385 results about "Ester derivatives" patented technology

The invention relates to a battery monomer, a battery device and a power utilization device, the battery monomer comprises an electrode assembly and an electrolyte, and the electrode assembly comprises a positive pole piece and a negative pole piece; the positive pole piece comprises a positive pole current collecting part and a positive pole film layer; the positive pole film layer comprises lithium-containing phosphate with an olivine structure; the negative pole piece comprises a negative pole current collecting part and a negative pole film layer, and the negative pole film layer comprises a carbon-based material; the electrolyte comprises a carboxylic ester solvent, a first additive and fluorine-containing lithium sulfimide, and the mass content of the carboxylic ester solvent is 8%-60%; the total mass content of the first additive is 2.5%-10%, the first additive comprises 1, 3-propane sultone with the mass content larger than or equal to 0, an ethylene carbonate derivative with the mass content larger than or equal to 0 and vinylene carbonate with the mass content larger than 0, and the ethylene carbonate derivative comprises a compound shown in the formula A; the mass content of the fluorine-containing lithium sulfimide is 4%-8%. According to the invention, the rapid charging performance and the cycle performance of the battery monomer can be improved. # imgabs0 # formula A

The invention relates to a battery monomer, a battery device and a power utilization device, the battery monomer comprises an electrode assembly and an electrolyte, and the electrode assembly comprises a positive pole piece and a negative pole piece; the positive pole piece comprises lithium-containing phosphate with an olivine structure; the negative pole piece comprises graphite particles; the electrolyte comprises a carboxylic ester solvent and a first additive, the thickness of the single-side negative electrode film layer is 50 microns to 75 microns, and the volume average particle size of the graphite particles is 8.5 microns to 13.5 microns; based on the mass of the electrolyte, the mass content of the carboxylic ester solvent is 8%-60%, the total mass content of the first additive is 3%-10%, the first additive comprises 1, 3-propane sultone with the mass content larger than or equal to 0, an ethylene carbonate derivative with the mass content larger than or equal to 0 and vinylene carbonate with the mass content larger than or equal to 3%, and the ethylene carbonate derivative comprises a compound shown in the formula A. According to the invention, the rapid charging performance and the cycle performance of the battery monomer under high energy density can be improved. # imgabs0 # formula A

The invention discloses a preparation method of a pyrazolone amino-acid ester derivative. The pyrazolone amino-acid ester derivative is obtained through three-component cascade reaction by taking pyrazolone imine, a pentafluorophenylacetate derivative and alcohol as reactants and chiral isothiourea as a catalyst. According to the invention, challenges of competitive side reactions between a plurality of reaction substrates and intermediates and stereoselectivity control are overcome, the application range of the substrate combination of the existing system is broken through, and synthesis of a series of pyrazolone amino-acid ester derivatives is realized in a green and efficient manner. According to the method disclosed by the invention, substrate preassembly is not needed, transition metal catalysis is not needed, raw materials and the catalyst are cheap and easy to obtain, reaction conditions are mild, and the substrate application range is wide. In addition, the invention also provides a new way for introducing the medicine bioactive molecules into the synthesis of the pyrazolone amino-acid ester compound.

The invention relates to the field of biological medicines, in particular to a composition containing pyruvate as well as a preparation method and application of the composition. The composition containing pyruvate is prepared from the following raw materials in percentage by mass: 0.05 to 0.1 percent of pyruvate, 0.02 to 0.04 percent of bergenin derivative, 5 to 10 percent of water for injection and the balance of propellant, the structural formula of the bergenin derivative is as follows: # imgabs0 #. The composition containing pyruvate can reduce the abundance of pathogenic bacteria and increase the abundance of probiotics, so that the effect of treating lung diseases is achieved by adjusting the respiratory tract micro-ecology.

The invention relates to the technical field of organic synthesis, in particular to a preparation method of ethylene sulfate and derivatives thereof, which comprises the following steps: S1, taking an aprotic solvent as a reaction solvent, adding urea peroxide, and stirring until the urea peroxide is dissolved; s2, dropwise adding ethylene sulfite or an ethylene sulfite derivative, stirring for reaction, and purifying to obtain ethylene sulfate or an ethylene sulfate derivative; the method has the advantages of reducing the catalyst cost and reducing the wastewater amount.

