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6 results about "Propofol" patented technology
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Propofol, marketed as Diprivan among other names, is a short-acting medication that results in a decreased level of consciousness and lack of memory for events. Its uses include the starting and maintenance of general anesthesia, sedation for mechanically ventilated adults, and procedural sedation. It is also used for status epilepticus if other medications have not worked. It is given by injection into a vein. Maximum effect takes about two minutes to occur and it typically lasts five to ten minutes.
Propofol analogues, methods of making and use in non-narcotic fields
The present application provides a propofol analogue, a preparation method thereof and application thereof in non-narcotic field. The propofol analogue has a structure as shown in general formula (G). The propofol analogue of the present application can greatly reduce or eliminate the affinity to GABA receptor, i.e. weaken or eliminate the narcotic property. It targets specific targets and shows effects in improving sleep, regulating blood pressure, relieving vomiting, resisting depression, protecting heart and brain, etc. (G).
Owner:BEIJING LIBANG MEDICAL INVESTMENT MANAGEMENT CO LTD
Propofol immunoassay
An antibody for binding propofol is provided. Also provided is an immunoassay for assaying propofol and an immunobiosensor for rapid, point-of-care of propofol.
Owner:SOMNUS SCI LTD
Use of propofol for the preparation of a medicament for the prevention or treatment of cognitive dysfunction
The application discloses application of propofol in preparation of a medicine for preventing or treating cognitive dysfunction, and realizes prevention or treatment of cognitive dysfunction by propofol through inhibition of nerve inflammation, reduction of oxidative stress and enhancement of synaptic plasticity, and has advantages of exact curative effect, small side effect, multi-target point intervention and controllable cost, overcomes defects of existing medicines, such as curative effect limitation, obvious side effect and single target point, and realizes timely prevention and treatment of senile cognitive dysfunction.
Owner:SUN YAT SEN UNIV
A method for constructing an animal model of light anesthesia via sublingual tablet administration
This invention discloses a method for constructing a light anesthesia lozenge administration animal model, belonging to the field of biotechnology. The method involves administering propofol to animals, and after the righting reflex disappears, administering a lozenge to obtain a light anesthesia lozenge administration animal model. This method has good reproducibility, the experimental animals exhibit good tolerance, and it accurately simulates the clinical lozenge administration process, solving the key problem of discrepancies between the gavage administration route and clinical practice in traditional lozenge animal experiments.
Owner:JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Piperazine substituted phenol derivative and use thereof
PendingUS20260137676A1Organic active ingredientsNervous disorderPharmaceutical SubstancesPhenol derivative
A piperazine substituted phenol derivative and its applications in pharmaceutical chemistry are provided. The compound, depicted by formula I, exhibits excellent salt formation properties and water solubility, meeting formulation requirements. It also has a low minimum effective anesthetic dose, enabling rapid onset and recovery. This addresses the drawbacks of propofol and ciprofol prodrugs and lipid emulsions. The compound shows promise in developing drugs with sedative, hypnotic, and / or anesthetic effects, as well as in drugs for controlling status epilepticus.
Owner:CHENGDU MFS PHARMA CO LTD