236 results about "Ester derivatives" patented technology

The invention relates to the field of medicinal chemistry, in particular to a long-acting ester derivative as well as a preparation method and application thereof. According to the invention, the structure of a parent compound is modified to prepare a prodrug with a long-acting property. The medicine is prepared into an injectable preparation through a preparation means, a medicine storage is formed in vivo, and the medicine is slowly, continuously and stably released from the storage and converted into a parent compound, so that a long-acting effect is achieved.

This invention relates to the field of medicinal chemistry, specifically to a long-acting ester derivative, its preparation method, and its uses. This invention modifies the structure of a parent compound to prepare a prodrug with long-acting properties. This type of drug is formulated into an injectable formulation, forming a drug reservoir in the body from which the drug is slowly, continuously, and stably released and converted into the parent compound, thereby exerting a long-acting effect.

The invention belongs to the field of synthesis of 4, 6-dihydroxypyrimidine, and discloses a preparation method of 4, 6-dihydroxypyrimidine, which comprises the following steps: S1, adding malonamide, a basic catalyst and an organic solvent into a reaction bottle, and fully stirring to obtain a mixed solution; s2, under the stirring condition, carboxylic ester derivatives are dropwise added into the mixed solution; s3, after the carboxylic ester derivative is dropwise added, carrying out a heat preservation reaction; and S4, carrying out post-treatment on the reaction liquid obtained by the heat preservation reaction to obtain the target product 4, 6-dihydroxypyrimidine. The post-treatment comprises acidification, filtration, washing and drying. The preparation method of 4, 6-dihydroxypyrimidine has the advantages of mild reaction conditions, simple and safe operation, cheap and easily available raw materials, high yield, good product purity and environmental friendliness, and has important practical significance and application value.

The disclosure generally relates to poly alpha-1,3-glucan compositions and articles containing them. In particular interest is comprising poly alpha-1,3-glucan ester derivatives. The poly alpha-1,3-glucan derivatives are useful in thermoprocesses and in particular, injection molding processes.

The invention relates to the technical field of batteries, and particularly discloses a composite current collector and a preparation method and application thereof. The composite current collector comprises a thin film substrate, and a phosphorus-containing monomer is introduced into the surface of the thin film substrate through plasma treatment; an aluminum conductive layer disposed on at least one side surface of the film substrate; the surface functional layer is arranged on the surface of one side, far away from the thin film substrate, of the aluminum conducting layer, and the surface functional layer comprises a fluorine-containing polymer layer and a nanotube composite layer which are sequentially arranged from inside to outside. Phosphorus-containing monomers (phosphoric acid groups and ester derivatives thereof) are introduced to a film substrate, oxygen atoms or hydroxyl groups in key functional groups of the phosphoric acid groups and the ester derivatives thereof interact with metal ions strongly to form coordinate bonds to enhance the interface bonding force between an aluminum conductive layer and a PET film, and a surface functional layer is combined to block electrolyte permeation, so that the film has a good anti-corrosion effect. And the nanotubes in the surface functional layer form a three-dimensional conductive network, so that the contact resistance is reduced, and the conductivity is enhanced.

The invention discloses application of dikafen phenolic acid and ester derivatives thereof in preparation of medicines for treating pulmonary fibrosis. On an MRC-5 cell model induced by TGF-beta1, the bikafen phenolic acid and the multiple ester derivatives thereof show the activity of inhibiting alpha-SMA and COL1A1 protein expression; on a bleomycin-induced pulmonary fibrosis mouse model, the dimethyl ester derivative of the dikafen phenolic acid shows a good protective effect on experimental animals. Therefore, the dicafen phenolic acid and the ester derivative thereof have good application in the field of preparation of medicines for treating pulmonary fibrosis diseases.

The invention provides an alcohol insect pheromone derivative, which takes a compound containing at least one active group such as carboxyl and amido as a carrier, and alcohol insect pheromone forms derivatives such as ester derivatives and anhydride derivatives with the compound through chemical reaction. The invention also provides a preparation method, application and a release method of the alcohol insect pheromone derivative. According to the alcohol insect pheromone derivative, alcohol insect pheromone is treated in a chemical reaction mode, the stability of the alcohol insect pheromone can be remarkably improved, slow release and controlled release of the pheromone can be achieved, the carrier material is wide in source, multiple in selectivity, convenient to use and economical, and in addition, the alcohol insect pheromone derivative can be used for preparing the alcohol insect pheromone derivative. The alcohol insect pheromone derivative provided by the invention can also realize combined release of various pheromones, so that trapping, prevention and control of various insects can be realized.

