313 results about "Ester derivatives" patented technology

The invention relates to a battery monomer, a battery device and a power utilization device, the battery monomer comprises an electrode assembly and an electrolyte, and the electrode assembly comprises a positive pole piece and a negative pole piece; the positive pole piece comprises a positive pole current collecting part and a positive pole film layer; the positive pole film layer comprises lithium-containing phosphate with an olivine structure; the negative pole piece comprises a negative pole current collecting part and a negative pole film layer, and the negative pole film layer comprises a carbon-based material; the electrolyte comprises a carboxylic ester solvent, a first additive and fluorine-containing lithium sulfimide, and the mass content of the carboxylic ester solvent is 8%-60%; the total mass content of the first additive is 2.5%-10%, the first additive comprises 1, 3-propane sultone with the mass content larger than or equal to 0, an ethylene carbonate derivative with the mass content larger than or equal to 0 and vinylene carbonate with the mass content larger than 0, and the ethylene carbonate derivative comprises a compound shown in the formula A; the mass content of the fluorine-containing lithium sulfimide is 4%-8%. According to the invention, the rapid charging performance and the cycle performance of the battery monomer can be improved. # imgabs0 # formula A

The invention relates to a battery monomer, a battery device and a power utilization device, the battery monomer comprises an electrode assembly and an electrolyte, and the electrode assembly comprises a positive pole piece and a negative pole piece; the positive pole piece comprises lithium-containing phosphate with an olivine structure; the negative pole piece comprises graphite particles; the electrolyte comprises a carboxylic ester solvent and a first additive, the thickness of the single-side negative electrode film layer is 50 microns to 75 microns, and the volume average particle size of the graphite particles is 8.5 microns to 13.5 microns; based on the mass of the electrolyte, the mass content of the carboxylic ester solvent is 8%-60%, the total mass content of the first additive is 3%-10%, the first additive comprises 1, 3-propane sultone with the mass content larger than or equal to 0, an ethylene carbonate derivative with the mass content larger than or equal to 0 and vinylene carbonate with the mass content larger than or equal to 3%, and the ethylene carbonate derivative comprises a compound shown in the formula A. According to the invention, the rapid charging performance and the cycle performance of the battery monomer under high energy density can be improved. # imgabs0 # formula A

The invention relates to the field of biological medicines, in particular to a composition containing pyruvate as well as a preparation method and application of the composition. The composition containing pyruvate is prepared from the following raw materials in percentage by mass: 0.05 to 0.1 percent of pyruvate, 0.02 to 0.04 percent of bergenin derivative, 5 to 10 percent of water for injection and the balance of propellant, the structural formula of the bergenin derivative is as follows: # imgabs0 #. The composition containing pyruvate can reduce the abundance of pathogenic bacteria and increase the abundance of probiotics, so that the effect of treating lung diseases is achieved by adjusting the respiratory tract micro-ecology.

The invention relates to a battery monomer, a battery device and a power utilization device. The battery monomer comprises a positive pole piece and a negative pole piece, the positive pole piece comprises lithium-containing phosphate; the negative pole piece comprises graphite particles; the electrolyte comprises a carboxylic ester solvent, a linear carbonic ester solvent and an additive, the mass content of the carboxylic ester solvent is 10%-30%, and the mass content of the linear carbonic ester solvent is 10%-50%; the mass content of the additive is 3%-9%, the additive comprises 1, 3-propane sultone with the mass content larger than or equal to 0, an ethylene carbonate derivative with the mass content larger than or equal to 0 and vinylene carbonate with the mass content larger than 0, and the ethylene carbonate derivative comprises a compound shown in the formula A; q1, Q2, Q3 and Q4 each independently comprise any one of a hydrogen atom, a halogen atom, a C1 to C5 alkyl group or a C1 to C5 halogenated alkyl group, and Q1, Q2, Q3 and Q4 are not hydrogen atoms at the same time. # imgabs0 # formula A is shown in the specification.

The invention discloses a method for preparing a chiral furanone ester derivative, which comprises the following steps: adding a metal catalyst into a solvent, sequentially adding a carboxylic acid compound I or a carboxylic acid compound II and a butene lactone compound III, introducing inert gas, stirring, post-treating and purifying to obtain a chiral furanone ester compound IV; the palladium catalysis system is composed of palladium salt and a chiral ligand V, and the chiral ligand has a structure shown in a formula V.

