified electrode for detecting myoglobin and its application. An electrode modified with gold nanoparticles, toluidine blue, and platinum nanoparticles is used as a catalytic electrode, and an electrode modified with an initiator is used as a working electrode. Constant current polymerization is performed for 1.5 hours to prepare an Au / AuNPs / Polymer electrode. The prepared electrode is then immersed in an SDS eluent to remove the template molecules, thereby preparing an Au / AuNPs / MIP electrode. The Au / AuNPs / MIP imprinted modified electrode of the present invention can effectively identify myoglobin and can be used as an electrochemical sensor for detecting myoglobin, enabling rapid and highly sensitive detection of myoglobin.
Owner:LIAONING NORMAL UNIVERSITY
Heterophile antibody blocking agent and myoglobin detection kit
The present invention provides a heterophilic antibody blocker comprising a light chain and a heavy chain; the amino acid sequence of the light chain is shown in SEQ ID NO.1, and the amino acid sequence of the heavy chain is shown in SEQ ID NO.2. The present invention also provides a use of the above-mentioned heterophilic antibody blocker in the preparation of a myoglobin detection kit and a corresponding kit. The heterophilic antibody blocker of the present invention is a self-developed product designed specifically for myoglobin detection and can effectively remove interfering substances in serum; the use of this heterophilic antibody blocker can greatly improve the performance of the reagent, reduce the false positive rate, and provide a reliable guarantee for the test results.
Owner:ANHUI DAQIAN BIO ENG LIMITED
A meat product colorant based on a double-enzyme cascade reaction, a color development method and application thereof
PendingCN122096374Ahigh activitypromote generationFood ingredient as colourAntibody mimetics/scaffoldsNitrosoSodium nitrite
The present application relates to a kind of meat product colorant based on double enzyme cascade reaction and coloration method and application, belong to meat science and technology field.The meat product colorant is composed of recombinant glucose dehydrogenase and one oxygen fusion enzyme NOS-YkuN-YumC of producing nitric oxide.The present application is by constructing the nicotinamide adenine dinucleotide phosphate (NADPH) regeneration system based on glucose dehydrogenase in recombinant bacillus subtilis, realize the continuous supply of key cofactor NADPH, to significantly enhance the catalytic activity of one oxygen fusion enzyme NOS-YkuN-YumC of producing nitric oxide under low temperature condition.It is applied to meat product, and the produced one oxygen is combined with myoglobin efficiently, generates nitrosylmyoglobin, so that meat product can obtain ideal red color even in low temperature processing with sodium nitrite treatment.The present application provides efficient and feasible solution for replacing nitrite coloration and improving meat product safety.
Owner:HEFEI UNIV OF TECH
Method for delaying color deterioration of minced beef during storage and improving quality of minced beef based on glucose oxidase
PendingCN120323505AFood ingredient as antioxidantMeat/fish preservation using chemicalsBiotechnologyMinced beef
The invention discloses a method for delaying color deterioration of minced beef during storage and improving quality of minced beef based on glucose oxidase, which comprises the following steps: slaughtering beef cattle according to an industrial standard slaughtering method, cutting carcasses by adopting a standardized cutting method, and taking cut fresh beef cubes; and processing the fresh beef into meat paste, adding glucose oxidase (the addition amount is 0.02 wt%), uniformly stirring, and storing. The method for improving the quality of the minced beef during the storage period comprises the following steps: improving the color of the minced beef during the storage period and the composition of three kinds of myoglobin, reducing the pH value of the minced beef and improving the texture characteristics of the minced beef; the fatty acid composition of the minced beef is improved, the free amino acid composition of the minced beef is changed, and the fat oxidation degree of the minced beef is reduced. Glucose oxidase is added into the minced beef, so that color deterioration of the minced beef during storage is effectively delayed, various quality characteristics of the minced beef during storage are improved, and the storage stability of the minced beef is improved.
Owner:JIANGNAN UNIV
Use of iron-containing substances
PendingCN121129891AHeavy metal active ingredientsPeptide/protein ingredientsWhite blood cellSuccinic acid
The invention discloses application of an iron-containing substance. The invention finds that the iron-containing substance can be used for preparing the medicine for treating leucopenia and / or thrombocytopenia; the iron-containing substance is selected from myoglobin and a derivative thereof, hemoglobin and a derivative thereof, ferrous sulfate, ferrous fumarate, ferrous gluconate, a polyferose compound, ferrous succinate, iron amino acid chelate, heme, heme iron polypeptide, ferric hydroxide polymaltose, ferrous lactate, ferric pyrophosphate and iron dextran; and one or more of iron hydroxymaltose. The iron-containing substance can effectively increase the number of leukocytes and / or platelets.
