149 results about "Ester derivatives" patented technology

The invention relates to the field of medicinal chemistry, in particular to a long-acting ester derivative as well as a preparation method and application thereof. According to the invention, the structure of a parent compound is modified to prepare a prodrug with a long-acting property. The medicine is prepared into an injectable preparation through a preparation means, a medicine storage is formed in vivo, and the medicine is slowly, continuously and stably released from the storage and converted into a parent compound, so that a long-acting effect is achieved.

This invention relates to the field of medicinal chemistry, specifically to a long-acting ester derivative, its preparation method, and its uses. This invention modifies the structure of a parent compound to prepare a prodrug with long-acting properties. This type of drug is formulated into an injectable formulation, forming a drug reservoir in the body from which the drug is slowly, continuously, and stably released and converted into the parent compound, thereby exerting a long-acting effect.

The disclosure generally relates to poly alpha-1,3-glucan compositions and articles containing them. In particular interest is comprising poly alpha-1,3-glucan ester derivatives. The poly alpha-1,3-glucan derivatives are useful in thermoprocesses and in particular, injection molding processes.

The invention relates to the technical field of batteries, and particularly discloses a composite current collector and a preparation method and application thereof. The composite current collector comprises a thin film substrate, and a phosphorus-containing monomer is introduced into the surface of the thin film substrate through plasma treatment; an aluminum conductive layer disposed on at least one side surface of the film substrate; the surface functional layer is arranged on the surface of one side, far away from the thin film substrate, of the aluminum conducting layer, and the surface functional layer comprises a fluorine-containing polymer layer and a nanotube composite layer which are sequentially arranged from inside to outside. Phosphorus-containing monomers (phosphoric acid groups and ester derivatives thereof) are introduced to a film substrate, oxygen atoms or hydroxyl groups in key functional groups of the phosphoric acid groups and the ester derivatives thereof interact with metal ions strongly to form coordinate bonds to enhance the interface bonding force between an aluminum conductive layer and a PET film, and a surface functional layer is combined to block electrolyte permeation, so that the film has a good anti-corrosion effect. And the nanotubes in the surface functional layer form a three-dimensional conductive network, so that the contact resistance is reduced, and the conductivity is enhanced.

The invention discloses application of dikafen phenolic acid and ester derivatives thereof in preparation of medicines for treating pulmonary fibrosis. On an MRC-5 cell model induced by TGF-beta1, the bikafen phenolic acid and the multiple ester derivatives thereof show the activity of inhibiting alpha-SMA and COL1A1 protein expression; on a bleomycin-induced pulmonary fibrosis mouse model, the dimethyl ester derivative of the dikafen phenolic acid shows a good protective effect on experimental animals. Therefore, the dicafen phenolic acid and the ester derivative thereof have good application in the field of preparation of medicines for treating pulmonary fibrosis diseases.

The invention provides an alcohol insect pheromone derivative, which takes a compound containing at least one active group such as carboxyl and amido as a carrier, and alcohol insect pheromone forms derivatives such as ester derivatives and anhydride derivatives with the compound through chemical reaction. The invention also provides a preparation method, application and a release method of the alcohol insect pheromone derivative. According to the alcohol insect pheromone derivative, alcohol insect pheromone is treated in a chemical reaction mode, the stability of the alcohol insect pheromone can be remarkably improved, slow release and controlled release of the pheromone can be achieved, the carrier material is wide in source, multiple in selectivity, convenient to use and economical, and in addition, the alcohol insect pheromone derivative can be used for preparing the alcohol insect pheromone derivative. The alcohol insect pheromone derivative provided by the invention can also realize combined release of various pheromones, so that trapping, prevention and control of various insects can be realized.

The invention discloses a 5-bromoindole-2-carboxylic acid methyl ester derivative as well as a preparation method and application thereof in a protein inhibitor, and relates to the technical field of synthesis and preparation of inhibitors. According to the 5-bromoindole-2-carboxylic acid methyl ester derivative, compared with a contrast product, the synthetic route steps of the prepared 5-bromoindole-2-carboxylic acid methyl ester derivative are simpler and more convenient, structural modification and preparation are easier, the application range of a substrate is widened, the yield of the product is increased, and the yield of the product is increased. The differentiated requirements on the molecular structure novelty in the field of kinase inhibitors can be met. An epidermal growth factor receptor (EGFR) inhibitor prepared from the 5-bromoindole-2-carboxylic acid methyl ester derivative is higher in inhibition efficiency on biological activity, the physiological solubility is improved more remarkably, a more excellent and stable target binding result can be shown, and the EGFR inhibitor can be used for preparing an epidermal growth factor receptor (EGFR) inhibitor. The application effect of the compound in scenes such as antitumor drug development and the like is favorably improved.