The invention provides a deuterated etomidate derivative as well as a preparation method, an intermediate and application thereof. Particularly, the invention relates to a deuterated etomidate derivative shown in a general formula I ', a preparation method and an intermediate of the deuterated etomidate derivative, a pharmaceutical composition containing the deuterated etomidate derivative, and application of the deuterated etomidate derivative or the pharmaceutical composition of the deuterated etomidate derivative as a GABBA receptor agonist in preparation of drugs in the field of central nervous systems.

The invention relates to the field of medicinal chemistry, in particular to a long-acting ester derivative as well as a preparation method and application thereof. According to the invention, the structure of a parent compound is modified to prepare a prodrug with a long-acting property. The medicine is prepared into an injectable preparation through a preparation means, a medicine storage is formed in vivo, and the medicine is slowly, continuously and stably released from the storage and converted into a parent compound, so that a long-acting effect is achieved.

A method of improving and / or enhancing at least one of bone mineralization, bone strength, bone mass, and bone mineral density in an individual in need thereof, the method comprising administering to the individual a composition comprising one or more anabolic amino acids, and the composition further comprising one or more autophagy-inducing compounds. In one embodiment, the one or more autophagy-inducing compounds are selected from the group consisting of thymol, carvacrol, spermidine, urolithin (e.g., Urolithin A, B or D), rapamycin, Torin1, valproic acid, polyphenols (e.g., resveratrol), caffeine, metformin, 5′ AMP-activated protein kinase (AMPK) activators, L-type calcium channel inhibitors, ketones (e.g. beta-hydroxybutyrate, ketone salts, or ketone ester derivatives), 4,4′-dimethoxychalcone and mixtures thereof.

The invention belongs to the technical field of analysis and detection of liquid nutritional agents, and provides a coniferous and cypress hydroformylation salicyl ester molecular device and a preparation method and application thereof. The method comprises the following steps: mixing a coniferyl aldehyde solution, a dehydrating agent dispersion liquid and a salicyl ester derivative solution, and carrying out a dehydration condensation reaction on the mixed solution to obtain the coniferyl hydroformylated salicyl ester molecular device. The coniferous hydroformylated salicylate molecular device has the advantages of high viscosity sensitivity coefficient, stable chemical structure, strong visualization effect, release of stable optical signals in a wide pH range, insensitivity to the polarity of the solvent, and good solvent tolerance; the device can be used as a molecular tool for in-situ measurement of viscosity in a nutritional agent microenvironment, detection can be realized without depending on shearing and relative movement in the measurement process, consumption of a large amount of samples can be avoided, the whole process is rapid, efficient and convenient, and viscosity change of a liquid nutritional agent containing a large amount of pseudoplastic fluid can be effectively measured.

The invention provides a fluorine-containing parthenolide derivative compound as shown in a formula (I), a deuterated substance, a tautomer, a stereoisomer, a hydrate, a solvate, a pharmaceutically acceptable salt or a prodrug thereof, and the fluorine-containing parthenolide derivative compound has a better tumor inhibition effect and can be used for preventing and / or treating cancers. The preparation method provided by the invention is simple to operate, and fluorine-containing parthenolide molecules can be efficiently and quickly constructed. # imgabs0 #

This invention relates to the field of medicinal chemistry, specifically to a long-acting ester derivative, its preparation method, and its uses. This invention modifies the structure of a parent compound to prepare a prodrug with long-acting properties. This type of drug is formulated into an injectable formulation, forming a drug reservoir in the body from which the drug is slowly, continuously, and stably released and converted into the parent compound, thereby exerting a long-acting effect.

The invention belongs to the field of synthesis of 4, 6-dihydroxypyrimidine, and discloses a preparation method of 4, 6-dihydroxypyrimidine, which comprises the following steps: S1, adding malonamide, a basic catalyst and an organic solvent into a reaction bottle, and fully stirring to obtain a mixed solution; s2, under the stirring condition, carboxylic ester derivatives are dropwise added into the mixed solution; s3, after the carboxylic ester derivative is dropwise added, carrying out a heat preservation reaction; and S4, carrying out post-treatment on the reaction liquid obtained by the heat preservation reaction to obtain the target product 4, 6-dihydroxypyrimidine. The post-treatment comprises acidification, filtration, washing and drying. The preparation method of 4, 6-dihydroxypyrimidine has the advantages of mild reaction conditions, simple and safe operation, cheap and easily available raw materials, high yield, good product purity and environmental friendliness, and has important practical significance and application value.

