The invention relates to a phosphoryl
carboxylic acid propofol ester derivative which has the general formula (I). The method comprises the following steps:
propofol reacts with 2-halogenated
carboxylic acid and a derivative thereof by alkali to obtain corresponding ester and then the product reacts with
phosphoric acid or
thiophosphoric acid and the derivative thereof by dissolvent to obtain a water-soluble product or the
propofol reacts with a 2-halogenated
carboxylic acid phosphate ester derivative by the alkali to obtain the corresponding ester and then the ester is catalyzed, hydrogenated and salified to obtain the water-soluble product (I). The preparation method has mild reaction condition, high yield, simple operation and industrialized prospect, and a prepared oral preparation has the characteristics of high
bioavailability, rapid absorption, high stability, and the like; and auxiliary materials with safety defects, such as a surface
active agent, and the like can not be added into the prepared injection, thereby improving the stability of the preparation, reducing or removing injection pain, increasing the compliance of patients, overcoming the defects of propofol
emulsion and having the
advantage of obvious effect. The invention has the structural general formula (I).