The invention discloses a 5-bromoindole-2-carboxylic acid methyl ester derivative as well as a preparation method and application thereof in a protein inhibitor, and relates to the technical field of synthesis and preparation of inhibitors. According to the 5-bromoindole-2-carboxylic acid methyl ester derivative, compared with a contrast product, the synthetic route steps of the prepared 5-bromoindole-2-carboxylic acid methyl ester derivative are simpler and more convenient, structural modification and preparation are easier, the application range of a substrate is widened, the yield of the product is increased, and the yield of the product is increased. The differentiated requirements on the molecular structure novelty in the field of kinase inhibitors can be met. An epidermal growth factor receptor (EGFR) inhibitor prepared from the 5-bromoindole-2-carboxylic acid methyl ester derivative is higher in inhibition efficiency on biological activity, the physiological solubility is improved more remarkably, a more excellent and stable target binding result can be shown, and the EGFR inhibitor can be used for preparing an epidermal growth factor receptor (EGFR) inhibitor. The application effect of the compound in scenes such as antitumor drug development and the like is favorably improved.

The present invention provides a polyester wherein: a dicarboxylic acid constituent unit includes 72.5 mol% or more of a constituent unit derived from 2,6-naphthalenedicarboxylic acid and / or an ester derivative thereof among a total 100 mol% of said dicarboxylic acid constituent units; and a diol constituent unit includes 27.5 mol% or more of a constituent unit derived from 1,4-cyclohexanedimethanol and a constituent unit derived from 2,2,4,4-tetramethyl-1,3-cyclobutanediol among a total 100 mol% of said diol constituent units. A feeding bottle according to the present invention is formed using said polyester.

The invention provides a phenolic ester derivative as well as a preparation method and application thereof. The structure of the phenolic ester derivative is shown as a formula (I), wherein the definition of each group is shown in the specification. The phenolic ester derivative disclosed by the invention has excellent oxidation stability, thermal stability, viscosity-temperature performance, low-temperature performance and lubricating performance, and is suitable for being used as lubricating oil base oil.

A method for increasing or improving nitric oxide signals or levels, the method comprising: administering a composition to a subject, the composition comprising: arginine or a pharmaceutically acceptable salt, ester, or derivative thereof; and tetrahydrocurcumin and / or β-aminoisobutyric acid or a pharmaceutically acceptable salt or ester thereof. The method and the composition can be used to increase, improve, or enhance nitric oxide signals or levels, inhibit nitric oxide decomposition, and increase or enhance nitrous acid and / or cyclic guanosine monophosphate levels, and can improve fatigue resistance or enhance muscle strength, maintain or improve cardiovascular health, maintain or improve vascular function and structure, inhibit or mitigate endothelial cell damage, or mitigate insufficient blood flow.

The ester derivatives of brefeldin A represented by Formula (I) in the inhibition of tumor proliferation. The compounds are prominent in the prevention or treatment of hyperproliferative diseases, including liver cancer, leukemia, breast cancer, colon adenocarcinoma, gastric cancer, lung cancer, Bart's esophageal cancer, cervical cancer, pancreatic cancer, endometrial cancer, bone cancer, lymphoma, kidney cancer, brain cancer, nerve cancer, nasopharyngeal cancer, oral cancer and colorectal cancer, and have the potential to be developed as antitumor agents.

Pharmaceutical combinations of etomidate derivatives and propofol and pharmaceutical compositions thereof for use in anesthesia, sedation and / or hypnosis of animals or humans. The pharmaceutical composition of the etomidate derivative and the propofol or the pharmaceutical composition of the etomidate derivative and the propofol shows an excellent synergistic effect compared with independent administration and combined administration.

