26 results about "Propofol" patented technology

The invention relates to the technical field of pharmaceutical analysis, and particularly discloses a high performance liquid chromatography-mass spectrometry tandem method (HPLC-MS / MS) for detecting a genotoxic impurity L-alanine isopropyl ester in an emtricitabine-propofol tenofovir tablet. By optimizing chromatographic column selection, a mobile phase gradient elution procedure and mass spectrometric detection parameters, the method realizes exclusive, sensitive and accurate detection of the L-isopropyl alanine. The methodological verification result shows that the detection limit is 1.00 ng / mL, the quantification limit is 2.00 ng / mL, the linear range is 2.00-100.00 ng / mL (the correlation coefficient r is equal to 0.9994), the recovery rate is stabilized between 92% and 98%, and the precision and repeatability are good. The detection method has the advantages of high sensitivity and strong selectivity, is suitable for quality control of emtricitabine propofol tenofovir tablets, meets the control requirements of ICH M7 guide on genotoxic impurities, and has good practicability and popularization value.

The present invention relates to a continuous process for the preparation of a highly pure compound of formula III i.e. propofol, suitable for industrial or pharmaceutical use:

Pharmaceutical combinations of etomidate derivatives and propofol and pharmaceutical compositions thereof for use in anesthesia, sedation and / or hypnosis of animals or humans. The pharmaceutical composition of the etomidate derivative and the propofol or the pharmaceutical composition of the etomidate derivative and the propofol shows an excellent synergistic effect compared with independent administration and combined administration.

The invention provides liquid compositions in the form of physically stable emulsions comprising a semifluorinated alkane. The semifluorinated alkane is comprised in the dispersed phase, which may also include an active pharmaceutical ingredient. One of the preferred active ingredients is propofol. The compositions are optionally heat sterilisable and can be used for pharmaceutical or cosmetic product applications, and administered topically, intravenously, or via other routes.

The utility model relates to the technical field of medicine pumping devices, and discloses a device for rapidly pumping a large amount of medicine at a time, which comprises a base, a plurality of medicine pumping devices and a plurality of medicine pumping devices, and is characterized in that the upper surface of the base is provided with a mounting frame; the medicine placing tray is arranged on the upper surface of the base, and medicine placing grooves are evenly distributed in the upper surface of the medicine placing tray; and the mounting grooves are formed in the two sides of the upper surface of the base, first hydraulic telescopic rods are mounted in the mounting grooves correspondingly, and a fixing frame is arranged above the base. A first hydraulic telescopic rod is started to drive a needle tube of an injector to be inserted into a propofol container, a second hydraulic telescopic rod is started to drive a mounting frame to move downwards, a motor is started to finally drive a medicine taking groove to move to the position below a push rod base, and the second hydraulic telescopic rod is started to drive the mounting frame to move upwards. And the push rod of the injector can be driven to move upwards to extract the liquid medicine in the propofol container, so that the time for extracting the propofol is saved, and meanwhile, the manpower of medical personnel is also saved.

The present application provides a propofol analogue, a preparation method thereof and application thereof in non-narcotic field. The propofol analogue has a structure as shown in general formula (G). The propofol analogue of the present application can greatly reduce or eliminate the affinity to GABA receptor, i.e. weaken or eliminate the narcotic property. It targets specific targets and shows effects in improving sleep, regulating blood pressure, relieving vomiting, resisting depression, protecting heart and brain, etc. (G).

The invention relates to the technical field of biochemical detection, in particular to a pretreatment method of a propofol-containing sample, a propofol detection method and a kit. The pretreatment method of the propofol-containing sample comprises the following steps: providing the propofol-containing sample; the method comprises the following steps: adding porous polymer lipophilic magnetic beads into a sample, carrying out adsorption treatment, and then carrying out leaching treatment by using water and a methanol solution in sequence to obtain a propofol-magnetic bead compound; and eluting the propofol-magnetic bead compound by using an ammonia water methanol solution to obtain a sample to be detected. The pretreatment method provided by the invention is simple in process and low in cost, the to-be-detected sample containing propofol can be efficiently obtained, and the to-be-detected sample containing propofol can be subsequently used for high-sensitivity detection of propofol by an ion mobility spectrometry technology, so that the pretreatment method has a very good application prospect in the field of propofol detection.