A method for increasing or improving nitric oxide signals or levels, the method comprising: administering a composition to a subject, the composition comprising: arginine or a pharmaceutically acceptable salt, ester, or derivative thereof; and tetrahydrocurcumin and / or β-aminoisobutyric acid or a pharmaceutically acceptable salt or ester thereof. The method and the composition can be used to increase, improve, or enhance nitric oxide signals or levels, inhibit nitric oxide decomposition, and increase or enhance nitrous acid and / or cyclic guanosine monophosphate levels, and can improve fatigue resistance or enhance muscle strength, maintain or improve cardiovascular health, maintain or improve vascular function and structure, inhibit or mitigate endothelial cell damage, or mitigate insufficient blood flow.

The ester derivatives of brefeldin A represented by Formula (I) in the inhibition of tumor proliferation. The compounds are prominent in the prevention or treatment of hyperproliferative diseases, including liver cancer, leukemia, breast cancer, colon adenocarcinoma, gastric cancer, lung cancer, Bart's esophageal cancer, cervical cancer, pancreatic cancer, endometrial cancer, bone cancer, lymphoma, kidney cancer, brain cancer, nerve cancer, nasopharyngeal cancer, oral cancer and colorectal cancer, and have the potential to be developed as antitumor agents.

The invention relates to the field of lubricating oil, in particular to a compressor oil composition which is prepared from the following components in parts by weight: 0.005 to 0.2 part of an anti-rust agent, 0.05 to 1 part of an extreme pressure anti-wear agent, 0.01 to 0.5 part of a friction reducing agent, 3 to 8 parts of synthetic ester, 0.01 to 1 part of an antioxidant, 0.001 to 0.1 part of an anti-foaming agent and 90 to 97 parts of base oil. The anti-friction agent is a trimethylolpropane-triacid ester derivative, the anti-rust agent is formed by mixing an alkenyl succinic acid half-ester derivative and a carboxyl imidazoline derivative, and the anti-wear reagent at extreme pressure is formed by mixing triphenyl phosphate and an alkyl thiophosphate derivative. The antioxidant is formed by mixing any two of alkyl diphenylamine, alkyl phenyl-alpha-naphthylamine and alkyl hindered phenol. The invention further relates to a preparation method of the compressor oil composition. The compressor oil composition provided by the invention has excellent washing resistance and rust resistance.

The invention discloses a preparation method of high-strength low-reverse-osmosis composite water-absorbent resin based on a polyurethane double-network interpenetrating structure, which comprises the following preparation steps: S1, adding cyclic carbonate derivatives, polyamine and water into a reaction container with a stirring function, and mixing to prepare gel; s2, gel obtained through reaction is taken out and sheared into small blocks, and the small blocks are put into a granulator to be mixed with hot water for primary granulation. S3, after granulation is completed, gel is put into a drying oven at the temperature of 150-200 DEG C to be dried, grinding materials are prepared according to particle size distribution after a crushing procedure, then surface treatment is conducted through surface treatment liquid at the high temperature, and after cooling, the grinding materials and quantitative inorganic powder are mixed to be uniform to obtain the ultrahigh-gel-strength composite material. The composite water-absorbent resin prepared by the method is good in performance, and has the performance characteristics of high strength and low reverse osmosis.

The invention belongs to the technical field of organic ultrathin nanomaterials, and particularly relates to a photoresponse type polymer ultrathin nanosheet as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) adding dicyclohexylcarbodiimide, N-hydroxysuccinimide, N, N-diisopropylethylamine and 4-carboxyl phenylboronic acid pinacol ester into a solvent, and reacting to obtain an intermediate product; (2) carrying out heating reaction on the intermediate product, triethylene glycol and a catalyst to obtain a phenylboronic acid pinacol ester derivative; (3) adding 4, 4-dibromo azobenzene, a phenylboronic acid pinacol ester derivative, a palladium catalyst and potassium carbonate into a solvent for reaction to obtain an amphiphilic alternating copolymer; and (4) dispersing the amphiphilic alternating copolymer in a solvent for self-assembly to obtain the amphiphilic alternating copolymer. According to the invention, a photoresponse group azobenzene structure is introduced into a polymer main chain, so that the ultrathin organic material is endowed with a unique photoresponse characteristic; the method is simple and easy to implement, good in repeatability and high in stability.

The present invention relates to a composition comprising: 1) at least one inorganic UV filter selected from titanium dioxide; 2) at least one α-cyanodiphenylacrylate derivative of the given formula; and 3) at least one 4-hydroxybenzylidenemalonate or 4-hydroxycinnamate derivative of the given formula. The present invention also relates to a cosmetic method for treating skin against UV radiation using said composition.