The invention relates to the field of lubricating oil, in particular to a compressor oil composition which is prepared from the following components in parts by weight: 0.005 to 0.2 part of an anti-rust agent, 0.05 to 1 part of an extreme pressure anti-wear agent, 0.01 to 0.5 part of a friction reducing agent, 3 to 8 parts of synthetic ester, 0.01 to 1 part of an antioxidant, 0.001 to 0.1 part of an anti-foaming agent and 90 to 97 parts of base oil. The anti-friction agent is a trimethylolpropane-triacid ester derivative, the anti-rust agent is formed by mixing an alkenyl succinic acid half-ester derivative and a carboxyl imidazoline derivative, and the anti-wear reagent at extreme pressure is formed by mixing triphenyl phosphate and an alkyl thiophosphate derivative. The antioxidant is formed by mixing any two of alkyl diphenylamine, alkyl phenyl-alpha-naphthylamine and alkyl hindered phenol. The invention further relates to a preparation method of the compressor oil composition. The compressor oil composition provided by the invention has excellent washing resistance and rust resistance.

The invention discloses a preparation method of high-strength low-reverse-osmosis composite water-absorbent resin based on a polyurethane double-network interpenetrating structure, which comprises the following preparation steps: S1, adding cyclic carbonate derivatives, polyamine and water into a reaction container with a stirring function, and mixing to prepare gel; s2, gel obtained through reaction is taken out and sheared into small blocks, and the small blocks are put into a granulator to be mixed with hot water for primary granulation. S3, after granulation is completed, gel is put into a drying oven at the temperature of 150-200 DEG C to be dried, grinding materials are prepared according to particle size distribution after a crushing procedure, then surface treatment is conducted through surface treatment liquid at the high temperature, and after cooling, the grinding materials and quantitative inorganic powder are mixed to be uniform to obtain the ultrahigh-gel-strength composite material. The composite water-absorbent resin prepared by the method is good in performance, and has the performance characteristics of high strength and low reverse osmosis.

The invention belongs to the technical field of organic ultrathin nanomaterials, and particularly relates to a photoresponse type polymer ultrathin nanosheet as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) adding dicyclohexylcarbodiimide, N-hydroxysuccinimide, N, N-diisopropylethylamine and 4-carboxyl phenylboronic acid pinacol ester into a solvent, and reacting to obtain an intermediate product; (2) carrying out heating reaction on the intermediate product, triethylene glycol and a catalyst to obtain a phenylboronic acid pinacol ester derivative; (3) adding 4, 4-dibromo azobenzene, a phenylboronic acid pinacol ester derivative, a palladium catalyst and potassium carbonate into a solvent for reaction to obtain an amphiphilic alternating copolymer; and (4) dispersing the amphiphilic alternating copolymer in a solvent for self-assembly to obtain the amphiphilic alternating copolymer. According to the invention, a photoresponse group azobenzene structure is introduced into a polymer main chain, so that the ultrathin organic material is endowed with a unique photoresponse characteristic; the method is simple and easy to implement, good in repeatability and high in stability.

The invention relates to a metal anti-corrosion cleaning agent, a preparation method and application, and the metal anti-corrosion cleaning agent comprises the following components in parts by weight: 0.001-0.06 part of a composite functional agent; 0.1 to 3 parts of a pH regulator; 0.01 to 1 part of inorganic acid; 50-80 parts of an organic solvent; and 20-50 parts of ultrapure water. The thienyl carboxylic ester derivative and the alkanol derivative are combined, the thienyl carboxylic ester derivative removes metal ions (such as Cu < + > and Fe < + >) in a targeted mode by means of the strong chelating capacity of ester groups, and organic pollutants are stripped through the pi-pi effect; the alkanol derivative wraps non-polar residual gum by using a long-chain hydrophobic end, and a hydrophilic end enhances the wettability of a solution, so that full-coverage cleaning of a nano-scale structure is realized.

The present invention provides a polyester wherein: a dicarboxylic acid constituent unit is a constituent unit derived from 2,6-naphthalenedicarboxylic acid and / or an ester derivative thereof; and a diol constituent unit includes a constituent unit derived from any isosorbide, and 27.5 mol% or more of a constituent unit derived from 1,4-cyclohexanedimethanol among a total 100 mol% of said diol constituent units. A feeding bottle according to the present invention is formed using said polyester.

