9 results about "Laboratory scale" patented technology

The application discloses a novel bismuth-based chelate CT contrast agent and a preparation method and application thereof. The synthesis method comprises the following steps: 2,6-pyridine dimethyl alcohol is reacted with chlorosulfoxide to obtain 2,6-bis(chloromethyl)pyridine; the 2,6-bis(chloromethyl)pyridine is reacted with N,N',N''-tris(p-tolylsulfonyl)divinyltriamine and an inorganic base in a solvent and is heated, is deprotected by concentrated sulfuric acid to obtain an intermediate pyclen; the pyclen is heated and reacted with a halogenated carboxylic acid ester under alkaline conditions in a polar organic solvent, is hydrolyzed to obtain a ligand product; and the ligand product is heated and chelated with a bismuth agent to obtain the target bismuth-based chelate. The application realizes the laboratory scale preparation of the small-molecule bismuth-based chelate CT contrast agent, and a non-ionic contrast agent is prepared, which has low osmotic pressure, high stability, high water solubility and good biological safety and is used for CT imaging of the digestive system, the urinary system and the circulatory system.

This invention provides a TEM sample, its preparation method, and its application. The TEM sample preparation method provided by this invention, without affecting the pore structure of the semiconductor device, first uses reactive ion etching to remove some residual polymer deposits blocking the pore openings on the semiconductor device. This enlarges the pore openings, preventing blockage and facilitating the entry of colloidal materials into the pore structure for filling and the deposition of precursor materials for atomic layer deposition. This enhances the clarity of the pore sidewalls, effectively improving the quality of the TEM sample and the final observation results. Furthermore, the TEM sample preparation method provided by this invention requires less equipment and technical investment, and the operation process is simpler and faster than Fab etching. It also enables batch laboratory-scale sample processing. In addition, compared to wet chemical etching cleaning techniques for removing residual polymers, it avoids problems such as chemical reagent residues at the bottom of deep pore structures and chemical reactant contamination.

The application discloses a synthesis method of a N,N-diphenyl-4-(pyridine-4-yl) aniline B-N coordination compound and application thereof. Under anhydrous and anaerobic conditions, (Me4N)B3H8 is reacted with I2 in THF to prepare an intermediate THF.B3H7, which is then reacted with a ligand N,N-diphenyl-4-(pyridine-4-yl) aniline to obtain a borane complex. Under anhydrous and anaerobic conditions, DMS.BH3 is reacted with the ligand N,N-diphenyl-4-(pyridine-4-yl) aniline in THF to obtain the borane complex. The synthesis method is simple, safe and high in yield, and is suitable for laboratory scale preparation. Optical property research shows that the prepared borane complexes all exhibit significant positive solvatochromic effect, aggregation-induced emission characteristics, mechanochromic performance and high quantum yield, and are ideal organic stimulus-responsive luminescent materials.

The present patent of invention describes an advanced method for producing kombucha, structured in distinct phases that separate the anaerobic and aerobic processes. In the first phase (anaerobic fermentation), sweetened tea and a symbiotic culture (SCOBY) are subjected to optimal conditions for yeast activity, generating an alcohol content of 1% to 8% within 2 to 8 days. The product is then transferred to an aerobic fermentation vessel, where the aerobic stage takes place, with continuous oxygenation and mechanical agitation. Temperature control and monitoring of pH and oxygen ensure a high conversion rate and stability of the bacterial culture after an initial adaptation period of 15 to 25 days. The final phase is characterized by a fed-batch regime every 18 to 24 hours, with harvesting of one-third of the volume and immediate replenishment, thereby enabling continuous and predictable fermentation and production. This set-up reduces the total processing time compared to traditional methods, providing a production time typical of laboratory scale for industrial use, whilst maintaining the product's sensory consistency and minimising the risk of contamination. The competitive advantages also include reduced production space requirements, lower operating costs, and greater large-scale production viability, resulting in a technically and commercially significant innovation in the fermented probiotic beverage sector.

A modular bioreactor system includes a set, or array, of smaller bioreactor chambers, such as laboratory-scale bioreactor chambers, which can be filled and drained together, while also being able to be isolated to permit the multiplexed bioreactor chambers to be used together to create a larger-scale reaction volume, thereby forming a manufacturing-scale bioreactor.

The application belongs to the technical field of perovskite material preparation, and particularly discloses a mixed halogen perovskite single crystal material and a preparation method thereof. 2.8 I 0.2 The obtained single crystal is treated at 20 DEG C and 90% RH for 3-6 h, surface defects are systematically repaired by using the moisture-induced lattice expansion and surface hydroxyl passivation mechanism, ion migration is inhibited, and the phase separation phenomenon is slowed down. The process is simple, controllable, and reproducible, and is suitable for laboratory-scale preparation and industrialization promotion.

Provided is a method to initiate and analyze chemical derivatives formed from pyrotechnic smoke reactions. Milligram quantities of a lab-scale pyrotechnic smoke composition are reacted by encapsulation with a metal probe that is rapidly heated, which then sublimes the organic dye, allowing for the testing of all of the gas-phase products for identification by pyrolysis-gas chromatography-mass spectrometry. The thermally decomposed ingredients and new side product derivatives are identified at lower relative abundances compared to the intact organic dye. Any remaining residues within the thermal probe are optionally reconstituted into solution for further analysis by liquid chromatography-mass spectrometry if desired. The results are processed via a machine learning quantitative structure-activity relationship model that provides data related to health and environmental hazards.

A light source includes a linear accelerator for accelerating an electron bunch to a relativistic energy. The light source further includes a first grating, downstream of the linear accelerator and arranged such that the electron bunch is transmitted through the grating to produce a diffraction pattern. The light source further includes an emittance exchange device, downstream of the first grating, that rotates the diffraction pattern to a direction substantially parallel to a direction of propagation of the electron bunch. The light source further includes a laser that produces a pulse of light. The light source is configured such that the pulse of light from the laser interacts with the electron bunch in an overtaking geometry at an interaction point, downstream of the emittance exchange device, while the diffraction pattern is substantially parallel to the direction of propagation of the electron bunch to produce light via inverse Compton scattering.

This invention relates to the field of water-rock reaction processes, specifically disclosing a water-rock interaction experimental device and its usage method. The device comprises a multi-dimensional dynamic water-rock interaction experimental system, consisting of a constant-temperature water tank, a constant-pressure water pump, and a reaction device module. This system adopts a modular design and an integrated architecture for precise control of environmental parameters, dynamic simulation of hydraulic conditions, and spatiotemporal evolution data acquisition. The core components of the water-rock interaction experimental device include a reconfigurable flow guidance system and a three-dimensional spatiotemporal sampling water tank. The specific steps for dynamically simulating multi-morphological groundwater flow paths at the laboratory scale are: calling preset parameters, setting path parameters, switching paths, starting the device to control temperature and pressure, collecting and analyzing data, and cleaning and verifying the data. This invention achieves dynamic simulation of multi-morphological groundwater flow paths at the laboratory scale for the first time, realizing full-element control of the water-rock reaction process.