The disclosure generally relates to poly alpha-1,3-glucan compositions and articles containing them. In particular interest is comprising poly alpha-1,3-glucan ester derivatives. The poly alpha-1,3-glucan derivatives are useful in thermoprocesses and in particular, injection molding processes.

The invention relates to the technical field of batteries, and particularly discloses a composite current collector and a preparation method and application thereof. The composite current collector comprises a thin film substrate, and a phosphorus-containing monomer is introduced into the surface of the thin film substrate through plasma treatment; an aluminum conductive layer disposed on at least one side surface of the film substrate; the surface functional layer is arranged on the surface of one side, far away from the thin film substrate, of the aluminum conducting layer, and the surface functional layer comprises a fluorine-containing polymer layer and a nanotube composite layer which are sequentially arranged from inside to outside. Phosphorus-containing monomers (phosphoric acid groups and ester derivatives thereof) are introduced to a film substrate, oxygen atoms or hydroxyl groups in key functional groups of the phosphoric acid groups and the ester derivatives thereof interact with metal ions strongly to form coordinate bonds to enhance the interface bonding force between an aluminum conductive layer and a PET film, and a surface functional layer is combined to block electrolyte permeation, so that the film has a good anti-corrosion effect. And the nanotubes in the surface functional layer form a three-dimensional conductive network, so that the contact resistance is reduced, and the conductivity is enhanced.

The invention discloses application of dikafen phenolic acid and ester derivatives thereof in preparation of medicines for treating pulmonary fibrosis. On an MRC-5 cell model induced by TGF-beta1, the bikafen phenolic acid and the multiple ester derivatives thereof show the activity of inhibiting alpha-SMA and COL1A1 protein expression; on a bleomycin-induced pulmonary fibrosis mouse model, the dimethyl ester derivative of the dikafen phenolic acid shows a good protective effect on experimental animals. Therefore, the dicafen phenolic acid and the ester derivative thereof have good application in the field of preparation of medicines for treating pulmonary fibrosis diseases.

The invention provides an alcohol insect pheromone derivative, which takes a compound containing at least one active group such as carboxyl and amido as a carrier, and alcohol insect pheromone forms derivatives such as ester derivatives and anhydride derivatives with the compound through chemical reaction. The invention also provides a preparation method, application and a release method of the alcohol insect pheromone derivative. According to the alcohol insect pheromone derivative, alcohol insect pheromone is treated in a chemical reaction mode, the stability of the alcohol insect pheromone can be remarkably improved, slow release and controlled release of the pheromone can be achieved, the carrier material is wide in source, multiple in selectivity, convenient to use and economical, and in addition, the alcohol insect pheromone derivative can be used for preparing the alcohol insect pheromone derivative. The alcohol insect pheromone derivative provided by the invention can also realize combined release of various pheromones, so that trapping, prevention and control of various insects can be realized.

The present invention relates to a mononitroisosorbide derivative, its preparation method, and application. The derivative has the following structure: #imgabs0#, wherein R is one of the following structures: #imgabs1#. The mononitroisosorbide derivative is prepared by reacting 5-isosorbide mononitrate with an acyl chloride (sulfonyl chloride) compound in the presence of triethylamine and a catalyst, 4-dimethylaminopyridine. The mononitroisosorbide derivative exhibits excellent anti-tumor activity. Compared to existing technologies, the present invention designs and synthesizes multiple compounds with novel structures, among which ZM533 exhibits moderate anti-tumor activity against the A549 cell line and is expected to be used in the preparation of anti-lung cancer drugs.

The invention discloses a 5-bromoindole-2-carboxylic acid methyl ester derivative as well as a preparation method and application thereof in a protein inhibitor, and relates to the technical field of synthesis and preparation of inhibitors. According to the 5-bromoindole-2-carboxylic acid methyl ester derivative, compared with a contrast product, the synthetic route steps of the prepared 5-bromoindole-2-carboxylic acid methyl ester derivative are simpler and more convenient, structural modification and preparation are easier, the application range of a substrate is widened, the yield of the product is increased, and the yield of the product is increased. The differentiated requirements on the molecular structure novelty in the field of kinase inhibitors can be met. An epidermal growth factor receptor (EGFR) inhibitor prepared from the 5-bromoindole-2-carboxylic acid methyl ester derivative is higher in inhibition efficiency on biological activity, the physiological solubility is improved more remarkably, a more excellent and stable target binding result can be shown, and the EGFR inhibitor can be used for preparing an epidermal growth factor receptor (EGFR) inhibitor. The application effect of the compound in scenes such as antitumor drug development and the like is favorably improved.