The invention relates to a method for constructing a C-N bond or a C-C bond through an insertion reaction of oxygen-sulfur ylide and aromatic amine. According to the method, tris (pentafluorophenyl) borane is taken as a catalyst, oxygen-sulfur ylide and aromatic amine are taken as raw materials, and N-H or C-H insertion reaction is carried out under different temperatures and solvents. According to the method, the defect that a metal catalyst or an oxidizing agent is used traditionally is overcome, and on the basis of the method, various alpha-amino-acid ester derivatives or diaryl acetate derivatives can be obtained by using different aromatic amines and oxygen-sulfur ylide as substrates. According to the method, the raw materials are easy to obtain, the operation is simple, the use of a catalyst and an oxidizing agent is avoided, and the method is a mild, effective, feasible and environment-friendly method for preparing the alpha-amino-acid ester and the diaryl acetate and has important application value.

The invention relates to a battery monomer, a battery device and a power utilization device. The battery monomer comprises a positive pole piece and a negative pole piece, the positive pole piece comprises lithium-containing phosphate; the negative pole piece comprises graphite particles; the electrolyte comprises a carboxylic ester solvent, a linear carbonic ester solvent and an additive, the mass content of the carboxylic ester solvent is 10%-30%, and the mass content of the linear carbonic ester solvent is 10%-50%; the mass content of the additive is 3%-9%, the additive comprises 1, 3-propane sultone with the mass content larger than or equal to 0, an ethylene carbonate derivative with the mass content larger than or equal to 0 and vinylene carbonate with the mass content larger than 0, and the ethylene carbonate derivative comprises a compound shown in the formula A; q1, Q2, Q3 and Q4 each independently comprise any one of a hydrogen atom, a halogen atom, a C1 to C5 alkyl group or a C1 to C5 halogenated alkyl group, and Q1, Q2, Q3 and Q4 are not hydrogen atoms at the same time. # imgabs0 # formula A is shown in the specification.

To provide a method for producing 4-ketobenzamide derivatives and 4-ketobenzoic acid derivatives.SOLUTION: The present invention provides a method for producing a 4-ketobenzamide compound represented by formula (2), by amidating a compound represented by formula (1), which is obtained through cyanation of a compound represented by formula (3), as well as a method for producing a 4-ketobenzoic acid derivative represented by formula (6), by hydrolyzing the compound represented by formula (1) or the compound represented by formula (2), and a method for producing a 4-ketobenzoic acid ester derivative represented by formula (5), by esterifying the compound represented by formula (2), wherein R1 represents a C1-C6 alkyl group or the like, R2 represents a C1-C6 alkyl group or the like, R3 represents a C1-C6 alkyl group or the like, X represents a halogen atom or the like, Y represents a C1-C6 alkyl group or the like, and n represents an integer of 0-3.SELECTED DRAWING: None

The invention provides a flame-retardant polycarbonate composite material and a preparation method thereof, the flame-retardant polycarbonate composite material comprises the following raw materials in parts by weight: 100 parts of polycarbonate, 3-5 parts of an organic boron flame retardant, 2-3 parts of a phosphate flame retardant and 0.1-0.5 part of an antioxidant, and the structural formula of the organic boron flame retardant is as shown in the following formula I. According to the invention, the triazine aniline derivative and the formylphenylboronic acid acetate derivative react to prepare the organic boron flame retardant, and the organic boron flame retardant not only significantly improves the flame retardant property of the composite material, but also has a high light transmittance retention value after high-temperature aging, so that good balance between flame retardance and transmission performance is realized.

The invention discloses a method for preparing a chiral furanone ester derivative, which comprises the following steps: adding a metal catalyst into a solvent, sequentially adding a carboxylic acid compound I or a carboxylic acid compound II and a butene lactone compound III, introducing inert gas, stirring, post-treating and purifying to obtain a chiral furanone ester compound IV; the palladium catalysis system is composed of palladium salt and a chiral ligand V, and the chiral ligand has a structure shown in a formula V.

The invention discloses a novel methylpyrazole propionamide derivative as well as a preparation method and application thereof. According to the invention, 3-hydroxypyrazole is used as an active matrix skeleton and is combined with a pharmacodynamic group propionamide with herbicidal activity to develop a novel hydroxypyrazole herbicide, and a series of novel 3-oxypropionamide-1-methylpyrazole-carboxylic ester derivatives are designed and synthesized. The invention also provides biological activity of the compounds for controlling agricultural, horticultural and forestry weeds, a determination method of the compounds, and application of the compounds in the fields of agriculture, horticultural and forestry.