The invention provides an asphalt cold-patch liquid and a preparation method thereof, and the asphalt cold-patch liquid comprises the following components in parts by mass: 100 parts of asphalt, 10-30 parts of resin containing unsaturated C = C double bonds, 20-50 parts of a long-chain unsaturated fatty acid compound and 1-2 parts of a photoinitiator, wherein the long-chain unsaturated fatty acid compound is selected from unsaturated fatty acid of which the carbon chain length is not less than C16 or ester derivatives thereof. The asphalt cold supplementing liquid abandons a traditional volatile solvent, emission of VOCs is eradicated fundamentally, and the asphalt cold supplementing liquid has excellent environment-friendly safety; long-chain unsaturated fatty acid contained in the asphalt can form a lubricating molecular film on the surfaces of asphalt particles, so that excellent flowability and construction convenience at normal temperature are guaranteed; unsaturated double bonds in the material can be subjected to rapid photopolymerization reaction under natural illumination to form a cross-linked network structure, so that intelligent curing from flowing state to high strength is realized. Through the mechanism, rapid forming can be achieved at the room temperature, the maintenance time is greatly shortened, and the maintenance efficiency is remarkably improved.

The invention discloses a biodegradable anti-aging agent as well as a preparation method and application thereof, and belongs to the field of biodegradable high polymer materials. Dibasic acid, dihydric alcohol and an acid compound containing a hindered phenol structure or an ester derivative of the acid compound are used as raw materials, esterification and condensation polymerization are performed, and then esterification or ester exchange reaction is performed to prepare the macromolecular anti-aging agent, so that high dispersity and migration resistance are realized; the anti-aging agent and the biodegradable resin are mixed and directly subjected to blow molding, film forming, extrusion casting and other melt forming, the hot working process is simplified, and the loss of material mechanics and aging resistance is reduced; the phenolic hydroxyl group can capture free radicals, so that the aging resistance of the biodegradable material is remarkably improved, and the service life of the material is prolonged. The prepared anti-aging biodegradable material can be applied to thin film products, and is particularly suitable for high-performance degradable mulching films and environment-friendly packaging materials.

The invention provides an anti-sticking asphalt cold patch material with a core-shell structure and a preparation method thereof.The anti-sticking asphalt cold patch material with the core-shell structure sequentially comprises an inner core, a bonding layer and an anti-sticking layer from inside to outside, the bonding layer comprises resin and asphalt, and the anti-sticking layer comprises a fatty acid compound; the fatty acid compound is at least one of long-chain unsaturated fatty acid, long-chain saturated fatty acid or ester derivatives thereof; the fatty acid compound comprises a non-polar long chain with the alkyl chain length of C12-C18 and a polar group, and the polar group comprises any one of an ester group and a carboxyl group. The anti-sticking asphalt cold patch material with the core-shell structure does not need compaction equipment and heating equipment during construction, an anti-sticking layer formed by the fatty acid compound can be destroyed only by means of a driving load, so that a cementing material in the bonding layer flows again and is bonded with each other, and meanwhile, stable structural strength is formed by virtue of an embedding and extruding effect among aggregates.

This invention relates to the field of chemical synthesis, specifically to a malonate dithioester compound, its preparation method, and its uses. The structural formula of the malonate dithioester derivative of this invention is shown in Formula I. The malonate dithioester compound of this invention is more stable than malonyl chloride and has the advantage of higher reactivity than ordinary malonate ester derivatives, and can be used as an excellent intermediate for the synthesis of pyrido[1,2-α]pyrimidinone mesoionic compounds.

The invention relates to the technical field of plant cultivation, and provides a sedge stress-resistant cultivation method and application of strigolactone derivatives in improvement of saline-alkaline resistance of sedge. According to the method, a plant growth regulator is used for carrying out exogenous spraying treatment on the sedge, the plant growth regulator comprises a strigolactone derivative, and the strigolactone derivative is selected from the following compounds shown in the specification. The cultivation method provided by the invention is efficient, environment-friendly and easy to operate, and can effectively relieve the damage of compound saline-alkaline stress to the sedge and improve the growth adaptability of the sedge in a saline-alkaline environment.