Owner:NORTHWEST UNIV
High expression of animal hemoproteins in plants
The present disclosure provides methods for producing heme proteins in transgenic plants, plant tissues, or plant cells, as well as methods for describing the expression of these heme proteins in seeds. The present disclosure also provides transgenic plants that express heme proteins, myoglobin, and hemoglobin by introducing and integrating recombinant DNA constructs into the host genetic material of a plant of interest. Certain combinations of regulatory factors disclosed herein enable high levels of heme protein expression in seeds.
Owner:MOOLEC SCIENCE LIMITED
Method and system for nondestructively measuring oxymyoglobin on surface of longissimus dorsi muscle of cattle
The invention discloses a method and a system for lossless measurement of oxymyoglobin on the surface of longissimus dorsi muscle, the method comprises the following steps: storing fresh longissimus dorsi muscle in a manner of simulating supermarket conditions, and collecting image information of the surface of the longissimus dorsi muscle in contact with oxygen; preprocessing the acquired image to obtain an effective muscular tissue part; extracting the overall color information of the effective muscle tissue part in the image; calculating the relative content of oxymyoglobin on the surface of each piece of beef; and inputting the storage time, the color information and the relative content of the oxymyoglobin corresponding to each sample into the model, and predicting the storage time of any given unknown beef and the corresponding relative content of the oxymyoglobin based on the convolutional neural network. According to the method, the beef does not need to be smashed by a chemical method to extract the myoglobin, only the picture on the surface of the beef at any moment needs to be given, the storage time and the oxymyoglobin content at the moment are predicted through the model, and the method has the characteristics of being simple to operate, time-saving and labor-saving, and high in prediction precision.
Owner:JIANGNAN UNIV
Meat substitute comprising animal myoglobin
To provide a gene construct comprising a nucleic acid encoding a protein, in a meat substitute comprising the myoglobin protein, a host cell comprising the gene construct, and a method for producing myoglobin or a meat substitute.SOLUTION: A method for producing a meat substitute comprising bovine myoglobin, the method comprising: a): a step of providing a host cell comprising a gene construct, wherein the gene construct is represented by a specific sequence; b) a step of culturing the host cell in a medium suitable for producing bovine myoglobin represented by a specific sequence different from the foregoing; c) a step of recovering the myoglobin; d) a step of purifying the myoglobin; and e) a step of blending the purified myoglobin into the meat substitute.SELECTED DRAWING: None
Owner:パレオ·ベスローテン·ヴェンノーツハップ
Rcom protein-based carbon monoxide scavengers and preparations for treating carbon monoxide poisoning
PendingJP2025161893AAntibody mimetics/scaffoldsMuscular disorderCarbon monoxide poisonCellular respiration
To provide RcoM protein-based carbon monoxide scavengers and preparations for treating carbon monoxide poisoning.SOLUTION: Disclosed herein is a method for rapid elimination of carbon monoxide (CO) from CO-bound hemoglobin, myoglobin and cytochrome C oxidase in a subject with CO poisoning. The disclosed therapeutic method comprises use of a rationally designed and modified regulatory factor of CO metabolism (RcoM) protein and pharmaceutical compositions thereof, which scavenge carbon monoxide from poisoned tissue. The recombinant RcoM composition is infused into blood to rapidly sequester carbon monoxide and limit the toxic effects of carbon monoxide on cellular respiration, oxygen transport and oxygen utilization.SELECTED DRAWING: None
Owner:UNIV OF PITTSBURGH OF THE COMMONWEALTH SYST OF HIGHER EDUCATION
Multi-equilibria system enables precise carboxylic acid engineering in proteins
PCT designated stageWO2025248559A1Peptide preparation methodsMaterial analysisCarboxylic acidLactalbumin
The present invention discloses a method for precision engineering of protein bioconjugates by harnessing complex multi-equilibria systems. The method allows for exclusive control over reaction pathways, achieving highly selective outcomes, even with complex substrates such as proteins. By manipulating proteinogenic functionalities, the invention enables pathway selectivity, chemoselectivity, and site selectivity, leading to single-site modifications in proteins. The versatility of the present invention is demonstrated through diverse protein examples, including insulin, RNase A, ubiquitin, cytochrome C, myoglobin, α-lactalbumin, and serum albumins, showcasing its broad applicability in protein engineering. Additionally, the method facilitates the synthesis of antibody-fluorophore conjugates (AFC) and antibody-drug conjugates (ADC), providing promising prospects for therapeutic applications.
Owner:INDIAN INST OF SCI EDUCATION & RES BHOPAL
High expression of animal heme protein in plants
The present disclosure provides methods of producing heme proteins in transgenic plants, plant tissues, or plant cells, as well as describing the expression of these heme proteins in seeds. Also, the present disclosure provides transgenic plants expressing the heme proteins, myoglobin and hemoglobin, by introducing and integrating the recombinant DNA constructs into the host genetic material of the subject plants. The specific combination of regulatory elements disclosed herein allows for high heme protein expression level in seeds.
Owner:MOOLEC SCIENCE LIMITED