The invention provides a deuterated etomidate derivative as well as a preparation method, an intermediate and application thereof. Particularly, the invention relates to a deuterated etomidate derivative shown in a general formula I ', a preparation method and an intermediate of the deuterated etomidate derivative, a pharmaceutical composition containing the deuterated etomidate derivative, and application of the deuterated etomidate derivative or the pharmaceutical composition of the deuterated etomidate derivative as a GABBA receptor agonist in preparation of drugs in the field of central nervous systems.

The invention belongs to the technical field of lithium ion batteries, and particularly relates to a lithium ion battery high-voltage electrolyte and a lithium ion battery. The high-voltage electrolyte comprises a lithium salt, a first additive, a second additive, an auxiliary additive and an organic solvent, the first additive is a sulfur-containing siloxy boric acid ester derivative, and the second additive is a benzofuran boric acid ester derivative. Borate groups and benzofuran groups in the first additive and the second additive can promote generation of CEI and SEI protective films on the surfaces of a positive electrode and a negative electrode, the stability of the material is enhanced, electrolyte decomposition is inhibited, and the high-voltage performance of the lithium battery is improved; the trimethylsiloxy group can remove HF in the system, can reduce the corrosion to the positive and negative electrode interface of the battery, and improves the cycle performance of the battery; boron and sulfur atoms in the additive can significantly reduce the internal resistance of the battery and improve the performance of the high-voltage battery at low temperature.

The invention relates to the field of medicinal chemistry, in particular to a long-acting ester derivative as well as a preparation method and application thereof. According to the invention, the structure of a parent compound is modified to prepare a prodrug with a long-acting property. The medicine is prepared into an injectable preparation through a preparation means, a medicine storage is formed in vivo, and the medicine is slowly, continuously and stably released from the storage and converted into a parent compound, so that a long-acting effect is achieved.

The present invention relates to alpha-tocopherol succinate (alpha-TOS) derivatives having ionizable properties or of the cationic type. The alpha-TOS derivative prepared by the invention can be used for preparing ionizable or cationic liposomes and lipid nano preparations. The compounds have good nano preparation formability and in-vivo anti-tumor activity superior to that of alpha-TOS, and have a synergistic anti-tumor effect when being combined with anti-tumor drugs such as doxorubicin hydrochloride and the like. The lipid nano preparation entrapped with the doxorubicin hydrochloride has high tumor inhibition capacity and does not have obvious toxic reaction. The invention firstly provides a class of relatively safe ionizable lipids and cationic lipids for preparing ionizable nano preparations, and secondly provides a class of new medicines and preparations thereof for treating tumors.

A method of improving and / or enhancing at least one of bone mineralization, bone strength, bone mass, and bone mineral density in an individual in need thereof, the method comprising administering to the individual a composition comprising one or more anabolic amino acids, and the composition further comprising one or more autophagy-inducing compounds. In one embodiment, the one or more autophagy-inducing compounds are selected from the group consisting of thymol, carvacrol, spermidine, urolithin (e.g., Urolithin A, B or D), rapamycin, Torin1, valproic acid, polyphenols (e.g., resveratrol), caffeine, metformin, 5′ AMP-activated protein kinase (AMPK) activators, L-type calcium channel inhibitors, ketones (e.g. beta-hydroxybutyrate, ketone salts, or ketone ester derivatives), 4,4′-dimethoxychalcone and mixtures thereof.

The invention belongs to the field of organic synthesis, and particularly relates to a sulfo-difluoro ester derivative, a preparation method thereof and application of the sulfo-difluoro ester derivative in the aspect of bacteriostasis. The preparation method of the thiodifluoroester derivative comprises the following steps: reacting styrene, a mixed solvent of BrF2COOEt, CS2, morpholine, choline chloride and glycerol and CuOTf in an air atmosphere under light irradiation for 24 hours, cooling to room temperature after the reaction is completed, and collecting a precipitate, namely thiodifluoroester, the preparation method disclosed by the invention is simple, efficient, green and pollution-free; the compound can be widely applied to the field of inhibition of gaeumannomyces graminis or valsa mali.

The invention relates to dexcamphanol or fenchol ester derivatives of 2-hydroxynicotinic acid and pharmaceutical application of the dexcamphanol or fenchol ester derivatives, and belongs to the technical field of biological medicine. The structural general formula of the derivative disclosed by the invention is # imgabs0 #, wherein R1 is selected from-H,-Cl, alkyl with 1 to 8 carbon atoms,-CF3,-CF2H,-CN,-SCH3,-OH,-CHO,-CH2OH,-CH2NH2,-COOH, halogenated phenyl or-NR4R5; r4 and R5 are independently selected from-H or-CH3; r2 is selected from-H, alkyl with 1-6 carbon atoms, and acyl or carbamoyl with 2-7 carbon atoms; r3 is selected from # imgabs1; # X is selected from-CH = or-N =. The derivative disclosed by the invention has a good inflammation inhibition effect; and under the condition of high concentration, the compound has lower cytotoxicity and is safer. The compound can be used for preparing medicines for treating inflammation and inflammation-related diseases such as cerebral apoplexy, neuropathic pain, depression and senile dementia.

