23 results about "Microbial contamination" patented technology

This invention discloses a method for preparing a water-based protective coating for pharmaceutical aluminum foil, relating to the field of pharmaceutical packaging materials technology. By using water as the core solvent, it solves the environmental pollution problems caused by traditional solvent-based coatings, while eliminating the fire safety hazards of flammable and explosive organic solvents. Furthermore, the addition of hydroxylated chitosan improves the adhesion between the coating and the aluminum foil substrate, effectively preventing coating peeling during transportation and storage, and also endows the coating with excellent antibacterial properties, reducing the risk of microbial contamination of pharmaceuticals. The introduction of polycaprolactone diol-modified acrylate significantly improves the coating's flexibility, preventing cracking at low temperatures, while also taking into account solvent resistance and abrasion resistance. This solves the problem of poor balance between flexibility and solvent resistance in existing water-based coatings, thereby ensuring the integrity of pharmaceutical packaging and the long-term stability of pharmaceutical quality.

The application discloses a stable anti-reversibility microbial community structure and a construction method and application thereof, and relates to the technical field of microbial community construction, and in particular to a stable anti-reversibility microbial community structure and a construction method and application thereof.

The present invention provides improved and / or shortened methods for expanding TILs and producing therapeutic populations of TILs, including novel methods for expanding TIL populations in a closed system that lead to improved efficacy, improved phenotype, and increased metabolic health of the TILs in a shorter time period, while allowing for reduced microbial contamination as well as decreased costs. Such TILs find use in therapeutic treatment regimens.

The utility model provides a kind of sterilization respiratory bag, belong to aseptic pharmaceutical technical field, including first piece and second piece, the bottom end and both sides of first piece and second piece are respectively heat-seal connection to form the bag body with the opening of upper end;First piece includes third piece and fourth piece sequentially heat-seal connection from top to bottom, and the middle heat-seal line is formed between third piece and fourth piece, second piece and third piece are transparent sheet layer, and fourth piece is breathable antibacterial sheet layer;The upper portion of bag body is provided with easy tear opening, and easy tear opening is located between opening and middle heat-seal line.The utility model provides a kind of sterilization respiratory bag, and easy tear opening is arranged between middle heat-seal line and opening, so that tear open operation is located in transparent sheet layer, avoid the risk that fiber debris or plastic microparticle is produced by breathable antibacterial sheet layer tearing, effectively avoid that microorganism pollution aseptic environment is carried by microparticle, and provide safeguard for the operation safety of medical, pharmaceutical and other high cleanliness scene.

This invention relates to the field of beer production technology and discloses a mixing device and process for beer production. The device includes a tank with an upper water pipe and a lower liquid pipe at its upper and lower ends, respectively. The side wall of the tank has inlet and outlet ports. An internal filter screen is installed inside the tank. The tank also contains a stirring shaft, a rotating ring, a vertical rod, an anchor-shaped paddle, and a tillering paddle. The stirring shaft is rotatably mounted inside the tank. This mixing device, through the arrangement of the stirring shaft, rotating ring, vertical rod, anchor-shaped paddle, and tillering paddle, and in conjunction with a lifting control mechanism, achieves synchronous reverse lifting and lowering movements of the anchor-shaped paddle and the tillering paddle. This eliminates the need to transfer the mash and malt between the mashing tank and the filter tank, thus completing the integrated mashing and malt washing process. This effectively shortens the production process, reduces equipment footprint, avoids heat loss and material residue during wort transfer, improves raw material utilization and production efficiency, reduces the risk of microbial contamination, and ultimately ensures the quality of the produced beer.