This invention relates to an oxobenzohexacyclic borate ester compound, its preparation method, and its uses, belonging to the pharmaceutical field. The derivatives of this invention are compounds represented by Formula I, or their salts, conformational isomers, or optical isomers. The oxobenzohexacyclic borate ester derivatives provided by this invention exhibit good, broad-spectrum inhibitory activity against clinically common metallo-β-lactamases (MBL) and serine β-lactamases (SBL), and show good antibacterial activity against various drug-resistant bacteria when used in combination with the β-lactam antibiotic meropenem. Therefore, the series of derivatives provided by this invention have great potential in the preparation of dual broad-spectrum inhibitors of MBL and SBL and in drugs to overcome β-lactam antibiotic-resistant bacteria. Formula I.

The present application belongs to the technical field of medicine, and relates to derivatives of carboxylic acid groups introduced by 10-position hydroxyl in the structure of ginkgolide B and ester derivatives of the carboxylic acid groups, and pharmaceutically acceptable organic or inorganic salts, as shown in formula 1 and formula 2. The present application takes ginkgolide B as a matrix, and is chemically modified to improve the solubility, increase the bioavailability, and enhance the curative effect of ginkgolide B. The prepared compound and carboxylic acid salt thereof have significant platelet activating factor antagonism, anticoagulation effect, and acute cerebral ischemia effect, and can be used for preparing medicines for preventing and treating ischemic stroke, thrombosis, angina pectoris, cardiopulmonary infarction, and diseases related to platelet activating factor, such as inflammation, asthma, and the like.

Provided is a rayon water jet treatment agent or the like that can reduce the deterioration of water drop foaming of fibers using rayon water jet treatment agent in a water jet step even when the drying temperature in a drying step of the fibers performed before a carding process is high. The rayon water jet treatment agent of the present invention contains a nonionic surfactant (X) containing a specific ether monoester derivative (A) and a specific ether diester derivative (B), and a specific fatty acid (D) or a polyhydric alcohol (E).

The application provides a slow-release tea preservative and a preparation method thereof, and belongs to the technical field of preservatives.The preparation method comprises the following steps: S1, dissolving a vitamin E derivative in oil, stirring and uniformly mixing to prepare an oil phase; S2, dissolving a hydrophilic emulsifier in water, adding sodium alginate, stirring and uniformly mixing to prepare an aqueous phase; S3, adding the oil phase into the aqueous phase, high-speed emulsifying to form an emulsion, heating to a reaction temperature, dropwise adding a calcium chloride solution, cooling and solidifying, filtering, and drying to obtain the slow-release tea preservative.The prepared VE citric acid ester derivative can significantly improve the antioxidant performance of VE, obviously improve the stability of VE to acid and heat, is not prone to oxidation and deterioration, has good sterilization, antibiosis, bacteriostasis and anti-inflammatory effects, and the prepared VE derivative can be slowly released due to the slow-release microcapsule structure, thereby achieving long-acting preservation.

A method to synthesize a silver nanohybrid material. The method includes mixing a nitrate solution with a citrate solution to form silver nanoparticles (AgNPs). The method further includes esterifying a first mixture including octadecanoic acid, octadec-9-enoic acid, and octadeca-9,12-dienoic acid with caffeic acid in the presence of an acid catalyst and a solvent to form an unsaturated carboxylic acid mixture including first, second, and third acrylic acid derivatives. The method includes reacting the unsaturated carboxylic acid mixture with ethylene glycol to form a second mixture including first, second, and third ester derivatives. The method further includes mixing the AgNPs with the second mixture to form a third mixture. The method includes evaporating water from the third mixture to form the silver nanohybrid material. The silver nanohybrid material includes a AgNP core covered with the first, second, and third ester derivatives bonded to the AgNP core.

This invention provides a hypophosphite derivative, its preparation method, and a liquid-phase synthesis method for peptides using the hypophosphite derivative as a carrier, belonging to the fields of organic synthesis and peptide chemistry. In this invention, a hypophosphite derivative is prepared. The hypophosphite derivative provided in this application has advantages such as simple preparation method, low-cost raw materials, and easily adjustable structure. The peptide liquid-phase synthesis method using the hypophosphite derivative as a carrier can efficiently synthesize peptides and improve the solubility of intermediates in the preparation process of peptides (especially hydrophobic peptides), avoiding aggregation or precipitation, and has practical application value for peptide chemical synthesis.

The invention provides a liquid hindered phenol antioxidant. The liquid hindered phenol antioxidant comprises 2-35 parts by mass of a monoester derivative and 65-98 parts by mass of a diester derivative, the invention also provides a preparation method and application of the liquid hindered phenol antioxidant. The liquid hindered phenol antioxidant provided by the invention has excellent oxidation resistance, is more convenient to use, store and transport in a liquid form, greatly reduces the manufacturing cost, remarkably improves the manufacturing efficiency, and is very beneficial to industrial production.