The present invention provides a polyester wherein: a dicarboxylic acid constituent unit includes 72.5 mol% or more of a constituent unit derived from 2,6-naphthalenedicarboxylic acid and / or an ester derivative thereof among a total 100 mol% of said dicarboxylic acid constituent units; and a diol constituent unit includes 27.5 mol% or more of a constituent unit derived from 1,4-cyclohexanedimethanol and a constituent unit derived from 2,2,4,4-tetramethyl-1,3-cyclobutanediol among a total 100 mol% of said diol constituent units. A feeding bottle according to the present invention is formed using said polyester.

The invention provides a phenolic ester derivative as well as a preparation method and application thereof. The structure of the phenolic ester derivative is shown as a formula (I), wherein the definition of each group is shown in the specification. The phenolic ester derivative disclosed by the invention has excellent oxidation stability, thermal stability, viscosity-temperature performance, low-temperature performance and lubricating performance, and is suitable for being used as lubricating oil base oil.

A method for increasing or improving nitric oxide signals or levels, the method comprising: administering a composition to a subject, the composition comprising: arginine or a pharmaceutically acceptable salt, ester, or derivative thereof; and tetrahydrocurcumin and / or β-aminoisobutyric acid or a pharmaceutically acceptable salt or ester thereof. The method and the composition can be used to increase, improve, or enhance nitric oxide signals or levels, inhibit nitric oxide decomposition, and increase or enhance nitrous acid and / or cyclic guanosine monophosphate levels, and can improve fatigue resistance or enhance muscle strength, maintain or improve cardiovascular health, maintain or improve vascular function and structure, inhibit or mitigate endothelial cell damage, or mitigate insufficient blood flow.

The ester derivatives of brefeldin A represented by Formula (I) in the inhibition of tumor proliferation. The compounds are prominent in the prevention or treatment of hyperproliferative diseases, including liver cancer, leukemia, breast cancer, colon adenocarcinoma, gastric cancer, lung cancer, Bart's esophageal cancer, cervical cancer, pancreatic cancer, endometrial cancer, bone cancer, lymphoma, kidney cancer, brain cancer, nerve cancer, nasopharyngeal cancer, oral cancer and colorectal cancer, and have the potential to be developed as antitumor agents.

Pharmaceutical combinations of etomidate derivatives and propofol and pharmaceutical compositions thereof for use in anesthesia, sedation and / or hypnosis of animals or humans. The pharmaceutical composition of the etomidate derivative and the propofol or the pharmaceutical composition of the etomidate derivative and the propofol shows an excellent synergistic effect compared with independent administration and combined administration.

The invention relates to the field of lubricating oil, in particular to a compressor oil composition which is prepared from the following components in parts by weight: 0.005 to 0.2 part of an anti-rust agent, 0.05 to 1 part of an extreme pressure anti-wear agent, 0.01 to 0.5 part of a friction reducing agent, 3 to 8 parts of synthetic ester, 0.01 to 1 part of an antioxidant, 0.001 to 0.1 part of an anti-foaming agent and 90 to 97 parts of base oil. The anti-friction agent is a trimethylolpropane-triacid ester derivative, the anti-rust agent is formed by mixing an alkenyl succinic acid half-ester derivative and a carboxyl imidazoline derivative, and the anti-wear reagent at extreme pressure is formed by mixing triphenyl phosphate and an alkyl thiophosphate derivative. The antioxidant is formed by mixing any two of alkyl diphenylamine, alkyl phenyl-alpha-naphthylamine and alkyl hindered phenol. The invention further relates to a preparation method of the compressor oil composition. The compressor oil composition provided by the invention has excellent washing resistance and rust resistance.