This utility model relates to the field of cell culture technology, specifically to a resealable, moisture-proof, and oxidation-proof dry powder cell culture medium bottle. It includes a storage bottle with a lower screw cap screwed onto its spout. An upper screw cap is screwed onto the top of the lower screw cap. A fixing plate is located in the center of the inner cavity of the lower screw cap. A rotating rod is rotatably connected to the top of the fixing plate via a bearing. A rotating plate is fixedly sleeved onto the outside of the rotating rod. Multiple storage cavities are formed on the rotating plate, and a baffle is located in the center of the inner cavity of each storage cavity. This utility model solves the problem that traditional dry powder cell culture medium bottles are typically single-use sealed structures. Although desiccants are added during packaging, they only provide some protection during the initial packaging. Once used and opened multiple times, their protective effect is greatly reduced, providing favorable conditions for microbial growth. Microbial contamination can damage the components of the culture medium and affect the normal progress of cell culture.

This utility model relates to the field of surface microbial sampling technology for aquatic products, specifically to an integrated sampling device for surface and deep microbial contamination of frozen aquatic products. It includes a grip and a sampling needle. A support plate is mounted at the bottom of the grip, and a groove is formed on the side wall of the support plate. A telescopic component for extending and retracting the sampling needle is installed within the groove. A breaking component is provided on the support plate for breaking the ice crystal layer on the surface of the frozen aquatic product during the extension and retraction of the sampling needle. This utility model overcomes the shortcomings of traditional sampling devices that can only perform single surface or deep sampling. Through its integrated design, it simplifies the operation process, reduces labor intensity, and improves sampling efficiency.

The utility model provides a kind of dicing equipment for edible mushroom processing, it is related to dicing equipment for edible mushroom processing technical field, the utility model includes operation platform, it is provided with conveyor belt on the operation platform, fixedly connected with gantry on the operation platform, slidingly connected with cutter in the gantry, it is provided with cleaning structure on the gantry, the cleaning structure is mainly composed of fixed plate, the fixed plate is fixedly connected on gantry, slidingly inserted with scraper on the fixed plate, fixedly connected with connecting block on the scraper, two slide rods are fixedly connected on the connecting block, the slide rod is slidingly inserted on the fixed plate, first spring is sleeved on the slide rod, one end of the first spring is fixedly connected on the connecting block, the utility model solves the problem that product quality is affected due to that edible mushroom is accumulated on blade surface for a long time, edible mushroom dice is easily contaminated by microorganism and deteriorated, bacteria breed.

The application belongs to the technical field of tea processing, and particularly discloses a processing method of white tea. The method aims at the problems of extensive existing Tianmu Lake white tea cake processing parameters, poor quality stability, insufficient health safety, and low utilization rate of fresh leaves of white tea, and uses the morning jade white one-bud-two-leaf Tianmu Lake white tea tender leaves in late April as raw materials. After the fresh leaf acceptance screening qualified raw materials, the temperature and humidity controllable natural withering is used to promote the transformation of tea leaf contents. According to the difference of tea cake specifications, the steaming pressure setting parameters are matched, and the large and small tea cake standardization setting is completed, and then the constant temperature ventilation drying process is used to lock the tea quality. Meanwhile, the application carries out the differential food-grade disinfection treatment on the packaging materials, avoids microbial pollution, and completes the white tea cake processing through clean packaging, constant temperature and humidity classification storage. The application precisely controls each processing procedure, improves the shape regularity and taste flavor of white tea cake, and can realize the high value deep processing of white tea.

According to the dialysis water microbial pollution detection equipment provided by the utility model, the antibacterial layer covering the surface of the flexible antibacterial covering film above the detection cavity can effectively inhibit the breeding of microorganisms at the contact part, and a user can drive the covering film to stably slide in the limiting edge only by rotating the first rotating shaft or the second rotating shaft, so that the detection efficiency is greatly improved. The unused, clean and sterile through hole area is rapidly and accurately moved to the working position above the detection cavity, the risk of cross contamination caused by long-term exposure of the detection cavity is avoided, the independence of each detection and the reliability of the result are ensured, a plurality of detection sites can be provided by a single roll of film covering, and the detection efficiency is improved. The replacement frequency of traditional disposable consumables is greatly reduced, the consumable cost and the waste treatment capacity are remarkably reduced, and the detection efficiency is improved; the arc-shaped guide sections at the two ends of the limiting edge can effectively guide the covering film to be in smooth transition, the covering film is prevented from being folded or clamped at the corner, it is guaranteed that the covering film slides smoothly and is located accurately, and the service life of the covering film is prolonged.