The present invention relates to a composition comprising: 1) at least one inorganic UV filter selected from titanium dioxide; 2) at least one α-cyanodiphenylacrylate derivative of the given formula; and 3) at least one 4-hydroxybenzylidenemalonate or 4-hydroxycinnamate derivative of the given formula. The present invention also relates to a cosmetic method for treating skin against UV radiation using said composition.

The present invention belongs to the technical field of biomedicine, and relates to a class of dexborneol or fenchyl alcohol ester derivatives of 2-hydroxynicotinic acid, and pharmaceutical uses thereof. The structural general formula of the derivatives is (1), R1 being selected from -H, -Cl, a hydrocarbon group having 1-8 carbon atoms, -CF3, -CF2H, -CN, -SCH3, -OH, -CHO, -CH2OH, -CH2NH2, -COOH, halogenated phenyl, or -NR4R5; R4, R5 are independently selected from -H or -CH3; R2 is selected from -H, an alkyl group having 1-6 carbon atoms, an acyl group having 2-7 carbon atoms, or a carbamoyl group; R 3 is selected from formula (a) or formula (b); X is selected from -CH= or -N=. The derivatives have good inflammation-inhibiting effects, and at high concentrations, they exhibit low cytotoxicity and are safer. The derivatives can be used for preparing a drug for treating inflammation and inflammation-related diseases such as stroke, neuropathic pain, depression and Alzheimer's disease.

The invention provides an asphalt cold-patch liquid and a preparation method thereof, and the asphalt cold-patch liquid comprises the following components in parts by mass: 100 parts of asphalt, 10-30 parts of resin containing unsaturated C = C double bonds, 20-50 parts of a long-chain unsaturated fatty acid compound and 1-2 parts of a photoinitiator, wherein the long-chain unsaturated fatty acid compound is selected from unsaturated fatty acid of which the carbon chain length is not less than C16 or ester derivatives thereof. The asphalt cold supplementing liquid abandons a traditional volatile solvent, emission of VOCs is eradicated fundamentally, and the asphalt cold supplementing liquid has excellent environment-friendly safety; long-chain unsaturated fatty acid contained in the asphalt can form a lubricating molecular film on the surfaces of asphalt particles, so that excellent flowability and construction convenience at normal temperature are guaranteed; unsaturated double bonds in the material can be subjected to rapid photopolymerization reaction under natural illumination to form a cross-linked network structure, so that intelligent curing from flowing state to high strength is realized. Through the mechanism, rapid forming can be achieved at the room temperature, the maintenance time is greatly shortened, and the maintenance efficiency is remarkably improved.

A pharmaceutical combination of an etomidate derivative and ciprofol, and a pharmaceutical composition comprising the etomidate derivative and ciprofol. Use of the pharmaceutical combination or the pharmaceutical composition in anesthesia, sedation, and / or hypnosis of animals or humans. Compared to the administration of the etomidate derivative or ciprofol alone and the combined administration of etomidate and ciprofol, the pharmaceutical combination or the pharmaceutical composition shows an excellent synergistic effect, significantly improving the recovery time after anesthesia withdrawal, etc.

The present invention relates to the use of compounds of formula (I), which are strigolactone derivatives and analogues, as nitrification inhibiting compounds, i.e. for reducing nitrification, in nitrifying microorganisms, as well as agrochemical mixtures and compositions comprising a nitrification inhibiting compound of formula (I).

The invention discloses a biodegradable anti-aging agent as well as a preparation method and application thereof, and belongs to the field of biodegradable high polymer materials. Dibasic acid, dihydric alcohol and an acid compound containing a hindered phenol structure or an ester derivative of the acid compound are used as raw materials, esterification and condensation polymerization are performed, and then esterification or ester exchange reaction is performed to prepare the macromolecular anti-aging agent, so that high dispersity and migration resistance are realized; the anti-aging agent and the biodegradable resin are mixed and directly subjected to blow molding, film forming, extrusion casting and other melt forming, the hot working process is simplified, and the loss of material mechanics and aging resistance is reduced; the phenolic hydroxyl group can capture free radicals, so that the aging resistance of the biodegradable material is remarkably improved, and the service life of the material is prolonged. The prepared anti-aging biodegradable material can be applied to thin film products, and is particularly suitable for high-performance degradable mulching films and environment-friendly packaging materials.

