21 results about "Flow chemistry" patented technology

The invention discloses a continuous kettle type nitromethane production process, and relates to the technical field of basic chemical raw material synthesis and flow chemical reaction process control, which comprises the following steps: quantitatively and continuously pumping a temperature-regulated sodium nitrite mixed solution into a raw material mixer in a closed-loop automatic control mode through a variable-frequency feeding pump matched with a mass flow meter; synchronously, quantitatively and continuously pumping dimethyl sulfate into the raw material mixer in a closed-loop automatic control manner by matching a feeding pump with a stop valve and a mass flow meter, and uniformly mixing the two raw materials in the raw material mixer according to the stoichiometric molar ratio of the dimethyl sulfate to the sodium nitrite, according to the tandem type segmented design, each reaction kettle can be subjected to customized temperature field control and heat transfer design specially aiming at the special thermodynamic and dynamic requirements of the reaction stage where the reaction kettle is located, the heat transfer efficiency of the whole system is greatly improved, and due to the fact that reaction heat is taken away timely and accurately, the heat transfer efficiency is greatly improved. And a by-product generation path induced by local abnormal high temperature is effectively restrained.

The present disclosure relates to a continuous flow process for synthesis of heterocyclic methanone compounds, and in particular 3'-substituted, 3-hydroxyl-(8-aza- bicyclo[3.2.1]oct-8-yl)-[5-(1h-pyrazol-4-yl)-thiophen-3-yl]-methanone compounds, and aza-bicyclo intermediates thereof. In particular, the present disclosure also relates to a continuous flow process that can be utilised toward the synthesis of Xanamem.

Provided herein are methods of synthesizing and compositions comprising an alpha isomer of mannose-1-phosphate (M1P). For example, such methods employ techniques in flow chemistry to achieve a substantially pure alpha isomer of M1P. Also provided are compositions, including pharmaceutical compositions, comprising substantially pure alpha isomer of M1P. Provided herein are also polymorphic forms of M1P, including polymorphic forms that may be produced from the substantially pure alpha isomer of M1P.

A process for forming polymer-grafted nanoparticles is provided. The process utilizes flow chemistry techniques to activate nanoparticle surfaces and then form polymer chains on the activated surfaces in a continuous process, thus avoiding the limitations and shortcomings of batch processes for forming polymer-grafted nanoparticles. The polymer-grafted nanoparticles are particularly useful as a filler or additive in fused deposition modeling (“FDM”) filaments, leading to printed parts having improved properties.

A computer-implemented method is disclosed for determining at least one set of target parameters for a flow chemistry setup (110) for flow chemistry in a slug. This method is a self-learning method. The method includes the steps of: a) determining at least one process variable using at least one sensor (122) of the flow chemistry setup (110); b) training at least one machine learning model (126) based on the process variable; c) determining the target parameter set by applying an optimization algorithm for at least one optimization objective to the trained machine learning model (126); d) providing and / or considering the determined target parameter set for evaluating the flow chemistry setup (110) and / or evaluating at least one flow chemistry product.

The invention discloses a method for preparing 3-hydroxypropyl nitrate by continuous flow, the 3-hydroxypropyl nitrate is continuously prepared by a three-step method of monoacetylation, nitration and hydrolysis, and the prepared compound can be confirmed by a 1H NMR (nuclear magnetic resonance) characterization method. Meanwhile, through a two-step continuous flow reaction technology and a two-step online continuous separation technology which are connected in series, continuous production is realized, and key reaction parameters such as material mixing, heating and retention time can be accurately controlled, so that the product quality is improved, impurities are controlled, the chemical reaction is allowed to react in a higher temperature range without temperature runaway, and the product quality is improved. The reaction speed can be increased in reaction thermodynamics, the production efficiency is improved, heat accumulation of kettle type reaction is avoided, and the reaction is safer; the post-treatment process of the flow chemistry is always online, so that the reaction is cleaner, automatic and online sample collection is convenient to realize, reaction parameters are convenient to change, optimal reaction conditions are convenient to find, and the process exploration and substrate screening efficiency is greatly improved.