An antibody for binding propofol is provided. Also provided is an immunoassay for assaying propofol and an immunobiosensor for rapid, point-of-care of propofol.

The invention relates to the technical field of knowledge bases, in particular to an anesthetic dosage prediction method and system based on machine learning, and the method comprises the following steps: obtaining preoperative genome data, metabonomics data, intraoperative real-time vital sign data and operating room environment data of a patient, the genome data comprises CYP450 enzyme gene polymorphism data, and the metabonomics data comprises CYP450 enzyme gene polymorphism data; the metabonomics data comprises propofol metabolite concentration data, and the intraoperative real-time vital sign data comprises a BIS value, an MAP value and an HR value; according to the method, a dynamic hypergraph model containing drug nodes, gene nodes, metabolite nodes and environment nodes is constructed, the drug nodes and the gene nodes are connected through hyperedge to represent the regulation and control effect of drug metabolism genes on drug metabolism, the anesthesia safety and effectiveness can be improved, and the urgent clinical requirements for personalized and precise anesthesia are met.

The invention relates to a transmission desorption electrospray low-pressure ion mobility spectrometry which comprises a transmission desorption electrospray ion source, an interface electrode and a low-pressure ion migration tube, the interface electrode is a metal sheet electrode with a through hole in the center, and the transmission desorption electrospray ion source is connected with the low-pressure ion migration tube through the interface electrode. The ion mobility spectrometry can realize efficient desorption spray ionization of substances difficult to volatilize in the detection process, the sample detection process is simplified, the working air pressure is lower than the atmospheric pressure, the detection sensitivity can be improved, furthermore, the ion mobility spectrometry is provided with a desolvation area and is combined with desolvation gas, the detection sensitivity can be further improved, and the detection accuracy is improved. High-sensitivity detection of anesthetic drugs such as propofol, etomidate, fentanyl and the like in blood can be realized through transmission-type desorption electrospray and low-pressure ion mobility spectrometry.

The invention discloses a plasma metabolism biomarker combination for predicting and intervening propofol-induced respiratory depression, a detection method and application, and relates to the technical field of biological science. According to the method, non-target metabonomics detection is conducted on preoperative plasma of 298 subjects through UPLC-MS, 14-metabolite panels are obtained through machine learning supervised feature screening, a diagnosis model is established through verification of discovery and verification queues, and the prediction AUC of severe respiratory depression reaches 0.86-0.91 (discovery queue) and 0.86-0.91 (verification queue). Mouse in-vivo function verification proves that the key metabolite alpha-linolenic acid obviously improves the respiratory rate, the tidal volume and the minute ventilation volume under two administration paradigms of pretreatment and treatment of a mouse propofol-RD model, shortens the recovery time of righting reflex, has a good safety foundation, and has a good application prospect. Prompt can be converted into a foresight supplement or rapid treatment medication thought in a perioperative period, and a'prediction and intervention 'integrated clinical value is formed.

The application discloses application of propofol in preparation of a medicine for preventing or treating cognitive dysfunction, and realizes prevention or treatment of cognitive dysfunction by propofol through inhibition of nerve inflammation, reduction of oxidative stress and enhancement of synaptic plasticity, and has advantages of exact curative effect, small side effect, multi-target point intervention and controllable cost, overcomes defects of existing medicines, such as curative effect limitation, obvious side effect and single target point, and realizes timely prevention and treatment of senile cognitive dysfunction.

The invention discloses a propofol drug delivery system and method based on appreciation electroencephalogram characteristics, a medium and a product, and relates to the field of intelligent medical systems, and the propofol drug delivery system comprises a signal collection module used for collecting original electroencephalogram signals; the signal processing module is used for mapping the real-time brain function state of the patient to a neural state space containing an appreciation related state and determining a neural state; the prediction calculation module is used for predicting a future evolution trajectory and a state transition probability of a neural state in a neural state space; the control decision module is used for generating a drug administration intervention strategy of propofol by taking the brain function state staying in the target appreciation area as a target; and the infusion execution module is used for adjusting the target control infusion pump according to the administration intervention strategy so as to guide and maintain the appreciation state. By implementing the application, the patient can be prevented from being in a poor sedative state as much as possible, and the operation prognosis effect is optimized.