The application discloses a kind of 18 beta-glycyrrhetinic acid ester derivatives with PPAR gamma agonistic activity and its preparation method and application, belongs to chemical pharmaceutical technical field, specifically related to a kind of 18 beta-glycyrrhetinic acid ester derivatives molecules and its application as PPAR gamma agonist in antitumor aspect.The application uses Steglich esterification reaction, with dicyclohexyl carbodiimide and 4-dimethylaminopyridine as catalyst, 18 beta-glycyrrhetinic acid is reacted with different types of carboxylic acid, and a kind of novel 18 beta-glycyrrhetinic acid ester derivative molecules are obtained by semi-synthesis;Computer simulation molecular docking and in vitro enzyme activity experiment show that this kind of molecule can be used as PPAR gamma agonist and play significant antitumor activity.

Methods are disclosed herein for producing ester derivatives of alpha-glucan comprising alpha-1,6 linkages. Such methods can comprise esterifying an alkalized alpha-glucan in an esterification reaction composition that otherwise does not contain any added alkalizing agent. Further disclosed are alpha-glucan ester compositions produced by the disclosed processes, as well as various applications of using these compositions.

The invention provides an anti-sticking asphalt cold patch material with a core-shell structure and a preparation method thereof.The anti-sticking asphalt cold patch material with the core-shell structure sequentially comprises an inner core, a bonding layer and an anti-sticking layer from inside to outside, the bonding layer comprises resin and asphalt, and the anti-sticking layer comprises a fatty acid compound; the fatty acid compound is at least one of long-chain unsaturated fatty acid, long-chain saturated fatty acid or ester derivatives thereof; the fatty acid compound comprises a non-polar long chain with the alkyl chain length of C12-C18 and a polar group, and the polar group comprises any one of an ester group and a carboxyl group. The anti-sticking asphalt cold patch material with the core-shell structure does not need compaction equipment and heating equipment during construction, an anti-sticking layer formed by the fatty acid compound can be destroyed only by means of a driving load, so that a cementing material in the bonding layer flows again and is bonded with each other, and meanwhile, stable structural strength is formed by virtue of an embedding and extruding effect among aggregates.

The present invention relates to processes for the formation of pyridinedicarboxylic acid (PDCA), in particular, 2,4-pyridinedicarboxylic acid (2,4-PDCA) and 2,5-pyridinedicarboxylic acid (2,5-PDCA), and mono- and diester derivatives thereof, from 3,4-dihydroxybenzoic acid, via a biocatalytic reaction using, for example, a protocatechuate dioxygenase such as protocatechuate 4,5-dioxygenase or protocatechuate 2,3-dioxygenase, and a nitrogen source. The invention also relates to copolymers that comprise the pyridinedicarboxylic acid monomers and derivatives thereof, processes for the formation of the copolymers and uses for the copolymers.

A battery cell, a battery device, and an electric device. The battery cell comprises an electrode assembly and an electrolyte, wherein the electrode assembly comprises a positive electrode sheet and a negative electrode sheet; the positive electrode sheet comprises a lithium-containing phosphate; the negative electrode sheet comprises graphite particles; the electrolyte comprises a carboxylate ester solvent, a linear carbonate solvent, and an additive; the mass content of the carboxylate ester solvent is 10% to 30%; the mass content of the linear carbonate solvent is 10% to 50%; the mass content of the additive is 3% to 9%; the additive comprises 1,3-propane sultone having a mass content greater than or equal to 0, an ethylene carbonate derivative having a mass content greater than or equal to 0, and vinylene carbonate having a mass content greater than 0; and the ethylene carbonate derivative comprises a compound represented by formula A, wherein in formula A, Q1, Q2, Q3, and Q4 each independently comprise any one of a hydrogen atom, a halogen atom, a C1 to C5 alkyl group, or a C1 to C5 haloalkyl group, and Q1, Q2, Q3, and Q4 are not simultaneously hydrogen atoms.

The present disclosure relates to an ester derivative prodrug of inotodiol and use thereof. The prodrug not only has increased solubility with respect to an inorganic solvent and an organic solvent, but also has improved stability, and thus can be used in the treatment of various inflammatory diseases, including inflammatory diseases or allergic diseases.