A process for forming polymer-grafted nanoparticles is provided. The process utilizes flow chemistry techniques to activate nanoparticle surfaces and then form polymer chains on the activated surfaces in a continuous process, thus avoiding the limitations and shortcomings of batch processes for forming polymer-grafted nanoparticles. The polymer-grafted nanoparticles are particularly useful as a filler or additive in fused deposition modeling (“FDM”) filaments, leading to printed parts having improved properties.

To provide a technique for obtaining an environment when a compound located in a specific range among compounds is synthesized in a flow chemistry system.SOLUTION: An environmental actual measurement value acquiring unit 63a that acquires an actual measurement value of the chemical reaction condition measured by the measuring device 222324 in the chemical reactor 2 as an environmental actual measurement value, an environmental actual measurement value storage unit 63b that stores the acquired environmental actual measurement value and information on a time at which the environmental actual measurement value is measured in association with each other in a storage medium, a passage time information calculating unit 64b that calculates information on a time at which a specific synthetic compound which is a synthetic compound located in a specific range among the synthetic compounds passes through a measurement point by the measuring device as passage time information based on at least the sending condition, and an environmental actual measurement value specifying unit 64c that specifies an environmental actual measurement value when the specific synthetic compound or raw materials thereof pass through the measurement point by the measuring device based on the passage time information.SELECTED DRAWING: Figure 2

The application belongs to the field of flow chemistry, and particularly relates to a continuous preparation method of 2-phenylbenzothiazole compounds, a micro-reactor and a micro-reaction system. The continuous preparation method of 2-phenylbenzothiazole compounds comprises the following steps: reacting a reaction solution in a micro-reactor under visible light irradiation and oxygen charging; the reaction solution comprises a thiobenzamide compound, a catalyst, a base and an organic solvent; the micro-reactor comprises a transparent pressurized container and a capillary micro-channel reactor arranged in the transparent pressurized container; the reaction solution is arranged in the capillary micro-channel reactor; and the transparent pressurized container is subjected to oxygen charging. In the application, oxygen permeates into the reaction tube to participate in the reaction, the permeation mode of oxygen is beneficial to accurately controlling the amount of oxygen participating in the reaction, reducing the generation of oxidation by-products, and is beneficial to realizing rapid mass transfer and heat transfer, and greatly improving the synthesis efficiency.

The invention discloses a continuous synthesis method and device of MSH.The continuous synthesis method of MSH comprises the steps that 2, 4, 6-trimethylbenzenesulfonyl chloride and an acid binding agent are dissolved in a first solvent to form a first solution, N-hydroxy-acetic acid imino ethyl ester is dissolved in the first solvent to form a second solution, and the second solution is dissolved in a third solvent to form a second solution; respectively pumping the first solution and the second solution into a first reaction container for reaction to obtain a first effluent; the first effluent, perchloric acid and a second solvent respectively flow into a second reaction container for reaction, and second effluent containing MSH is obtained. According to the present invention, the flow chemical design idea is adopted to continuously synthesize MSH, the stability of the raw material is good, the intermediate high-energy product and the high-energy end product can be rapidly utilized, and the accumulation and the long-time retention are effectively avoided so as to effectively avoid the decomposition and reduce the safety risk; the device disclosed by the invention is simple in structure, suitable for being matched with a production line of MSH derivative products, and convenient for synthesizing MSH at present.

The invention relates to a synthesis method, in particular to an alpha-fluorochlorosulfoxide imine reagent and a method for preparing tetra-substituted fluorochlorine terminal olefin with high stereoselectivity, and high-efficiency and high-selectivity chemical synthesis of polysubstituted fluorochlorine terminal olefin is realized by utilizing the technology. The method has the advantages of high yield, cheap and easily available raw materials, good selectivity, low toxicity of the raw materials, simple and convenient preparation of the raw materials, and wide application range of a substrate. Through combination with a flow chemical technology, the method can realize a hectogram-scale amplification reaction and maintain high selectivity in an amplification process. The invention opens up a new way for drug research and development personnel to carry out wide drug synthesis research, and widens the space of fluorine-containing drugs for constructing brand new molecules at the same time.