The invention discloses a preparation method of high-strength low-reverse-osmosis composite water-absorbent resin based on a polyurethane double-network interpenetrating structure, which comprises the following preparation steps: S1, adding cyclic carbonate derivatives, polyamine and water into a reaction container with a stirring function, and mixing to prepare gel; s2, gel obtained through reaction is taken out and sheared into small blocks, and the small blocks are put into a granulator to be mixed with hot water for primary granulation. S3, after granulation is completed, gel is put into a drying oven at the temperature of 150-200 DEG C to be dried, grinding materials are prepared according to particle size distribution after a crushing procedure, then surface treatment is conducted through surface treatment liquid at the high temperature, and after cooling, the grinding materials and quantitative inorganic powder are mixed to be uniform to obtain the ultrahigh-gel-strength composite material. The composite water-absorbent resin prepared by the method is good in performance, and has the performance characteristics of high strength and low reverse osmosis.

The invention relates to a SpyCatcher / SpyTags-polyethylene glycol tissue sealant as well as a preparation method and application thereof, and belongs to the technical field of tissue sealants. The preparation method comprises the following steps: sequentially adding SpyCatcher protein, EDTA (Ethylene Diamine Tetraacetic Acid) and 2-imino sulfane hydrochloride into a buffer solution, stirring at 0-4 DEG C overnight, and dialyzing to obtain SpyCatcher-SH; the preparation method comprises the following steps: adding a polyethylene glycol acrylate derivative and SpyCatcher-SH (or SpyTag fusion protein) into a buffer solution, and reacting to obtain a first solution (or a second solution); and mixing and stirring the first solution and the second solution, and adding an enzyme initiation component for catalysis to obtain the product. The SpyCatcher / SpyTag system and the PEG acrylate derivative are catalyzed by the enzyme initiation system to prepare the tissue sealant, so that the problem of poor mechanical property of Spy protein gel is solved, and the potential toxicity of a composite system is reduced.

The invention relates to a pyrazole substituted cyclopentyl ester derivative and application thereof, in particular to a compound as shown in a formula (I), and an isomer or pharmaceutically acceptable salt of the compound. # imgabs0 #

The invention belongs to the technical field of organic ultrathin nanomaterials, and particularly relates to a photoresponse type polymer ultrathin nanosheet as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) adding dicyclohexylcarbodiimide, N-hydroxysuccinimide, N, N-diisopropylethylamine and 4-carboxyl phenylboronic acid pinacol ester into a solvent, and reacting to obtain an intermediate product; (2) carrying out heating reaction on the intermediate product, triethylene glycol and a catalyst to obtain a phenylboronic acid pinacol ester derivative; (3) adding 4, 4-dibromo azobenzene, a phenylboronic acid pinacol ester derivative, a palladium catalyst and potassium carbonate into a solvent for reaction to obtain an amphiphilic alternating copolymer; and (4) dispersing the amphiphilic alternating copolymer in a solvent for self-assembly to obtain the amphiphilic alternating copolymer. According to the invention, a photoresponse group azobenzene structure is introduced into a polymer main chain, so that the ultrathin organic material is endowed with a unique photoresponse characteristic; the method is simple and easy to implement, good in repeatability and high in stability.

The invention relates to a metal anti-corrosion cleaning agent, a preparation method and application, and the metal anti-corrosion cleaning agent comprises the following components in parts by weight: 0.001-0.06 part of a composite functional agent; 0.1 to 3 parts of a pH regulator; 0.01 to 1 part of inorganic acid; 50-80 parts of an organic solvent; and 20-50 parts of ultrapure water. The thienyl carboxylic ester derivative and the alkanol derivative are combined, the thienyl carboxylic ester derivative removes metal ions (such as Cu < + > and Fe < + >) in a targeted mode by means of the strong chelating capacity of ester groups, and organic pollutants are stripped through the pi-pi effect; the alkanol derivative wraps non-polar residual gum by using a long-chain hydrophobic end, and a hydrophilic end enhances the wettability of a solution, so that full-coverage cleaning of a nano-scale structure is realized.

The present invention provides a polyester wherein: a dicarboxylic acid constituent unit is a constituent unit derived from 2,6-naphthalenedicarboxylic acid and / or an ester derivative thereof; and a diol constituent unit includes a constituent unit derived from any isosorbide, and 27.5 mol% or more of a constituent unit derived from 1,4-cyclohexanedimethanol among a total 100 mol% of said diol constituent units. A feeding bottle according to the present invention is formed using said polyester.