The invention relates to the field of detection of harmful substances in
food contact materials and products, in particular to a method for simultaneously determining migration volumes of three
acrylamide compounds in
food contact materials and products, which comprises the following steps: S1, preparing a standard working solution, S2, preparing a food simulant, and S3, performing instrumental analysis. According to the method, the liquid
chromatography-
tandem mass spectrometry method is adopted for detection, the sensitivity is high, MRM
ion mode collection is achieved, the anti-interference capacity is high, and the three
acrylamide compounds can be measured at the same time. According to the method, the detection limits of three
acrylamide compounds in water-based, acidic,
ethanol-containing food simulants,
grease-containing food simulants and chemical substitute
solvent ethanol with the
volume fraction of 95% are all 0.005 mg / kg, the quantitation limits are all 0.01 mg / kg, the
recovery rate is 86.4%-98.8%, the
repeatability is 2.1%-9.5%, the precision is high, and the requirements of laws and regulations are met.