The invention discloses a full-automatic solid-phase polypeptide synthesis system and a full-automatic solid-phase polypeptide synthesis method based on flow chemistry, and belongs to the technical field of chemical synthesis automation equipment. Wherein the liquid storage module is used for respectively storing different liquid reaction reagents, including a deprotection reagent, a main solvent, an activating agent, alkali and amino acid, required by solid-phase polypeptide synthesis; the transmission module is connected between the liquid storage module and the mixer and is used for selecting and accurately extracting the corresponding required liquid reaction reagent from the liquid storage module to the mixer according to different stages of solid-phase polypeptide synthesis, and the liquid reaction reagent is rapidly and fully mixed when flowing through the mixer; the preheating module is connected between the mixer and the reactor, and is used for preheating the mixed liquid reaction reagent from the mixer, so that the preheated liquid reaction reagent completes the reaction of the corresponding stage of solid-phase polypeptide synthesis when flowing through the reactor. The method is high in polypeptide synthesis speed, high in synthesized polypeptide purity, simple in instrument structure and low in cost.

A continuous process for preparing a compound of Formula (III)or a salt and / or solvate thereof, includes forming a first reaction stream comprising a compound of Formula (I) dissolved in an alcohol;flowing the reaction stream from step (a) through a continuous flow reactor at a temperature of about 100° C. to about 160° C. and at a flow rate of about 0.2 mL / min to about 5 mL / min; contacting the reaction stream from step (b) with a second reaction stream comprising a hydrazine source to form a combined reaction stream; and (d) flowing the combined reaction stream from step (c) through a continuous flow reactor at a temperature of about 100° C. to about 160° C. and at a flow rate of about 0.2 mL / min to about 5 mL / min.

The utility model discloses a coil reactor and a system for flow chemistry. The coil reactor comprises a heat conduction inner core, a reaction coil and a shell, the heat-conducting inner core is made of a heat-conducting material, is internally provided with a heating rod and is fixed by heat-conducting glue; the heating rod is provided with an external wire or interface for connecting a power supply and a temperature control device; the reaction coil is of a spiral coil structure and is wound on the outer surface of the heat-conducting inner core, and joints at two ends of the reaction coil are used for connecting external liquid, namely a fluid inlet and a fluid outlet; the shell is matched with the heat-conducting inner core, the reaction coil pipe is clamped between the shell and the heat-conducting inner core, the heat-conducting inner core, the reaction coil pipe and the shell are tightly attached, and if a gap exists between the reaction coil pipe and the heat-conducting inner core and / or the shell, the gap is filled with a heat-conducting medium. The coil reactor disclosed by the utility model is rapid, accurate and uniform in temperature control, small and flexible in structure, convenient to mount, replace and dismount, and convenient to use; and fluid heat transfer is not used, so that leakage risk is avoided, and safety and convenience are achieved.

The application discloses a flow chemistry method for reducing carboxylic acid to alcohol by diisobutylaluminum hydride, which comprises the following steps: S1, dissolving a reaction substrate containing a carboxyl group in a first solvent to prepare solution A; S2, dissolving diisobutylaluminum hydride in a second solvent to prepare solution B; and S3, pumping solution A and solution B into a coil through a pump respectively, quenching the reaction liquid after the reaction is completed, and obtaining a target product. The flow chemistry method for reducing carboxylic acid to alcohol by diisobutylaluminum hydride has mild reaction conditions, reduces the reaction risk, avoids the risk of material flushing, and realizes stable operation.

The invention belongs to the technical field of flowing chemical synthesis, and particularly relates to a method for continuously preparing nitroisopropane. The method comprises the following steps: mixing an N-isopropyl hydroxylamine solution with gas by using a plate-type micro-nano bubble reactor, and conveying acetic acid and hydrogen peroxide into the plate-type micro-channel reactor through a high-pressure infusion pump to continuously prepare peracetic acid on line; the N-isopropyl hydroxylamine solution mixed with the gas and peracetic acid are subjected to an oxidation reaction in the RTB reactor and / or the TTSTR reactor to prepare the nitroisopropane. According to the invention, the gas-liquid phase interface area is greatly increased, the risks of decomposition, leakage or explosion of the storage tank are eliminated from the source, the reaction is converted from mass transfer control to intrinsic dynamic control, the reaction rate is rapidly accelerated, the reaction time is shortened from hour level to minute level or even second level, the space-time yield (unit volume equipment productivity) is greatly improved, and the production cost is reduced. The side reaction and decomposition are inhibited to the maximum extent, the product selectivity reaches 99% or above, and the method is efficient and safe.