The present application belongs to the technical field of inactivation of pathogenic microorganisms in water bodies, and discloses a method for inactivating pathogenic microorganisms in water bodies by activating persulfate oxidation with Bordeaux mixture and application thereof. The method is as follows: Bordeaux mixture is added to water bodies contaminated with pathogenic microorganisms, and then a persulfate solution is added to form a reaction system, and the reaction system is shaken at room temperature to simulate real water bodies, so as to inactivate the pathogenic microorganisms. The present application provides a new method for inactivating pathogenic microorganisms such as Escherichia coli and Enterococcus faecalis in water bodies. Sulfate radicals and hydroxyl radicals are generated by activating persulfate with Bordeaux mixture, and alkaline copper sulfate and calcium sulfate precipitate and flocculate and settle the pathogenic bacteria residues in cooperation. The inactivation effect of the Bordeaux / PS system within 5 minutes reaches more than 99%.

The present invention provides improved and / or shortened methods for expanding TILs and producing therapeutic populations of TILs, including novel methods for expanding TIL populations in a closed system that lead to improved efficacy, improved phenotype, and increased metabolic health of the TILs in a shorter time period, while allowing for reduced microbial contamination as well as decreased costs. Such TILs find use in therapeutic treatment regimens.

The application discloses a human rhubarb extract with anti-influenza A virus activity and a preparation method thereof. The preparation method comprises the following steps: preparing the human rhubarb by fermenting licorice with an artificial synthetic flora (15 kinds of probiotics are mixed according to a specific ratio), and then performing ultrasonic extraction with water as a solvent; and the optimized extraction conditions are as follows: a solid-liquid ratio of 1:30 g / mL, an ultrasonic power of 500 W, an ultrasonic temperature of 50 DEG C, an ultrasonic time of 35 min, and an extraction frequency of 2 times. Compared with traditional extraction and decoction methods, the extract yield is higher, the inhibitory effect on H1N1 influenza A virus is significantly enhanced, the blood clotting titer of mouse lung tissue is reduced to 0.6+ / -0.4, and is equivalent to that of the positive drug oseltamivir phosphate. The application avoids the risk of pathogenic microorganism pollution in traditional pit fermentation, simplifies the medication mode, realizes the reduction and efficiency increase, the process is stable and controllable, is suitable for industrial production, and provides technical support for modern anti-influenza application of the human rhubarb.

The present invention provides improved and / or shortened methods for expanding TILs and producing therapeutic populations of TILs, including novel methods for expanding TIL populations in a closed system that lead to improved efficacy, improved phenotype, and increased metabolic health of the TILs in a shorter time period, while allowing for reduced microbial contamination as well as decreased costs. Such TILs find use in therapeutic treatment regimens.

The present invention provides improved and / or shortened methods for expanding TILs and producing therapeutic populations of TILs, including novel methods for expanding TIL populations in a closed system that lead to improved efficacy, improved phenotype, and increased metabolic health of the TILs in a shorter time period, while allowing for reduced microbial contamination as well as decreased costs. Such TILs find use in therapeutic treatment regimens.

This invention discloses a highly efficient offline cleaning method for microbial fouling of reverse osmosis membranes, belonging to the field of reverse osmosis membrane cleaning technology. The method includes: firstly, pre-treating the reverse osmosis membrane; then, placing it in a cleaning water tank containing nutrients for carbon source circulation; anaerobic fermentation; and finally, enhancing biofilm loosening through an aerobic-anaerobic environment. The membrane is then cleaned offline under high pressure, followed by alkaline washing, acid washing, and rinsing. The method of this invention achieves a reverse osmosis membrane standardized permeate flow recovery rate >80% and a pressure differential increase rate >1.8 Pa / m² after cleaning. 2 / h; After cleaning using this method, the standardized permeate flow rate of the reverse osmosis membrane recovered to >97%, and the rate of pressure differential increase decreased to 1.4 Pa / m 2 The method of this invention is more membrane-friendly and has wide applicability.