The present application belongs to the technical field of chemical analysis and detection, and particularly relates to a method for improving the response speed of continuous monitoring of humidified propofol gas. The disclosed technical solution is characterized in that the sampling system and the gas transmission system are optimized in coordination. In the analysis mode, the flow meter (1) and the air suction pump are continuously operated to extract humidified propofol gas for sample analysis. In the cleaning mode, the flow meter (1) and the air suction pump are continuously operated, the flow meter (2) extracts clean air, the cleaning flow rate is controlled to be greater than the sample flow rate, the sample analysis is performed, and the heat tracing pipe and the buffer tank are cleaned. The monitoring is performed according to the analysis mode-cleaning mode-analysis mode switching, the rapid analysis and rapid cleaning are realized, the propofol adsorption and residue are reduced, the T90 and T10 of the system are significantly shortened, and the effects of continuous monitoring and rapid response are achieved.

Provided are a method and system for determining a population pharmacokinetic model of propofol and derivatives thereof. The method comprises determining a formula as a population pharmacokinetic model of a compound of formula (I) or propofol: wherein the formula of the pharmacokinetic parameters in the population pharmacokinetic model of the compound of formula (I) comprises: and the formula of the pharmacokinetic parameters in the population pharmacokinetic model of propofol comprises: formula (I).

This invention discloses a method for constructing a light anesthesia lozenge administration animal model, belonging to the field of biotechnology. The method involves administering propofol to animals, and after the righting reflex disappears, administering a lozenge to obtain a light anesthesia lozenge administration animal model. This method has good reproducibility, the experimental animals exhibit good tolerance, and it accurately simulates the clinical lozenge administration process, solving the key problem of discrepancies between the gavage administration route and clinical practice in traditional lozenge animal experiments.

Provided are a method and system for determining a population pharmacokinetic model of propofol and a derivative thereof. The method comprises determining a population pharmacokinetic model of a compound of formula (I) or propofol, wherein an equation of pharmacokinetic parameters in the population pharmacokinetic model of the compound of formula (I) comprises: CLi=exp(4.20÷0.349·log(WT / 63.9)−0.749·log(TP / 72.4)+0.238·SITE+ηCL,i); an equation of pharmacokinetic parameters in the population pharmacokinetic model of propofol comprises: CLi=exp(4.56÷ηCL,i).

The invention discloses a multi-stage image enhancement method and system for anesthetic psychotropic drug identification. The method comprises the following steps: obtaining an original anesthetic psychotropic drug color image in a complex scene; gaussian filtering processing is carried out on the original image to suppress image noise, and a filtered image is obtained; performing weighted gray level conversion processing on the filtered image, and converting a color image into a gray level image by using a weight coefficient based on human visual characteristics; performing single-scale Retinex processing on the grayscale image, and estimating and separating illumination components to correct illumination unevenness and suppress reflection interference to obtain a final enhanced image; and outputting the final enhanced image for recognition of a subsequent target detection model. The method has the beneficial effects that after the technical scheme is subjected to multi-stage enhancement, the mAP50 of the target detection model is improved to 99.31% from 82.09% of an original image, and the recognition accuracy of 36 types of drugs such as propofol and fentanyl reaches a clinical practical standard.

This disclosure relates to a process for preparing 2,6-diisopropyl phenol. The process includes a step of decarboxylating 4-hydroxy-3,5-diisopropylbenzoic acid or one of its salts in an aqueous medium under pressure.

A drug combination based on an etomidate derivative and propofol, and a pharmaceutical composition thereof; and the use thereof in anesthesia, sedation and / or hypnosis of animals or humans. The drug combination based on an etomidate derivative and propofol or the pharmaceutical composition thereof exhibits great synergistic effects with respect to both separate administration and combined administration.

A piperazine substituted phenol derivative and its applications in pharmaceutical chemistry are provided. The compound, depicted by formula I, exhibits excellent salt formation properties and water solubility, meeting formulation requirements. It also has a low minimum effective anesthetic dose, enabling rapid onset and recovery. This addresses the drawbacks of propofol and ciprofol prodrugs and lipid emulsions. The compound shows promise in developing drugs with sedative, hypnotic, and / or anesthetic effects, as well as in drugs for controlling status epilepticus.