This invention discloses a method for the continuous flow synthesis of β-silyl-based aza-aromatic compounds catalyzed by Cu / Ni-ZSM-5 molecular sieves. The method provides a microchannel reactor loaded with a heterogeneous catalyst from a Cu / Ni-ZSM-5 bimetallic molecular sieve. Aza-aromatic vinyl compounds and pinacol ester (dimethylbenzyl)borate are dissolved in a mixed solvent of methanol and water. The premixed reaction solution is continuously passed into the microchannel reactor, and the catalytic reaction is carried out at 25-30°C. The target β-silyl-based aza-aromatic product is obtained after separation and purification. This invention utilizes a copper-nickel bimetallic synergistic catalysis, combined with the regular pore structure of ZSM-5 molecular sieves, to achieve a highly regioselective β-silyl addition reaction of aza-aromatic vinyl compounds. This technology not only provides a new strategy for the functionalization of aza-aromatics but also promotes a paradigm shift in flow chemistry for the green manufacturing of fine chemicals.

The application discloses a sodium hydride suspension liquid, wherein sodium hydride is dispersed in an organic solvent with a density of 1.2-1.5 g / mL or an organic solvent with a viscosity of 5-30 mm 2 / s, a suspension liquid with a concentration of 0.02-0.05 g / mL is formed, and the suspension liquid can be used in a flow chemical reaction. The application has the advantages of safe scale-up production and high reaction yield.

The embodiment of the application provides a device and method suitable for removing fluorine ions from coking fluorine-containing wastewater, relates to the technical field of sewage treatment, and comprises a reaction tank, a mounting barrel, a filtering assembly, a chemical precipitation assembly and an operation plate, wherein a water pump is arranged on the operation plate; the mounting barrel is arranged at the center position of the reaction tank and forms a water space for wastewater circulation flow with the reaction tank; the filtering assembly, the chemical precipitation assembly and the operation plate are all arranged in the water space, so that the water space is divided into three small spaces, and the wastewater circulates and flows in the three small spaces through the filtering assembly, the chemical precipitation assembly and the operation plate; a reagent placing groove is arranged in the chemical precipitation assembly, and the wastewater flows through the reagent placing groove when circulating and flowing in the water space; a first driving assembly is arranged in the mounting barrel, a stirring piece is arranged in the reagent placing groove, and the first driving assembly is connected with the stirring piece through a first connecting piece. The embodiment of the application can not only remove fluorine ions in wastewater, but also has small occupied space and high treatment efficiency.

The present disclosure relates to a continuous flow process for the synthesis of heterocyclic ketone compounds, and in particular 3 '-substituted 3-hydroxy-(8-aza-bicyclo [3.2. 1] oct-8-yl)-[5-(1h-pyrazol-4-yl)-thiophen-3-yl]-ketone compounds and aza-bicyclo intermediates thereof. In particular, the present disclosure also relates to a continuous flow process that can be used in the synthesis of Xanamem.

The invention discloses an acid fracturing formation parameter prediction method based on multi-physics coupling, and relates to the field of oil and gas field development engineering and multi-physics coupling numerical simulation. In order to solve the problem that a traditional single field model cannot comprehensively describe complex behaviors of an acid liquid corrosion stratum, the method comprises the following steps: constructing a fluid-solid-heat-chemical multi-physics field coupling equation set covering fluid flow, chemical reaction, heat conduction and solid deformation, and combining finite element spatial discretization and step-by-step iteration solution; dynamic high-precision prediction of key stratum parameters such as porosity, permeability, temperature, rock mechanical parameters, acid liquor concentration field and solid displacement in the acid fracturing process is achieved. The method can provide theoretical basis and technical support for optimization of a gas storage acid liquid transformation scheme and hydraulic fracturing engineering design.