This invention relates to an environmentally friendly, low-solvent inkjet ink and its preparation method, belonging to the technical field of inkjet printing inks. The environmentally friendly, low-solvent inkjet ink comprises, by weight, 25-45 parts of bio-based γ-valerol or its derivatives, 15-25 parts of cyclic carbonate derivatives, and 8-15 parts of modified lactic acid ester solvents; 10-15 parts of core-shell structured nano-pigments; 4-8 parts of photo-thermal dual-curing bio-based polyurethane acrylate and 1-4 parts of modified rosin resin or its derivatives; 1-5 parts of microencapsulated HALS-UV absorber complex, 0.5-2 parts of superdispersant, and 0.5-3 parts of bio-based surfactants. This invention innovatively integrates core technologies such as photo-thermal dual-curing bio-based polyurethane acrylate, a microencapsulated light stabilizer slow-release system, and core-shell structured nano-pigments, achieving excellent outdoor durability, rapid drying, and superior adhesion while maintaining low VOC emissions.

The application discloses a preparation method and application of a cyclodextrin polymer composite adsorbing material. The preparation method of the adsorbing material comprises the following steps: under the action of NaH, β-cyclodextrin is subjected to hydroxyl activation, then maleic anhydride is slowly added to carry out a reaction, and thus a β-cyclodextrin-dibutenedioic acid ester derivative is prepared; under the action of an initiator and a crosslinking agent, the β-cyclodextrin-dibutenedioic acid ester, a double-bond-containing monomer and a functional monomer are subjected to a polymerization reaction, and then are washed and dried, so as to obtain the cyclodextrin polymer composite adsorbing material; the functional monomer is silanized montmorillonite or Fe3O4-dibutenedioic acid ester; and the double-bond-containing monomer is one of acrylic acid, acrylamide and styrene. The cyclodextrin polymer composite adsorbing material with multiple action sites is prepared by using β-cyclodextrin and the functional monomer as raw materials, and by utilizing the structural advantages of different compounds; the preparation conditions of the obtained composite material are mild, the post-treatment is simple, and the composite material has high adsorbing efficiency as an adsorbent.

The present application provides a kind of benzothiazole amino acid ester derivative and its preparation method and purposes, the structural formula of the benzothiazole amino acid ester derivative is as shown in formula I, formula II or formula III. Wherein, R1 It is selected from H atom or the linear or branched alkyl of carbon atom number 8~20, R2 It is selected from H,‑CH(CH3)2,‑(CH2) n COOR1 Wherein n=1‑6, benzothiazole amino acid ester derivative of the present application has significantly antiwear, friction reducing and anti-rust performance, while also having excellent thermal stability.

A lithium-ion battery electrolyte and a lithium-ion battery. In order to solve the problem of poor high-temperature performance and normal-temperature cycle performance of a high-voltage NCM system lithium-ion battery, the electrolyte comprises: an organic solvent, a lithium salt, and an additive, wherein the organic solvent comprises a fluorinated carboxylic ester and a carbonate excluding ethylene carbonate, and wherein the additive comprises one or more of an alkynyl carbonate derivative, a dioxane compound, and a cyclic anhydride, and one or more of vinylene carbonate, fluoroethylene carbonate, ethylene sulfate, lithium difluorophosphate, lithium difluoro bis(oxalato) phosphate, and tris(trimethylsilyl) phosphate. The stability of the high-voltage NCM system lithium-ion battery at a high voltage is greatly improved by means of optimizing the combination of a solvent system and an additive, wherein the solvent system has a mixture of a fluorinated carboxylic ester and a carbonate excluding EC, such that the normal-temperature cycle performance, high-temperature cycle performance, high-temperature storage, and other such capabilities of said high-voltage NCM system lithium-ion battery are all improved.

The invention relates to the technical field of organic chemistry, and particularly discloses a preparation method of (6S) 4, 6, 7, 8-tetrahydro-4-oxopyrrolo [1, 2-a] pyrimidine-6-carboxylic acid. The method comprises the following steps: in the presence of an additive, reacting a compound I or a salt thereof with a hydrogen source or a nucleophilic reagent in a solvent under the catalysis of different metal catalysts to obtain (6S) 4, 6, 7, 8-tetrahydro-4-oxopyrrolo [1, 2-a] pyrimidine-6-carboxylic acid or a salt thereof. According to the invention, allyl ester and benzyl ester derivatives are ingeniously used for replacing common alkyl ester, and mild reaction conditions avoid strong acid and strong alkali environments, so that not only can the phenomenon of chiral racemization caused by product hydrolysis be avoided, but also ester functional groups can be adjusted, and isomer byproducts during ring closing are greatly reduced.