(Main claim) Disposal container for the irreversible deactivation of anesthetic drug residues, comprising a multi-layered binding system arranged from top to bottom and including: 1. an upper layer of adsorbent and / or ion exchange resin, 2. a middle layer of activated carbon or another adsorption matrix, 3. a lower layer of a polymer gel for solidifying residual liquids, the layers are designed in such a way that propofol, opioids and ketamine are bound and solidified sequentially, and recovery of the active ingredients is impossible.

The invention discloses a preparation method and application of a novel water-soluble propofol nano-composite, and relates to the technical field of nano-composite drug research and development, and the key points of the technical scheme are as follows: firstly, preparing Pdots from a conjugated polymer F8BT and an amphiphilic polymer PSMA through a nano coprecipitation method; then promoting a phenolic hydroxyl group of propofol and an acylation reagent chloroacetyl chloride to be subjected to a substitution reaction by DMAP to generate ester, and reacting amino on cystamine and an acyl chloride bond on the ester under the catalysis of potassium carbonate and potassium iodide to generate PPF-SS-NH2; carrying out condensation reaction on amino of the PPF-SS-Pdots and carboxyl of Pdots to obtain a PPF-SS-Pdots nano compound; and finally, synthesizing the PRP from the nano-composite and RVG-29 through an electrostatic adsorption effect. The anesthesia onset time and maintenance time of PRP are equivalent to those of common propofol, the awakening time is remarkably shortened, meanwhile, injection pain and other side effects are reduced, and rapid detection is achieved.

The application provides a combined drug for improving embryo implantation efficiency of RIF patients and a screening method, and belongs to the technical field of embryo implantation. In order to solve the problem of how to screen a general drug combination on the basis of a large heterogeneous RIF population, the application locks 1119 kinds of drugs that may have a therapeutic effect in a large range through a six-step screening method combined with advanced RNA sequencing technology, and then further screens the drugs by using a highly simulated endometrial epithelial organoid and stromal cell model, tests the influence of the 1119 kinds of drugs on the activity of the endometrial epithelial organoid and stromal cell, and finally screens 7 kinds of effective drugs which can form a broad-spectrum drug with significant therapeutic effect on RIF in a combined form. The 7 kinds of effective drugs screened by the application are icotinib, fumaric acid propofol tenofovir tablets, clopidogrel, tizacat, osimertinib, venetoclax and rebastinib.

The invention provides a combined medicine for improving the embryo implantation efficiency of RIF patients and a screening method, and belongs to the technical field of embryo implantation. In order to solve the problem of how to screen general drug combinations on the basis of a huge heterogeneity RIF group, 1119 drugs which possibly have treatment effects are locked in a large range through a six-step screening method in combination with an advanced RNA (Ribonucleic Acid) sequencing technology; the method comprises the following steps: selecting 1119 types of medicines, then further utilizing a highly simulated endometrial epithelium organ and interstitial cell model to screen medicines, testing the influence of the 1119 types of medicines on the activity of the endometrial epithelium organ and interstitial cell, and finally screening 7 types of effective medicines to form a broad-spectrum medicine with a remarkable curative effect on RIF through a combination form. The seven effective drugs screened by the invention are respectively icotinib, a propofol fumarate tenofovir tablet, clopidogrel, tizacarbox, osimertinib, Vinetogram and ribotinib.

The invention discloses a method for improving the detection sensitivity of propofol in whole blood, and belongs to the technical field of separation, analysis and detection. The anion and photoionization ion mobility spectrometry technology is used as a basic detection technology, no sample pretreatment is needed, and the ionization and thermal desorption efficiency is enhanced by adding an alcohol mixed auxiliary agent without peculiar smell into a sample carrier gas; the method solves the problems of low sensitivity and susceptibility to matrix interference when the conventional ion mobility spectrometry is used for detecting whole-blood propofol, reduces the detection limit to 0.1 ng / mu L or below, meets the rapid detection requirement of trace propofol, and is suitable for the scenes of clinical anesthesia monitoring, drug residue analysis and the like. According to the measurement method, analysis is performed after background signals are deducted in signal collection, and the method is simple, convenient, rapid, easy to correct and high in data accuracy and has wide clinical application prospects.