12 results about "Propofol" patented technology

The present application provides a propofol analogue, a preparation method thereof and application thereof in non-narcotic field. The propofol analogue has a structure as shown in general formula (G). The propofol analogue of the present application can greatly reduce or eliminate the affinity to GABA receptor, i.e. weaken or eliminate the narcotic property. It targets specific targets and shows effects in improving sleep, regulating blood pressure, relieving vomiting, resisting depression, protecting heart and brain, etc. (G).

The invention relates to the technical field of biochemical detection, in particular to a pretreatment method of a propofol-containing sample, a propofol detection method and a kit. The pretreatment method of the propofol-containing sample comprises the following steps: providing the propofol-containing sample; the method comprises the following steps: adding porous polymer lipophilic magnetic beads into a sample, carrying out adsorption treatment, and then carrying out leaching treatment by using water and a methanol solution in sequence to obtain a propofol-magnetic bead compound; and eluting the propofol-magnetic bead compound by using an ammonia water methanol solution to obtain a sample to be detected. The pretreatment method provided by the invention is simple in process and low in cost, the to-be-detected sample containing propofol can be efficiently obtained, and the to-be-detected sample containing propofol can be subsequently used for high-sensitivity detection of propofol by an ion mobility spectrometry technology, so that the pretreatment method has a very good application prospect in the field of propofol detection.

An antibody for binding propofol is provided. Also provided is an immunoassay for assaying propofol and an immunobiosensor for rapid, point-of-care of propofol.

The invention relates to a transmission desorption electrospray low-pressure ion mobility spectrometry which comprises a transmission desorption electrospray ion source, an interface electrode and a low-pressure ion migration tube, the interface electrode is a metal sheet electrode with a through hole in the center, and the transmission desorption electrospray ion source is connected with the low-pressure ion migration tube through the interface electrode. The ion mobility spectrometry can realize efficient desorption spray ionization of substances difficult to volatilize in the detection process, the sample detection process is simplified, the working air pressure is lower than the atmospheric pressure, the detection sensitivity can be improved, furthermore, the ion mobility spectrometry is provided with a desolvation area and is combined with desolvation gas, the detection sensitivity can be further improved, and the detection accuracy is improved. High-sensitivity detection of anesthetic drugs such as propofol, etomidate, fentanyl and the like in blood can be realized through transmission-type desorption electrospray and low-pressure ion mobility spectrometry.

The application discloses application of propofol in preparation of a medicine for preventing or treating cognitive dysfunction, and realizes prevention or treatment of cognitive dysfunction by propofol through inhibition of nerve inflammation, reduction of oxidative stress and enhancement of synaptic plasticity, and has advantages of exact curative effect, small side effect, multi-target point intervention and controllable cost, overcomes defects of existing medicines, such as curative effect limitation, obvious side effect and single target point, and realizes timely prevention and treatment of senile cognitive dysfunction.

This invention discloses a method for constructing a light anesthesia lozenge administration animal model, belonging to the field of biotechnology. The method involves administering propofol to animals, and after the righting reflex disappears, administering a lozenge to obtain a light anesthesia lozenge administration animal model. This method has good reproducibility, the experimental animals exhibit good tolerance, and it accurately simulates the clinical lozenge administration process, solving the key problem of discrepancies between the gavage administration route and clinical practice in traditional lozenge animal experiments.

This disclosure relates to a process for preparing 2,6-diisopropyl phenol. The process includes a step of decarboxylating 4-hydroxy-3,5-diisopropylbenzoic acid or one of its salts in an aqueous medium under pressure.

A piperazine substituted phenol derivative and its applications in pharmaceutical chemistry are provided. The compound, depicted by formula I, exhibits excellent salt formation properties and water solubility, meeting formulation requirements. It also has a low minimum effective anesthetic dose, enabling rapid onset and recovery. This addresses the drawbacks of propofol and ciprofol prodrugs and lipid emulsions. The compound shows promise in developing drugs with sedative, hypnotic, and / or anesthetic effects, as well as in drugs for controlling status epilepticus.

(Main claim) Disposal container for the irreversible deactivation of anesthetic drug residues, comprising a multi-layered binding system arranged from top to bottom and including: 1. an upper layer of adsorbent and / or ion exchange resin, 2. a middle layer of activated carbon or another adsorption matrix, 3. a lower layer of a polymer gel for solidifying residual liquids, the layers are designed in such a way that propofol, opioids and ketamine are bound and solidified sequentially, and recovery of the active ingredients is impossible.

The invention discloses a preparation method and application of a novel water-soluble propofol nano-composite, and relates to the technical field of nano-composite drug research and development, and the key points of the technical scheme are as follows: firstly, preparing Pdots from a conjugated polymer F8BT and an amphiphilic polymer PSMA through a nano coprecipitation method; then promoting a phenolic hydroxyl group of propofol and an acylation reagent chloroacetyl chloride to be subjected to a substitution reaction by DMAP to generate ester, and reacting amino on cystamine and an acyl chloride bond on the ester under the catalysis of potassium carbonate and potassium iodide to generate PPF-SS-NH2; carrying out condensation reaction on amino of the PPF-SS-Pdots and carboxyl of Pdots to obtain a PPF-SS-Pdots nano compound; and finally, synthesizing the PRP from the nano-composite and RVG-29 through an electrostatic adsorption effect. The anesthesia onset time and maintenance time of PRP are equivalent to those of common propofol, the awakening time is remarkably shortened, meanwhile, injection pain and other side effects are reduced, and rapid detection is achieved.

The application provides a combined drug for improving embryo implantation efficiency of RIF patients and a screening method, and belongs to the technical field of embryo implantation. In order to solve the problem of how to screen a general drug combination on the basis of a large heterogeneous RIF population, the application locks 1119 kinds of drugs that may have a therapeutic effect in a large range through a six-step screening method combined with advanced RNA sequencing technology, and then further screens the drugs by using a highly simulated endometrial epithelial organoid and stromal cell model, tests the influence of the 1119 kinds of drugs on the activity of the endometrial epithelial organoid and stromal cell, and finally screens 7 kinds of effective drugs which can form a broad-spectrum drug with significant therapeutic effect on RIF in a combined form. The 7 kinds of effective drugs screened by the application are icotinib, fumaric acid propofol tenofovir tablets, clopidogrel, tizacat, osimertinib, venetoclax and rebastinib.

The invention discloses a method for improving the detection sensitivity of propofol in whole blood, and belongs to the technical field of separation, analysis and detection. The anion and photoionization ion mobility spectrometry technology is used as a basic detection technology, no sample pretreatment is needed, and the ionization and thermal desorption efficiency is enhanced by adding an alcohol mixed auxiliary agent without peculiar smell into a sample carrier gas; the method solves the problems of low sensitivity and susceptibility to matrix interference when the conventional ion mobility spectrometry is used for detecting whole-blood propofol, reduces the detection limit to 0.1 ng / mu L or below, meets the rapid detection requirement of trace propofol, and is suitable for the scenes of clinical anesthesia monitoring, drug residue analysis and the like. According to the measurement method, analysis is performed after background signals are deducted in signal collection, and the method is simple, convenient, rapid, easy to correct and high in data accuracy and has wide clinical application prospects.