The invention belongs to the technical field of analysis and detection of liquid nutritional agents, and provides a coniferous and cypress hydroformylation salicyl ester molecular device and a preparation method and application thereof. The method comprises the following steps: mixing a coniferyl aldehyde solution, a dehydrating agent dispersion liquid and a salicyl ester derivative solution, and carrying out a dehydration condensation reaction on the mixed solution to obtain the coniferyl hydroformylated salicyl ester molecular device. The coniferous hydroformylated salicylate molecular device has the advantages of high viscosity sensitivity coefficient, stable chemical structure, strong visualization effect, release of stable optical signals in a wide pH range, insensitivity to the polarity of the solvent, and good solvent tolerance; the device can be used as a molecular tool for in-situ measurement of viscosity in a nutritional agent microenvironment, detection can be realized without depending on shearing and relative movement in the measurement process, consumption of a large amount of samples can be avoided, the whole process is rapid, efficient and convenient, and viscosity change of a liquid nutritional agent containing a large amount of pseudoplastic fluid can be effectively measured.

The invention provides a fluorine-containing parthenolide derivative compound as shown in a formula (I), a deuterated substance, a tautomer, a stereoisomer, a hydrate, a solvate, a pharmaceutically acceptable salt or a prodrug thereof, and the fluorine-containing parthenolide derivative compound has a better tumor inhibition effect and can be used for preventing and / or treating cancers. The preparation method provided by the invention is simple to operate, and fluorine-containing parthenolide molecules can be efficiently and quickly constructed. # imgabs0 #

Provided are a method for producing a cellulose acylate film, which makes it possible to produce a film having a reduced amount of residual solvent and a reduced amount of elution with good productivity even in a case where the film is relatively thick; and a cellulose acylate film. A cellulose acylate film (23) is produced by a method for producing a cellulose acylate film, the method including a casting step of forming a cast film by casting a dope (14) containing a cellulose acylate (11), a sugar ester derivative, and a polyester having a weight-average molecular weight in a range of 50000 or more and 1000000 or less and represented by a specific formula on a support; and a peeling step of peeling the cast film from the support.

This invention relates to the field of medicinal chemistry, specifically to a long-acting ester derivative, its preparation method, and its uses. This invention modifies the structure of a parent compound to prepare a prodrug with long-acting properties. This type of drug is formulated into an injectable formulation, forming a drug reservoir in the body from which the drug is slowly, continuously, and stably released and converted into the parent compound, thereby exerting a long-acting effect.

The invention belongs to the field of synthesis of 4, 6-dihydroxypyrimidine, and discloses a preparation method of 4, 6-dihydroxypyrimidine, which comprises the following steps: S1, adding malonamide, a basic catalyst and an organic solvent into a reaction bottle, and fully stirring to obtain a mixed solution; s2, under the stirring condition, carboxylic ester derivatives are dropwise added into the mixed solution; s3, after the carboxylic ester derivative is dropwise added, carrying out a heat preservation reaction; and S4, carrying out post-treatment on the reaction liquid obtained by the heat preservation reaction to obtain the target product 4, 6-dihydroxypyrimidine. The post-treatment comprises acidification, filtration, washing and drying. The preparation method of 4, 6-dihydroxypyrimidine has the advantages of mild reaction conditions, simple and safe operation, cheap and easily available raw materials, high yield, good product purity and environmental friendliness, and has important practical significance and application value.

The disclosure generally relates to poly alpha-1,3-glucan compositions and articles containing them. In particular interest is comprising poly alpha-1,3-glucan ester derivatives. The poly alpha-1,3-glucan derivatives are useful in thermoprocesses and in particular, injection molding processes.

The invention provides an etomidate derivative, a preparation method thereof and application of the etomidate derivative in preparation of anesthetic drugs, and belongs to the field of chemical medicines. The structure of the etomidate derivative is shown as a formula I in the specification. Compared with etomidate, the compound disclosed by the invention has the advantage that the anesthesia time is remarkably shortened. The anesthesia time is shortened, so that some side effects after anesthesia can be relieved; rapid recovery of the autonomous regulation ability of important organs of a patient and postoperative nursing are facilitated; and the risk of wake-up delay is reduced. The etomidate derivative provided by the invention has a good application prospect in preparation of anesthetic drugs for shortening anesthesia time. And # imgabs0 #.

