34 results about "Flow chemistry" patented technology

The invention provides a method for preparing a compound or a product having one or more characteristics that meet or exceed a user specification, the process comprising the step of selecting a first combination of chemical inputs, optionally together with physical inputs, and supplying those inputs to a reaction space, thereby to generate a first product; analyzing one or more characteristics of the product generated; comparing the one or more characteristics against a user specification; using a genetic algorithm selecting a second combination of chemical inputs, optionally together with physical inputs, wherein the second combination differs from the first combination, and supplying those inputs to the reaction space, thereby to generate a second product; analyzing one or more characteristics of the second product generated; comparing the one or more characteristics generated against the user specification; repeating the selecting and analyzing steps for further individual combinations of chemical and / or physical inputs, to provide an array of products wherein the flow chemistry system operates continuously to provide the first, second and further products, thereby to identify one or more products meeting or exceeding the user specification.

The invention relates to a preparation method of a heterocycle boric acid compound. The preparation method comprises the following steps: (1) preparing a halogenated heterocycle compound and triisobutyl aluminum into a solution 1; (2) preparing tributyl borate into a solution 2; (3) injecting the solution 1 and the solution 2 into an inflow end of a flowing chemical reaction tube for a reaction, wherein the reaction time in the reaction tube is 1 to 20 min, and the reaction temperature is 0 to 25 DEG C; and (4) mixing an effluent reaction solution and strong acid in a flow ratio of 1:(2-3) inside the inflow end of the flowing chemical reaction tube, mixing a mixed solution and water in the volume ratio of 1:(10-20), standing, collecting an obtained precipitate, and filtering, washing and drying the precipitate to obtain the heterocycle boric acid compound. The yield of the product can be increased to 95%, the purity of the product can be increased to 98.5%, moreover, the production energy consumption and danger can be further reduced, and the compound is more applicable for industrial large-scale production.

Belonging to the field of flow chemistry, the invention provides a method for continuous preparation of a chiral alpha-hydroxy-beta-dicarbonyl compound by visible light catalyzed molecular oxygen oxidation with a microreactor. The method utilizes a chiral quinine derivative quaternary ammonium salt as the chiral phase transfer catalyst, in the presence of an organic photosensitizer, by means of microreactor, preparation of the chiral alpha-hydroxy-beta-dicarbonyl compound by visible light activated gas molecular oxygen catalyzed continuous oxidation of a beta-dicarbonyl compound. The method provided by the invention can achieve a substrate conversion rate close to 100% in 1-10min reaction residence time, a product selectivity higher than 95%, and a product stereoselectivity ee value higherthan 80%. The reaction is green, the environmental burden is low, and the method realizes a continuous process, and has the advantages of large-scale production and low cost.

The invention discloses a method for on-line synthesis of phenylethanol β-amino alcohol derivatives based on flow chemical enzymatic aminolysis reaction: using methanol as a reaction solvent, aniline compounds and benzene oxide with a molar ratio of 1:0.6-1.4 Ethylene is used as a raw material, and lipase Lipozyme RM IM is used as a catalyst. The raw material and reaction solvent are placed in a syringe, and the lipase Lipozyme RM IM is evenly filled in the reaction channel of the microfluidic channel reactor, driven by a syringe pump. The raw materials and the reaction solvent are continuously fed into the reaction channel to carry out the ring-opening reaction. The inner diameter of the reaction channel of the microfluidic channel reactor is 0.8-2.4mm, and the length of the reaction channel is 0.5-1.0m; the ring-opening reaction temperature is controlled at 30 ~50°C, the ring-opening reaction time is 10-30min, the reaction solution is collected online by the product collector, and the reaction solution is subjected to conventional post-treatment to obtain phenylethyl alcohol β-amino alcohol derivatives. The invention has the advantages of short reaction time, high selectivity and high yield.

The invention discloses a cloth chip gravity / capillary flow chemiluminescence method, in particular discloses a cloth chip with gravity / capillary force coupling driving fluid and its application in detecting heavy metal ions. The cloth chip of the present invention is divided into a hydrophobic area and a hydrophilic area, and the hydrophilic area is further divided into three parts: a sampling area, a detection area and a fluid channel area; when in use, the cloth chip should be placed on a support closely, The inclined surface of the bracket forms an included angle with the horizontal plane. After placement, the sample loading area and fluid channel area should be on the inclined surface of the bracket, and the detection area should be on the horizontal part of the bracket. At the same time, a hydrophobic sheet should be placed under the detection area of ​​the cloth chip. Compared with traditional flow chemiluminescence, the cloth chip and detection method of the present invention do not need any expensive pump device (precision syringe pump, peristaltic pump, etc.) to drive liquid flow. The invention only drives the liquid flow through the natural gravity of the liquid and the capillary force of the cloth fiber gap.

The invention relates to a measuring method for a spreading rate in a paper-making reconstituted tobacco production process, belonging to the technical field of paper-making reconstituted tobacco production. The measuring method for the spraying rate in the paper-making reconstituted tobacco production process comprises the following steps: (1) measuring chlorine content c1 of approached stock in the production process by adopting a flow chemical analyzer; (2) measuring the chlorine content c2 in coating liquor in the production process by adopting the flow chemical analyzer; (3) measuring the chlorine content c3 of a reconstituted tobacco finished product by adopting the flow chemical analyzer; (4) calculating the spreading rate x of paper-making reconstituted tobacco according to the following formula: x=(c3-c1) / (c2-c1)*100%. The measuring method for the spreading rate in the paper-making reconstituted tobacco is higher in degree of accuracy and capable of objectively representing the spreading rate of the paper-making reconstituted tobacco.

The invention discloses a tandem synthesis method of 2-(phenylmethylene) malononitrile or its derivatives, the structural formula of the 2-(phenylmethylene) malononitrile or its derivatives is wherein, R 1 is hydrogen, p-methoxy, 2-bromine, 3-bromine or 4-bromine, R 2 For cyano or ester group. The present invention has synthesized a kind of chlorine ball acid-base functionalization catalyst, and successfully applied in series reaction to flow chemistry, and synthesized 2-(phenylmethylene) malononitrile or derivatives thereof at the gram level, compared with traditional test tubes Compared with the reaction, the reaction time is greatly reduced, the yield and product purity are improved, and the separation process of the catalyst and the product is avoided.