This utility model relates to the field of syringe manufacturing technology and discloses an airtightness testing device, including a platform. A support side plate is fixedly connected to one side of the upper end face of the platform, and a fixing plate is connected to one side of the support side plate. A connecting column is connected to the lower end face of the fixing plate, and an airtightness testing head for supplying air to the injection end of the syringe to be tested for airtightness testing is connected to the lower end of the connecting column. This utility model can provide basic protection for the opening of the water tank by setting a shielding structure. Secondly, when the syringe is inserted, its inner lip fits against the outer wall by elastic deformation, forming a double seal with the inner protrusion, completely blocking the contact between the test water and the air, avoiding the water from being contaminated by dust, microorganisms and oxidation, and maintaining the long-term cleanliness of the water. After the syringe is pulled out, the dust cover quickly closes the lip by elasticity to prevent impurities from adhering and negative pressure from being sucked in, achieving no leakage during insertion and no contamination during withdrawal.

The utility model provides a kind of detection device for detecting mould in food, including the detection box of one side setting sampling opening, the detection component of being movably installed in the detection box, and the sampling component of being movably installed in the detection box;The sampling component includes the sampling transmission piece of being movably installed in the detection box, the sampling piece of being installed on the sampling transmission piece, the closed movable piece of being movably installed in the detection box with the transmission connection of the sampling transmission piece, and the baffle of being installed on the closed movable piece;When the sampling piece enters the detection box from the sampling opening, the baffle covers the sampling opening;When the sampling piece is stretched from the detection box to the sampling opening, the baffle is opened from the sampling opening;The utility model discloses a kind of detection device for detecting mould in food, improve the accuracy of detection result, prevent the microbial pollution sample in external environment.

This invention relates to a portable kit for rapid detection of microbial contamination of water, which includes two vials containing lactose broth culture medium and bromothymol blue color indicator, a dropper for sample collection, and an activatable heating pad. The main innovation of this invention is the use of an insulated box covered with a foil layer and, together with the heating pad, acting as an independent incubator. The vials are fixed inside a cylindrical foam and the sample, after addition, is placed at the appropriate growth temperature without the need for an incubator. This system allows for rapid and field detection of water-polluting bacteria, especially coliforms and Escherichia coli.

This invention discloses a method for controlling the flavor stability of craft beer during storage, relating to the field of craft beer storage and quality control technology. It addresses the technical problems of easy oxidation, microbial contamination, flavor degradation, batch inconsistency, and lack of systematic control in existing craft beer storage. The method comprises six steps: pre-treatment before storage, graded constant temperature and humidity storage, dynamic environmental control, real-time flavor monitoring, emergency intervention, and post-storage re-freshness. Through precise parameter control and inhibition of oxidation and microbial growth, it achieves stable preservation of flavor substances, reduces off-flavors, extends shelf life, reduces losses, and is adaptable to various storage scenarios, demonstrating strong practicality.

The present disclosure relates to the technical field of organic fertilizer preparation related equipment, and an embodiment of the present disclosure provides a self-cleaning crushing equipment for biological organic fertilizer preparation, which comprises a shell, a top plate and a pretreatment box, the top plate is arranged at the top of the shell, the pretreatment box is arranged in the top plate, a feeding pipeline is connected to the side surface of the shell, a feeding crushing assembly is arranged on the top plate and the pretreatment box, an internal crushing assembly is arranged inside the shell, a feeding hopper is arranged at the upper end of the feeding pipeline, a movable cover is arranged in the top part of the pretreatment box, a second high-speed motor is arranged inside the movable cover, a crushing cutter head is arranged at the output end of the first high-speed motor, mesh holes are arranged at the bottom of the movable cover, and a water inlet pipe is arranged on the movable cover. Through the above technical scheme, the technical problem that residual materials are prone to corruption and deterioration due to long-term accumulation, causing microbial pollution, affecting the activity of the microbial population in the subsequent fermentation process, and leading to a decrease in the fertilizer efficiency of the organic fertilizer cannot be solved in the prior art.