The invention relates to the technical field of batteries, and particularly discloses a composite current collector and a preparation method and application thereof. The composite current collector comprises a thin film substrate, and a phosphorus-containing monomer is introduced into the surface of the thin film substrate through plasma treatment; an aluminum conductive layer disposed on at least one side surface of the film substrate; the surface functional layer is arranged on the surface of one side, far away from the thin film substrate, of the aluminum conducting layer, and the surface functional layer comprises a fluorine-containing polymer layer and a nanotube composite layer which are sequentially arranged from inside to outside. Phosphorus-containing monomers (phosphoric acid groups and ester derivatives thereof) are introduced to a film substrate, oxygen atoms or hydroxyl groups in key functional groups of the phosphoric acid groups and the ester derivatives thereof interact with metal ions strongly to form coordinate bonds to enhance the interface bonding force between an aluminum conductive layer and a PET film, and a surface functional layer is combined to block electrolyte permeation, so that the film has a good anti-corrosion effect. And the nanotubes in the surface functional layer form a three-dimensional conductive network, so that the contact resistance is reduced, and the conductivity is enhanced.

The invention discloses application of dikafen phenolic acid and ester derivatives thereof in preparation of medicines for treating pulmonary fibrosis. On an MRC-5 cell model induced by TGF-beta1, the bikafen phenolic acid and the multiple ester derivatives thereof show the activity of inhibiting alpha-SMA and COL1A1 protein expression; on a bleomycin-induced pulmonary fibrosis mouse model, the dimethyl ester derivative of the dikafen phenolic acid shows a good protective effect on experimental animals. Therefore, the dicafen phenolic acid and the ester derivative thereof have good application in the field of preparation of medicines for treating pulmonary fibrosis diseases.

The invention provides an alcohol insect pheromone derivative, which takes a compound containing at least one active group such as carboxyl and amido as a carrier, and alcohol insect pheromone forms derivatives such as ester derivatives and anhydride derivatives with the compound through chemical reaction. The invention also provides a preparation method, application and a release method of the alcohol insect pheromone derivative. According to the alcohol insect pheromone derivative, alcohol insect pheromone is treated in a chemical reaction mode, the stability of the alcohol insect pheromone can be remarkably improved, slow release and controlled release of the pheromone can be achieved, the carrier material is wide in source, multiple in selectivity, convenient to use and economical, and in addition, the alcohol insect pheromone derivative can be used for preparing the alcohol insect pheromone derivative. The alcohol insect pheromone derivative provided by the invention can also realize combined release of various pheromones, so that trapping, prevention and control of various insects can be realized.

The present invention relates to a mononitroisosorbide derivative, its preparation method, and application. The derivative has the following structure: #imgabs0#, wherein R is one of the following structures: #imgabs1#. The mononitroisosorbide derivative is prepared by reacting 5-isosorbide mononitrate with an acyl chloride (sulfonyl chloride) compound in the presence of triethylamine and a catalyst, 4-dimethylaminopyridine. The mononitroisosorbide derivative exhibits excellent anti-tumor activity. Compared to existing technologies, the present invention designs and synthesizes multiple compounds with novel structures, among which ZM533 exhibits moderate anti-tumor activity against the A549 cell line and is expected to be used in the preparation of anti-lung cancer drugs.

The invention discloses a 5-bromoindole-2-carboxylic acid methyl ester derivative as well as a preparation method and application thereof in a protein inhibitor, and relates to the technical field of synthesis and preparation of inhibitors. According to the 5-bromoindole-2-carboxylic acid methyl ester derivative, compared with a contrast product, the synthetic route steps of the prepared 5-bromoindole-2-carboxylic acid methyl ester derivative are simpler and more convenient, structural modification and preparation are easier, the application range of a substrate is widened, the yield of the product is increased, and the yield of the product is increased. The differentiated requirements on the molecular structure novelty in the field of kinase inhibitors can be met. An epidermal growth factor receptor (EGFR) inhibitor prepared from the 5-bromoindole-2-carboxylic acid methyl ester derivative is higher in inhibition efficiency on biological activity, the physiological solubility is improved more remarkably, a more excellent and stable target binding result can be shown, and the EGFR inhibitor can be used for preparing an epidermal growth factor receptor (EGFR) inhibitor. The application effect of the compound in scenes such as antitumor drug development and the like is favorably improved.